Impact of the interaction between the 5HTTLPR polymorphism and maltreatment on adolescent depression. A population-based study

Behavior Genetics

Volumn 39, Issue 5, 2009, Pages 524-531

  Åslund, Cecilia ^a   Leppert, Jerzy ^a   Comasco, Erika ^a   Nordquist, Niklas ^a   Oreland, Lars ^a   Nilsson, Kent W ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

5HTTLPR; Child maltreatment; Depression; Gene environment interaction; Serotonin transporter; Sex characteristics

Indexed keywords

DNA; SEROTONIN TRANSPORTER; SEROTONIN TRANSPORTER PROTEIN 5HTTLPR; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CHILD ABUSE; COHORT ANALYSIS; DEPRESSION; DNA EXTRACTION; ETHNICITY; FEMALE; FUNCTIONAL GENOMICS; GENE EXPRESSION; GENE FREQUENCY; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HEALTH SURVEY; HUMAN; LIFE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; POPULATION BASED CASE CONTROL STUDY; PREDICTION; SALIVA; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADOLESCENT BEHAVIOR; ALLELES; CHILD ABUSE; COHORT STUDIES; ENVIRONMENT; EPIGENESIS, GENETIC; FEMALE; HUMANS; MALE; POLYMORPHISM, GENETIC; SALIVA; SEQUENCE ANALYSIS, DNA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX FACTORS;

EID: 69049095945     PISSN: 00018244     EISSN: 15733297     Source Type: Journal    
DOI: 10.1007/s10519-009-9285-9     Document Type: Article

References (50)

1. American Psychiatric Association (APA) (2000) Diagnostic and statistical manual of mental disorders - Text revision. American Psychiatric Association Press, Washington DC
2. Araya R, Hu K, Heron J, Enoch M-A, Evans J, Lewis G, Nutt D, Goldman D (2008) Effects of stressful life events, maternal depression and 5-HTTLPR genotype on emotional symptoms in pre-adolescent children. Am J Med Genet Part B (Neuropsychiatr Genet) E-pub 14 nov 2008
3. F Biver F Lotstra M Monclus D Wikler P Damhaut J Mendlewicz S Goldman 1996 Sex difference in 5HT2 receptor in the living human brain Neurosci Lett 204 1-2 25 28
4. BH Brummett SH Boyle CM Kuhn IC Siegler RB Williams 2008 Associations among central nervous system serotonergic function and neuroticism are moderated by gender Biol Psychiatry 78 200 203
5. BH Brummett SH Boyle IC Siegler CM Kuhn A Ashely-Koch CR Jonassaint S Zücher A Collins RB Williams 2008 Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR) Behav Genet 38 34 43
6. BH Brummett CL Muller AL Collins SH Boyle CM Kuhn IC Siegler RB Williams A Ashely-Koch 2008 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion Behav Genet 38 476 483
7. A Caspi K Sugden TE Moffitt A Taylor IW Craig H Harrington J McClay J Mill J Martin A Braithwaite R Poulton 2003 Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene Science 301 5631 386 389
8. JA Cervilla E Molina M Rivera F Torres-González JA Bellón B Moreno JD Luna JA Lorente F Mayoral M King I Nazareth B Gutiérrez 2007 The risk for depression conferred by stressful life events is modified by variation at the serotonin transporter 5HTTLPR genotype: evidence from the Spanish PREDICT-Gene cohort Mol Psychiatry 12 748 755
9. P Chipman AF Jorm M Prior A Sanson D Smart X Tan S Easteal 2007 No interaction between the serotonin transporter polymorphism (5-HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: results from two community surveys Am J Med Genet Part B (Neuropsyhiatr Genet) 144B 561 565
10. DA Collier G Stober T Li A Heils M Catalano D Di Bella MJ Arranz RM Murray HP Vallada D Bengel CR Muller GW Roberts E Smeraldi G Kirov P Sham KP Lesch 1996 A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders Mol Psychiatry 1 6 453 460
11. N Costes I Merlet K Ostrowsky I Faillenot F Lavenne L Zimmer P Ryvlin D Le Bars 2005 A 18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging J Nucl Med 46 12 1980 1989
12. WL Dragan W Oniszczenko 2006 Association of a functional polymorphism in the serotonin transporter gene with personality traits in females in a Polish population Neuropsychobiology 54 45 50
13. L Du D Bakish PD Hrdina 2000 Gender differences in association between serotonin transporter gene polymorphism and personality traits Psychiatr Genet 10 4 159 164
14. TC Eley K Sugden A Corsico AM Gregory P Sham P McGuffin R Plomin IW Craig 2004 Gene-environment interaction analysis of serotonin system markers with adolescent depression Mol Psychiatry 9 10 908 915
15. NA Gillespie JB Whitfield B Williams AC Heath NG Martin 2005 The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression Psychol Med 35 1 101 111
16. HJ Grabe M Lange B Wolff H Volzke M Lucht HJ Freyberger U John I Cascorbi 2005 Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden Mol Psychiatry 10 220 224
17. BL Hankin LY Abramson TE Moffitt PA Silva R McGee KE Angell 1998 Development of depression from preadolescence to young adulthood: emerging gender differences in a 10-year longitudinal study J Abnorm Psychol 107 128 140
18. A Heils A Teufel S Petri G Stober P Riederer D Bengel KP Lesch 1996 Allelic variation of human serotonin transporter gene expression J Neurochem 66 6 2621 2624
19. X Hu G Oroszi J Chun TL Smith D Goldman MA Schuckit 2005 An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk Alcohol Clin Exp Res 29 1 8 16
20. N Jacobs G Kenis F Peeters C Derom R Vlietinck J van Os 2006 Stress-related negative affectivity and genetically altered serotonin transporter function. Evidence of synergism in shaping risk of depression Arch Gen Psychiatry 63 989 996
21. J Kaufman B-Z Yang H Douglas-Palumberi D Grasso D Lipschitz S Houshyar JH Krystal J Gelernter 2006 Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children Biol Psychiatry 59 673 680
22. KS Kendler JW Kuhn J Vittum CA Prescott B Riley 2005 The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication Arch Gen Psychiatry 62 5 529 535
23. SB Kornstein AF Schatzberg ME Thase KA Yonkers JP McCullough GI Keitner AJ Gelenberg SM Davis WM Harrison MB Keller 2001 Gender differences in treatment response to sertraline versus imipramine in chronic depression Am J Psychiatry 157 9 1445 1452
24. JB Kraft SL Slager PJ McGrath SP Hamilton 2005 Sequence analysis of the serotonin transporter and associations with antidepressant response Biol Psychiatry 58 5 374 381
25. Laucht M, Treutlein J, Blomeyer D, Buchmann AF, Schmid B, Becker K, Zimmermann US, Schmidt MH, Esser G, Rietschel M, Banaschewski T (2009) Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adults. Int J Neuropsychopharmacol E-pub 20 jan 2009
26. J Lazary A Lazary X Gonda A Benko E Molnar G Juhasz G Bagdy 2008 New evidence for the association of the serotonin transporter gene (SLC6A4) haplotypes, threatening life events, and depressive phenotype Biol Psychiatry 64 6 498 504
27. KP Lesch U Balling J Gross K Strauss BL Wolozin DL Murphy P Riederer 1994 Organization of the human serotonin transporter gene J Neural Transm Gen Sect 95 2 157 162
28. KP Lesch D Bengel A Heils SZ Sabol BD Greenberg S Petri J Benjamin CR Muller DH Hamer DL Murphy 1996 Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 5292 1527 1531
29. LE Miller KL Smith 1983 Handling nonresponse issues J Ext 21 5 45 50
30. MR Munafo T Clark J Flint 2005 Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis Mol Psychiatry 10 415 419
31. M Nakamura S Ueno H Tanabe 2000 The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows then novel allelic variants Mol Psychiatry 5 32 38
32. KW Nilsson RL Sjoberg M Damberg J Leppert J Ohrvik PO Alm L Lindstrom L Oreland 2006 Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity Biol Psychiatry 59 2 121 127
33. KW Nilsson RL Sjoberg HL Wargelius J Leppert L Lindstrom L Oreland 2007 The monoamine oxidase A (MAO-A) gene, family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption Addiction 102 3 389 398
34. KW Nilsson H-L Wargelius RL Sjöberg J Leppert L Oreland 2008 The MAOA gene, platelet MAO-B activity and psychosocial environment in adolescent female and alcohol-related problem behaviour Drug Alcohol Depend 93 51 62
35. S Nishizawa C Benkelfat SN Young M Leyton S Mzengeza C de Montigny P Blier M Diksic 1997 Differences between males and females in rates of serotonin synthesis in human brain Proc Natl Acad Sci USA 94 10 5308 5313
36. RE Orstavik KS Kendler N Czajkowski K Tambs T Reichborn-Kjennerud 2007 Genetic and environmental contributions to depressive personality disorder in a population-based sample of Norwegian twins J Affect Disord 99 181 189
37. Pinker S (2003) The blank slate: the modern denial of human nature. Penguin, London
38. F Rice GT Harold KH Shelton A Thapar 2006 Family conflict interacts with genetic liability in predicting childhood and adolescent depression J Am Acad Child Adolesc Psychiatry 45 7 841 848
39. M Rutter J Silberg 2002 Gene-environment interplay in relation to emotional and behavioral disturbance Annu Rev Psychol 53 463 490
40. M Rutter A Caspi TE Moffitt 2003 Using sex differences in psychopathology to study causal mechanisms: unifying issues and research strategies J Child Psychol Psychiatry 44 8 1092 1115
41. RL Sjoberg KW Nilsson N Nordquist J Öhrvik J Leppert L Lindström L Oreland 2006 Development of depression-sex and the interaction between environment and promoter polymorphism of the serotonin transporter gene Int J Neuropsychopharmacol 9 4 443 449
42. RL Sjoberg KW Nilsson HL Wargelius J Leppert L Lindstrom L Oreland 2007 Adolescent girls and criminal activity: role of MAOA-LPR genotype and psychosocial factors Am J Med Genet Part B (Neuropsychiatr Genet) 144B 159 164
43. PG Surtees NW Wainwright SA Willis-Owen R Luben NE Day J Flint 2006 Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder Biol Psychiatry 59 224 229
44. P Svanborg L Ekselius 2003 Self-assessment of DSM-IV criteria for major depression in psychiatric out- and inpatients Nord J Psychiatry 57 4 291 296
45. SE Taylor BM Way WT Welch CJ Hilmert BJ Lehman NI Eisenberger 2006 Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology Biol Psychiatry 60 671 676
46. R Uher P McGuffin 2008 The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis Mol Psychiatry 13 131 146
47. E Walderhaug A Magnusson A Neumeister J Lappalainen H Lunde H Refsum NI Landro 2007 Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people Biol Psychiatry 62 593 599
48. K Wilhelm PB Mitchell H Niven A Finch L Wedgwood A Scimone IP Blair G Parker PR Schofield 2006 Life events, first depression onset and the serotonin transporter gene Br J Psychiatry 188 210 215
49. RB Williams DA Marchuk KM Gadde JC Barefoot K Grichnik MJ Helms CM Kuhn JG Lewis SM Schanberg M Stafford-Smith EC Suarez GL Clary IK Svenson IC Siegler 2003 Serotonin-related gene polymorphisms and central nervous system serotonin function Neuropsychopharmacology 28 533 541
50. G Zalsman Y-Y Huan MA Oquendo AK Burke X-Z Hu DA Brent SP Ellis D Goldman JJ Mann 2006 Association of a triallelic serotonin transporter gene promoter region (5HTTLPR) polymorphism with stressful life events and severity of depression Am J Psychiatry 163 9 1588 1593