Anti-atherosclerotic mechanisms of statin therapy

Current Opinion in Pharmacology

Volumn 13, Issue 2, 2013, Pages 260-264

  Babelova, Andrea ^a   Sedding, Daniel G ^b   Brandes, Ralf P ^a  

^a GOETHE UNIVERSITY   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; KRUPPEL LIKE FACTOR 2; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PRAVASTATIN; RAC PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; ROSUVASTATIN; SIMVASTATIN;

ANTIINFLAMMATORY ACTIVITY; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; DRUG DOSE COMPARISON; DRUG MEGADOSE; HEART INFARCTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; LOW DRUG DOSE; MYALGIA; NONHUMAN; PRIORITY JOURNAL; REVIEW; THROMBOSIS;

ANIMALS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA;

EID: 84879419196     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2013.01.004     Document Type: Review

References (43)

1. V.J. Dzau, R.C. Braun-Dullaeus, and D.G. Sedding Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies Nat Med 8 2002 1249 1256 (Pubitemid 35373556)
2. P. Libby, P.M. Ridker, and G.K. Hansson Progress and challenges in translating the biology of atherosclerosis Nature 473 2011 317 325
3. Q. Zhou, and J.K. Liao Pleiotropic effects of statins. Basic research and clinical perspectives Circ J 74 2010 818 826
4. P.H. Joshi, and T.A. Jacobson Therapeutic options to further lower C-reactive protein for patients on statin treatment Curr Atheroscler Rep 12 2010 34 42
5. R. Virmani, A.P. Burke, A. Farb, and F.D. Kolodgie Pathology of the vulnerable plaque J Am Coll Cardiol 47 2006 C13 C18
6. M. Singh, and U.S. Bedi Is atherosclerosis regression a realistic goal of statin therapy and what does that mean? Curr Atheroscler Rep 15 2013 294
7. J.K. Williams, G.K. Sukhova, D.M. Herrington, and P. Libby Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys J Am Coll Cardiol 31 1998 684 691 (Pubitemid 28144138)
8. M. Shiomi, T. Ito, T. Tsukada, T. Yata, Y. Watanabe, Y. Tsujita, M. Fukami, J. Fukushige, T. Hosokawa, and A. Tamura Reduction of serum cholesterol levels alters lesional composition of atherosclerotic plaques. Effect of pravastatin sodium on atherosclerosis in mature WHHL rabbits Arterioscler Thromb Vasc Biol 15 1995 1938 1944
9. K. Hattori, Y. Ozaki, T.F. Ismail, M. Okumura, H. Naruse, S. Kan, M. Ishikawa, T. Kawai, M. Ohta, and H. Kawai Impact of statin therapy on plaque characteristics as assessed by serial OCT, grayscale and integrated backscatter-IVUS JACC Cardiovasc Imaging 5 2012 169 177
10. J. Tian, X. Gu, Y. Sun, X. Ban, Y. Xiao, S. Hu, and B. Yu Effect of statin therapy on the progression of coronary atherosclerosis BMC Cardiovasc Disord 12 2012 70
11. I. Cicha, N. Schneiderhan-Marra, A. Yilmaz, C.D. Garlichs, and M. Goppelt-Struebe Monitoring the cellular effects of HMG-CoA reductase inhibitors in vitro and ex vivo Arterioscler Thromb Vasc Biol 24 2004 2046 2050 (Pubitemid 39482428)
12. A.L. Van, and C. D'Souza-Schorey Rho GTPases and signaling networks Genes Dev 11 1997 2295 2322 (Pubitemid 27408529)
13. U. Laufs, F.V. La, J. Plutzky, and J.K. Liao Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors Circulation 97 1998 1129 1135 (Pubitemid 28152885)
14. L.A. Holowatz, L. Santhanam, A. Webb, D.E. Berkowitz, and W.L. Kenney Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans J Physiol 589 2011 2093 2103
15. P.Y. Liu, Y.W. Liu, L.J. Lin, J.H. Chen, and J.K. Liao Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation Circulation 119 2009 131 138
16. U. Landmesser, F. Bahlmann, M. Mueller, S. Spiekermann, N. Kirchhoff, S. Schulz, C. Manes, D. Fischer, G.K. de, and D. Fliser Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans Circulation 111 2005 2356 2363 (Pubitemid 40647072)
17. M.A. Ostad, S. Eggeling, P. Tschentscher, E. Schwedhelm, R. Boger, P. Wenzel, T. Meinertz, T. Munzel, and A. Warnholtz Flow-mediated dilation in patients with coronary artery disease is enhanced by high dose atorvastatin compared to combined low dose atorvastatin and ezetimibe: results of the CEZAR study Atherosclerosis 205 2009 227 232
18. K.M. Parmar, V. Nambudiri, G. Dai, H.B. Larman, M.A. Gimbrone Jr., and G. Garcia-Cardena Statins exert endothelial atheroprotective effects via the KLF2 transcription factor J Biol Chem 280 2005 26714 26719 (Pubitemid 41040703)
19. S. Sen-Banerjee, S. Mir, Z. Lin, A. Hamik, G.B. Atkins, H. Das, P. Banerjee, A. Kumar, and M.K. Jain Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells Circulation 112 2005 720 726 (Pubitemid 41099052)
20. A. Pfenniger, C. Wong, E. Sutter, S. Cuhlmann, S. Dunoyer-Geindre, F. Mach, A.J. Horrevoets, P.C. Evans, R. Krams, and B.R. Kwak Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells J Mol Cell Cardiol 53 2012 299 309
21. D.X. Bu, M. Tarrio, N. Grabie, Y. Zhang, H. Yamazaki, G. Stavrakis, E. Maganto-Garcia, Z. Pepper-Cunningham, P. Jarolim, and M. Aikawa Statin-induced Kruppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses J Clin Invest 120 2010 1961 1970
22. M. Aikawa, E. Rabkin, S. Sugiyama, S.J. Voglic, Y. Fukumoto, Y. Furukawa, M. Shiomi, F.J. Schoen, and P. Libby An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro Circulation 103 2001 276 283 (Pubitemid 32095415)
23. T.T. Tuomisto, H. Lumivuori, E. Kansanen, S.K. Hakkinen, M.P. Turunen, J.V. van Thienen, A.J. Horrevoets, A.L. Levonen, and S. Yla-Herttuala Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2 Cardiovasc Res 78 2008 175 184 (Pubitemid 351430960)
24. J.E. Feig, Y. Shang, N. Rotllan, Y. Vengrenyuk, C. Wu, R. Shamir, I.P. Torra, C. Fernandez-Hernando, E.A. Fisher, and M.J. Garabedian Statins promote the regression of atherosclerosis via activation of the CCR7-dependent emigration pathway in macrophages PLoS ONE 6 2011 e28534
25. U. Laufs, D. Marra, K. Node, and J.K. Liao 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1) J Biol Chem 274 1999 21926 21931
26. Y. Fukumoto, P. Libby, E. Rabkin, C.C. Hill, M. Enomoto, Y. Hirouchi, M. Shiomi, and M. Aikawa Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits Circulation 103 2001 993 999 (Pubitemid 32183806)
27. G. Zhou, S. Ge, D. Liu, G. Xu, R. Zhang, Q. Yin, W. Zhu, J. Chen, and X. Liu Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway Cardiology 115 2010 221 228
28. L. Lacoste, J.Y. Lam, J. Hung, G. Letchacovski, C.B. Solymoss, and D. Waters Hyperlipidemia and coronary disease. Correction of the increased thrombogenic potential with cholesterol reduction Circulation 92 1995 3172 3177
29. S. Kaul, B.J. Waack, R.C. Padgett, R.M. Brooks, and D.D. Heistad Altered vascular responses to platelets from hypercholesterolemic humans Circ Res 72 1993 737 743 (Pubitemid 23077764)
30. P. Pignatelli, R. Carnevale, D. Pastori, R. Cangemi, L. Napoleone, S. Bartimoccia, C. Nocella, S. Basili, and F. Violi Immediate antioxidant and antiplatelet effect of atorvastatin via inhibition of Nox2 Circulation 126 2012 92 103
31. P. Pignatelli, R. Carnevale, S.S. Di, S. Bartimoccia, C. Nocella, T. Vicario, L. Loffredo, F. Angelico, and F. Violi Rosuvastatin reduces platelet recruitment by inhibiting NADPH oxidase activation Biochem Pharmacol 84 2012 1635 1642
32. R. Ni, T. Peleg, and P.L. Gross Atorvastatin delays murine platelet activation in vivo even in the absence of endothelial NO synthase Arterioscler Thromb Vasc Biol 32 2012 2609 2615
33. A.P. Owens III, F.H. Passam, S. Antoniak, S.M. Marshall, A.L. McDaniel, L. Rudel, J.C. Williams, B.K. Hubbard, J.A. Dutton, and J. Wang Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin J Clin Invest 122 2012 558 568
34. E.J. Mills, P. Wu, G. Chong, I. Ghement, S. Singh, E.A. Akl, O. Eyawo, G. Guyatt, O. Berwanger, and M. Briel Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170,255 patients from 76 randomized trials QJM 104 2011 109 124
35. Z. Zhou, E. Rahme, and L. Pilote Are statins created equal? Evidence from randomized trials of pravastatin, simvastatin, and atorvastatin for cardiovascular disease prevention Am Heart J 151 2006 273 281 (Pubitemid 43144726)
36. M. Fujita, T. Yamazaki, D. Hayashi, T. Kohro, Y. Okada, and R. Nagai Pleiotropic effects of statins on cardiovascular events in the Japanese Coronary Artery Disease study Int J Cardiol 129 2008 294 296
37. E. Istvan Statin inhibition of HMG-CoA reductase: a 3-dimensional view Atheroscler Suppl 4 2003 3 8 (Pubitemid 38234501)
38. W.L. Baker, and R. Datta Pitavastatin: a new 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor for the treatment of hyperlipidemia Adv Ther 28 2011 13 27
39. M. Yamazaki, H. Suzuki, M. Hanano, T. Tokui, T. Komai, and Y. Sugiyama Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver Am J Physiol 264 1993 G36 G44
40. N.A. Turner, L. Midgley, D.J. O'Regan, and K.E. Porter Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion J Cardiovasc Pharmacol 50 2007 458 461 (Pubitemid 350303825)
41. J.R. Murrow, S. Sher, S. Ali, I. Uphoff, R. Patel, M. Porkert, N.A. Le, D. Jones, and A.A. Quyyumi The differential effect of statins on oxidative stress and endothelial function: atorvastatin versus pravastatin J Clin Lipidol 6 2012 42 49
42. G. Weitz-Schmidt, K. Welzenbach, V. Brinkmann, T. Kamata, J. Kallen, C. Bruns, S. Cottens, Y. Takada, and U. Hommel Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site Nat Med 7 2001 687 692 (Pubitemid 32588024)
43. M. Jasinska-Stroschein, J. Owczarek, I. Wejman, and D. Orszulak-Michalak Novel mechanistic and clinical implications concerning the safety of statin discontinuation Pharmacol Rep 63 2011 867 879