Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans

Journal of Physiology

Volumn 589, Issue 8, 2011, Pages 2093-2103

  Holowatz, Lacy A ^a,b   Santhanam, Lakshmi ^a,b   Webb, Alanah ^a,b   Berkowitz, Dan E ^a,b   Kenney, W Larry ^a,b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE 1; ARGINASE 2; ARGININE; ATORVASTATIN; CHOLESTEROL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HEATING; HUMAN; HUMAN TISSUE; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; IN VIVO STUDY; MALE; MICRODIALYSIS; PRIORITY JOURNAL; SKIN BIOPSY; SKIN BLOOD FLOW; SKIN CONDUCTANCE; VASODILATATION;

ADMINISTRATION, ORAL; ADULT; ANALYSIS OF VARIANCE; ARGINASE; ARGININE; BIOLOGICAL MARKERS; BIOPSY; BLOOD FLOW VELOCITY; CHOLESTEROL; DOWN-REGULATION; ENZYME INHIBITORS; FEMALE; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; LIPOPROTEINS, LDL; MALE; MICROCIRCULATION; MICRODIALYSIS; MIDDLE AGED; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PENNSYLVANIA; PYRROLES; REGIONAL BLOOD FLOW; SKIN; TIME FACTORS; TREATMENT OUTCOME; TRIGLYCERIDES;

EID: 79954564392     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2010.203935     Document Type: Article

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