Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform

Journal of Bioenergetics and Biomembranes

Volumn 44, Issue 4, 2012, Pages 421-437

  Nadanaciva, Sashi ^a   Rana, Payal ^a   Beeson, Gyda C ^b   Chen, Denise ^c   Ferrick, David A ^c   Beeson, Craig C ^b   Will, Yvonne ^a  

^a PFIZER INC   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c Seahorse Bioscience   (United States)

Author keywords

Extracellular acidification; Mitochondrial dysfunction; Oxygen consumption; Respiration; Toxicity

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACETYLSALICYLIC ACID; BENOXAPROFEN; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CHLORPROMAZINE; CIGLITAZONE; CITRININ; CLOZAPINE; DEOXYGLUCOSE; DIFLUNISAL; ENTACAPONE; FLUTAMIDE; LIDOCAINE; NILUTAMIDE; OLIGOMYCIN; PIOGLITAZONE; QUINISOCAINE; ROSIGLITAZONE; ROTENONE; TOLCAPONE; TROGLITAZONE;

ACIDIFICATION; ANALYZER; ANIMAL CELL; ARTICLE; CAT; CELL RESPIRATION; CELL STRAIN HEPG2; CELL TYPE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG INDUCED DISEASE; DRUG INDUCED MITOCHONDRIAL DYSFUNCTION; DRUG INDUSTRY; GLYCOLYSIS; HEART FAILURE; HEART MUSCLE CELL; HUMAN; LIVER INJURY; MEASUREMENT; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; TARDIVE DYSKINESIA;

ANIMALS; CATS; DRUG EVALUATION, PRECLINICAL; FEMALE; GLYCOLYSIS; HEP G2 CELLS; HUMANS; MALE; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; THIAZOLIDINEDIONES;

FELIDAE;

EID: 84866736730     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-012-9446-z     Document Type: Article

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