Interaction of 5-HTTLPR and idiographic stressors predicts prospective depressive symptoms specifically among youth in a multiwave design

Journal of Clinical Child and Adolescent Psychology

Volumn 40, Issue 4, 2011, Pages 572-585

  Hankin, Benjamin L ^a   Jenness, Jessica ^a   Abela, John R Z ^b   Smolen, Andrew ^c  

^a UNIVERSITY OF DENVER   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

ADOLESCENT; ALLELE; ARTICLE; CHILD; DEPRESSION; FEMALE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; LIFE EVENT; MALE; MENTAL STRESS; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; QUESTIONNAIRE; SEX DIFFERENCE;

ADOLESCENT; ALLELES; CHILD; DEPRESSION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LIFE CHANGE EVENTS; MALE; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; QUESTIONNAIRES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX FACTORS; STRESS, PSYCHOLOGICAL;

EID: 79960529148     PISSN: 15374416     EISSN: None     Source Type: Journal    
DOI: 10.1080/15374416.2011.581613     Document Type: Article

References (105)

1. Abela, J. R. Z., & Hankin, B. L. (2008). Cognitive vulnerability to depression in children and adolescents: A developmental psychopathology perspective. In J. R. Z. Abela & B. L. Hankin (Eds.), Handbook of child and adolescent depression (pp. 35-78). New York: Guilford.
2. Abela, J. R. Z., Skitch, S. A., Adams, P., & Hankin, B. L. (2006). The timing of parent and child depression: A hopelessness theory perspective. Journal of Clinical Child and Adolescent Psychology, 35, 253-263.
3. Abela, J. R. Z., Webb, C. A., Ho, M., Wagner, C., & Adams, P. (2006). The role of self-criticism, dependency, and hassles in the course of depressive illness: A multi-wave longitudinal study of vulnerability and resiliency. Personality and Social Psychology Bulletin, 32, 328-338.
4. Abela, J. R. Z., Zuroff, D. C., Ho, M. R., Adams, P., & Hankin, B. L. (2006). Excessive reassurance seeking, hassles, and depressive symptoms in children of affectively-ill parents: A multi-wave longitudinal study. Journal of Abnormal Child Psychology, 34, 171-187.
5. Abramson, L., Metalsky, G., & Alloy, L. (1989). Hopelessness depression: A theory-based subtype of depression. Psychological Review, 96, 358-372.
6. Anchordoquy, H. C., McGeary, C., Liu, L., Krauter, K. S., & Smolen, A. (2003). Genotyping of three candidate genes following whole genome preamplification of DNA collected from buccal cells. Behavior Genetics, 33, 73-78.
7. Baldwin, J., & Dadds, M. (2007). Reliability and validity of parent and child versions of the Multidimensional Anxiety Scale for Children in community samples. Journal of the American Academy of Child & Adolescent Psychiatry, 46, 252-260.
8. Beck, A. (1987). Cognitive models of depression. Journal of Cognitive Psychotherapy, 1(1), 5-37.
9. Beesdo, K., Bittner, A., Pine, D., Stein, M., Hofler, M., Lieb, R., et al. (2007). Incidence of social anxiety disorder and the consistent risk for secondary depression in the first three decades of life. Archives of General Psychiatry, 64, 903-912.
10. Belsky, J. (1997). Variation in susceptibility to environmental influence: An evolutionary argument. Psychological Inquiry, 8, 182-186.
11. Belsky, J., Bakermans-Kranenburg, M., & van IJzendoorn, M. (2007). For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 300-304.
12. Belsky, J., & Pluess, M. (2009a). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885-908.
13. Belsky, J., & Pluess, M. (2009b). The nature (and nurture?) of plasticity in early human development. Perspectives on Psychological Science, 4, 345-351.
14. Boyce, W., & Ellis, B. (2005). Biological sensitivity to context: I. An evolutionary-developmental theory of the origins and functions of stress reactivity. Development and Psychopathology, 17, 271-301.
15. Brewin, C. R., Andrews, B., & Gotlib, I. H. (1993). Psychopathology and early experience: A reappraisal of retrospective reports. Psychological Bulletin, 113, 82-98.
16. Brown, G., & Harris, T. (2008). Depression and the serotonin transporter 5-HTTLPR polymorphism: A review and a hypothesis concerning gene-environment interaction. Journal of Affective Disorders, 111, 1-12.
17. Canli, T., & Lesch, K. P. (2007). Long story short: The serotonin transporter in emotion regulation and social cognition. Nature Neuroscience Review, 10, 1103-1109.
18. Caspi, A., Ahmad, R., Holmes, A., Uher, R., & Moffitt, T. E. (2010). Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits. American Journal of Psychiatry, 167, 509-527.
19. Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, Terrie E. (2010). Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits. The American Journal of Psychiatry, 167(5), 509-527.
20. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTTLPR gene. Science, 301, 386-389.
21. Chavira, D. A., Stein, M. B., Bailey, K., & Stein, M. T. (2004). Comorbidity of generalized social anxiety disorder and depression in a pediatric primary care sample. Journal of Affective Disorders, 80, 163-171.
22. Cicchetti, D., Rogosch, F. A., & Sturge-Apple, M. L. (2007). Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: Depressive symptomatology among adolescents from low socioeconomic status backgrounds. Development and Psychopathology, 19, 1161-1180.
23. Cohen, J. (1988). Statistical power analysis for the behavioral sciences. (2nd ed). Hillsdale, NJ: Erlbaum.
24. Cohen, P., & Cohen, J. (1984). The clinician's illusion. Archives of General Psychiatry, 41, 1178-1182.
25. Cole, D. A., Peeke, L. G., Martin, J. M., Truglio, R., & Seroczynski, A. D. (1998). Longitudinal look at the relation between depression and anxiety in children and adolescents. Journal of Consulting and Clinical Psychology, 66, 41-460.
26. Costello, J. E., Mustillo, S., Erkanli, A., Keeler, G., & Angold, A. (2003). Prevalence and development of psychiatric disorders in childhood and adolescence. Archives of General Psychiatry, 60, 837-844.
27. Curran, P. J., & Willoughby, M. T. (2003). Implications of latent trajectory models for the study of developmental psychopathology. Development and Psychopathology, 15, 581-612.
28. Dohrenwend, B. P. (2006). Inventorying stressful life events as risk factors for psychopathology: Toward resolution of the problem of intracategory variability. Psychological Bulletin, 132, 477-495.
29. Eley, T. C., Sugden, K., Corsico, A., Gregory, A. M., Sham, P., McGuffin, P., et al. (2004). Gene-environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry, 9, 908-915.
30. Ellis, B., & Boyce, W. (2008). Biological sensitivity to context. Current Directions in Psychological Science, 17, 183-187.
31. Garber, J., Clarke, G. N., Weersing, V. R., Beardslee, W. R., Brent, D. A., Gladstone, T. R. G., et al. (2009). Prevention of depression in at-risk adolescents: A randomized controlled trial. Journal of American Medical Association, 301, 2215-2224.
32. Gibb, B., Beevers, C., Andover, M., & Holleran, K. (2006). The hopelessness theory of depression: A prospective multi-wave test of the vulnerability-stress hypothesis. Cognitive Therapy and Research, 30, 763-772.
33. Gibb, B., Benas, J., Grassia, M., & McGeary, J. (2009). Children's attentional biases and 5-HTTLPR genotype: Potential mechanisms linking mother and child depression. Journal of Clinical Child and Adolescent Psychology, 38, 415-426.
34. Gibb, B., Uhrlass, D., Grassia, M., Benas, J., & McGeary, J. (2009). Children's inferential styles, 5-HTTLPR genotype, and maternal expressed emotion-criticism: An integrated model for the intergenerational transmission of depression. Journal of Abnormal Psychology, 118(4), 734-745.
35. Gillespie, N., Whitfield, J., Williams, B., Heath, A., & Martin, N. (2005). The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychological Medicine: A Journal of Research in Psychiatry and the Allied Sciences, 35(1), 101-111.
36. Gonda, X., Fountoulakis, K. N., Juhasz, G., Rihmer, Z., Lazary, J., Laszik, A., et al. (2009). Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population. European Archives of Psychiatry and Clinical Neuroscience, 259, 106-113.
37. Gotlib, I. H., Joormann, J., Minor, K. L., & Hallmayer, J. (2008). HPA axis reactivity: A mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biological Psychiatry, 63, 847-851.
38. Gotlib, I. H., Lewinsohn, P. M., & Seeley, J. R. (1995). Symptoms versus a diagnosis of depression: Differences in psychosocial functioning. Journal of Consulting and Clinical Psychology, 63, 90-100.
39. Grabe, H., Lange, M., Wolff, B., Völzke, H., Lucht, M., Freyberger, H., et al. (2005). Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden. Molecular Psychiatry, 10, 220-224.
40. Gunthert, K., Conner, T., Armeli, S., Tennen, H., Covault, J., & Kranzler, H. (2007). Serotonin transporter gene polymorphism (5-HTTLPR) and anxiety reactivity in daily life: A daily process approach to gene-environment interaction. Psychosomatic Medicine, 69, 762-768.
41. Hammen, C., Brennan, P., Keenan-Miller, D., Hazel, N., & Najman, J. (2010). Chronic and acute stress, gender, and serotonin transporter gene environment interactions predicting depression symptoms in youth. Journal of Child Psychology and Psychiatry, 51, 180-187.
42. Hankin, B. L. (2008). Cognitive vulnerability-stress model of depression during adolescence: Investigating symptom specificity in a multi-wave prospective study. Journal of Abnormal Child Psychology, 36, 999-1014.
43. Hankin, B. L., & Abramson, L. Y. (2001). Development of gender differences in depression: An elaborated cognitive vulnerability-transactional stress theory. Psychological Bulletin, 127, 773-796.
44. Hankin, B. L., & Abramson, L. Y. (2002). Measuring cognitive vulnerability to depression in adolescence: Reliability, validity and gender differences. Journal of Clinical Child and Adolescent Psychology, 31, 491-504.
45. Hankin, B., Badanes, L., Abela, J., & Watamura, S. (2010). Hypothalamic-pituitary-adrenal axis dysregulation in dysphoric children and adolescents: Cortisol reactivity to psychosocial stress from preschool through middle adolescence. Biological Psychiatry, 68, 484-490.
46. Hankin, B. L., Fraley, R. C., Lahey, B. B., & Waldman, I. (2005). Is youth depressive disorder best viewed as a continuum or discrete category? A taxometric analysis of childhood and adolescent depression in a population-based sample. Journal of Abnormal Psychology, 114, 96-110.
47. Hankin, B. L., Stone, L. B., & Wright, P. A. (2010). Co-rumination, interpersonal stress generation, and internalizing symptoms: Sex differences and transactional influences in a multi-wave study of adolescents. Development and Psychopathology, 22, 217-235.
48. Hariri, A., Mattay, V., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297, 400-403.
49. Hu, X. Y., Lipsky, R. H., Zhu, G., Akhtar, L. A., Taubman, J., Greenberg, B. D., et al. (2006). Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. American Journal of Human Genetics, 78, 815-826.
50. Hu, X., Oroszi, G., Chun, J., Smith, T. L., Goldman, D., & Schuckit, M. A. (2005). An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol: Clinical and Experimental Research, 29, 8-16.
51. Kaufman, J., Yang, B., Douglas-Palumberi, H., Grasso, D., Lipshitz, D., Houshyar, S., et al. (2006). Brain-derived neurotrophic factor 5-HHTLPR gene interactions and environmental modifiers of depression in children. Biological Psychiatry, 59, 673-680.
52. Kazdin, A. E. (1989). Identifying depression in children: A comparison of alternative selection criteria. Journal of Abnormal Child Psychology, 17, 437-454.
53. Kendler, K. S., Kuhn, J. W., Vittum, J., Prescott, C. A., & Riley, B. (2005). The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression. Archives of General Psychiatry, 62, 529-535.
54. Klein, D. N., Dougherty, L. R., & Olino, T. M. (2005). Toward guidelines for evidence-based assessment of depression in children and adolescents. Journal of Clinical Child and Adolescent Psychology, 34, 412-432.
55. Klein, D. N., Shankman, S. A., Lewinsohn, P. M., & Seeley, J. R. (2009). Subthreshold depressive disorder in adolescents: Predictors of escalation to full-syndrome depressive disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 703-710.
56. Kovacs, M. (1985). The Children's Depression Inventory (CDI). Psychopharmacology Bulletin, 21, 995-998.
57. Laucht, M., Treutlein, J., Blomeyer, D., Buchmann, A., Schmid, B., Becker, K., et al. (2009). Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: Evidence from a high-risk community sample of young adults. International Journal of Neuropsychopharmacology, 12, 737-747.
58. Lesch, K. (2003). Neuroticism and serotonin: A developmental genetic perspective. In R. Plomin, J. C. DeFries, I. W. Craig, P. McGuffin, R. Plomin, J. C. DeFries, et al. (Eds.), Behavioral genetics in the postgenomic era (pp. 389-423). Washington, DC: American Psychological Association.
59. Lesch, K., Bengel, D., Heils, A., Sabol, S., Greenberg, B. D., Petri, S., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531.
60. Levinson, D. (2006). The genetics of depression: A review. Biological Psychiatry, 60, 84-92.
61. Lewinsohn, P., Hops, H., Roberts, R., Seeley, J., & Andrews, J. (1993). Adolescent psychopathology: I. Prevalence and incidence of depression and other DSM-III-R disorders in high school students. Journal of Abnormal Psychology, 102(1), 133-144.
62. Lewinsohn, P., Zinbarg, R., Seeley, J., Lewinsohn, M., & Sack, W. (1997). Lifetime comorbidity among anxiety disorders and between anxiety disorders and other mental disorders in adolescents. Journal of Anxiety Disorders, 11, 377-394.
63. Li, Q., Wichems, C., Heils, A., Van D Dar, L. D., Lesch, K. P., & Murphy, D. L. (1999). Reduction of 5-HT1a binding sites in 5-HT transporter knockout mice. Journal of Pharmacology and Experimental Therapeutics, 291, 999-1007.
64. Luan, J. A., Wong, M. Y., Day, N. E., & Wareham, N. J. (2001). Sample size determination of gene-environment interaction. International Journal of Epidemiology, 30, 1035-1040.
65. March, J. S., Sullivan, K., & Parker, J. (1999). Test-retest reliability of the Multidimensional Anxiety Scale for Children. Journal of Anxiety Disorders, 13, 349-358.
66. Martin, J., Cleak, J., Willis-Owen, S. A. G., Flint, J., & Shifman, S. (2007). Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance. Molecular Psychiatry, 12, 421-422.
67. McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., et al. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience, 12, 342-348.
68. Mill, J., & Petronis, A. (2007).Molecular studies ofmajor depressive disorder: The epigenetic perspective. Molecular Psychiatry, 12, 799-814.
69. Moffitt, T. E., Caspi, A., & Rutter, M. (2006). Measured gene-environment interactions in psychopathology. Perspective on Psychological Science, 1, 5-27.
70. Monroe, S. M., & Reid, M. W. (2008). Gene-environment interactions in depression research: Genetic polymorphisms and life-stress polyprocedures. Psychological Science, 19, 947-956.
71. Munafo, M. R., Freimer, N. B., Ng, W., Ophoff, R., Veijola, J., Miettunen, J., et al. (2008). 5-HTTLPR genotype and anxietyrelated personality traits: A meta-analysis and new data. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics. Advance online publication. doi:10.1002=ajmg.b.30808
72. Nobile, M., Rusconi, M., Bellina, M., Marino, C., Giorda, R., Carlet, O., et al. (2009). The influence of family structure, the TPH2G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10-14 years. Journal of Child Psychology and Psychiatry, 50, 317-325.
73. Olsson, C. A., Byrnes, G. B., Lotfi-Miri, M., Collins, V., Williamson, R., Patton, C., et al. (2005). Association between 5-HTTLPR genotypes and persisting patterns of anxiety and alcohol use: Results from a 10-year longitudinal study of adolescent mental health. Molecular Psychiatry, 10, 868-876.
74. Petersen, A., Compas, B., Brooks-Gunn, J., Stemmler, M., Ey, S., & Grant, K. (1993). Depression in adolescence. American Psychologist, 48, 155-168.
75. Pine, D., Cohen, E., Cohen, P., & Brook, J. (1999). Adolescent depressive symptoms as predictors of adult depression: Moodiness or mood disorder? The American Journal of Psychiatry, 156(1), 133-135.
76. Pine, D. S., Cohen, P., Gurley, D., Brook, J., & Ma, Y. (1998). The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Archives of General Psychiatry, 55, 56-64.
77. Raudenbush, S. W., Bryk, A., Cheong, Y. F., & Congdon, R. (2001). Hierarchical linear and nonlinear modeling 5.04. Lincolnwood, IL: Scientific Software International.
78. Risch, N., Herrell, R., Lehner, T., Liang, K-Y., Eaves, L., Hoh, J., et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. Journal of the American Medical Association, 301, 2462-2471.
79. Rosenthal, R.,& Rosnow, R. L. (1991). Essentials of behavioral research: Methods and data analysis (2nd ed.). New York: McGraw Hill.
80. Rudolph, K. D., & Flynn, M. (2007). Childhood adversity and youth depression: The role of gender and pubertal status. Development and Psychopathology, 19, 497-521.
81. Rutter, M. (2005). Environmentally mediated risks for psychopathology: Research strategies and findings. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 3-18.
82. Rutter, M., Kim-Cohen, J., & Maughan, B. (2006). Continuities and discontinuities in psychopathology between childhood and adult life. Journal of Child Psychology and Psychiatry, 47(3-4), 276-295.
83. Rutter, M., Thapar, A., & Pickles, A. (2009). Gene-environment interactions: Biologically valid pathway or artifact? Archives of General Psychiatry, 66, 1287-1289.
84. Schinka, J., Busch, R., & Robichaux-Keene, N. (2004). A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Molecular Psychiatry, 9, 197-202.
85. Silberg, J., Pickles, A., Rutter, M., Hewitt, J., Simonoff, E., Maes, H., et al. (1999). The influence of genetic factors and life stress on depression among adolescent girls. Archives of General Psychiatry, 56, 225-232.
86. Silverman, W. K., & Ollendick, T. H. (2005). Evidence-based assessment of anxiety and its disorders in children and adolescents. Journal of Clinical Child and Adolescent Psychology, 34, 380-411.
87. Smucker, M. R., Craighead, W. E., Craighead, L. W, & Green, B. J. (1986). Normative and reliability data for the Children's Depression nventory. Journal of Abnormal Child Psychology, 14, 25-40.
88. Snijders, T. A. B., & Bosker, R. J. (1999). Multilevel analysis: An ntroduction to basic and advanced multilevel modeling. London:Sage.
89. Stein, M., Schork, N., & Gelernter, J. (2008). Gene-by-environment serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders.Neuropsychopharmacology, 33, 312-319.
90. Stone, L., Gibb, B., & Coles, M. (2010). Does the hopelessness theory account for sex differences in depressive symptoms among young adults? Cognitive Therapy and Research, 34, 177-187.
91. Strickland, P. L., Deakin, J. F. W., Percival, C., Dixon, J., Gater, R. A., & Goldberg, D. P. (2002). Bio-social origins of depression in the community: Interactions between social adversity, cortisol and serotonin neurotransmission. British Journal of Psychiatry, 180,168-173.
92. Taylor, S., Way, B., Welch, W., Hilmert, C., Lehman, B., & Eisenberger, N. (2006). Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biological Psychiatry, 60, 671-676.
93. Tolonen, H. (2005). Towards the high quality of population health surveys. Standardization and quality control (National Public Health Institute A27=2005, Helsinki). Available from http://www.ktl.fi/attachments/suomi/julkaisut/julkaisusarja_a/2005/2005a27.pdf
94. Tolonen, H., Dobson, A., & Kulathinal, S. (2005). Effect on trend estimates of the difference between survey respondents and nonrespondents: Results from 27 populations in the WHO MONICA Project. European Journal of Epidemiology, 20, 887-898.
95. Tsankova, B., Renthal, W., Kumar, A., & Nestler, E. J. (2007). Epigenetic regulation in psychiatric disorders. Nature Reviews Neuroscience, 8, 355-367.
96. Uher, R. (2008). The implications of gene-environment interactions in depression: Will cause inform cure? Molecular Psychiatry, 13, 1070-1078.
97. Uher, R., & McGuffin, P. (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis. Molecular Psychiatry, 13, 131-146.
98. Uher, R., & McGuffin, P. (2010). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of depression: 2009 update. Molecular Psychiatry, 15, 18-22.
99. Weaver, I., Cervoni, N., Champagne, F., D'Alessio, A., Sharma, S., Seckl, J., et al. (2004). Epigenetic programming by maternal behavior. Nature Neuroscience, 7, 847-854.
100. Wendland, J. R., Martin, B. J., Kruse, M. R, Lesch, K.-P., & Murphy, D. L. (2006). Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Molecular Psychiatry, 11, 224-226.
101. Wilhelm, K., Mitchell, P., Niven, H., Finch, A., Wedgwood, L., Scimone, A., et al. (2006). Life events, first depression onset and the serotonin transporter gene. British Journal of Psychiatry, 188, 210-215.
102. Williams, L. M., Gatt, J. M., Schofield, P. R., Olivieri, G., Peduto, A., & Gordon, E. (2009). "Negativity bias" in risk for depression and anxiety: brain-body fear circuitry correlates, 5-HTT-LPR and early life stress. Neuroimage, 47, 804-814.
103. Wong, M. Y., Day, N. E., Luan, J. A., Chan, K. P., & Wareham, N. J. (2003). The detection of gene-environment interaction for continuous traits: Should we deal with measurement error by bigger studies or better measurement? International Journal of Epidemiology, 32, 51-57.
104. Xie, P.,Kranzler, H.,Poling, J., Stein, M.,Anton, R.,Brady, K.,etal. (2009). Interactive effect of stressful life events and the serotonin transporter5-HTTLPRgenotype on posttraumatic stress disorder diagnosis in 2 independent populations. Archives of General Psychiatry, 66, 1201-1209.
105. Zalsman, G., Huang, Y., Oquendo, M., Burke, A., Hu, X., Brent, D., et al. (2006). Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. The American Journal of Psychiatry,163, 1588-1593.