Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Wang, Haoran ^a   Liu, Lei ^a   Zhao, Jinzhao ^a   Cui, Guanglin ^a   Chen, Chen ^a   Ding, Hu ^a   Wang, Dao Wen ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE; GLUCOKINASE REGULATOR PROTEIN; GLUCOSE; GLUCOSE 6 PHOSPHATASE; MELATONIN RECEPTOR; PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ASIAN; CAUCASIAN; CONTROLLED STUDY; DISEASE PREDISPOSITION; ETHNICITY; FEMALE; G6PC2 GENE; GCK GENE; GCKR GENE; GENE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; MTNR1B GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; QUALITY CONTROL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FASTING; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE-6-PHOSPHATASE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR, MELATONIN, MT1; RISK;

EID: 84879515633     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067665     Document Type: Article

References (69)

1. Piche ME, Arcand-Bosse JF, Despres JP, Perusse L, Lemieux S, et al. (2004) What is a normal glucose value? Differences in indexes of plasma glucose homeostasis in subjects with normal fasting glucose. Diabetes Care 27: 2470-2477.
2. Tirosh A, Shai I, Tekes-Manova D, Israeli E, Pereg D, et al. (2005) Normal fasting plasma glucose levels and type 2 diabetes in young men. N Engl J Med 353: 1454-1462.
3. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, et al. (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42: 105-116.
4. Hu C, Zhang R, Wang C, Yu W, Lu J, et al. (2010) Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion. PLoS One 5: e11761.
5. Reiling E, van 't Riet E, Groenewoud MJ, Welschen LM, van Hove EC, et al. (2009) Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. Diabetologia 52: 1866-1870.
6. Cauchi S, Ezzidi I, El Achhab Y, Mtiraoui N, Chaieb L, et al. (2012) European genetic variants associated with type 2 diabetes in North African Arabs. Diabetes Metab 38: 316-323.
7. Takeuchi F, Katsuya T, Chakrewarthy S, Yamamoto K, Fujioka A, et al. (2010) Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations. Diabetologia 53: 299-308.
8. Matsutani A, Janssen R, Donis-Keller H, Permutt MA, (1992) A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p. Genomics 12: 319-325.
9. Warner JP, Leek JP, Intody S, Markham AF, Bonthron DT, (1995) Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization. Mamm Genome 6: 532-536.
10. Martin CC, Bischof LJ, Bergman B, Hornbuckle LA, Hilliker C, et al. (2001) Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes. J Biol Chem 276: 25197-25207.
11. Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, et al. (2009) Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 41: 82-88.
12. Rose CS, Ek J, Urhammer SA, Glumer C, Borch-Johnsen K, et al. (2005) A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites. Diabetes 54: 3026-3031.
13. Sparso T, Andersen G, Nielsen T, Burgdorf KS, Gjesing AP, et al. (2008) The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. Diabetologia 51: 70-75.
14. Tam CH, Ho JS, Wang Y, Lee HM, Lam VK, et al. (2010) Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects. PLoS One 5: e11428.
15. Rees SD, Hydrie MZ, O'Hare JP, Kumar S, Shera AS, et al. (2011) Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes. PLoS One 6: e24710.
16. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, et al. (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 6: e1000100.
17. Attia J, Thakkinstian A, D'Este C, (2003) Meta-analyses of molecular association studies: methodologic lessons for genetic epidemiology. J Clin Epidemiol 56: 297-303.
18. Thakkinstian A, McEvoy M, Minelli C, Gibson P, Hancox B, et al. (2005) Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review. Am J Epidemiol 162: 201-211.
19. Fleiss JL, (1993) The statistical basis of meta-analysis. Stat Methods Med Res 2: 121-145.
20. Higgins JP, Thompson SG, Deeks JJ, Altman DG, (2003) Measuring inconsistency in meta-analyses. BMJ 327: 557-560.
21. Petitti DB, (2001) Approaches to heterogeneity in meta-analysis. Stat Med 20: 3625-3633.
22. Begg CB, Mazumdar M, (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50: 1088-1101.
23. Egger M, Davey Smith G, Schneider M, Minder C, (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634.
24. Brito EC, Lyssenko V, Renstrom F, Berglund G, Nilsson PM, et al. (2009) Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults. Diabetes 58: 1411-1418.
25. Chen G, Bentley A, Adeyemo A, Shriner D, Zhou J, et al. (2012) Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans. Hum Mol Genet 21: 4530-4536.
26. Ramos E, Chen G, Shriner D, Doumatey A, Gerry NP, et al. (2011) Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans. Diabetologia 54: 783-788.
27. Renstrom F, Shungin D, Johansson I, Investigators M, Florez JC, et al. (2011) Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study. Diabetes 60: 345-354.
28. Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, et al. (2010) Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 42: 142-148.
29. Wagner R, Dudziak K, Herzberg-Schafer SA, Machicao F, Stefan N, et al. (2011) Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin. PLoS One 6: e23639.
30. Bonetti S, Trombetta M, Boselli ML, Turrini F, Malerba G, et al. (2011) Variants of GCKR affect both beta-cell and kidney function in patients with newly diagnosed type 2 diabetes: the Verona newly diagnosed type 2 diabetes study 2. Diabetes Care 34: 1205-1210.
31. Hishida A, Morita E, Naito M, Okada R, Wakai K, et al. (2012) Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese- a cross-sectional data from the J-MICC Study. Endocr J 59: 589-599.
32. Chambers JC, Zhang W, Zabaneh D, Sehmi J, Jain P, et al. (2009) Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians. Diabetes 58: 2703-2708.
33. Stancakova A, Paananen J, Soininen P, Kangas AJ, Bonnycastle LL, et al. (2011) Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men. Diabetes 60: 1608-1616.
34. Vaxillaire M, Cavalcanti-Proenca C, Dechaume A, Tichet J, Marre M, et al. (2008) The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. Diabetes 57: 2253-2257.
35. Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, et al. (2009) Variants in MTNR1B influence fasting glucose levels. Nat Genet 41: 77-81.
36. Balkau B, Lange C, Fezeu L, Tichet J, de Lauzon-Guillain B, et al. (2008) Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Diabetes Care 31: 2056-2061.
37. Xia Q, Chen ZX, Wang YC, Ma YS, Zhang F, et al. (2012) Association between the melatonin receptor 1B gene polymorphism on the risk of type 2 diabetes, impaired glucose regulation: a meta-analysis. PLoS One 7: e50107.
38. Tabara Y, Osawa H, Kawamoto R, Onuma H, Shimizu I, et al. (2011) Genotype risk score of common susceptible variants for prediction of type 2 diabetes mellitus in Japanese: the Shimanami Health Promoting Program (J-SHIPP study). Development of type 2 diabetes mellitus and genotype risk score. Metabolism 60: 1634-1640.
39. Olsson L, Pettersen E, Ahlbom A, Carlsson S, Midthjell K, et al. (2011) No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trondelag Health Study. Diabetologia 54: 1375-1378.
40. Cho YS, Chen CH, Hu C, Long J, Ong RT, et al. (2012) Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet 44: 67-72.
41. Kooner JS, Saleheen D, Sim X, Sehmi J, Zhang W, et al. (2011) Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet 43: 984-989.
42. Been LF, Hatfield JL, Shankar A, Aston CE, Ralhan S, et al. (2012) A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity. Nutr Metab Cardiovasc Dis 22: 944-951.
43. Bi M, Kao WH, Boerwinkle E, Hoogeveen RC, Rasmussen-Torvik LJ, et al. (2010) Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study. PLoS One 5: e11690.
44. Bouatia-Naji N, Rocheleau G, Van Lommel L, Lemaire K, Schuit F, et al. (2008) A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science 320: 1085-1088.
45. Cauchi S, Nead KT, Choquet H, Horber F, Potoczna N, et al. (2008) The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies. BMC Med Genet 9: 45.
46. Dietrich K, Birkmeier S, Schleinitz D, Breitfeld J, Enigk B, et al. (2011) Association and evolutionary studies of the melatonin receptor 1B gene (MTNR1B) in the self-contained population of Sorbs from Germany. Diabet Med 28: 1373-1380.
47. Ezzidi I, Mtiraoui N, Cauchi S, Vaillant E, Dechaume A, et al. (2009) Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study. BMC Med Genet 10: 33.
48. Florez JC, Jablonski KA, McAteer JB, Franks PW, Mason CC, et al. (2012) Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program. PLoS One 7: e44424.
49. Fujita H, Hara K, Shojima N, Horikoshi M, Iwata M, et al. (2012) Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits. J Hum Genet 57: 776-779.
50. Holmkvist J, Almgren P, Lyssenko V, Lindgren CM, Eriksson KF, et al. (2008) Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes. Diabetes 57: 1738-1744.
51. Iwata M, Maeda S, Kamura Y, Takano A, Kato H, et al. (2012) Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals. Diabetes Care 35: 1763-1770.
52. Ling Y, Li X, Gu Q, Chen H, Lu D, et al. (2011) Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study. BMC Med Genet 12: 66.
53. Ling Y, Li X, Gu Q, Chen H, Lu D, et al. (2011) A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals. Cardiovasc Diabetol 10: 27.
54. Liu C, Wu Y, Li H, Qi Q, Langenberg C, et al. (2010) MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai. BMC Med Genet 11: 59.
55. Mohas M, Kisfali P, Jaromi L, Maasz A, Feher E, et al. (2010) GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness? Cardiovasc Diabetol 9: 79.
56. Ng MC, Saxena R, Li J, Palmer ND, Dimitrov L, et al. (2013) Transferability and fine mapping of type 2 diabetes Loci in african americans: the candidate gene association resource plus study. Diabetes 62: 965-976.
57. Ohshige T, Iwata M, Omori S, Tanaka Y, Hirose H, et al. (2011) Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. PLoS One 6: e26911.
58. Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, et al. (2010) The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population. J Hum Genet 55: 600-604.
59. Qi Q, Wu Y, Li H, Loos RJ, Hu FB, et al. (2009) Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population. Diabetologia 52: 834-843.
60. Ronn T, Wen J, Yang Z, Lu B, Du Y, et al. (2009) A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia 52: 830-833.
61. Rose CS, Grarup N, Krarup NT, Poulsen P, Wegner L, et al. (2009) A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads. Diabetologia 52: 2122-2129.
62. Sparso T, Bonnefond A, Andersson E, Bouatia-Naji N, Holmkvist J, et al. (2009) G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans. Diabetes 58: 1450-1456.
63. Tabassum R, Chauhan G, Dwivedi OP, Mahajan A, Jaiswal A, et al. (2013) Genome-wide association study for type 2 diabetes in indians identifies a new susceptibility locus at 2q21. Diabetes 62: 977-986.
64. Vaxillaire M, Veslot J, Dina C, Proenca C, Cauchi S, et al. (2008) Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study. Diabetes 57: 244-254.
65. Wen J, Ronn T, Olsson A, Yang Z, Lu B, et al. (2010) Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. PLoS One 5: e9153.
66. Teo YY, Ong RT, Sim X, Tai ES, Chia KS, (2010) Identifying candidate causal variants via trans-population fine-mapping. Genet Epidemiol 34: 653-664.
67. Hunter DJ, (2005) Gene-environment interactions in human diseases. Nat Rev Genet 6: 287-298.
68. Yang Q, Khoury MJ, Sun F, Flanders WD, (1999) Case-only design to measure gene-gene interaction. Epidemiology 10: 167-170.
69. Weber MB, Oza-Frank R, Staimez LR, Ali MK, Narayan KM, (2012) Type 2 diabetes in Asians: prevalence, risk factors, and effectiveness of behavioral intervention at individual and population levels. Annu Rev Nutr 32: 417-439.