More insights into the immunosuppressive potential of tumor exosomes

Journal of Translational Medicine

Volumn 6, Issue , 2008, Pages

  Huber, Veronica ^a   Filipazzi, Paola ^a   Iero, Manuela ^a   Fais, Stefano ^b   Rivoltini, Licia ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CANCER VACCINE; CARCINOEMBRYONIC ANTIGEN; CD11B ANTIGEN; CD14 ANTIGEN; CD86 ANTIGEN; CERAMIDE; CHOLESTEROL; CURCUMIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FAS LIGAND; GANGLIOSIDE GM3; GLYCOPROTEIN GP 100; HLA ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 2; MATRIX METALLOPROTEINASE; MELAN A; NATURAL KILLER CELL RECEPTOR NKG2D; SPHINGOMYELIN; T LYMPHOCYTE RECEPTOR; TAXANE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VASCULOTROPIN; VINCA ALKALOID; VINCRISTINE;

ADVANCED CANCER; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTINEOPLASTIC ACTIVITY; B LYMPHOCYTE; BREAST CARCINOMA; CANCER IMMUNIZATION; CELL CONTACT; CELL MATURATION; CLINICAL TRIAL; COLON CARCINOMA; CROSS PRESENTATION; CYTOKINE RELEASE; DENDRITIC CELL; DRUG SELECTIVITY; DRUG TARGETING; EDITORIAL; EXOCYTOSIS; EXOSOME; HEAD AND NECK CANCER; HUMAN; MELANOMA; NATURAL KILLER CELL; PROTEIN EXPRESSION; RETICULOCYTE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TUMOR ESCAPE; TUMOR IMMUNITY; ANIMAL; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; NEOPLASM; NOTE; PATHOLOGY;

ANIMALS; EXOSOMES; HUMANS; IMMUNE TOLERANCE; NEOPLASMS;

EID: 57249105222     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-6-63     Document Type: Editorial

References (34)

1. Ichim TE Zhong Z Kaushal S Zheng X Ren X Hao X Joyce JA Hanley HH Riordan NH Koropatnick J Bogin V Minev BR Min WP Tullis RH Exosomes as a tumor immune escape mechanism: Possible therapeutic implications J Transl Med 2008, 6:37. 2504474 18644158
2. Valenti R Huber V Iero M Filipazzi P Parmiani G Rivoltini L Tumor-released microvesicles as vehicles of immunosuppression Cancer Res 2007, 67:2912-2915. 17409393
3. Iero M Valenti R Huber V Filipazzi P Parmiani G Fais S Rivoltini L Tumour-released exosomes and their implications in cancer immunity Cell Death Differ 2008, 15:80-88. 17932500
4. Marincola FM Jaffee EM Hicklin DJ Ferrone S Escape of human solid tumors from T-cell recognition: Molecular mechanisms and functional significance Adv Immunol 2000, 74:181-273. 10605607
5. Rivoltini L Canese P Huber V Iero M Pilla L Valenti R Fais S Lozupone F Casati C Castelli C Parmiani G Escape strategies and reasons for failure in the interaction between tumour cells and the immune system: How can we tilt the balance towards immune-mediated cancer control? Expert Opin Biol Ther 2005, 5:463-476. 15934826
6. van Niel G Porto-Carreiro I Simoes S Raposo G Exosomes: A common pathway for a specialized function J Biochem 2006, 140:13-21. 16877764
7. Johnstone RM The Jeanne Manery-Fisher Memorial Lecture 1991. Maturation of reticulocytes: Formation of exosomes as a mechanism for shedding membrane proteins Biochem Cell Biol 1992, 70:179-190. 1515120
8. Johnstone RM Exosomes biological significance: A concise review Blood Cells Mol Dis 2006, 36:315-321. 16487731
9. Andre F Schartz NE Movassagh M Flament C Pautier P Morice P Pomel C Lhomme C Escudier B Le Chevalier T Tursz T Amigorena S Raposo G Angevin E Zitvogel L Malignant effusions and immunogenic tumour-derived exosomes Lancet 2002, 360:295-305. 12147373
10. Andreola G Rivoltini L Castelli C Huber V Perego P Deho P Squarcina P Accornero P Lozupone F Lugini L Stringaro A Molinari A Arancia G Gentile M Parmiani G Fais S Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles J Exp Med 2002, 195:1303-1316. 2193755 12021310
11. Huber V Fais S Iero M Lugini L Canese P Squarcina P Zaccheddu A Colone M Arancia G Gentile M Seregni E Valenti R Ballabio G Belli F Leo E Parmiani G Rivoltini L Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: Role in immune escape Gastroenterology 2005, 128:1796-1804. 15940614
12. Chaput N Schartz NE Andre F Zitvogel L Exosomes for immunotherapy of cancer Adv Exp Med Biol 2003, 532:215-221. 12908560
13. Taylor DD Gerçel-Taylor C Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects Br J Cancer 2005, 92:305-311. 15655551
14. Whiteside TL Tumour-derived exosomes or microvesicles: Another mechanism of tumour escape from the host immune system? Br J Cancer 2005, 92:209-211. 15702078
15. Hahne M Rimoldi D Schröter M Romero P Schreier M French LE Schneider P Bornand T Fontana A Lienard D Cerottini J Tschopp J Melanoma cell expression of Fas(Apo-1/CD95) ligand: Implications for tumor immune escape Science 1996, 274:1363-1366. 8910274
16. Kim JW Wieckowski E Taylor DD Reichert TE Watkins S Whiteside TL Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes Clin Cancer Res 2005, 11:1010-1020. 15709166
17. Clayton A Mitchell JP Court J Mason MD Tabi Z Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2 Cancer Res 2007, 67:7458-7466. 17671216
18. Clayton A Mitchell JP Court J Linnane S Mason MD Tabi Z Human tumor-derived exosomes down-modulate NKG2D expression J Immunol 2008, 180:7249-7258. 18490724
19. Valenti R Huber V Filipazzi P Pilla L Sovena G Villa A Corbelli A Fais S Parmiani G Rivoltini L Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes Cancer Res 2006, 66:9290-9298. 16982774
20. Filipazzi P Valenti R Huber V Pilla L Canese P Iero M Castelli C Mariani L Parmiani G Rivoltini L Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine J Clin Oncol 2007, 25:2546-2553. 17577033
21. Serafini P Borrello I Bronte V Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression Semin Cancer Biol 2006, 16:53-65. 16168663
22. Yu S Liu C Su K Wang J Liu Y Zhang L Li C Cong Y Kimberly R Grizzle WE Falkson C Zhang HG Tumor exosomes inhibit differentiation of bone marrow dendritic cells J Immunol 2007, 178:6867-6875. 17513735
23. Théry C Zitvogel L Amigorena S Exosomes: Composition, biogenesis and function Nat Rev Immunol 2002, 2:569-579. 12154376
24. Gould SJ Booth AM Hildreth JE The Trojan exosome hypothesis Proc Natl Acad Sci USA 2003, 100:10592-10597. 196848 12947040
25. Fevrier B Vilette D Archer F Loew D Faigle W Vidal M Laude H Raposo G Cells release prions in association with exosomes Proc Natl Acad Sci USA 2004, 9683:9688-470735. 15210972
26. Trajkovic K Hsu C Chiantia S Rajendran L Wenzel D Wieland F Schwille P Brügger B Simons M Ceramide triggers budding of exosome vesicles into multivesicular endosomes Science 2008, 319:1244-1247. 18309083
27. Subra C Laulagnier K Perret B Record M Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies Biochimie 2007, 89:205-212. 17157973
28. Al-Nedawi K Meehan B Micallef J Lhotak V May L Guha A Rak J Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells Nat Cell Biol 2008, 10:619-624. 18425114
29. Gesierich S Berezovskiy I Ryschich E Zöller M Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029 Cancer Res 2006, 66:7083-7094. 16849554
30. Valadi H Ekström K Bossios A Sjöstrand M Lee JJ Lötvall JO Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells Nature Cell Biol 2007, 9:654-659. 17486113
31. Groth-Pedersen L Ostenfeld MS Høyer-Hansen M Nylandsted J Jäättelä M Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine Cancer Res 2007, 67:2217-2225. 17332352
32. Luciani F Spada M De Milito A Molinari A Rivoltini L Montinaro A Marra M Lugini L Logozzi M Lozupone F Federici C Iessi E Parmiani G Arancia G Belardelli F Fais S Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs J Natl Cancer Inst 2004, 96(22):1702-1713. 15547183
33. Hang HG Kim H Liu C Yu S Wang J Grizzle WE Kimberly RP Barnes S Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity Biochim Biophys Acta 2007, 1773:1116-1123. 17555831 2577190
34. Cheng P Corzo CA Luetteke N Yu B Nagaraj S Bui MM Ortiz M Nacken W Sorg C Vogl T Roth J Gabrilovich DI Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein J Exp Med 2008, 205:2235-2249. 18809714