Characterization of TAE684 as a potent LRRK2 kinase inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 5, 2012, Pages 1864-1869

  Zhang, Jinwei ^a   Deng, Xianming ^b,c   Choi, Hwan Geun ^b,c   Alessi, Dario R ^a   Gray, Nathanael S ^b,c  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

LRRK2; Parkinson's disease; TAE684

Indexed keywords

2,4 DIANILINO 5 CHLORO PYRIMIDINE; ANTIPARKINSON AGENT; LEUCINE RICH REPEAT KINASE 2; PHOSPHOTRANSFERASE INHIBITOR; SERINE; TAE 684; UNCLASSIFIED DRUG;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PARKINSON DISEASE; PHARMACODYNAMICS; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION;

ANIMALS; BRAIN; CELL LINE; CELLS, CULTURED; HUMANS; MICE; MODELS, MOLECULAR; MUTATION; PARKINSON DISEASE; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES;

EID: 84862777331     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.084     Document Type: Article

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