Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant

Biochemistry

Volumn 50, Issue 43, 2011, Pages 9399-9408

  Liu, Min ^a   Kang, Stephanie ^a   Ray, Soumya ^b   Jackson, Justin ^a   Zaitsev, Alexandra D ^a   Gerber, Scott A ^c   Cuny, Gregory D ^a   Glicksman, Marcie A ^a  

^a The Harvard Center for Neurodegeneration & Repair   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; CATALYTIC MECHANISMS; CHEMICAL TRANSFER; CLOSED FORM; ENZYMATIC PROPERTIES; FRACTIONATION FACTORS; GENERAL BASE; GENETIC FACTORS; GTP BINDING; GTPASE ACTIVITY; HOMOLOGY MODELING; KINASE ACTIVITY; KINASE DOMAINS; KINETIC PROPERTIES; LEUCINE-RICH REPEATS; PARKINSONS DISEASE; PEPTIDE SUBSTRATES; SOLVENT KINETIC ISOTOPE EFFECTS; STRUCTURAL INTERPRETATION; STRUCTURAL MODELING; SUBSTRATE RECOGNITION; WILD TYPES;

AMINO ACIDS; BINDING ENERGY; ISOTOPES; KINETICS; PEPTIDES; PH EFFECTS; PROTONS; STRUCTURAL ANALYSIS; SUBSTRATES;

ENZYMES;

BASE; GUANOSINE TRIPHOSPHATE; LEUCINE RICH REPEAT KINASE 2; MUTANT PROTEIN; PROTEIN G2019S; SERINE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FRACTIONATION; HUMAN; KINETICS; MUTATION; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; STATIC ELECTRICITY; STRUCTURAL HOMOLOGY; WILD TYPE;

AMINO ACID SEQUENCE; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PARKINSON DISEASE; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES;

EID: 80054979896     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201173d     Document Type: Article

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