Reduced signal transduction by 5-HT 4 receptors after long-term venlafaxine treatment in rats

British Journal of Pharmacology

Volumn 161, Issue 3, 2010, Pages 695-706

  Vidal, R ^a,b,c   Valdizan, E M ^a,b,c   Vilaro M T ^c,d   Pazos, A ^a,b,c   Castro, E ^a,b,c  

^a University of Cantabria   (Spain)

^b UNIVERSITY OF CANTABRIA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

5 HT 4 receptors; adenylate cyclase; electrophysiology; in situ hybridization; venlafaxine

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; MESSENGER RNA; REBOXETINE; SEROTONIN 4 RECEPTOR; VENLAFAXINE; ZACOPRIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MEGADOSE; ENZYME ACTIVATION; GENE EXPRESSION; GLOBUS PALLIDUS; HIPPOCAMPUS; LONG TERM CARE; LOW DRUG DOSE; MALE; NEUROTRANSMISSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PUTAMEN; RAT; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA;

ACTION POTENTIALS; ADENYLATE CYCLASE; ADRENERGIC UPTAKE INHIBITORS; ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BENZAMIDES; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; CA1 REGION, HIPPOCAMPAL; CYCLOHEXANOLS; DRUG INTERACTIONS; MALE; MORPHOLINES; PYRAMIDAL CELLS; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN, 5-HT4; SIGNAL TRANSDUCTION;

EID: 77956318009     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00903.x     Document Type: Article

References (69)

1. Adell A, Castro E, Celada P, Bortolozzi A, Pazos A, Artigas F (2005). Strategies for producing faster acting antidepressants. Drug Discov Today 10 : 578 585.
2. Alex KD, Pehek EA (2007). Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther 113 : 296 320.
3. Alexander SPH, Mathie A, Peters JA (2009). Guide to Receptors and Channels (GRAC), 4th edn. Br J Pharmacol 158 (Suppl. 1 S1 S254.
4. Andrade R, Chaput YJ (1991). 5-Hydroxytryptamine4-like receptors mediate the slow excitatory response to serotonin in the rat hippocampus. J Pharmacol Exp Ther 257 : 930 937.
5. Artaiz I, Zazpe A, Innerarity A, Del Olmo E, Diaz A, Ruiz-Ortega JA et al. (2005). Preclinical pharmacology of F-98214-TA, a novel potent serotonin and norepinephrine uptake inhibitor with antidepressant and anxiolytic properties. Psychopharmacology (Berl) 182 : 400 413.
6. Beiqüe J-C, de Montigny C, Blier P, Debonnel G (2000a). Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: I. In vivo electrophysiological studies in the rat. Neuropharmacology 39 : 1800 1812.
7. Beiqüe J-C, de Montigny C, Blier P, Debonnel G (2000b). Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: II. In vitro studies in the rat. Neuropharmacology 39 : 1813 1822.
8. Benmansour S, Altamirano AV, Jones DJ, Sanchez TA, Gould GG, Pardon MC et al. (2004). Regulation of the norepinephrine transporter by chronic administration of antidepressants. Biol Psychiatry 55 : 313 316.
9. 1B receptor systems by phospholipids signalling cascades. Brain Res Bull 56 : 471 477.
10. Bianchi C, Rodi D, Marino S, Beani L, Siniscalchi A (2002). Dual effects of 5-HT4 receptor activation on GABA release from guinea pig hippocampal slices. Neuroreport 13 : 2177 2180.
11. 4 receptor activation in the rat hippocampus. Naunyn Schmiedebergs Arch Pharmacol 355 : 14 19.
12. 4 receptor activation. Naunyn Schmiedebergs Arch Pharmacol 363 : 491 498.
13. Blier P, de Montigny C (1994). Current advances and trends in the treatment of depression. Trends Pharmacol Sci 15 : 220 226.
14. 4 receptors. Curr Drug Targets CNS Neurol Disord 3 : 39 51.
15. 4 receptors: history, molecular pharmacology and brain functions. Neuropharmacology 55 : 922 931.
16. Bolden-Watson C, Richelson E (1993). Blockade by newly-developed antidepressants of biogenic amine uptake into rat brain synaptosomes. Life Sci 52 : 1023 1029.
17. Brunello N, Mendlewiczc J, Kasperd S, Leonard B, Montgomery S, Nelson J et al. (2002). The role of noradrenaline and selective noradrenaline reuptake inhibition in depression. Eur Neuropsychopharmacol 12 : 461 475.
18. Bymaster FP, Dreshfield-Ahmad LJ, Threlkeld PG, Shaw JL, Thompson L, Nelson DL et al. (2001). Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology 25 : 871 880.
19. 1A receptors in rat brain. Neuropharmacology 44 : 93 101.
20. 1A receptor functionality. Neuropharmacology 55 : 1391 1396.
21. 4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain. Mol Pharmacol 55 : 910 920.
22. Conductier G, Dusticier N, Lucas G, Cote F, Debonnel G, Daszuta A et al. (2006). Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT4 receptor knock-out mouse. Eur J Neurosci 24 : 1053 1062.
23. Coppen A (1967). The biochemistry of affective disorders. Br J Psychiatry 113 : 1237 1264.
24. Donati RJ, Rasenick MM (2003). G protein signaling and the molecular basis of antidepressant action. Life Sci 73 : 1 17.
25. Dowlatshahi D, MacQueen GM, Wang J-F, Reiach JS, Young LT (1999). G protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death. J Neurochem 73 : 1121 1126.
26. Drew MR, Hen R (2007). Adult hippocampal neurogenesis as target for the treatment of depression. CNS Neurol Disord Drug Targets 6 : 205 218
27. Duman RS, Nakagawa S, Malberg J (2001). Regulation of adult neurogenesis by antidepressant treatment. Neuropsychopharmacology 25 : 836 844.
28. + current in colliculi neurones via activation of a cyclic AMP-dependent protein kinase. Br J Pharmacol 105 : 973 979.
29. Frodl T, Möller HJ, Meisenzahl E (2008). Neuroimaging genetics: new perspectives in research on major depression? Acta Psychiatr Scand 118 : 363 372
30. Gerald C, Adham N, Kao HT, Olsen MA, Laz TM, Schechter LE et al. (1995). The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants. EMBO J 14 : 2806 2815.
31. 4 receptors in rats. Naunyn Schmiedebergs Arch Pharmacol 356 : 22 28.
32. 1A receptor-G protein interactions in brain following chronic antidepressant administration. Neuropsychopharmacology 26 : 565 573.
33. 1A autoreceptors by a low chronic fluoxetine dose effect of the concurrent administration of WAY-100635. Neuropsychopharmacology 24 : 11 20.
34. Horschitz S, Hummerich R, Schloss P (2001). Structure, function and regulation of the 5-hydroxytryptamine (serotonin) transporter. Biochem Soc Trans 29 : 728 732.
35. Hoyer D, Hannon JP, Martin GR (2002). Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 71 : 533 554.
36. 3H]imipramine localization and relationship to serotonin transporter. J Pharmacol Exper Ther 252 : 410 418.
37. Invernizzi RW, Garattini S (2004). Role of presynaptic alpha2-adrenoceptors in antidepressant action: recent findings from microdialysis studies. Prog Neuropsychopharmacol Biol Psychiatry 28 : 819 827.
38. 2- adrenoceptors in the prefrontal cortex. Br J Pharmacol 132 : 183 188.
39. 6 receptors in learning and memory. Trends Pharmacol Sci 29 : 482 492.
40. Lanni C, Govoni S, Lucchelli A, Boselli C (2009). Depression and antidepressants: molecular and cellular aspects. Cell Mol Life Sci 66 : 2985 3008.
41. 1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn Schmiedebergs Arch Pharmacol 352 : 141 148.
42. 4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration. J Neurochem 109 : 1369 1374.
43. 4 receptors exert a frequency-related facilitatory control on dorsal raphé nucleus 5-HT neuronal activity. Eur J Neurosci 16 : 817 822.
44. 4 agonists. Biol Psychiatry 57 : 918 925.
45. Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S et al. (2007). Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action. Neuron 55 : 712 725.
46. Mateo Y, Fernández-Pastor B, Meana JJ (2001). Acute and chronic effects of desipramine and clorgyline on alpha(2)-adrenoceptors regulating noradrenergic transmission in the rat brain: a dual-probe microdialysis study. Br J Pharmacol 133 : 1362 1370.
47. Millan MJ, Dekeyne A, Papp M, La Rochelle CD, MacSweeny C, Peglion JL et al. (2001). S33005, a novel ligand at both serotonin and norepinephrine transporters: II. Behavioral profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. J Pharmacol Exp Ther 298 : 581 591.
48. Mostany R, Valdizan EM, Pazos A (2008). A role for nuclear β-catenin in SNRI antidepressant-induced hippocampal cell proliferation. Neuropharmacology 55 : 18 26.
49. Muth EA, Haskins JT, Moyer JA, Husbands GE, Nielsen ST, Sigg EB (1986). Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. Biochem Pharmacol 35 : 4493 4497.
50. 3H]paroxetine binding to serotonin transporters in rat brain. Neurochem Res 33 : 2250 2250.
51. Parini S, Renoldi G, Battaglia A, Invernizzi RW (2005). Chronic reboxetine desensitizes terminal but not somatodendritic alpha2-adrenoceptors controlling noradrenaline release in the rat dorsal hippocampus. Neuropsychopharmacology 30 : 1048 1055.
52. 4 receptor agonist. Society for Neurosciences Abstract, Chigaco, USA. Program No. 549.15.
53. Paxinos G, Watson C (1982). The Rat Brain in Stereotaxic Coordinates. Academic Press : Sydney.
54. Pejchal T, Foley MA, Kosofsky BE, Waeber C (2002). Chronic fluoxetine treatment selectively uncouples raphe 5-HT(1A) receptors as measured by [(35)S]-GTP gamma S autoradiography. Br J Pharmacol 135 : 1115 1122.
55. Ray AM, Kelsell RE, Houp JA, Kelly FM, Medhurst AD, Cox HM et al. (2009). Identification of a novel 5-HT(4) receptor splice variant (r5-HT(4c1)) and preliminary characterisation of specific 5-HT(4a) and 5-HT(4b) receptor antibodies. Eur J Pharmacol 604 : 1 11.
56. 4 postsynaptic receptors and their intracellular signalling systems IP3 and cAMP in brains from depressed violent suicide victims. Neuropsychobiology 49 : 189 195.
57. Schechter LE, Ring RH, Beyer CE, Hughes ZA, Khawaja X, Malberg JE (2005). Innovative approaches for the development of antidepressant drugs: current and future strategies. NeuroRx 2 : 590 611.
58. Schildkraut JJ (1965). The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry 122 : 509 522.
59. 4 receptor partial agonist, SL65.0155: behavioral and neurochemical studies in rats. Prog Neuropsychopharmacol Biol Psychiatry 33 : 1205 1210.
60. 4 agonists on the population spike recorded in hippocampal CA1 cells do not involve presynaptic effects on excitatory synaptic transmission. Pol J Pharmacol 48 : 565 573.
61. Valdizán EM, Gutierrez O, Pazos A (2003). Adenylate cyclase activity in postmortem brain of suicide subjects: reduced response to β-adrenergic stimulation. Biol Psychiatry 54 : 1457 1464.
62. 1A receptors in rat dorsal raphe nucleus. Int J Neuropsychopharmacol Epub ahead of print
63. Vetulani J, Nalepa I (2000). Antidepressants: past, present and future. Eur J Pharmacol 405 : 351 363.
64. 4 receptor-dependent signalling and functionality in rat brain. J Neurochem 110 : 1120 1127.
65. 2 receptor mRNA expression in cholinergic and non-cholinergic cells in the rat brain: a correlative study using in situ hybridization histochemistry and receptor autoradiography. Neuroscience 47 : 367 393.
66. 4 receptor mRNA in rat brain by in situ hybridization histochemistry. Brain Res Mol Brain Res 43 : 356 360.
67. 4 receptors and their mRNAs in rat and guinea pig brain: distribution and effects of neurotoxic lesions. J Comp Neurol 484 : 418 439.
68. 4 binding sites in rodent brain. Neuropharmacology 33 : 527 541.
69. 4 receptors. Naunyn Schmiedebergs Arch Pharmacol 356 : 712 720.