5-HTTLPR X stress in adolescent depression: Moderation by MAOA and gender

Journal of Abnormal Child Psychology

Volumn 41, Issue 2, 2013, Pages 281-294

  Priess Groben, Heather A ^a,b   Hyde, Janet Shibley ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Adolescent development; Behavioral genetics; Depression; Gender differences

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); SEROTONIN; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

ADOLESCENT; ADOLESCENT DEVELOPMENT; ADULT; ALLELE; ARTICLE; BEHAVIOR GENETICS; BIOLOGICAL MODEL; CHILD; DEPRESSION; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; LIFE EVENT; LONGITUDINAL STUDY; MALE; MENTAL STRESS; METABOLISM; PHYSIOLOGY; REGRESSION ANALYSIS; SEXUAL DEVELOPMENT; VARIABLE NUMBER OF TANDEM REPEAT;

ADOLESCENT; ADOLESCENT DEVELOPMENT; ADULT; ALLELES; CHILD; DEPRESSION; FEMALE; GENE FREQUENCY; GENETICS, BEHAVIORAL; GENOTYPE; HUMANS; LIFE CHANGE EVENTS; LONGITUDINAL STUDIES; MALE; MINISATELLITE REPEATS; MODELS, GENETIC; MONOAMINE OXIDASE; POLYMORPHISM, GENETIC; REGRESSION ANALYSIS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX CHARACTERISTICS; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 84879463948     PISSN: 00910627     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10802-012-9672-1     Document Type: Article

References (91)

1. Achenbach, T. M.; & Rescorla, L. A. (2001). Manual for the ASEBA school-age forms & profiles. Burlington: University of Vermont, Research Center for Children, Youth, & Families.
2. Angold, A. (1988). Childhood and adolescent depression. I. Epidemiological and aetiological aspects. The British Journal of Psychiatry, 152, 601-617.
3. Arbuckle, J. L. (1996). Full information estimation in the presence of incomplete data. In G. A. Marcoulides & R. E. Schumacker (Eds.), Advanced structural equation modeling: Issues and techniques (pp. 243-277). Mahwah: Erlbaum.
4. Asherson, P.; & Price, T. S. (2012). Commentary: replication, replication, replication: the continued need to substantiate GxE effects in child psychopathology - a response to Laucht et al. (2012). Journal of Child Psychology and Psychiatry, 53, 360-362.
5. Åslund, C.; Leppert, J.; Comasco, E.; Nordquist, N.; Oreland, L.; & Nilsson, K. W. (2009). Impact of the interaction between the 5HTTLPR polymorphism and maltreatment on adolescent depression. A population-based study. Behavior Genetics, 39, 524-531.
6. Åslund, C.; Nordquist, N.; Comasco, E.; Leppert, J.; Oreland, N.; & Nilsson, K. W. (2011). Maltreatment, MAOA, and delinquency: sex differences in gene-environment interaction in a large population-based cohort of adolescents. Behavior Genetics, 41, 262-272.
7. Belsky, J.; & Pluess, M. (2009). Beyond diathesis stress: differential susceptibility to environmental influences. Psychological Bulletin, 135, 885-908.
8. Benmansour, S.; Weaver, R. S.; Barton, A. K.; Adeniji, O. S.; & Frazer, A. (2012). Comparison of the effects of estradiol and progesterone on serotonergic function. Biological Psychiatry, 71, 633-641.
9. Bethea, C. L.; Pecins-Thompson, M.; Schutzer, W. E.; Gundlah, C.; & Lu, Z. N. (1998). Ovarian steroids and serotonin neural function. Molecular Neurobiology, 18, 87-123. (Pubitemid 29083005)
10. Bose, C. E. (1985). Jobs and gender: A study of occupational prestige. New York: Praeger.
11. Brummett, B. H.; Krystal, A. D.; Siegler, I. C.; Kuhn, C.; Surwit, R. S.; Züchner, S.; et al. (2007). Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. Psychosomatic Medicine, 69, 396-401. (Pubitemid 46987881)
12. Brummett, B. H.; Boyle, S. H.; Siegler, I. C.; Kuhn, C. M.; Ashley-Koch, A.; Jonassaint, C. R.; et al. (2008). Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). Behavior Genetics, 38, 34-43. (Pubitemid 351164912)
13. Caputo, J. L.; Rudolph, D. L.; & Morgan, D. W. (1998). Influence of positive life events on blood pressure in adolescents. Journal of Behavioral Medicine, 21, 115-129. (Pubitemid 28231992)
14. Casey, B. J.; Glatt, C. E.; Tottenham, N.; Soliman, F.; Bath, K.; Amso, D.; et al. (2009). Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development. Neuroscience, 164, 108-120.
15. Caspi, A.; Sugden, K.; Moffitt, T. E.; Taylor, A.; Craig, I. W.; Harrington, H.; et al. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389. (Pubitemid 36877077)
16. Cicchetti, D.; Rogosch, F. A.; & Sturge-Apple, M. L. (2007). Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: depressive symptomatology among adolescents from low socioeconomic status backgrounds. Development and Psychopathology, 19, 1161-1180. (Pubitemid 47578019)
17. Coleman, C. A.; Friedman, A. G.; & Burright, R. G. (1998). The relationship of daily stress and health-related behaviors to adolescents' cholesterol levels. Adolescence, 33, 447-460. (Pubitemid 128453583)
18. Compas, C.; Davis, G.; Forsythe, C.; & Wagner, B. (1987). Assessment of major and daily stressful events during adolescence: the Adolescent Perceived Events Scale. Journal of Consulting and Clinical Psychology, 55, 534-541.
19. 1A receptor binding in humans. Journal of Neuroscience, 25, 2586-2590. (Pubitemid 40365170)
20. Deckert, J.; Catalano, M.; Syagailo, Y. V.; Bosi, M.; Okladnova, O.; Di Bella, D.; et al. (1999). Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Human Molecular Genetics, 8, 621-624. (Pubitemid 29139976)
21. Denney, R. M.; Koch, H.; & Craig, I. W. (1999). Association between monoamine oxidase A activity in human male skin fibroblasts and genotype of the MAOA promoter-associated variable number tandem repeat. Human Genetics, 105, 542-551. (Pubitemid 30026030)
22. Doornbos, B.; Janneke Dijck-Brouwer, D. A.; Kema, I. P.; Tanke, M. A. C.; van Goor, S. A.; Muskiet, F. A. J.; et al. (2009). The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT, and COMT. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33, 1250-1254.
23. Duncan, L. E.; & Keller, M. C. (2011). A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. The American Journal of Psychiatry, 168, 1041-1049.
24. Eley, T. C.; Sugden, K.; Corsico, A.; Gregory, A. M.; Sham, P.; McGuffin, P.; et al. (2004). Gene-environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry, 9, 908-915. (Pubitemid 39381955)
25. Elhwuegi, A. S. (2004). Central monoamines and their role in major depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 28, 435-451. (Pubitemid 38490755)
26. Ellegren, H.; & Parsch, J. (2007). The evolution of sex-biased genes and sex-biased gene expression. Nature Reviews Genetics, 8, 689-698. (Pubitemid 47281991)
27. Fan, M.; Liu, B.; Jiang, T.; Jiang, X.; Zhao, H.; & Zhang, J. (2010). Meta-analysis of the association between the monoamine oxidase-A gene and mood disorders. Psychiatric Genetics, 20, 1-7.
28. Fowler, J. S.; Alia-Klein, N.; Kriplani, A.; Logan, J.; Williams, B.; Zhu, W.; et al. (2007). Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects. Biological Psychiatry, 62, 355-358. (Pubitemid 47444275)
29. Gotlib, I. H.; Lewinsohn, P. M.; & Seeley, J. R. (1995). Symptoms versus a diagnosis of depression: differences in psychosocial functioning. Journal of Consulting and Clinical Psychology, 63, 90-100.
30. Gundlah, C.; Lu, N. Z.; & Bethea, C. L. (2002). Ovarian steroid regulation of monoamine oxidase-A and -B mRNAs in the macaque dorsal raphe and hypothalamic nuclei. Psychopharmacology, 160, 271-282. (Pubitemid 34230679)
31. Gutiérrez, B.; Arias, B.; Gastó, C.; Catalán, R.; Papiol, S.; Pintor, L.; et al. (2004). Association analysis between a functional polymorphism in the monoamine oxidase A gene promoter and severe mood disorders. Psychiatric Genetics, 14, 203-208. (Pubitemid 40054346)
32. Hammen, C. (1991). Generation of stress in the course of unipolar depression. Journal of Abnormal Psychology, 100, 555-561.
33. Hammen, C.; Brennan, P. A.; Keenan-Miller, D.; Hazel, N. A.; & Najman, J. M. (2010). Chronic and acute stress, gender, and serotonin transporter gene-environment interactions predicting depression symptoms in youth. Journal of Child Psychology and Psychiatry, 51, 180-187.
34. Hankin, B. L.; Abramson, L. Y.; Moffitt, T. E.; Silva, P. A.; McGee, R.; & Angell, K. E. (1998). Development of depression from preadolescence to young adulthood: emerging gender differences in a 10-year longitudinal study. Journal of Abnormal Psychology, 107, 128-140. (Pubitemid 28102960)
35. Hankin, B. L.; Fraley, R. C.; Lahey, B. B.; & Waldman, I. (2005). Is youth depressive disorder best viewed as a continuum or discrete category? A taxometric analysis of childhood and adolescent depression in a population-based sample. Journal of Abnormal Psychology, 114, 96-110. (Pubitemid 40261859)
36. Hankin, B. L.; Jenness, J.; Abela, J. Z.; & Smolen, A. (2011a). Interaction of 5-HTTLPR and idiographic stressors predicts prospective depressive symptoms specifically among youth in a multiwave design. Journal of Clinical Child and Adolescent Psychology, 40, 572-585.
37. Hankin, B. L.; Nederhof, E.; Oppenheimer, C. W.; Jenness, J.; Young, J. F.; Abela, J. R. Z.; et al. (2011b). Differential susceptibility in youth: evidence that 5-HTTLPR x positive parenting is associated with positive affect 'for better and worse. Translational Psychiatry, 1, e44.
38. Heils, A.; Teufel, A.; Petri, S.; Stöber, G.; Riederer, P.; Bengel, D.; et al. (1996). Allelic variation of human serotonin transporter gene expression. Journal of Neurochemisty, 66, 2621-2624. (Pubitemid 26159101)
39. Herman, A. I.; Kaiss, K. M.; Ma, R.; Philbeck, J. W.; Hasan, A.; Dasti, H.; et al. (2005). Serotonin transporter promoter polymorphism and monoamine oxidase type A VNTR allelic variants together influence alcohol binge drinking risk in young women. American Journal of Medical Genetics, Neuropsychiatric Genetics, Part B, 133B, 74-78. (Pubitemid 40175619)
40. Hilt, L. M.; Sander, L. C.; Nolen-Hoeksema, S.; & Simen, A. A. (2007). The BDNF Val66Met polymorphism predicts rumination and depression differently in young adolescent girls and their mothers. Neuroscience Letters, 429, 12-16. (Pubitemid 350116345)
41. Homberg, J. R.; & Lesch, K. P. (2011). Looking on the bright side of serotonin transporter gene variation. Biological Psychiatry, 69, 513-519.
42. Hu, X. Z.; Lipsky, R. H.; Zhu, G.; Akhtar, L. A.; Taubman, J.; Greenberg, B. D.; et al. (2006). Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. American Journal of Human Genetics, 78, 815-826.
43. Hyde, J. S.; Klein, M. H.; Essex, M. J.; & Clark, R. (1995). Maternity leave and women's mental health. Psychology of Women Quarterly, 19, 257-285.
44. Hyde, J. S.; Mezulis, A. H.; & Abramson, L. Y. (2008). The ABCs of depression: integrating affective, biological, and cognitive models to explain the emergence of a gender difference in depression. Psychological Review, 115, 291-313.
45. Jenness, J. L.; Hankin, B. L.; Abela, J. Z.; Young, J. F.; & Smolen, A. (2011). Chronic family stress interacts with 5-HTTLPR to predict prospective depressive symptoms among youth. Depression and Anxiety, 28, 1074-1080.
46. Josephs, R. A.; Telch, M. J.; Hixon, J. G.; Evans, J. J.; Lee, H.; Knopik, V. S.; et al. (2011). Genetic and hormonal sensitivity to threat: testing a serotonin transporter genotype x testosterone interaction. Psychoneuroendocrinology. Advance of publication.
47. Karg, K.; Burmeister, M.; Shedden, K.; & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Archives of General Psychiatry, 68, 444-454.
48. Karssen, A. M.; Her, S.; Li, J. Z.; Patel, P. D.; Meng, F.; Bunney, W. E.; Jr.; et al. (2007). Stress-induced changes in primate prefrontal profiles of gene expression. Molecular Psychiatry, 12, 1089-1102. (Pubitemid 350191369)
49. Kessler, R. C. (2003). Epidemiology of women and depression. Journal of Affective Disorders, 74, 5-13. (Pubitemid 36329172)
50. Kessler, R.; McGonagle, K.; Swartz, M.; Blazer, D.; & Nelson, C. (1993). Sex and depression in the National Comorbidity Survey. I: lifetime prevalence, chronicity and recurrence. Journal of Affective Disorders, 29, 85-96. (Pubitemid 23334116)
51. Kim-Cohen, J.; Caspi, A.; Taylor, A.; Williams, B.; Newcombe, R.; Craig, I. W.; et al. (2006). MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis. Molecular Psychiatry, 11, 903-913. (Pubitemid 44470213)
52. Klein, D. N.; Dougherty, L. R.; & Olino, T. M. (2005). Toward guidelines for evidence-based assessment of depression in children and adolescents. Journal of Clinical Child and Adolescent Psychology, 34, 412-432. (Pubitemid 41355522)
53. Kovacs, M. (1981). The Children's Depression Inventory (CDI). Psychopharmacology Bulletin, 21, 995-998.
54. Kraft, J. B.; Slager, S. L.; McGrath, P. J.; & Hamilton, S. P. (2005). Sequence analysis of the serotonin transporter and associations with antidepressant response. Biological Psychiatry, 58, 374-381. (Pubitemid 41219705)
55. Lander, E. S.; & Schork, N. J. (1994). Genetic dissection of complex traits. Science, 265, 2037-2048. (Pubitemid 24325685)
56. Laucht, M.; Treutlein, J.; Blomeyer, D.; Buchmann, A. F.; Schmid, B.; Becker, K.; et al. (2009). Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adults. The International Journal of Neuropsychopharmacology, 12, 737-747.
57. Lesch, K. P.; Bengel, D.; Heils, A.; Sabol, S. Z.; Greenberg, B. D.; Petri, S.; et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531. (Pubitemid 26403928)
58. Marmorstein, N. R.; & Hart, D. (2011). Interactions between MAOA genotype and receipt of public assistance: predicting change in depressive symptoms and body mass index. Journal of Research on Adolescence, 21, 619-630.
59. McGuffin, P.; Alsabban, S.; & Uher, R. (2011). The truth about genetic variation in the serotonin transporter gene and response to stress and medication. The British Journal of Psychiatry, 198, 424-427.
60. Meyer-Lindenberg, A.; Buckholtz, J. W.; Kolachana, B.; Hariri, A. R.; Pezawas, L.; Blasi, G.; et al. (2006). Neural mechanisms of genetic risk for impulsivity and violence in humans. Proceedings of the National Academy of Sciences of the United States of America, 103, 6269-6274.
61. Mickey, B. J.; Ducci, F.; Hodgkinson, C. A.; Langenecker, S. S.; Goldman, D.; & Zubieta, J. K. (2008). Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivo. The Journal of Neuroscience, 28, 11354-11359.
62. Murphy, D. L.; Uhl, G. R.; Holmes, A.; Ren-Patterson, R.; Hall, F. S.; Sora, I.; et al. (2003). Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders. Genes, Brain, and Behavior, 2, 350-364. (Pubitemid 37463200)
63. Muthén, L. K.; & Muthén, B. O. (2010). Mplus user's guide (6th ed.). Los Angeles: Muthén & Muthén.
64. Nilsson, K. W.; Wargelius, H. L.; Sjöberg, R. L.; Leppert, J.; & Oreland, L. (2008). The MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behaviour. Drug and Alcohol Dependence, 93, 51-62. (Pubitemid 350236589)
65. Nolen-Hoeksema, S. (1987). Sex differences in unipolar depression: evidence and theory. Psychological Bulletin, 101, 259-282.
66. Nordquist, N.; & Oreland, L. (2010). Serotonin, genetic variability, behaviour, and psychiatric disorders - a review. Upsala Journal of Medical Sciences, 115, 2-10.
67. Petersen, I. T.; Bates, J. E.; Goodnight, J. A.; Dodge, K. A.; Lansford, J. E.; Pettit, G. S.; et al. (2012). Interaction between serotonin transporter polymorphism (5-HTTLPR) and Stressful life events in adolescents' trajectories of anxious/depressed symptoms. Developmental Psychology. Advance of publication, doi: 10.1037/a0027471
68. Pluess, M.; Belsky, J.; Way, B. M.; & Taylor, S. E. (2010). 5-HTTLPR moderates effects of current life events on neuroticism: differential susceptibility to environmental influences. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34, 1070-1074.
69. Priess, H. A.; Lindberg, S. M.; & Hyde, J. S. (2009). Adolescent gender-role identity and mental health: gender intensification revisited. Child Development, 80, 1531-1544.
70. Ramamoorthy, S.; Bauman, A. L.; Moore, K. R.; Han, H.; Yang-Feng, T.; Chang, A. S.; et al. (1993). Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proceedings of the National Academy of Sciences of the United States of America, 90, 2542-2546. (Pubitemid 23078664)
71. Risch, N.; Herrell, R.; Lehner, T.; Liang, K. Y.; Eaves, L.; Hoh, J.; et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. Journal of the American Medical Association, 301, 2462-2471.
72. Rivera, M.; Gutiérrez, B.; Molina, E.; Torres-González, F.; Bellón, J. A.; Moreno-Küstner, B.; et al. (2009). High-activity variants of the uMAOA polymorphism increase the risk for depression in a large primary care sample. American Journal of Medical Genetics, Neuropsychiatric Genetics, Part B, 150B, 395-402.
73. Ruscio, J.; & Ruscio, A. M. (2000). Informing the continuity controversy: a taxometric analysis of depression. Journal of Abnormal Psychology, 109, 473-487.
74. Rutter, M.; Graham, P.; Chadwick, O.; & Yule, W. (1976). Adolescent turmoil: fact or fiction? Journal of Child Psychology and Psychiatry, and Allied Disciplines, 17, 35-56.
75. Sabol, S. Z.; Hu, S.; & Hamer, D. (1998). A functional polymorphism in the monoamine oxidase A gene promoter. Human Genetics, 103, 273-279. (Pubitemid 28470076)
76. Saylor, C. F.; Finch, A. J.; Spirito, A.; & Bennett, B. (1984). The Children's Depression Inventory: a systematic evaluation of psychometric properties. Journal of Consulting and Clinical Psychology, 52, 955-967. (Pubitemid 15082522)
77. Schulze, T. G.; Müller, D. J.; Krauss, H.; Scherk, H.; Ohlraun, S.; Syagailo, Y. V.; et al. (2000). Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder. American Journal of Medical Genetics, Neuropsychiatric Genetics, 96, 801-803.
78. Sjöberg, R. L.; Nilsson, K. W.; Nordquist, N.; Öhrvik, J.; Leppert, J.; Lindström, L.; et al. (2006). Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene. The International Journal of Neuropsychopharmacology, 9, 443-449. (Pubitemid 43979704)
79. Smucker, M. R.; Craighead, W. E.; Craighead, L. W.; & Green, B. J. (1986). Normative and reliability data for the Children's Depression Inventory. Journal of Abnormal Child Psychology, 14, 25-39. (Pubitemid 16172595)
80. Taylor, A.; & Kim-Cohen, J. (2007). Meta-analysis of gene-environment interactions in developmental psychopathology. Development and Psychopathology, 19, 1029-1037. (Pubitemid 47591294)
81. Turner, C.; Ku, L.; Rogers, S.; Lindberg, L.; Pleck, J.; & Sonenstein, F. (1998). Adolescent sexual behavior, drug use, and violence: increased reporting with computer survey technology. Science, 280, 867-873. (Pubitemid 28215590)
82. Uddin, M.; de los Santos, R.; Bakshis, E.; Cheng, C.; & Aiello, A. E. (2011). Building conditions, 5-HTTLPR genotype, and depressive symptoms in adolescent males and females. Journal of Adolescent Health, 49, 379-385.
83. Uher, R.; & McGuffin, P. (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Molecular Psychiatry, 13, 131-146.
84. Urwin, R. E.; & Nunn, K. P. (2005). Epistatic interaction between the monoamine oxidase A and serotonin transporter genes in anorexia nervosa. European Journal of Human Genetics, 13, 370-375. (Pubitemid 40360793)
85. U.S. Department of Labor. (1993). Twenty facts on women workers. Washington, DC: U.S. Government Printing Office.
86. van Roekel, E.; Engels, R. E.; Verhagen, M.; Goossens, L.; & Scholte, R. J. (2011). Parental depressive feelings, parental support, and the serotonin transporter gene as predictors of adolescent depressive feelings: a latent growth curve analysis. Journal of Youth and Adolescence, 40, 453-462.
87. Veenstra-VanderWeele, J.; Anderson, G. M.; & Cook, E. H.; Jr. (2000). Pharmacogenetics and the serotonin system: initial studies and future directions. European Journal of Pharmacology, 410, 165-181. (Pubitemid 32008142)
88. Weissman, M.; & Klerman, G. (1977). Sex differences and the epidemiology of depression. Archives of General Psychiatry, 34, 98-111. (Pubitemid 8023189)
89. Wendland, J. R.; Martin, B. J.; & Kruse, M. R. (2006). Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Molecular Psychiatry, 11, 224-226.
90. Yang, J.; et al. (2010). Common SNPs explain a large proportion of the heritability for human height. Nature Genetics, 42, 565-571.
91. Yu, Y. W. Y.; Tsai, S. J.; Hong, C. J.; Chen, T. J.; Chen, M. C.; & Yang, C. W. (2005). Association study of a monoamine oxidase A gene promoter polymorphism with major depressive disorder and antidepressant response. Neuropsychopharmacology, 30, 1719-1723. (Pubitemid 43086029)