MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai

BMC Medical Genetics

Volumn 11, Issue 1, 2010, Pages

  Liu, Chen ^a,b   Wu, Ying ^a,b   Li, Huaixing ^a,b   Qi, Qibin ^a,b   Langenberg, Claudia ^c   Loos, Ruth J F ^c   Lin, Xu ^a,b  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INSULIN; MELATONIN 1 RECEPTOR; PROTEIN MTNR1B; UNCLASSIFIED DRUG; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; MELATONIN 2 RECEPTOR;

ADULT; AGED; ARTICLE; ASIAN; CHINA; CHINESE; COHORT ANALYSIS; CONTROLLED STUDY; EFFECT SIZE; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; POPULATION RESEARCH; SLEEP DISORDER; BLOOD; DIET RESTRICTION; ETHNIC GROUP; ETHNOLOGY; GENETIC VARIABILITY; GENETICS; HOMEOSTASIS; INSULIN RESISTANCE; INTRON; METABOLISM; MIDDLE AGED; PATHOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEP;

ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD GLUCOSE; CHINA; COHORT STUDIES; ETHNIC GROUPS; FASTING; GENETIC VARIATION; HEMOGLOBIN A, GLYCOSYLATED; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; INTRONS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, MELATONIN, MT2; SLEEP;

EID: 77950641869     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-11-59     Document Type: Article

References (15)

1. Green CB, Takahashi JS, Bass J. The meter of metabolism. Cell 2008, 134(5):728-742. 10.1016/j.cell.2008.08.022, 18775307.
2. Peschke E. Melatonin, endocrine pancreas and diabetes. JPineal Res 2008, 44(1):26-40.
3. Dubocovich ML. Melatonin receptors: role on sleep and circadian rhythm regulation. Sleep Med 2007, 8(Suppl 3):34-42. 10.1016/j.sleep.2007.10.007, 18032103.
4. Ramracheya RD, Muller DS, Squires PE, Brereton H, Sugden D, Huang GC, Amiel SA, Jones PM, Persaud SJ. Function and expression of melatonin receptors on human pancreatic islets. JPineal Res 2008, 44(3):273-279.
5. Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spegel P, Bugliani M, Saxena R, Fex M, Pulizzi N, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. NatGenet 2009, 41(1):82-88.
6. Bouatia-Naji N, Bonnefond A, Cavalcanti-Proenca C, Sparso T, Holmkvist J, Marchand M, Delplanque J, Lobbens S, Rocheleau G, Durand E, et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. NatGenet 2009, 41(1):89-94.
7. Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, et al. Variants in MTNR1B influence fasting glucose levels. NatGenet 2009, 41(1):77-81.
8. Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA, Varilo T, Kaakinen M, et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. NatGenet 2009, 41(1):35-46.
9. Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJ, Wareham NJ, Walker M. Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response. Diabetologia 2009, 52(8):1537-1542. 10.1007/s00125-009-1392-x, 2709880, 19455304.
10. Reiling E, van't Riet E, Groenewoud MJ, Welschen LM, van Hove EC, Nijpels G, Maassen JA, Dekker JM, t Hart LM. Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. Diabetologia 2009, 52(9):1866-1870. 10.1007/s00125-009-1413-9, 2723681, 19533084.
11. Sparso T, Bonnefond A, Andersson E, Bouatia-Naji N, Holmkvist J, Wegner L, Grarup N, Gjesing AP, Banasik K, Cavalcanti-Proenca C, et al. G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans. Diabetes 2009, 58(6):1450-1456. 10.2337/db08-1660, 19324940.
12. Takeuchi F, Katsuya T, Chakrewarthy S, Yamamoto K, Fujioka A, Serizawa M, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, et al. Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations. Diabetologia 53(2):299-308. 10.1007/s00125-009-1595-1, 19937311.
13. Ronn T, Wen J, Yang Z, Lu B, Du Y, Groop L, Hu R, Ling C. A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia 2009, 52(5):830-833. 10.1007/s00125-009-1297-8, 19241057.
14. Staiger H, Machicao F, Schafer SA, Kirchhoff K, Kantartzis K, Guthoff M, Silbernagel G, Stefan N, Haring H-U, Fritsche A. Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function. PLoS ONE 2008, 3(12):e3962. 10.1371/journal.pone.0003962, 2597741, 19088850.
15. Ye X, Yu Z, Li H, Franco OH, Liu Y, Lin X. Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people. JAmCollCardiol 2007, 49(17):1798-1805.