-
1
-
-
42149181885
-
Structural diversity of G protein-coupled receptors and significance for drug discovery.
-
Lagerström MC, Schiöth HB. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov 2008, 7:339-357.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 339-357
-
-
Lagerström, M.C.1
Schiöth, H.B.2
-
2
-
-
1942487845
-
Recent advances in drug action and therapeutics: relevance of novel concepts in G-protein-coupled receptor and signal transduction pharmacology.
-
Brink CB, Harvey BH, Bodenstein J, Venter DP, Oliver DW. Recent advances in drug action and therapeutics: relevance of novel concepts in G-protein-coupled receptor and signal transduction pharmacology. Br J Clin Pharmacol 2004, 57:373-387.
-
(2004)
Br J Clin Pharmacol
, vol.57
, pp. 373-387
-
-
Brink, C.B.1
Harvey, B.H.2
Bodenstein, J.3
Venter, D.P.4
Oliver, D.W.5
-
3
-
-
13344280365
-
Classification and nomenclature of 5-HT receptors: a comment on current issues.
-
Hoyer D, Martin GR. Classification and nomenclature of 5-HT receptors: a comment on current issues. Behav Brain Res 1996, 73:263-268.
-
(1996)
Behav Brain Res
, vol.73
, pp. 263-268
-
-
Hoyer, D.1
Martin, G.R.2
-
4
-
-
16444376787
-
Serotonin 5-HT4 receptors and their mRNAs in rat and guinea pig brain: distribution and effects of neurotoxic lesions.
-
Vilaró MT, Cortés R, Mengod G. Serotonin 5-HT4 receptors and their mRNAs in rat and guinea pig brain: distribution and effects of neurotoxic lesions. J Comp Neurol 2005, 484:418-439.
-
(2005)
J Comp Neurol
, vol.484
, pp. 418-439
-
-
Vilaró, M.T.1
Cortés, R.2
Mengod, G.3
-
5
-
-
78650224893
-
Profiles of serotonin receptors in the developing human thalamus.
-
Wai MS, Lorke DE, Kwong WH, Zhang L, Yew DT. Profiles of serotonin receptors in the developing human thalamus. Psychiatry Res 2011, 185:238-242.
-
(2011)
Psychiatry Res
, vol.185
, pp. 238-242
-
-
Wai, M.S.1
Lorke, D.E.2
Kwong, W.H.3
Zhang, L.4
Yew, D.T.5
-
6
-
-
33747059826
-
Investigation of serotonin type 4 receptor expression in human and non-human primate gastrointestinal samples.
-
Mader R, Kocher T, Haier J, Wieczorek G, Pfannkuche HJ, Ito M. Investigation of serotonin type 4 receptor expression in human and non-human primate gastrointestinal samples. Eur J Gastroenterol Hepatol 2006, 18:945-950.
-
(2006)
Eur J Gastroenterol Hepatol
, vol.18
, pp. 945-950
-
-
Mader, R.1
Kocher, T.2
Haier, J.3
Wieczorek, G.4
Pfannkuche, H.J.5
Ito, M.6
-
7
-
-
0034745301
-
5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle.
-
Bach T, Syversveen T, Kvingedal AM, Krobert KA, Brattelid T, Kaumann AJ, Levy F. 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. Naunyn Schmiedebergs Arch Pharmacol 2001, 363:146-160.
-
(2001)
Naunyn Schmiedebergs Arch Pharmacol
, vol.363
, pp. 146-160
-
-
Bach, T.1
Syversveen, T.2
Kvingedal, A.M.3
Krobert, K.A.4
Brattelid, T.5
Kaumann, A.J.6
Levy, F.7
-
8
-
-
77249125796
-
Brain imaging of serotonin 4 receptors in humans with [11C]SB207145-PET.
-
Marner L, Gillings N, Madsen K, Erritzoe D, Baaré WF, Svarer C, Hasselbalch SG, Knudsen GM. Brain imaging of serotonin 4 receptors in humans with [11C]SB207145-PET. Neuroimage 2010, 50:855-61.
-
(2010)
Neuroimage
, vol.50
, pp. 855-861
-
-
Marner, L.1
Gillings, N.2
Madsen, K.3
Erritzoe, D.4
Baaré, W.F.5
Svarer, C.6
Hasselbalch, S.G.7
Knudsen, G.M.8
-
9
-
-
52949134083
-
5-HT4 receptor agonism in the five-choice serial reaction time task.
-
Hille C, Bate S, Davis J, Gonzalez MI. 5-HT4 receptor agonism in the five-choice serial reaction time task. Behav Brain Res 2008, 195:180-186.
-
(2008)
Behav Brain Res
, vol.195
, pp. 180-186
-
-
Hille, C.1
Bate, S.2
Davis, J.3
Gonzalez, M.I.4
-
10
-
-
0030610872
-
5-HT4 receptors improve social olfactory memory in the rat.
-
Letty S, Child R, Dumuis A, Pantaloni A, Bockaert J, Rondouin G. 5-HT4 receptors improve social olfactory memory in the rat. Neuropharmacology 1997, 36:681-687.
-
(1997)
Neuropharmacology
, vol.36
, pp. 681-687
-
-
Letty, S.1
Child, R.2
Dumuis, A.3
Pantaloni, A.4
Bockaert, J.5
Rondouin, G.6
-
11
-
-
16844371069
-
Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: viral transfections, subacute and chronic treatments with 5-HT4 agonists.
-
Lucas G, Compan V, Charnay Y, Neve RL, Nestler EJ, Bockaert J, Barrot M, Debonnel G. Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: viral transfections, subacute and chronic treatments with 5-HT4 agonists. Biol Psychiatry 2005, 57:918-925.
-
(2005)
Biol Psychiatry
, vol.57
, pp. 918-925
-
-
Lucas, G.1
Compan, V.2
Charnay, Y.3
Neve, R.L.4
Nestler, E.J.5
Bockaert, J.6
Barrot, M.7
Debonnel, G.8
-
12
-
-
9144257880
-
Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice.
-
Compan V, Zhou M, Grailhe R, Gazzara RA, Martin R, Gingrich J, Dumuis A, Brunner D, Bockaert J, Hen R. Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice. J Neurosci 2004, 24:412-419.
-
(2004)
J Neurosci
, vol.24
, pp. 412-419
-
-
Compan, V.1
Zhou, M.2
Grailhe, R.3
Gazzara, R.A.4
Martin, R.5
Gingrich, J.6
Dumuis, A.7
Brunner, D.8
Bockaert, J.9
Hen, R.10
-
13
-
-
22144493355
-
New insights into serotonin 5-HT4 receptors: a novel therapeutic target for Alzheimer's disease?
-
Maillet M, Robert SJ, Lezoualc'h F. New insights into serotonin 5-HT4 receptors: a novel therapeutic target for Alzheimer's disease? Curr Alzheimer Res 2004, 1:79-85.
-
(2004)
Curr Alzheimer Res
, vol.1
, pp. 79-85
-
-
Maillet, M.1
Robert, S.J.2
Lezoualc'h, F.3
-
14
-
-
34548246547
-
Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action.
-
Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, et al. Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action. Neuron 2007, 55:712-725.
-
(2007)
Neuron
, vol.55
, pp. 712-725
-
-
Lucas, G.1
Rymar, V.V.2
Du, J.3
Mnie-Filali, O.4
Bisgaard, C.5
Manta, S.6
Lambas-Senas, L.7
Wiborg, O.8
Haddjeri, N.9
Piñeyro, G.10
-
15
-
-
77949523855
-
Debonnel G. Selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat.
-
Lucas G, Du J, Romeas T, Mnie-Filali O, Haddjeri N, Piñeyro G. Debonnel G. Selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat. PLoS ONE 2010, 5:e9253.
-
(2010)
PLoS ONE
, vol.5
-
-
Lucas, G.1
Du, J.2
Romeas, T.3
Mnie-Filali, O.4
Haddjeri, N.5
Piñeyro, G.6
-
16
-
-
0027054187
-
Characterization of homologous 5-hydroxytryptamine4 receptor desensitization in colliculi neurons.
-
Ansanay H, Sebben M, Bockaert J, Dumuis A. Characterization of homologous 5-hydroxytryptamine4 receptor desensitization in colliculi neurons. Mol Pharmacol 1992, 42:808-816.
-
(1992)
Mol Pharmacol
, vol.42
, pp. 808-816
-
-
Ansanay, H.1
Sebben, M.2
Bockaert, J.3
Dumuis, A.4
-
17
-
-
23044461829
-
Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements.
-
Barthet G, Gaven F, Framery B, Shinjo K, Nakamura T, Claeysen S, Bockaert J, Dumuis A. Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements. J Biol Chem 2005, 280:27924-27934.
-
(2005)
J Biol Chem
, vol.280
, pp. 27924-27934
-
-
Barthet, G.1
Gaven, F.2
Framery, B.3
Shinjo, K.4
Nakamura, T.5
Claeysen, S.6
Bockaert, J.7
Dumuis, A.8
-
18
-
-
65549162668
-
The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration.
-
Licht CL, Marcussen AB, Wegener G, Overstreet DH, Aznar S, Knudsen GM. The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration. J Neurochem 2009, 109:1363-1374.
-
(2009)
J Neurochem
, vol.109
, pp. 1363-1374
-
-
Licht, C.L.1
Marcussen, A.B.2
Wegener, G.3
Overstreet, D.H.4
Aznar, S.5
Knudsen, G.M.6
-
19
-
-
67650446830
-
Long-term treatment with fluoxetine induces desensitization of 5-HT4 receptor-dependent signalling and functionality in rat brain.
-
Vidal R, Valdizán EM, Mostany R, Pazos A, Castro E. Long-term treatment with fluoxetine induces desensitization of 5-HT4 receptor-dependent signalling and functionality in rat brain. J Neurochem 2009, 110:1120-1127.
-
(2009)
J Neurochem
, vol.110
, pp. 1120-1127
-
-
Vidal, R.1
Valdizán, E.M.2
Mostany, R.3
Pazos, A.4
Castro, E.5
-
20
-
-
77956318009
-
Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats.
-
Vidal R, Valdizan EM, Vilaró MT, Pazos A, Castro E. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats. Br J Pharmacol 2010, 161:695-706.
-
(2010)
Br J Pharmacol
, vol.161
, pp. 695-706
-
-
Vidal, R.1
Valdizan, E.M.2
Vilaró, M.T.3
Pazos, A.4
Castro, E.5
-
21
-
-
0032216590
-
5-HT4 receptors: gene, transduction and effects on olfactory memory.
-
Bockaert J, Claeysen S, Sebben M, Dumuis A. 5-HT4 receptors: gene, transduction and effects on olfactory memory. Ann N Y Acad Sci 1998, 861:1-15.
-
(1998)
Ann N Y Acad Sci
, vol.861
, pp. 1-15
-
-
Bockaert, J.1
Claeysen, S.2
Sebben, M.3
Dumuis, A.4
-
22
-
-
0030751064
-
Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium.
-
Blondel O, Vandecasteele G, Gastineau M, Leclerc S, Dahmoune Y, Langlois M, Fischmeister R. Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium. FEBS Lett 1997, 412:465-474.
-
(1997)
FEBS Lett
, vol.412
, pp. 465-474
-
-
Blondel, O.1
Vandecasteele, G.2
Gastineau, M.3
Leclerc, S.4
Dahmoune, Y.5
Langlois, M.6
Fischmeister, R.7
-
23
-
-
0030828015
-
Cloning and expression of a human serotonin 5-HT4 receptor cDNA.
-
Van den Wyngaert I, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W, Bender E. Cloning and expression of a human serotonin 5-HT4 receptor cDNA. J Neurochem 1997, 69:1810-1819.
-
(1997)
J Neurochem
, vol.69
, pp. 1810-1819
-
-
Van Den Wyngaert, I.1
Gommeren, W.2
Verhasselt, P.3
Jurzak, M.4
Leysen, J.5
Luyten, W.6
Bender, E.7
-
24
-
-
0031747387
-
Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus.
-
Blondel O, Gastineau M, Dahmoune Y, Langlois M, Fischmeister R. Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. J Neurochem 1998, 70:2252-2261.
-
(1998)
J Neurochem
, vol.70
, pp. 2252-2261
-
-
Blondel, O.1
Gastineau, M.2
Dahmoune, Y.3
Langlois, M.4
Fischmeister, R.5
-
25
-
-
0033968216
-
Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.
-
Bender E, Pindon A, van Oers I, Zhang YB, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W. Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant. J Neurochem 2000, 74:478-489.
-
(2000)
J Neurochem
, vol.74
, pp. 478-489
-
-
Bender, E.1
Pindon, A.2
van Oers, I.3
Zhang, Y.B.4
Gommeren, W.5
Verhasselt, P.6
Jurzak, M.7
Leysen, J.8
Luyten, W.9
-
26
-
-
0032534260
-
5-HT4 receptors: cloning and expression of new splice variants.
-
Claeysen S, Faye P, Sebben M, Taviaux S, Bockaert J, Dumuis A. 5-HT4 receptors: cloning and expression of new splice variants. Ann N Y Acad Sci 1998, 861:49-56.
-
(1998)
Ann N Y Acad Sci
, vol.861
, pp. 49-56
-
-
Claeysen, S.1
Faye, P.2
Sebben, M.3
Taviaux, S.4
Bockaert, J.5
Dumuis, A.6
-
27
-
-
2142732025
-
Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i).
-
Brattelid T, Kvingedal AM, Krobert KA, Andressen KW, Bach T, Hystad ME, Kaumann AJ, Levy FO. Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i). Naunyn Schmiedebergs Arch Pharmacol 2004, 369:616-628.
-
(2004)
Naunyn Schmiedebergs Arch Pharmacol
, vol.369
, pp. 616-628
-
-
Brattelid, T.1
Kvingedal, A.M.2
Krobert, K.A.3
Andressen, K.W.4
Bach, T.5
Hystad, M.E.6
Kaumann, A.J.7
Levy, F.O.8
-
28
-
-
0036141275
-
Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants.
-
Vilaró MT, Doménech T, Palacios JM, Mengod G. Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants. Neuropharmacology 2002, 42:60-73.
-
(2002)
Neuropharmacology
, vol.42
, pp. 60-73
-
-
Vilaró, M.T.1
Doménech, T.2
Palacios, J.M.3
Mengod, G.4
-
29
-
-
17844405273
-
Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and β-arrestin-mediated endocytosis.
-
Ponimaskin E, Dumuis A, Gaven F, Barthet G, Heine M, Glebov K, Richter DW, Oppermann M. Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and β-arrestin-mediated endocytosis. Mol Pharmacol 2005, 67:1434-1443.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 1434-1443
-
-
Ponimaskin, E.1
Dumuis, A.2
Gaven, F.3
Barthet, G.4
Heine, M.5
Glebov, K.6
Richter, D.W.7
Oppermann, M.8
-
30
-
-
0037169528
-
The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites, and acylation is critically involved in regulation of receptor constitutive activity.
-
Ponimaskin EG, Heine M, Joubert L, Sebben M, Bickmeyer U, Richter DW, Dumuis A. The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites, and acylation is critically involved in regulation of receptor constitutive activity. J Biol Chem 2002, 277:2534-2546.
-
(2002)
J Biol Chem
, vol.277
, pp. 2534-2546
-
-
Ponimaskin, E.G.1
Heine, M.2
Joubert, L.3
Sebben, M.4
Bickmeyer, U.5
Richter, D.W.6
Dumuis, A.7
-
31
-
-
0032938367
-
Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain.
-
Claeysen S, Sebben M, Becamel C, Bockaert J, Dumuis A. Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain. Mol Pharmacol 1999, 55:910-920.
-
(1999)
Mol Pharmacol
, vol.55
, pp. 910-920
-
-
Claeysen, S.1
Sebben, M.2
Becamel, C.3
Bockaert, J.4
Dumuis, A.5
-
32
-
-
0037332227
-
Characterization of human 5-HT4(d) receptor desensitization in CHO cells.
-
Mialet J, Fischmeister R, Lezoualc'h F. Characterization of human 5-HT4(d) receptor desensitization in CHO cells. Br J Pharmacol 2003, 138:445-452.
-
(2003)
Br J Pharmacol
, vol.138
, pp. 445-452
-
-
Mialet, J.1
Fischmeister, R.2
Lezoualc'h, F.3
-
33
-
-
23944450841
-
Internalization of human 5-HT4a and 5-HT4b receptors is splice variant dependent.
-
Pindon A, Van Hecke G, Josson K, Van Gompel P, Lesage A, Leysen JE, Jurzak M. Internalization of human 5-HT4a and 5-HT4b receptors is splice variant dependent. Biosci Rep 2004, 24:215-223.
-
(2004)
Biosci Rep
, vol.24
, pp. 215-223
-
-
Pindon, A.1
Van Hecke, G.2
Josson, K.3
Van Gompel, P.4
Lesage, A.5
Leysen, J.E.6
Jurzak, M.7
-
34
-
-
71349084215
-
Serotonin 4 receptor (5-HT4R) internalization is isoform-specific: effects of 5-HT and RS67333 on isoforms A and B.
-
Mnie-Filali O, Amraei MG, Benmbarek S, Archer-Lahlou E, Peñas-Cazorla R, Vilaró MT, Boye SM, Piñeyro G. Serotonin 4 receptor (5-HT4R) internalization is isoform-specific: effects of 5-HT and RS67333 on isoforms A and B. Cell Signal 2010, 22:501-509.
-
(2010)
Cell Signal
, vol.22
, pp. 501-509
-
-
Mnie-Filali, O.1
Amraei, M.G.2
Benmbarek, S.3
Archer-Lahlou, E.4
Peñas-Cazorla, R.5
Vilaró, M.T.6
Boye, S.M.7
Piñeyro, G.8
-
35
-
-
77951475671
-
Investigations into the binding affinities of different human 5-HT4 receptor splice variants.
-
Irving HR, Tochon-Danguy N, Chinkwo KA, Li JG, Grabbe C, Shapiro M, Pouton CW, Coupar IM. Investigations into the binding affinities of different human 5-HT4 receptor splice variants. Pharmacology 2010, 85:224-233.
-
(2010)
Pharmacology
, vol.85
, pp. 224-233
-
-
Irving, H.R.1
Tochon-Danguy, N.2
Chinkwo, K.A.3
Li, J.G.4
Grabbe, C.5
Shapiro, M.6
Pouton, C.W.7
Coupar, I.M.8
-
36
-
-
0031747997
-
The role of receptor kinases and arrestins in G protein-coupled receptor regulation.
-
Krupnick JG, Benovic JL. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol 1998, 38:289-319.
-
(1998)
Annu Rev Pharmacol Toxicol
, vol.38
, pp. 289-319
-
-
Krupnick, J.G.1
Benovic, J.L.2
-
38
-
-
0032563291
-
G protein-coupled receptors. III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization.
-
Lefkowitz RJ. G protein-coupled receptors. III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization. J Biol Chem 1998, 273:18677-18680.
-
(1998)
J Biol Chem
, vol.273
, pp. 18677-18680
-
-
Lefkowitz, R.J.1
-
39
-
-
0023052241
-
Studies and perspectives of protein kinase C.
-
Nishizuka Y. Studies and perspectives of protein kinase C. Science 1986, 233:305-312.
-
(1986)
Science
, vol.233
, pp. 305-312
-
-
Nishizuka, Y.1
-
40
-
-
0025250147
-
Multiple pathways of rapid β2-adrenergic receptor desensitization. Delineation with specific inhibitors.
-
Lohse MJ, Benovic JL, Caron MG, Lefkowitz RJ. Multiple pathways of rapid β2-adrenergic receptor desensitization. Delineation with specific inhibitors. J Biol Chem 1990, 265:3202-3211.
-
(1990)
J Biol Chem
, vol.265
, pp. 3202-3211
-
-
Lohse, M.J.1
Benovic, J.L.2
Caron, M.G.3
Lefkowitz, R.J.4
-
41
-
-
0023610955
-
Agonist-dependent phosphorylation of the α 2-adrenergic receptor by the β-adrenergic receptor kinase.
-
Benovic JL, Regan JW, Matsui H, Mayor F Jr, Cotecchia S, Leeb-Lundberg LM, Caron MG, Lefkowitz RJ. Agonist-dependent phosphorylation of the α 2-adrenergic receptor by the β-adrenergic receptor kinase. J Biol Chem 1987, 262:17251-17253.
-
(1987)
J Biol Chem
, vol.262
, pp. 17251-17253
-
-
Benovic, J.L.1
Regan, J.W.2
Matsui, H.3
Mayor, F.4
Cotecchia, S.5
Leeb-Lundberg, L.M.6
Caron, M.G.7
Lefkowitz, R.J.8
-
42
-
-
33947375174
-
Physiological roles of G protein-coupled receptor kinases and arrestins.
-
Premont RT, Gainetdinov RR. Physiological roles of G protein-coupled receptor kinases and arrestins. Annu Rev Physiol 2007, 69:511-534.
-
(2007)
Annu Rev Physiol
, vol.69
, pp. 511-534
-
-
Premont, R.T.1
Gainetdinov, R.R.2
-
43
-
-
33748749459
-
Arrestin serves as a molecular switch, linking endogenous α2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activation.
-
Wang Q, Lu R, Zhao J, Limbird LE. Arrestin serves as a molecular switch, linking endogenous α2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activation. J Biol Chem 2006, 281:25948-25955.
-
(2006)
J Biol Chem
, vol.281
, pp. 25948-25955
-
-
Wang, Q.1
Lu, R.2
Zhao, J.3
Limbird, L.E.4
-
44
-
-
33644857279
-
β-arrestin-dependent, G protein-independent ERK1/2 activation by the β2 adrenergic receptor.
-
Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ. β-arrestin-dependent, G protein-independent ERK1/2 activation by the β2 adrenergic receptor. J Biol Chem 2006, 281:1261-1273.
-
(2006)
J Biol Chem
, vol.281
, pp. 1261-1273
-
-
Shenoy, S.K.1
Drake, M.T.2
Nelson, C.D.3
Houtz, D.A.4
Xiao, K.5
Madabushi, S.6
Reiter, E.7
Premont, R.T.8
Lichtarge, O.9
Lefkowitz, R.J.10
-
45
-
-
0028985595
-
Agonist-induced desensitization of the mu opioid receptor-coupled potassium channel (GIRK1).
-
Kovoor A, Henry DJ, Chavkin C. Agonist-induced desensitization of the mu opioid receptor-coupled potassium channel (GIRK1). J Biol Chem 1995, 270:589-595.
-
(1995)
J Biol Chem
, vol.270
, pp. 589-595
-
-
Kovoor, A.1
Henry, D.J.2
Chavkin, C.3
-
46
-
-
0030613761
-
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A.
-
Daaka Y, Luttrell LM, Lefkowitz RJ. Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A. Nature 1997, 390:88-91.
-
(1997)
Nature
, vol.390
, pp. 88-91
-
-
Daaka, Y.1
Luttrell, L.M.2
Lefkowitz, R.J.3
-
47
-
-
32244432344
-
β-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor.
-
Jones BW, Hinkle PM. β-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor. J Biol Chem 2005, 280:38346-38354.
-
(2005)
J Biol Chem
, vol.280
, pp. 38346-38354
-
-
Jones, B.W.1
Hinkle, P.M.2
-
48
-
-
33845868504
-
Characterization of β2-adrenergic receptor dephosphorylation: Comparison with the rate of resensitization.
-
Tran TM, Friedman J, Baameur F, Knoll BJ, Moore RH, Clark RB. Characterization of β2-adrenergic receptor dephosphorylation: Comparison with the rate of resensitization. Mol Pharmacol 2007, 71:47-60.
-
(2007)
Mol Pharmacol
, vol.71
, pp. 47-60
-
-
Tran, T.M.1
Friedman, J.2
Baameur, F.3
Knoll, B.J.4
Moore, R.H.5
Clark, R.B.6
-
49
-
-
80052768977
-
CXCR7/CXCR4 heterodimer constitutively recruits β-arrestin to enhance cell migration.
-
Décaillot FM, Kazmi MA, Lin Y, Ray-Saha S, Sakmar TP, Sachdev P. CXCR7/CXCR4 heterodimer constitutively recruits β-arrestin to enhance cell migration. J Biol Chem 2011, 286:32188-32197.
-
(2011)
J Biol Chem
, vol.286
, pp. 32188-32197
-
-
Décaillot, F.M.1
Kazmi, M.A.2
Lin, Y.3
Ray-Saha, S.4
Sakmar, T.P.5
Sachdev, P.6
-
50
-
-
70349210074
-
β-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.
-
Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier LP, Augier J, Kang DS, et al. β-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. EMBO J 2009, 28:2706-2718.
-
(2009)
EMBO J
, vol.28
, pp. 2706-2718
-
-
Barthet, G.1
Carrat, G.2
Cassier, E.3
Barker, B.4
Gaven, F.5
Pillot, M.6
Framery, B.7
Pellissier, L.P.8
Augier, J.9
Kang, D.S.10
-
51
-
-
0028987398
-
Homologous desensitization of 5-hydroxytryptamine4 receptors in rat esophagus: functional and second messenger studies.
-
Rondé P, Ansanay H, Dumuis A, Miller R, Bockaert J. Homologous desensitization of 5-hydroxytryptamine4 receptors in rat esophagus: functional and second messenger studies. J Pharmacol Exp Ther 1995, 272:977-983.
-
(1995)
J Pharmacol Exp Ther
, vol.272
, pp. 977-983
-
-
Rondé, P.1
Ansanay, H.2
Dumuis, A.3
Miller, R.4
Bockaert, J.5
-
52
-
-
78549293219
-
Tissue dependent differences in G-protein coupled receptor kinases associated with 5-HT4 receptor desensitization in the rat gastro-intestinal tract.
-
Nedi T, White PJ, Coupar IM, Irving HR. Tissue dependent differences in G-protein coupled receptor kinases associated with 5-HT4 receptor desensitization in the rat gastro-intestinal tract. Biochem Pharmacol 2011, 81:123-133.
-
(2011)
Biochem Pharmacol
, vol.81
, pp. 123-133
-
-
Nedi, T.1
White, P.J.2
Coupar, I.M.3
Irving, H.R.4
-
53
-
-
33644866358
-
Desensitization of the peristaltic reflex induced by mucosal stimulation with the selective 5-HT4 agonist tegaserod.
-
Grider JR. Desensitization of the peristaltic reflex induced by mucosal stimulation with the selective 5-HT4 agonist tegaserod. Am J Physiol Gastrointest Liver Physiol 2006, 290:G319-G327.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Grider, J.R.1
-
54
-
-
0034006037
-
Identification of threonine residues controlling the agonist-dependent phosphorylation and desensitization of the rat A(3) adenosine receptor.
-
Palmer TM, Stiles GL. Identification of threonine residues controlling the agonist-dependent phosphorylation and desensitization of the rat A(3) adenosine receptor. Mol Pharmacol 2000, 57:539-545.
-
(2000)
Mol Pharmacol
, vol.57
, pp. 539-545
-
-
Palmer, T.M.1
Stiles, G.L.2
-
55
-
-
0027500394
-
Altered phosphorylation and desensitization patterns of a human β2-adrenergic receptor lacking the palmitoylated Cys341.
-
Moffett S, Mouillac B, Bonin H, Bouvier M. Altered phosphorylation and desensitization patterns of a human β2-adrenergic receptor lacking the palmitoylated Cys341. EMBO J 1993, 12:349-356.
-
(1993)
EMBO J
, vol.12
, pp. 349-356
-
-
Moffett, S.1
Mouillac, B.2
Bonin, H.3
Bouvier, M.4
-
56
-
-
0035374624
-
Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-β-arrestin complexes after receptor endocytosis.
-
Oakley RH, Laporte SA, Holt JA, Barak LS, Caron MG. Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-β-arrestin complexes after receptor endocytosis. J Biol Chem 2001, 276:19452-19460.
-
(2001)
J Biol Chem
, vol.276
, pp. 19452-19460
-
-
Oakley, R.H.1
Laporte, S.A.2
Holt, J.A.3
Barak, L.S.4
Caron, M.G.5
-
57
-
-
4944255131
-
Agonist-induced internalization of leukotriene B(4) receptor 1 requires G-protein-coupled receptor kinase 2 but not arrestins.
-
Chen Z, Gaudreau R, Le Gouill C, Rola-Pleszczynski M, Stanková J. Agonist-induced internalization of leukotriene B(4) receptor 1 requires G-protein-coupled receptor kinase 2 but not arrestins. Mol Pharmacol 2004, 66:377-386.
-
(2004)
Mol Pharmacol
, vol.66
, pp. 377-386
-
-
Chen, Z.1
Gaudreau, R.2
Le Gouill, C.3
Rola-Pleszczynski, M.4
Stanková, J.5
-
58
-
-
0037067705
-
Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G protein-coupled receptor kinase 2.
-
Dhami GK, Anborgh PH, Dale LB, Sterne-Marr R, Ferguson SS. Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G protein-coupled receptor kinase 2. J Biol Chem 2002, 277:25266-72.
-
(2002)
J Biol Chem
, vol.277
, pp. 25266-25272
-
-
Dhami, G.K.1
Anborgh, P.H.2
Dale, L.B.3
Sterne-Marr, R.4
Ferguson, S.S.5
-
59
-
-
0042575596
-
Phosphorylation-independent desensitization of GABA(B) receptor by GRK4.
-
Perroy J, Adam L, Qanbar R, Chénier S, Bouvier M. Phosphorylation-independent desensitization of GABA(B) receptor by GRK4. EMBO J 2003, 22:3816-3824.
-
(2003)
EMBO J
, vol.22
, pp. 3816-3824
-
-
Perroy, J.1
Adam, L.2
Qanbar, R.3
Chénier, S.4
Bouvier, M.5
-
60
-
-
77952840083
-
The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets.
-
Penela P, Murga C, Ribas C, Lafarga V, Mayor F Jr. The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets. Br J Pharmacol 2010, 160:821-832.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 821-832
-
-
Penela, P.1
Murga, C.2
Ribas, C.3
Lafarga, V.4
Mayor, F.5
-
61
-
-
78649740904
-
Combining resonance energy transfer methods reveals a complex between the α2A-adrenergic receptor, Gαi1β1γ2, and GRK2.
-
Breton B, Lagacé M, Bouvier M. Combining resonance energy transfer methods reveals a complex between the α2A-adrenergic receptor, Gαi1β1γ2, and GRK2. FASEB J 2010, 24:4733-4743.
-
(2010)
FASEB J
, vol.24
, pp. 4733-4743
-
-
Breton, B.1
Lagacé, M.2
Bouvier, M.3
-
62
-
-
28844463975
-
Snapshot of activated G proteins at the membrane: the Gαq-GRK2-Gβγ complex.
-
Tesmer VM, Kawano T, Shankaranarayanan A, Kozasa T, Tesmer JJ. Snapshot of activated G proteins at the membrane: the Gαq-GRK2-Gβγ complex. Science 2005, 310:1686-1690.
-
(2005)
Science
, vol.310
, pp. 1686-1690
-
-
Tesmer, V.M.1
Kawano, T.2
Shankaranarayanan, A.3
Kozasa, T.4
Tesmer, J.J.5
-
63
-
-
13444291851
-
Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling.
-
Kim J, Ahn S, Ren XR, Whalen EJ, Reiter E, Wei H, Lefkowitz RJ. Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling. Proc Natl Acad Sci U S A 2005, 102:1442-1447.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 1442-1447
-
-
Kim, J.1
Ahn, S.2
Ren, X.R.3
Whalen, E.J.4
Reiter, E.5
Wei, H.6
Lefkowitz, R.J.7
-
64
-
-
34250320534
-
5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or β-arrestin signaling.
-
Barthet G, Framery B, Gaven F, Pellissier L, Reiter E, Claeysen S, Bockaert J, Dumuis A. 5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or β-arrestin signaling. Mol Biol Cell 2007, 18:1979-1991.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 1979-1991
-
-
Barthet, G.1
Framery, B.2
Gaven, F.3
Pellissier, L.4
Reiter, E.5
Claeysen, S.6
Bockaert, J.7
Dumuis, A.8
-
65
-
-
40349114499
-
Agonist-selective mechanisms of GPCR desensitization.
-
Kelly E, Bailey CP, Henderson G. Agonist-selective mechanisms of GPCR desensitization. Br J Pharmacol 2008, 153:S379-388.
-
(2008)
Br J Pharmacol
, vol.153
-
-
Kelly, E.1
Bailey, C.P.2
Henderson, G.3
-
66
-
-
0026611546
-
The 5-HT4 receptor: a place in the sun.
-
Bockaert J, Fozard JR, Dumuis A, Clarke DE. The 5-HT4 receptor: a place in the sun. Trends Pharmacol Sci 1992, 13:141-145.
-
(1992)
Trends Pharmacol Sci
, vol.13
, pp. 141-145
-
-
Bockaert, J.1
Fozard, J.R.2
Dumuis, A.3
Clarke, D.E.4
-
67
-
-
0028210437
-
5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons.
-
Pan H, Galligan JJ. 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am J Physiol 1994, 266:G230-G238.
-
(1994)
Am J Physiol
, vol.266
-
-
Pan, H.1
Galligan, J.J.2
-
68
-
-
9444267090
-
New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting.
-
Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, Marin P, Dumuis A, Bockaert J. New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting. J Cell Sci 2004, 117:5367-5379.
-
(2004)
J Cell Sci
, vol.117
, pp. 5367-5379
-
-
Joubert, L.1
Hanson, B.2
Barthet, G.3
Sebben, M.4
Claeysen, S.5
Hong, W.6
Marin, P.7
Dumuis, A.8
Bockaert, J.9
-
69
-
-
55749087186
-
Subunit-specific regulation of Kir3 channels by sorting nexin 27.
-
Nassirpour R, Slesinger PA. Subunit-specific regulation of Kir3 channels by sorting nexin 27. Channels (Austin) 2007, 1:331-333.
-
(2007)
Channels (Austin)
, vol.1
, pp. 331-333
-
-
Nassirpour, R.1
Slesinger, P.A.2
-
70
-
-
0029083085
-
Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo.
-
Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD. Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br J Pharmacol 1995, 115:1387-1392.
-
(1995)
Br J Pharmacol
, vol.115
, pp. 1387-1392
-
-
Eglen, R.M.1
Bonhaus, D.W.2
Johnson, L.G.3
Leung, E.4
Clark, R.D.5
-
71
-
-
63849323943
-
Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors.
-
Pellissier LP, Sallander J, Campillo M, Gaven F, Queffeulou E, Pillot M, Dumuis A, Claeysen S, Bockaert J, Pardo L. Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol 2009, 75:982-990.
-
(2009)
Mol Pharmacol
, vol.75
, pp. 982-990
-
-
Pellissier, L.P.1
Sallander, J.2
Campillo, M.3
Gaven, F.4
Queffeulou, E.5
Pillot, M.6
Dumuis, A.7
Claeysen, S.8
Bockaert, J.9
Pardo, L.10
-
72
-
-
47249147029
-
Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing δ-opioid receptors and heterotrimeric G proteins.
-
Audet N, Galés C, Archer-Lahlou E, Vallières M, Schiller PW, Bouvier M, Pineyro G. Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing δ-opioid receptors and heterotrimeric G proteins. J Biol Chem 2008, 283:15078-15088.
-
(2008)
J Biol Chem
, vol.283
, pp. 15078-15088
-
-
Audet, N.1
Galés, C.2
Archer-Lahlou, E.3
Vallières, M.4
Schiller, P.W.5
Bouvier, M.6
Pineyro, G.7
-
73
-
-
0035793059
-
Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus.
-
Barak LS, Oakley RH, Laporte SA, Caron MG. Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus. Proc Natl Acad Sci U S A 2001, 98:93-98.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 93-98
-
-
Barak, L.S.1
Oakley, R.H.2
Laporte, S.A.3
Caron, M.G.4
-
74
-
-
0034646719
-
Type-specific sorting of G protein-coupled receptors after endocytosis.
-
Tsao PI, von Zastrow M. Type-specific sorting of G protein-coupled receptors after endocytosis. J Biol Chem 2000, 275:11130-11140.
-
(2000)
J Biol Chem
, vol.275
, pp. 11130-11140
-
-
Tsao, P.I.1
von Zastrow, M.2
-
75
-
-
20444416043
-
Constitutive dimerization of human serotonin 5-HT4 receptors in living cells.
-
Berthouze M, Ayoub M, Russo O, Rivail L, Sicsic S, Fischmeister R, Berque-Bestel I, Jockers R, Lezoualc'h F. Constitutive dimerization of human serotonin 5-HT4 receptors in living cells. FEBS Lett 2005, 579:2973-2980.
-
(2005)
FEBS Lett
, vol.579
, pp. 2973-2980
-
-
Berthouze, M.1
Ayoub, M.2
Russo, O.3
Rivail, L.4
Sicsic, S.5
Fischmeister, R.6
Berque-Bestel, I.7
Jockers, R.8
Lezoualc'h, F.9
-
76
-
-
24044443262
-
Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants.
-
Krobert KA, Brattelid T, Levy FO, Kaumann AJ. Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants. Naunyn Schmiedebergs Arch Pharmacol 2005, 371:473-479.
-
(2005)
Naunyn Schmiedebergs Arch Pharmacol
, vol.371
, pp. 473-479
-
-
Krobert, K.A.1
Brattelid, T.2
Levy, F.O.3
Kaumann, A.J.4
-
77
-
-
84857471063
-
Regulation of G protein-coupled receptor activity, trafficking and localization by GPCR-interacting proteins.
-
Epub ahead of print] (doi:10.1111/j.1476-5381.2011.01552.x).
-
Magalhaes AC, Dunn H, Ferguson SS. Regulation of G protein-coupled receptor activity, trafficking and localization by GPCR-interacting proteins. Br J Pharmacol 2011. [Epub ahead of print] (doi:10.1111/j.1476-5381.2011.01552.x).
-
(2011)
Br J Pharmacol
-
-
Magalhaes, A.C.1
Dunn, H.2
Ferguson, S.S.3
-
78
-
-
0032042756
-
G protein-coupled receptor adaptation mechanisms.
-
Ferguson SS, Caron MG. G protein-coupled receptor adaptation mechanisms. Semin Cell Dev Biol 1998, 9:119-127.
-
(1998)
Semin Cell Dev Biol
, vol.9
, pp. 119-127
-
-
Ferguson, S.S.1
Caron, M.G.2
-
79
-
-
0038757730
-
Role of palmitoylation/depalmitoylation reactions in G protein-coupled receptor function.
-
Qanbar R, Bouvier M. Role of palmitoylation/depalmitoylation reactions in G protein-coupled receptor function. Pharmacol Ther 2003, 97:1-33.
-
(2003)
Pharmacol Ther
, vol.97
, pp. 1-33
-
-
Qanbar, R.1
Bouvier, M.2
-
80
-
-
77953798683
-
G protein-mediated signaling: same receptor, multiple effectors.
-
Woehler A, Ponimaskin EG. G protein-mediated signaling: same receptor, multiple effectors. Curr Mol Pharmacol 2009, 2:237-248.
-
(2009)
Curr Mol Pharmacol
, vol.2
, pp. 237-248
-
-
Woehler, A.1
Ponimaskin, E.G.2
-
81
-
-
57649157684
-
Membrane signalling complexes: implications for development of functionally selective ligands modulating heptahelical receptor signalling.
-
Piñeyro G. Membrane signalling complexes: implications for development of functionally selective ligands modulating heptahelical receptor signalling. Cell Signal 2009, 21:179-185.
-
(2009)
Cell Signal
, vol.21
, pp. 179-185
-
-
Piñeyro, G.1
|