Β-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT 4 receptor signalling

EMBO Journal

Volumn 28, Issue 18, 2009, Pages 2706-2718

  Barthet, Gaël ^a,b   Carrat, Gaëlle ^a,b   Cassier, Elizabeth ^a,b   Barker, Breann ^c   Gaven, Florence ^a,b   Pillot, Marion ^a,b   Framery, Bérénice ^a,b   Pellissier, Lucie P ^a,b   Augier, Julie ^a,b   Kang, Dong Soo ^c   Claeysen, Sylvie ^a,b   Reiter, Eric ^d,e,f   Banères, Jean Louis ^g   Benovic, Jeffrey L ^c   Marin, Philippe ^a,b   Bockaert, Joël ^a,b,h   Dumuis, Aline ^a,b,h  

^a UNIV MONTPELLIER   (France)

^b INSERM   (France)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d UMR85 PHYSIOLOGIE DE LA REPRODUCTION ET DES COMPORTEMENTS   (France)

^e CNRS   (France)

^f UNIVERSITÉ DE TOURS   (France)

^g UNIVERSITÉ DE MONTPELLIER   (France)

^h INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

Author keywords

5 HT4R; ERK signalling; GRK5; P S412 b arrestin1; Src family kinase

Indexed keywords

BETA ARRESTIN 1; G PROTEIN COUPLED RECEPTOR KINASE 5; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SEROTONIN 4 RECEPTOR;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DESENSITIZATION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INFERIOR COLLICULUS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

ARRESTINS; CELL LINE; G-PROTEIN-COUPLED RECEPTOR KINASE 5; GTP-BINDING PROTEINS; HUMANS; MUTATION; NEURONS; PEPTIDES; PHOSPHORYLATION; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, SEROTONIN, 5-HT4; RNA, SMALL INTERFERING; SERINE; SRC-FAMILY KINASES;

EID: 70349210074     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2009.215     Document Type: Article

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