Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2

Cardiovascular Research

Volumn 78, Issue 1, 2008, Pages 175-184

  Tuomisto, Tiina T ^a   Lumivuori, Henri ^a   Kansanen, Emilia ^a   Häkkinen, Sanna Kaisa ^a   Turunen, Mikko P ^a   Van Thienen, Johannes V ^b   Horrevoets, Anton J ^b,d   Levonen, Anna Liisa ^a   Ylä Herttuala, Seppo ^a,c  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Atherosclerosis; Gene array analysis; Inflammation; Macrophages; Statins

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 2 RECEPTOR BETA; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 2; LYMPHOTOXIN BETA; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; SIMVASTATIN; SYNAPTOTAGMIN I; THROMBOPLASTIN; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE TRANSFER; HUMAN; HUMAN CELL; LENTIVIRINAE; MACROPHAGE ACTIVATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; UNINDEXED SEQUENCE; VASCULAR DISEASE;

ANTI-INFLAMMATORY AGENTS; CELL LINE; CELLS, CULTURED; CHEMOKINE CCL2; CYTOKINES; GENE EXPRESSION PROFILING; GENE TRANSFER TECHNIQUES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MACROPHAGES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN PRENYLATION; PROTO-ONCOGENE PROTEINS C-ETS; RNA, MESSENGER; SIMVASTATIN; THROMBOPLASTIN; TIME FACTORS; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTORS; UP-REGULATION;

EID: 41149135364     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvn007     Document Type: Article

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