Characterization of subcellular localization and Ca2+ modulation of calsenilin/DREAM/KChIP3

NeuroReport

Volumn 19, Issue 12, 2008, Pages 1193-1197

  Woo, Ha Na ^a   Chang, Jae Woong ^b   Choi, Yun Hyung ^a   Gwon, A Ryeong ^a   Jung, Yong Keun ^b   Jo, Dong Gyu ^a  

^a Sungkyunkwan University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Calcium; Calsenilin DREAM KChIP3; Subcellular localization

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CALSENILIN; COMPLEMENTARY DNA; CALCIUM; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; KCNIP3 PROTEIN, HUMAN; KV CHANNEL INTERACTING PROTEIN; REPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL FRACTIONATION; CELL NUCLEUS; CELL STRAIN COS7; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; HELA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; PROTEOMICS; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; FLUORESCENCE MICROSCOPY; GENETICS; INTRACELLULAR SPACE; LEUKEMIA CELL LINE; METABOLISM; METHODOLOGY; PLASMID; TUMOR CELL LINE;

ANIMALS; CALCIUM; CELL FRACTIONATION; CELL LINE, TUMOR; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; COS CELLS; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SPACE; JURKAT CELLS; KV CHANNEL-INTERACTING PROTEINS; MICROSCOPY, FLUORESCENCE; PLASMIDS; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SUBCELLULAR FRACTIONS;

EID: 51649097735     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e3283089209     Document Type: Article

References (18)

1. Buxbaum JD, Choi E, Luo Y, Lilliehook C, Crowley AC, Merriam DE, et al. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat Med 1998; 4:1177-1181.
2. 2+-regulated transcriptional repressor. Nature 1999; 398:80-84.
3. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature 2000; 403:553-556.
4. Jo DG, Kim MJ, Choi YH, Kim IK, Song YH, Woo HN, et al. Proapoptotic function of calsenilin/DREAM/KChIP3. FASEB J 2001; 15:589-591.
5. Jo DG, Lee JY, Hong YM, Song S, Mook-Jung I, Koh JY, et al. Induction of proapoptotic calsenilin/DREAM/KChIP3 in Alzheimer's disease and cultured neurons after amyloid-β exposure. J Neurochem 2004; 88:604-611.
6. Jin JK, Choi JK, Wasco W, Buxbaum JD, Kozlowski PB, Carp RI, et al. Expression of calsenilin in neurons and astrocytes in the Alzheimer's disease brain. Neuroreport 2005; 16:451-455.
7. Lilliehook C, Chan S, Choi EK, Zaidi NF, Wasco W, Mattson MP, Buxbaum JD. Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling. Mol Cell Neurosci 2002; 19:552-559.
8. Jo DG, Jang J, Kim BJ, Lundkvist J, Jung YK. Overexpression of calsenilin enhances γ-secretase activity. Neurosci Lett 2005; 378:59-64.
9. Jo DG, Chang JW, Hong HS, Mook-Jung I, Jung YK. Contribution of presenilin/γ-secretase to calsenilin-mediated apoptosis. Biochem Biophys Res Commun 2005; 305:62-66.
10. Lilliehook C, Bozdagi O, Yao J, Gomez-Ramirez M, Zaidi NF, Wasco W, et al. Altered Aγ formation and long-term potentiation in a calsenilin knockout. J Neurosci 2003; 23:9097-9106.
11. Kovacs DM, Fausett HJ, Page KJ, Kim TW, Mori RD, Merriam DE, et al. Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med 1996; 2:224-229.
12. Wang HG, Rapp UR, Reed JC. Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 1996; 87:629-638.
13. 45Ca autoradiography on nitrocellulose membrane after sodium dodecyl sulfate gel electrophoresis. J Biochem (Tokyo) 1984; 95:511-519.
14. Spreafico F, Barski JJ, Farina C, Meyer M. Mouse DREAM/calsenilin/ KChIP3: gene structure, coding potential, and expression. Mol Cell Neurosci 2001; 17:1-16.
15. Burnstock G. Purinergic receptors. J Theor Biol 1976; 62:491-503.
16. Burnstock G. Neurotransmitters and trophic factors in the autonomic nervous system. J Phsiol (Lond) 1981; 313:1-35.
17. Gordon JL. Extracellular ATP: effects, sources and fate. Biochem J 1986; 233:309-319.
18. Dubyak GR, Cowen DS, Meuller LM. Activation of inositol phospholipid breakdown in HL-60 cells by P2-purinergic receptors for extracellular ATP. Evidence for mediation by both pertussis toxin-sensitive and pertussis toxin-insensitive mechanisms. J Biol Chem 1988; 263:18108-18117.