Triazolopyridazine LRRK2 kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 7, 2013, Pages 1967-1973

  Franzini, Maurizio ^a   Ye, Xiaocong M ^a   Adler, Marc ^a   Aubele, Danielle L ^a   Garofalo, Albert W ^a   Gauby, Shawn ^a   Goldbach, Erich ^a   Probst, Gary D ^a   Quinn, Kevin P ^a   Santiago, Pam ^a   Sham, Hing L ^a   Tam, Danny ^a   Truong, Anh ^a   Ren, Zhao ^a  

^a ELAN PHARMACEUTICALS   (United States)

Author keywords

Activity; Binding mode; Bioisostere; Discovery; G2019S mutant; Hinge; HTS; Inhibition; Kinase; LRRK2; Oxidative metabolism; Parkinson's; Phosphorylation; SAR; Selectivity; Synthesis; Treatment; Wild type

Indexed keywords

[1,2,4]TRIAZOLO[4,3 B]PYRIDAZINE DERIVATIVE; ATENOLOL; LEUCINE RICH REPEAT KINASE 2; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; NONHUMAN; RAT;

DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875213269     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.043     Document Type: Article

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