Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits

Journal of Human Genetics

Volumn 57, Issue 12, 2012, Pages 776-779

  Fujita, Hayato ^a   Hara, Kazuo ^a   Shojima, Nobuhiro ^a   Horikoshi, Momoko ^a   Iwata, Minoru ^b   Hirota, Yushi ^c   Tobe, Kazuyuki ^b   Seino, Susumu ^c   Kadowaki, Takashi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

common disease; single nucleotide polymorphism; type 2 diabetes

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INSULIN;

AGED; ARTICLE; CONTROLLED STUDY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HIGH RISK POPULATION; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL MARKERS; BLOOD GLUCOSE; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INSULIN; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84871504859     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2012.110     Document Type: Article

References (17)

1. Stumvoll, M., Goldstein, B. J. & van Haeften, T. W. Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365, 1333-1346 (2005).
2. Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D. et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445, 881-885 (2007).
3. Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J, Li, Y, Duren, W. L. et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316, 1341-1345 (2007).
4. Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U. et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat. Genet. 42, 105-U32 (2010).
5. Yasuda, K., Miyake, K., Horikawa, Y., Hara, K., Osawa, H., Furuta, H. et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat. Genet. 40, 1092-1097 (2008).
6. Unoki, H., Takahashi, A., Kawaguchi, T., Hara, K., Horikoshi, M., Andersen, G. et al. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat. Genet. 40, 1098-1102 (2008).
7. Yamauchi, T., Hara, K., Maeda, S., Yasuda, K., Takahashi, A., Horikoshi, M. et al. A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat. Genet. 42, 864-868 (2010).
8. Takeuchi, F., Serizawa, M., Yamamoto, K., Fujisawa, T., Nakashima, E., Ohnaka, K. et al. Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 58, 1690-1699 (2009).
9. Mori, S., Tanaka, Y., Takahashi, A., Hirose, H., Kashiwagi, A., Kaku, K et al. Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 57, 791-795 (2008).
10. Ohshige, T., Iwata, M., Omori, S., Tanaka, Y., Hirose, H., Kaku, K. et al. Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. PLoS One 6, e26911 (2011).
11. Gibson, G. Rare and common variants: twenty arguments. Nat. Rev. Genet. 13, 135-145 (2011).
12. Alberti, K. G. & Zimmet, P. Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet. Med. 15, 539-553 (1998).
13. Horikoshi, M., Hara, K., Ito, C., Nagai, R., Froguel, P. & Kadowaki, T. A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population. Diabetologia 50, 747-751 (2007).
14. Horikoshi, M., Hara, K., Ito, C., Shojima, N., Nagai, R., Ueki, K. et al. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia 50, 2461-2466 (2007).
15. Iwata, M., Maeda, S., Kamura, Y., Takano, A., Kato, H., Murakami, S. et al. Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals. Diabetes Care 35, 1763-1770 (2012).
16. Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate-a practical and powerful approach to multiple testing. J. Roy. Stat. Soc. Ser. B 57, 289-300 (1995).
17. Hu, C., Zhang, R., Wang, C., Wang, J., Ma, X., Hou, X. et al. Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese. PLoS One 5, e15542 (2010).