메뉴 건너뛰기




Volumn 74, Issue 2, 2000, Pages 478-489

Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant

Author keywords

G protein coupled receptor; Gene structure; Human; Serotonin; Serotonin 5 HT(4(hb)) variant; Serotonin 5 HT4 receptor; Splice variant

Indexed keywords

1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 8 AMINO 7 CHLORO 1,4 BENZODIOXAN 5 CARBOXYLIC ACID 1 BUTYL 4 PIPERIDINYLMETHYL ESTER; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; RADIOLIGAND; SEROTONIN 4 AGONIST; SEROTONIN 4 ANTAGONIST; SEROTONIN 4 RECEPTOR;

EID: 0033968216     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.740478.x     Document Type: Article
Times cited : (127)

References (45)
  • 1
    • 0029890441 scopus 로고    scopus 로고
    • Biochemistry and regulation of pre-mRNA splicing
    • Adams M. D., Rudner D. Z., and Rio D. C. (1996) Biochemistry and regulation of pre-mRNA splicing. Curr. Opin. Cell Biol. 8, 331-339.
    • (1996) Curr. Opin. Cell Biol. , vol.8 , pp. 331-339
    • Adams, M.D.1    Rudner, D.Z.2    Rio, D.C.3
  • 6
    • 0028986136 scopus 로고
    • Evidence for 5-HT4 receptor subtype involvement in the enhancement of striatal dopamine release induced by serotonin: A microdialysis study in the halothane-anesthetized rat
    • Bonhomme N., De Deurwaerdere P., Le Moal M., and Spampinato U. (1995) Evidence for 5-HT4 receptor subtype involvement in the enhancement of striatal dopamine release induced by serotonin: a microdialysis study in the halothane-anesthetized rat. Neuropharmacology 34, 269-279.
    • (1995) Neuropharmacology , vol.34 , pp. 269-279
    • Bonhomme, N.1    De Deurwaerdere, P.2    Le Moal, M.3    Spampinato, U.4
  • 8
    • 0029658137 scopus 로고    scopus 로고
    • Neural 5-HT4 receptors in the human isolated detrusor muscle: Effects of indole, benzimidazolone and substituted benzamide agonists and antagonists
    • Candura S. M., Messori E., Franceschetti G. P., D'Agostino G., Vicini D., Tagliani M., and Tonini M. (1996) Neural 5-HT4 receptors in the human isolated detrusor muscle: effects of indole, benzimidazolone and substituted benzamide agonists and antagonists. Br. J. Pharmacol. 118, 1965-1970.
    • (1996) Br. J. Pharmacol. , vol.118 , pp. 1965-1970
    • Candura, S.M.1    Messori, E.2    Franceschetti G, P.3    D'Agostino, G.4    Vicini, D.5    Tagliani, M.6    Tonini, M.7
  • 10
    • 0030602208 scopus 로고    scopus 로고
    • Cloning, expression and pharmacology of the mouse 5-HT4L receptor
    • Claeysen S., Sebben M., Laurent J., Bockaert J., and Dumuis A. (1996) Cloning, expression and pharmacology of the mouse 5-HT4L receptor. FEBS Lett. 398, 19-25.
    • (1996) FEBS Lett. , vol.398 , pp. 19-25
    • Claeysen, S.1    Sebben, M.2    Laurent, J.3    Bockaert, J.4    Dumuis, A.5
  • 11
    • 0030828512 scopus 로고    scopus 로고
    • Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase
    • Claeysen S., Faye P., Sebben M., Lemaire S., Bockaert J., and Dumuis A. (1997) Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase. Neuroreport 8, 3189-3196.
    • (1997) Neuroreport , vol.8 , pp. 3189-3196
    • Claeysen, S.1    Faye, P.2    Sebben, M.3    Lemaire, S.4    Bockaert, J.5    Dumuis, A.6
  • 12
    • 0032938367 scopus 로고    scopus 로고
    • 4 receptor splice variants show marked constitutive activity: Role of the C-terminal intracellular domain
    • 4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain. Mol. Pharmacol. 55, 910-920.
    • (1999) Mol. Pharmacol. , vol.55 , pp. 910-920
    • Claeysen, S.1    Sebben, M.2    Becamel, C.3    Bockaert, J.4    Dumuis, A.5
  • 13
    • 0024263139 scopus 로고
    • A non-classical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system
    • Dumuis A., Bouhelal R., Sebben M., Cory R., and Bockaert J. (1988) A non-classical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Mol. Pharmacol 34, 880-887.
    • (1988) Mol. Pharmacol , vol.34 , pp. 880-887
    • Dumuis, A.1    Bouhelal, R.2    Sebben, M.3    Cory, R.4    Bockaert, J.5
  • 15
    • 0026092384 scopus 로고
    • Identification of putative 5-HT4 receptors in guinea-pig ascending colon
    • Elswood C. J., Bunce K. T., and Humphrey P. P. A. (1991) Identification of putative 5-HT4 receptors in guinea-pig ascending colon. Eur. J. Pharmacol. 196, 149-155.
    • (1991) Eur. J. Pharmacol. , vol.196 , pp. 149-155
    • Elswood, C.J.1    Bunce, K.T.2    Humphrey, P.P.A.3
  • 16
    • 0030955397 scopus 로고    scopus 로고
    • The effects of novel 5-hydroxytryptamine (5-HT)4 receptor ligands in rat spatial navigation
    • Fontana D. J., Daniels S. E., Wong E. H., Clark R. D., and Eglen R. M. (1997) The effects of novel 5-hydroxytryptamine (5-HT)4 receptor ligands in rat spatial navigation. Neuropharmacology 36, 689-696.
    • (1997) Neuropharmacology , vol.36 , pp. 689-696
    • Fontana, D.J.1    Daniels, S.E.2    Wong, E.H.3    Clark, R.D.4    Eglen, R.M.5
  • 18
    • 0032158693 scopus 로고    scopus 로고
    • Role of 5-HT4 receptors in the mouse passive avoidance test
    • Galeotti N., Ghelardini C., and Bautolini A. (1998) Role of 5-HT4 receptors in the mouse passive avoidance test. J. Pharmacol. Exp. Ther. 286, 1115-1121.
    • (1998) J. Pharmacol. Exp. Ther. , vol.286 , pp. 1115-1121
    • Galeotti, N.1    Ghelardini, C.2    Bautolini, A.3
  • 21
    • 0030265544 scopus 로고    scopus 로고
    • Peripheral 5-HT4 receptors
    • Hedge S. S. and Eglen R. M. (1996) Peripheral 5-HT4 receptors. FASEB J. 10, 1398-1407.
    • (1996) FASEB J. , vol.10 , pp. 1398-1407
    • Hedge, S.S.1    Eglen, R.M.2
  • 22
    • 0030610194 scopus 로고    scopus 로고
    • 7) receptor isoforms in human and rat produced by alternative splicing: Species differences due to altered intron-exon organization
    • 7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. J. Neurochem. 68, 1372-1381.
    • (1997) J. Neurochem. , vol.68 , pp. 1372-1381
    • Heidmann, D.E.A.1    Metcalf, M.A.2    Kohen, R.3    Hamblin, M.W.4
  • 24
    • 0026566742 scopus 로고
    • Serotonin-induced stimulation of cortisol secretion from human adrenocortical tissue is mediated through activation of a serotonin4 receptor subtype
    • Lefebvre H., Contesse V., Delarue C., Fevilloley M., Hery F., Grise P., Raynaud G., Verhofstad A. A. J., Wolfe L. M., and Vaudry H. (1992) Serotonin-induced stimulation of cortisol secretion from human adrenocortical tissue is mediated through activation of a serotonin4 receptor subtype. Neuroscience 47, 999-1007.
    • (1992) Neuroscience , vol.47 , pp. 999-1007
    • Lefebvre, H.1    Contesse, V.2    Delarue, C.3    Fevilloley, M.4    Hery, F.5    Grise, P.6    Raynaud, G.7    Verhofstad, A.A.J.8    Wolfe, L.M.9    Vaudry, H.10
  • 28
    • 0029058239 scopus 로고
    • A comparative study of functional 5-HT4 receptors in human colon, rat oesophagus and rat ileum
    • McLean P. G., Coupar I. M., and Molenaar P. (1995) A comparative study of functional 5-HT4 receptors in human colon, rat oesophagus and rat ileum. Br. J. Pharmacol. 115, 47-56.
    • (1995) Br. J. Pharmacol. , vol.115 , pp. 47-56
    • McLean, P.G.1    Coupar, I.M.2    Molenaar, P.3
  • 29
    • 0027330085 scopus 로고
    • 4 receptor mediating tachycardia in piglet isolated right atrium
    • 4 receptor mediating tachycardia in piglet isolated right atrium. Br. J. Pharmacol. 110, 1023-1030.
    • (1993) Br. J. Pharmacol. , vol.110 , pp. 1023-1030
    • Medhurst, A.D.1    Kaumann, A.J.2
  • 30
    • 0026580387 scopus 로고
    • Is the action of cisapride on the guinea pig ileum mediated via 5-HT4 receptors
    • Meulemans A. L. and Schuurkes A. J. (1992) Is the action of cisapride on the guinea pig ileum mediated via 5-HT4 receptors. Eur. J. Pharmacol. 212, 51-59.
    • (1992) Eur. J. Pharmacol. , vol.212 , pp. 51-59
    • Meulemans, A.L.1    Schuurkes, A.J.2
  • 31
    • 0027477974 scopus 로고
    • Pharmacological characterization of the 5-hydroxytryptamine receptor coupled to adenylyl cyclase stimulation in human brain
    • Monferini E., Gaetani P., Baena R. R., Giraldo E., Parenti M., Zocchetti A., and Rizzi C. A. (1993) Pharmacological characterization of the 5-hydroxytryptamine receptor coupled to adenylyl cyclase stimulation in human brain. Life Sci. 52, 61-65.
    • (1993) Life Sci. , vol.52 , pp. 61-65
    • Monferini, E.1    Gaetani, P.2    Baena, R.R.3    Giraldo, E.4    Parenti, M.5    Zocchetti, A.6    Rizzi, C.A.7
  • 32
    • 0026610799 scopus 로고
    • 5-HT4 receptor activation induces relaxation and associated cAMP generation in rat esophagus
    • Moummi C., Yang D.-C., and Gullikson G. W. (1992) 5-HT4 receptor activation induces relaxation and associated cAMP generation in rat esophagus. Eur. J. Pharmacol. 216, 47-52.
    • (1992) Eur. J. Pharmacol. , vol.216 , pp. 47-52
    • Moummi, C.1    Yang, D.-C.2    Gullikson, G.W.3
  • 33
    • 0027258001 scopus 로고
    • Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity
    • Namba T., Sugimoto Y., Negishi M., Irie A., Ushikubi F., Kakizuka A., Ho S., Ichikawa A., and Narumiya S. (1993) Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature 365, 166-170.
    • (1993) Nature , vol.365 , pp. 166-170
    • Namba, T.1    Sugimoto, Y.2    Negishi, M.3    Irie, A.4    Ushikubi, F.5    Kakizuka, A.6    Ho, S.7    Ichikawa, A.8    Narumiya, S.9
  • 34
    • 0023160069 scopus 로고
    • A microcomputer program for fitting enzyme inhibition equations
    • Oestreicher E. G. and Pinto G. F. (1987) A microcomputer program for fitting enzyme inhibition equations. Comput. Biol. Med. 17, 53-68.
    • (1987) Comput. Biol. Med. , vol.17 , pp. 53-68
    • Oestreicher, E.G.1    Pinto, G.F.2
  • 36
    • 0026476478 scopus 로고
    • Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes
    • Pin J.-P., Waeber C., Prezeau L., Bockaert J., and Heinemann S. H. (1992) Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes. Proc. Natl. Acad. Sci. USA 89, 10331-10335.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10331-10335
    • Pin, J.-P.1    Waeber, C.2    Prezeau, L.3    Bockaert, J.4    Heinemann, S.H.5
  • 37
    • 0027055590 scopus 로고
    • β-adrenergic agonists that down-regulate receptor mRNA up-regulate a Mr 35,000 protein(s) that selectively binds to β-adrenergic receptor mRNAs
    • Port J. D., Huang L.-Y., and Malbon C. C. (1992) β-Adrenergic agonists that down-regulate receptor mRNA up-regulate a Mr 35,000 protein(s) that selectively binds to β-adrenergic receptor mRNAs. J. Biol. Chem. 267, 24103-24108.
    • (1992) J. Biol. Chem. , vol.267 , pp. 24103-24108
    • Port, J.D.1    Huang, L.-Y.2    Malbon, C.C.3
  • 38
    • 0030586396 scopus 로고    scopus 로고
    • Effects of 5-HT4 receptor antagonists on rat behavior in the elevated plus-maze test
    • Silvestre J. S., Fernandez A. J., and Palacios J. M. (1996) Effects of 5-HT4 receptor antagonists on rat behavior in the elevated plus-maze test. Eur. J. Pharmacol. 309, 219-222.
    • (1996) Eur. J. Pharmacol. , vol.309 , pp. 219-222
    • Silvestre, J.S.1    Fernandez, A.J.2    Palacios, J.M.3
  • 40
    • 0028978002 scopus 로고
    • The Mr 35000 β-adrenergic receptor mRNA-binding protein binds transcripts of G-protein-linked receptors which undergo agonist-induced destabilization
    • Tholanikunnel B. G., Granneman J. G., and Malbon C. C. (1995) The Mr 35000 β-adrenergic receptor mRNA-binding protein binds transcripts of G-protein-linked receptors which undergo agonist-induced destabilization. J. Biol. Chem. 270, 12787-12793.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12787-12793
    • Tholanikunnel, B.G.1    Granneman, J.G.2    Malbon, C.C.3
  • 41
    • 0029156503 scopus 로고
    • Expression of serotonin receptor mRNAs in blood vessels
    • Ullmer C., Schmuck K., Kalkman H. O., and Lübbert H. (1995) Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett. 370, 215-221.
    • (1995) FEBS Lett. , vol.370 , pp. 215-221
    • Ullmer, C.1    Schmuck, K.2    Kalkman, H.O.3    Lübbert, H.4
  • 43
    • 0027525330 scopus 로고
    • The two isoforms of the mouse somatostatin receptor (mSSTR2A and mSSTR2B) differ in coupling efficiency to adenylate cyclase and in agonist-induced receptor desensitization
    • Vanetti M., Vogt G., and Höllt V. (1993) The two isoforms of the mouse somatostatin receptor (mSSTR2A and mSSTR2B) differ in coupling efficiency to adenylate cyclase and in agonist-induced receptor desensitization. FEBS Lett. 331, 260-266.
    • (1993) FEBS Lett. , vol.331 , pp. 260-266
    • Vanetti, M.1    Vogt, G.2    Höllt, V.3
  • 44
    • 0030608470 scopus 로고    scopus 로고
    • Localization of 5-HT4 receptor mRNA in rat brain by in situ hybridization histochemistry
    • Vilaro M. T., Cortes R., Gerald C., Branchek T. A., Palacios J. M., and Mengod G. (1996) Localization of 5-HT4 receptor mRNA in rat brain by in situ hybridization histochemistry. Mol. Brain Res. 43, 356-360.
    • (1996) Mol. Brain Res. , vol.43 , pp. 356-360
    • Vilaro, M.T.1    Cortes, R.2    Gerald, C.3    Branchek, T.A.4    Palacios, J.M.5    Mengod, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.