Investigation of serotonin type 4 receptor expression in human and non-human primate gastrointestinal samples

European Journal of Gastroenterology and Hepatology

Volumn 18, Issue 9, 2006, Pages 945-950

  Mader, Robert ^a   Kocher, Thomas ^c,d   Haier, Joerg ^c   Wieczorek, Grazyna ^b   Pfannkuche, Hans Juergen ^a   Ito, Moriko ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b AT Department   (Switzerland)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d Hospital Baden   (Switzerland)

Author keywords

Gastrointestinal tract; Irritable bowel syndrome; Messenger RNA; Reverse transcription polymerase chain reaction; Serotonin type 4 receptor

Indexed keywords

MESSENGER RNA; SEROTONIN 4 RECEPTOR; TEGASEROD;

ABDOMINAL SURGERY; ANIMAL TISSUE; ARTICLE; BRAIN; CECUM; CONSTIPATION; DUODENUM; ESOPHAGUS; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRACT; HEART; HUMAN; HUMAN TISSUE; ILEUM; INTESTINE SECRETION; JEJUNUM; NONHUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIMATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE TONE; STOMACH; STOMACH EMPTYING;

ANIMALS; FEMALE; GASTROINTESTINAL TRACT; HUMANS; MALE; PRIMATES; RECEPTORS, SEROTONIN, 5-HT4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEX FACTORS;

EID: 33747059826     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.meg.0000228975.87645.27     Document Type: Article

References (37)

1. Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, et al. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 2004; 126:1657-1664.
2. 4 receptors: an update. In: Baumgarten HH, Göthert M, editors. Handbook of experimental pharmacology. Berlin, Heidelberg: Springer-Verlag; 1997. pp. 439-474.
3. 4 receptor: molecular cloning and pharmacological characterization of two splice variants. EMBO J 1995; 14:2806-2815.
4. 4 receptor cloned from human atrium. FEBS Lett 1997; 412:465-474.
5. Blondel O, Gastineau M, Dahmoune Y, Langlois M, Fischmeister R. Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. J Neurochem 1998; 70:2252-2261.
6. 4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain. Mol Pharmacol 1999; 55: 910-920.
7. 4 receptor partial agonist, accelerates gastric emptying and gastrointestinal transit in healthy male subjects. Aliment Pharmacol Therap 2001; 15:1745-1751.
8. Gremlich HU, Martinez V, Kneuer R, Kinzy W, Weber E, Pfannkuche HJ, et al. Noninvasive assessment of gastric emptying by near-infrared fluorescence reflectance imaging in mice: pharmacological validation with tegaserod, cisapride, and clonidine. Mol Imag 2004; 3:303-311.
9. Gralnek IM, Hays RD, Kilbourne A, Naliboff B, Mayer EA. The impact of irritable bowel syndrome on health-related quality of life. Gastroenterology 2000; 119:654-660.
10. Chang L, Heitkemper MM. Gender differences in irritable bowel syndrome. Gastroenterology 2002; 123:1686-1701.
11. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3:1-12.
12. 4 receptor in the human and the guinea pig colon. Eur J Pharmacol 1999; 383:281-285.
13. 4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. AJP Gastrointest Liver Physiol 1994; 266:G230-G238.
14. 4 receptor agonist, on gastric emptying in a murine model of diabetes mellitus. Neurogastroenterol Motil 2005; 17:738-743.
15. 4(i). Naunyn-Schmiedeberg's Arch Pharmacol 2004; 369:616-628.
16. 4 receptor in the central nervous system by TaqMan real time RT-PCR. Mol Brain Res 2001; 90:125-134.
17. 4 receptors in the mouse enteric nervous system. AJP Gastrointest Liver Physiol 2005; 289:G1148-G1163.
18. 4 receptor mRNA in rat brain by in situ hybridization histochemistry. Mol Brain Res 1996; 43:356-360.
19. 4 receptor variants. Neuropharmacology 2002; 42:60-73.
20. 4splice variant. J Neurochem 2000; 74:478-489.
21. 4 mRNA in heart failure. Naunyn-Schmiedeberg's Arch Pharmacol 2004; 370:157-166.
22. (b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. Naunyn-Schmiedeberg's Arch Pharmacol 2001; 363:146-160.
23. 4 receptors, beta 1- and beta 2-adrenoceptors in human atrium: functional implications. Naunyn-Schmiedeberg's Arch Pharmacol 1996; 353:592-595.
24. Jahnel U, Rupp J, Ertl R, Nawrath H. Positive inotropic response to 5-HT in human atrial but not in ventricular heart muscle. Naunyn-Schmiedeberg's Arch Pharmacol 1992; 346:482-485.
25. Shoemaker RG, Du XY, Bax WA, Bos E, Saxena PR. 5-Hydroxytryptamine stimulates human isolated atrium but not ventricle. Eur J Pharmacol 1993; 230:103-105.
26. 4(b) receptors is splice variant dependent. Biosci Rep 2004; 24:215-223.
27. 4 receptor cDNA. J Neurochem 1997; 69:1810-1819.
28. Hiroi T, Hayashi-Kobayashi N, Nagumo S, Ino M, Okawa Y, Aoba A, et al. Identification and characterization of the human serotonin-4 receptor gene promoter. Biochem Biophys Res Commun 2001; 289:337-344.
29. 4 receptor splice variants: compound specificity and dual coupling with G alpha s- and G alpha i/o-proteins. Mol Pharmacol 2002; 61:85-96.
30. Ponimaskin EG, Profirovic J, Vaiskunaite R, Richter DW, Voyno-Yasenetskaya TA. 5-Hydroxytryptamine 4(a) receptor is coupled to the G alpha subunit of heterotrimeric G13 protein. J Biol Chem 2002; 277:20812-20819.
31. 4(d) receptor desensitization in CHO cells. Br J Pharmacol 2003; 138:445-452.
32. Ponimaskin E, Dumuis A, Gaven F, Barthet G, Heine M, Glebov K, et al. Palmitoylation of the 5-hydroxytryptamine 4(a) receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis. Mol Pharmacol 2005; 67:1434-1443.
33. Barthet G, Gaven F, Framery B, Shinjo K, Nakamura T, Claeysen S, et al. Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors: distinct molecular events with different GRK2 requirements. J Biol Chem 2005; 280:27924-27934.
34. 4 receptors in living cells. FEBS Lett 2005; 579:2973-2980.
35. 4 receptor antagonism in irritable bowel syndrome: effect of SB-207266-A on rectal sensitivity and small bowel transit. Aliment Pharmacol Therapeut 1999; 13:1437-1444.
36. Ning Y, Zhu JX, Chan HC. Regulation of ion transport by 5-hydroxytryptamine in rat colon. Clin Exp Pharmacol Physiol 2004; 31:424-428.
37. 4 receptors in mice. Am J Physiol-Gastrointest Liver Physiol 2004; 286:G444-G451.