Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 7, 2013, Pages 1974-1977

  Garofalo, Albert W ^a   Adler, Marc ^a   Aubele, Danielle L ^a   Brigham, Elizabeth F ^a   Chian, David ^a   Franzini, Maurizio ^a   Goldbach, Erich ^b   Kwong, Grace T ^a   Motter, Ruth ^a   Probst, Gary D ^a   Quinn, Kevin P ^b   Ruslim, Lany ^a   Sham, Hing L ^a   Tam, Danny ^a   Tanaka, Pearl ^a   Truong, Anh P ^a   Ye, Xiaocong M ^a   Ren, Zhao ^a  

^a ELAN PHARMACEUTICALS   (United States)

^b Department of Drug Metabolism and Pharmacokinetics ^*  (United States)

Author keywords

Leucine rich repeat kinase 2; Lrrk2; Parkinson's disease

Indexed keywords

4 ALKYLAMINO 7 ARYL 3 CYANOQUINOLINE; LEUCINE RICH REPEAT KINASE 2; PROTEIN SERINE THREONINE KINASE INHIBITOR; SERINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL ASSAY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VIVO STUDY; MOUSE; NONHUMAN; PHARMACODYNAMICS; SINGLE DRUG DOSE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HEK293 CELLS; HUMANS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875213646     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.041     Document Type: Article

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