Contribution of presenilin/γ-secretase to calsenilin-mediated apoptosis

Biochemical and Biophysical Research Communications

Volumn 305, Issue 1, 2003, Pages 62-66

  Jo, Dong Gyu ^a   Chang, Jae Woong ^a   Hong, Hyun Seok ^b   Mook Jung, Inhee ^b   Jung, Yong Keun ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Ajou University School of Medicine   (South Korea)

Author keywords

Alzheimer's disease; A ; Calsenilin; Cell death; Presenilin; Secretase

Indexed keywords

AMYLOID BETA PROTEIN; CALSENILIN; ENZYME INHIBITOR; GAMMA SECRETASE; ISOPROTEIN; MUTANT PROTEIN; PRESENILIN 1; PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL DEATH; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; FAMILIAL DISEASE; FIBROBLAST; HUMAN; HUMAN CELL; INCIDENCE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; UPREGULATION;

EID: 0038069158     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00688-0     Document Type: Article

References (25)

1. Price D.L., Sisodia S.S. Mutant genes in familial Alzheimer's disease and transgenic models. Anuu. Rev. Neurosci. 21:1998;479-505.
2. Loo D.T., Copani A., Pike C.J., Whittemore E.R., Walencewicz A., Cotman C.W. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. USA. 90:1993;7951-7955.
3. Estus S., Tucker H.M., van Rooyen C., Wright S., Brigham E.F., Wogulis M., Rydel R.E. Aggregated amyloid-β protein induces cortical neuronal apoptosis and concomitant apoptotic pattern of gene induction. J. Neurosci. 17:1997;7736-7745.
4. LeBlanc A. Increased production of 4. kDa amyloid β peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis J. Neurosci. 15:1995;7837-7846.
5. Gervais F.G., Xu D., Robertson G.S., Vaillancourt J.P., Zhu Y., Huang J., LeBlanc A., Smith D., Rigby M., Shearman M.S., Clarke E.F., Zheng H., Van Der Ploeg L.H., Ruffolo S.C., Thornberry N.A., Xanthoudakis S., Zamboni R.J., Roy S., Nicholson D.W. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-. rbeta precursor protein and amyloidogenic A β peptide formation Cell. 97:1999;395-406.
6. Yuan J., Yankner N.A. Apoptosis in the nervous system. Nature. 407:2000;802-809.
7. Deng G., Pike C.J., Cotman C.W., Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells FEBS Lett. 397:1996;50-54.
8. Guo Q., Furukawa K., Sopher B.L., Pham D.G., Robinson N., Martin G.M., Mattson M.P. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide. NeuroReport. 8:1996;379-383.
9. 2+ -binding protein ALG-2 and Alzheimer's disease gene ALG-3 Science. 271:1996;521-525.
10. Wolozin B., Iwasaki K., Vito P., Ganjei J.K., Lacana E., Sunderland T., Zhao B., Kusiak J.W., Wasco W., D'Adamio L. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science. 274:1996;1710-1713.
11. Guo Q., Sopher B.L., Furukawa K., Pham D.G., Robinson N., Martin G.M., Mattson M.P. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: involvement of calcium and oxyradicals. J. Neurosci. 17:1997;4212-4222.
12. Janicki S., Monteiro M.J. Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I). J. Cell Biol. 139:1997;485-495.
13. Vito P., Wolozin B., Ganjei J.K., Katsunori I., Lacan E., D'Adamio L. Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3. J. Biol. Chem. 271:1996;31025-31028.
14. Tomita T., Takikawa R., Koyama A., Morohashi Y., Takisugi N., Saido T.C., Maruyama K., Iwatsubo T. C terminus of presenilin is required for overproduction of Aβ42 through stabilization and endoproteolysis of presenilin. J. Neurosci. 19:1999;10627-10634.
15. Buxbaum J.D., Choi E., Luo Y., Lilliehook C., Crowley A.C., Merriam D.E., Wasco W. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat. Med. 4:1998;1177-1181.
16. Frank An W., Bowlby M.R., Betty M., Cao J., Ling H.P., Mendoza G., Hinson J.W., Mattsson K.I., Strassle B.W., Trimmer J.S., Rhodes K.J. Modulation of A-type potassium channels by a family of calcium sensors. Nature. 403:2000;553-556.
17. 2+ -regulated transcriptional repressor Nature. 398:1999;80-84.
18. Jo D.G., Kim M.J., Choi Y.H., Kim I.K., Song Y.H., Woo H.N., Chung C.W., Jung Y.K. Pro-apoptotic function of calsenilin/DREAM/KChIP3. FASEB J. 15:2001;589-591. (first published on January 19, 2001: 10.1096/fj.00-0541fje).
19. De Strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J.S., Schroeter E.H., Schrijvers V., Wolfe M.S., Ray W.J., Goate A., Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 398:1999;518-522.
20. Dovey H.F., John V., Anderson J.P., Chen L.Z., de Saint Andrieu P., Fang L.Y., Freedman S.B., Folmer B., Goldbach E., Holsztynska E.J., Hu K.L., Johnson-Wood K.L., Kennedy S.L., Kholodenko D., Knops J.E., Latimer L.H., Lee M., Liao Z., Lieberburg I.M., Motter R.N., Mutter L.C., Nietz J., Quinn K.P., Sacchi K.L., Seubert P.A., Shopp G.M., Thorsett E.D., Tung J.S., Wu J., Yang S., Yin C.T., Schenk D.B., May P.C., Altstiel L.D., Bender M.H., Boggs L.N., Britton T.C., Clemens J.C., Czilli D.L., Dieckman-McGinty D.K., Droste J.J., Fuson K.S., Gitter B.D., Hyslop P.A., Johnstone E.M., Li W.Y., Little S.P., Mabry T.E., Miller F.D., Audia J.E. Functional γ-secretase inhibitors reduce β-amyloid peptide levels in brain. J. Neurochem. 76:2001;173-181.
21. Seiffert D., Bradley J.D., Rominger C.M., Rominger D.H., Yang F., Meredith J.E., Wang Q. Jr., Roach A.H., Thompson L.A., Spitz S.M., Higaki J.N., Prakash S.R., Combs A.P., Copeland R.A., Arneric S.P., Hartig P.R., Robertson D.W., Cordell B., Stern A.M., Olson R.E., Zaczek R. Presenilin-1 and -2 are molecular targets for γ-secretase inhibitors. J. Biol. Chem. 275:2000;34086-34091.
22. Li Y.M., Lai M.T., Xu M., Huang Q., DiMuzio-Mower J., Sardana M.K., Shi X.P., Yin K.C., Shafer J.A., Gardell S.J. Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state. Proc. Natl. Acad. Sci. USA. 97:2000;6138-6143.
23. Esler W.P., Kimberly W.T., Ostaszewski B.L., Ye W., Diehl T.S., Selkoe D.J., Wolfe M.S. Activity-dependent isolation of presenilin-γ-secretase complex reveals nicarstin and a γ substrate. Proc. Natl. Acad. Sci. USA. 99:2002;2720-2725.
24. Wolfe M.S., Xia W., Ostaszewski B.L., Diehl T.S., Kimberly W.T., Selkoe D.J. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature. 398:1999;513-517.
25. Li Y.M., Xu M., Lai M.T., Huang Q., Castro J., DiMuzio-Mower J., Harrison T., Lellis C., Nadin A., Neduvelil J., Register R., Sardana M., Shearman M., Smith A., Shi X.P., Yin K.C., Shafer J., Gardell S.J. Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1. Nature. 405:2000;689-694.