Calsenilin contributes to neuronal cell death in ischemic stroke

Brain Pathology

Volumn 23, Issue 4, 2013, Pages 402-412

  Park, Jong Sung ^a   Manzanero, Silvia ^b   Chang, Jae Woong ^c   Choi, Yuri ^a   Baik, Sang Ha ^a   Cheng, Yi Lin ^b   Li, Yu I ^d   Gwon, A Ryeong ^a   Woo, Ha Na ^a   Jang, Jiyeon ^a   Choi, In Young ^a   Lee, Joo Yong ^e   Jung, Yong Keun ^c   Tang, Sung Chun ^d   Sobey, Christopher G ^f   Arumugam, Thiruma V ^b   Jo, Dong Gyu ^a  

^a Sungkyunkwan University   (South Korea)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c Seoul National University   (South Korea)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^e Asan Medical Center   (South Korea)

^f MONASH UNIVERSITY   (Australia)

Author keywords

secretase; calsenilin; ischemic stroke; neuronal cell death; Notch

Indexed keywords

CALSENILIN; CASPASE 3; GAMMA SECRETASE; NOTCH1 RECEPTOR; PLASMID DNA; PRESENILIN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; ANOXIA; APOPTOSIS; BRAIN; BRAIN ISCHEMIA; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; GLUCOSE; INFARCTION, MIDDLE CEREBRAL ARTERY; KV CHANNEL-INTERACTING PROTEINS; MALE; MICE; MICE, INBRED C57BL; NEURONS; PRESENILINS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS; UP-REGULATION;

EID: 84879231919     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/bpa.12013     Document Type: Article

References (29)

1. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, et al (2000) Modulation of A-type potassium channels by a family of calcium sensors. Nature 403: 553-556.
2. Arumugam TV, Chan SL, Jo DG, Yilmaz G, Tang SC, Cheng A, et al (2006) Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med 12: 621-623.
3. Arumugam TV, Cheng YL, Choi Y, Choi YH, Yang S, Yun YK, et al (2011) Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke. Mol Pharmacol 80: 23-31.
4. Baulac S, LaVoie MJ, Kimberly WT, Strahle J, Wolfe MS, Selkoe DJ, Xia W, (2003) Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates. Neurobiol Dis 14: 194-204.
5. Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W, (1998) Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat Med 4: 1177-1181.
6. Carrion AM, Link WA, Ledo F, Mellstrom B, Naranjo JR, (1999) DREAM is a Ca2+-regulated transcriptional repressor. Nature 398: 80-84.
7. Chang JW, Choi H, Kim HJ, Jo DG, Jeon YJ, Noh JY, et al (2007) Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin. Hum Mol Genet 16: 317-326.
8. Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, et al (2001) Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. J Biol Chem 276: 19197-19204.
9. Choi YH, Gwon AR, Jeong HY, Park JS, Baik SH, Arumugam TV, Jo DG, (2010) Contribution of gamma-secretase to calcium-mediated cell death. Neurosci Lett 469: 425-428.
10. De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, et al (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391: 387-390.
11. Fedrizzi L, Lim D, Carafoli E, Brini M, (2008) Interplay of the Ca2+-binding protein DREAM with presenilin in neuronal Ca2+ signaling. J Biol Chem 283: 27494-27503.
12. Gwon AR, Park JS, Arumugam TV, Kwon YK, Chan SL, Kim SH, et al (2012) Oxidative lipid modification of nicastrin enhances amyloidogenic gamma-secretase activity in Alzheimer's disease. Aging Cell 11: 559-568.
13. Hendriks L, Thinakaran G, Harris CL, De Jonghe C, Martin JJ, Sisodia SS, Van Broeckhoven C, (1997) Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls. Neuroreport 8: 1717-1721.
14. Jin JK, Choi JK, Wasco W, Buxbaum JD, Kozlowski PB, Carp RI, et al (2005) Expression of calsenilin in neurons and astrocytes in the Alzheimer's disease brain. Neuroreport 16: 451-455.
15. Jo DG, Arumugam TV, Woo HN, Park JS, Tang SC, Mughal M, et al (2010) Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease. Neurobiol Aging 31: 917-925.
16. Jo DG, Chang JW, Hong HS, Mook-Jung I, Jung YK, (2003) Contribution of presenilin/gamma-secretase to calsenilin-mediated apoptosis. Biochem Biophys Res Commun 305: 62-66.
17. Jo DG, Jang J, Kim BJ, Lundkvist J, Jung YK, (2005) Overexpression of calsenilin enhances gamma-secretase activity. Neurosci Lett 378: 59-64.
18. Jo DG, Kim MJ, Choi YH, Kim IK, Song YH, Woo HN, et al (2001) Pro-apoptotic function of calsenilin/DREAM/KChIP3. FASEB J 15: 589-591.
19. Kopan R, (2002) Notch: a membrane-bound transcription factor. J Cell Sci 115: 1095-1097.
20. Lilliehook C, Chan S, Choi EK, Zaidi NF, Wasco W, Mattson MP, Buxbaum JD, (2002) Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling. Mol Cell Neurosci 19: 552-559.
21. Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, et al (2002) A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J 21: 1948-1956.
22. Okun E, Arumugam TV, Tang SC, Gleichmann M, Albeck M, Sredni B, Mattson MP, (2007) The organotellurium compound ammonium trichloro(dioxoethylene-0,0') tellurate enhances neuronal survival and improves functional outcome in an ischemic stroke model in mice. J Neurochem 102: 1232-1241.
23. Song W, Nadeau P, Yuan M, Yang X, Shen J, Yankner BA, (1999) Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci U S A 96: 6959-6963.
24. Supnet C, Bezprozvanny I, (2011) Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis. Cell Calcium 50: 303-309.
25. Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, et al (2006) Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126: 981-993.
26. Wei Z, Chigurupati S, Arumugam TV, Jo DG, Li H, Chan SL, (2011) Notch activation enhances the microglia-mediated inflammatory response associated with focal cerebral ischemia. Stroke 42: 2589-2594.
27. Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ, (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398: 513-517.
28. Woo HN, Chang JW, Choi YH, Gwon AR, Jung YK, Jo DG, (2008) Characterization of subcellular localization and Ca2+ modulation of calsenilin/DREAM/KChIP3. Neuroreport 19: 1193-1197.
29. Zaidi NF, Berezovska O, Choi EK, Miller JS, Chan H, Lilliehook C, et al (2002) Biochemical and immunocytochemical characterization of calsenilin in mouse brain. Neuroscience 114: 247-263.