Validation of a HTS-amenable assay to detect drug-induced mitochondrial toxicity in the absence and presence of cell death

Toxicology in Vitro

Volumn 27, Issue 6, 2013, Pages 1789-1797

  Swiss, Rachel ^a   Niles, Andrew ^b   Cali, James J ^b   Nadanaciva, Sashi ^a   Will, Yvonne ^a  

^a PFIZER INC   (United States)

^b PROMEGA CORPORATION   (United States)

Author keywords

Glucose galactose; High throughput; Mitochondria; Toxicity

Indexed keywords

ANTIMYCIN A1; BEPRIDIL; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CHEMICAL COMPOUND; CHLORPROMAZINE; CLOTRIMAZOLE; DASATINIB; DIFLUNISAL; DIGITONIN; DIPYRIDAMOLE; DROPERIDOL; ERGOCALCIFEROL; FIPEXIDE; FLUTAMIDE; GALACTOSE; GLUCOSE; HEXACHLOROPHENE; KETOCONAZOLE; MICONAZOLE; MONTELUKAST; NEFAZODONE; NICARDIPINE; NORTRIPTYLINE; OXYBUTYNIN; PAROXETINE; PIMOZIDE; PROGESTERONE; REAGENT; TOXIC SUBSTANCE; UNINDEXED DRUG;

ARTICLE; CELL DEATH; CELL STRAIN K 562; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DEVICES; DRUG INDUCED DISEASE; EQUIPMENT; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INCUBATION TIME; ISOLATION PROCEDURE; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL TOXICITY; REPRODUCIBILITY; VALIDATION PROCESS;

GLUCOSE/GALACTOSE; HIGH THROUGHPUT; MITOCHONDRIA; TOXICITY;

BIOLOGICAL ASSAY; CELL DEATH; CELL LINE; DRUG EVALUATION, PRECLINICAL; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; HEPATOCYTES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; K562 CELLS; MITOCHONDRIA; MYOCYTES, CARDIAC; REPRODUCIBILITY OF RESULTS; STEM CELLS;

EID: 84879353352     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.05.007     Document Type: Article

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