메뉴 건너뛰기




Volumn 12, Issue 9, 2013, Pages 885-893

Ectopic germinal centers, BAFF and anti-B-cell therapy in myasthenia gravis

Author keywords

Anti acetylcholine receptor antibodies; Anti B cell therapies; B cells; BAFF; Germinal centers; Myasthenia gravis

Indexed keywords

ATACICEPT; B CELL ACTIVATING FACTOR; BELIMUMAB; CXCL13 CHEMOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 6; RITUXIMAB; STROMAL CELL DERIVED FACTOR 1; SUPPRESSOR OF CYTOKINE SIGNALING 1;

EID: 84879167016     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2013.03.011     Document Type: Review
Times cited : (81)

References (190)
  • 1
    • 33645517263 scopus 로고    scopus 로고
    • Clinical aspects of neuromuscular transmission disorders
    • Evoli A. Clinical aspects of neuromuscular transmission disorders. Acta Neurol Scand Suppl 2006, 183:8-11.
    • (2006) Acta Neurol Scand Suppl , vol.183 , pp. 8-11
    • Evoli, A.1
  • 2
    • 84859939384 scopus 로고    scopus 로고
    • Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis
    • Zhang B., Tzartos J.S., Belimezi M., Ragheb S., Bealmear B., Lewis R.A., et al. Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis. Arch Neurol 2012, 69:445-451.
    • (2012) Arch Neurol , vol.69 , pp. 445-451
    • Zhang, B.1    Tzartos, J.S.2    Belimezi, M.3    Ragheb, S.4    Bealmear, B.5    Lewis, R.A.6
  • 3
    • 0023625297 scopus 로고
    • Clinical correlations of antibodies that bind, block, or modulate human acetylcholine receptors in myasthenia gravis
    • Howard F.M., Lennon V.A., Finley J., Matsumoto J., Elveback L.R. Clinical correlations of antibodies that bind, block, or modulate human acetylcholine receptors in myasthenia gravis. Ann N Y Acad Sci 1987, 505:526-538.
    • (1987) Ann N Y Acad Sci , vol.505 , pp. 526-538
    • Howard, F.M.1    Lennon, V.A.2    Finley, J.3    Matsumoto, J.4    Elveback, L.R.5
  • 4
    • 0017191868 scopus 로고
    • Pathological mechanisms in experimental autoimmune myasthenia gravis. II. Passive transfer of experimental autoimmune myasthenia gravis in rats with anti-acetylcholine receptor antibodies
    • Lindstrom J.M., Engel A.G., Seybold M.E., Lennon V.A., Lambert E.H. Pathological mechanisms in experimental autoimmune myasthenia gravis. II. Passive transfer of experimental autoimmune myasthenia gravis in rats with anti-acetylcholine receptor antibodies. J Exp Med 1976, 144:739-753.
    • (1976) J Exp Med , vol.144 , pp. 739-753
    • Lindstrom, J.M.1    Engel, A.G.2    Seybold, M.E.3    Lennon, V.A.4    Lambert, E.H.5
  • 5
    • 0019201756 scopus 로고
    • Monoclonal anti-acetylcholine receptor antibodies can cause experimental myasthenia
    • Richman D.P., Gomez C.M., Berman P.W., Burres S.A., Fitch F.W., Arnason B.G. Monoclonal anti-acetylcholine receptor antibodies can cause experimental myasthenia. Nature 1980, 286:738-739.
    • (1980) Nature , vol.286 , pp. 738-739
    • Richman, D.P.1    Gomez, C.M.2    Berman, P.W.3    Burres, S.A.4    Fitch, F.W.5    Arnason, B.G.6
  • 6
    • 33645521800 scopus 로고    scopus 로고
    • Induction of myasthenia by immunization against muscle-specific kinase
    • Shigemoto K., Kubo S., Maruyama N., Hato N., Yamada H., Jie C., et al. Induction of myasthenia by immunization against muscle-specific kinase. J Clin Invest 2006, 116:1016-1024.
    • (2006) J Clin Invest , vol.116 , pp. 1016-1024
    • Shigemoto, K.1    Kubo, S.2    Maruyama, N.3    Hato, N.4    Yamada, H.5    Jie, C.6
  • 7
    • 84879191215 scopus 로고    scopus 로고
    • Mechanisms associated with the pathogenicity of antibodies against muscle-specific kinase in myasthenia gravis
    • (this issue)
    • Mori S., Shigemoto K. Mechanisms associated with the pathogenicity of antibodies against muscle-specific kinase in myasthenia gravis. Autoimmun Rev 2013, 12:912-917. (this issue).
    • (2013) Autoimmun Rev , vol.12 , pp. 912-917
    • Mori, S.1    Shigemoto, K.2
  • 8
    • 0030456897 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice
    • Wolf S.D., Dittel B.N., Hardardottir F., Janeway C.A. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med 1996, 184:2271-2278.
    • (1996) J Exp Med , vol.184 , pp. 2271-2278
    • Wolf, S.D.1    Dittel, B.N.2    Hardardottir, F.3    Janeway, C.A.4
  • 10
  • 11
    • 0026027752 scopus 로고
    • T-cell antigenic sites involved in myasthenia gravis: correlations with antibody titre and disease severity
    • Berrih-Aknin S., Cohen-Kaminsky S., Lepage V., Neumann D., Bach J.F., Fuchs S. T-cell antigenic sites involved in myasthenia gravis: correlations with antibody titre and disease severity. J Autoimmun 1991, 4:137-153.
    • (1991) J Autoimmun , vol.4 , pp. 137-153
    • Berrih-Aknin, S.1    Cohen-Kaminsky, S.2    Lepage, V.3    Neumann, D.4    Bach, J.F.5    Fuchs, S.6
  • 12
    • 0020413269 scopus 로고
    • T-lymphocytes in experimental autoimmune myasthenia gravis. Isolation of T-helper cell lines
    • Hohlfeld R., Kalies I., Ernst M., Ketelsen U.P., Wekerle H. T-lymphocytes in experimental autoimmune myasthenia gravis. Isolation of T-helper cell lines. J Neurol Sci 1982, 57:265-280.
    • (1982) J Neurol Sci , vol.57 , pp. 265-280
    • Hohlfeld, R.1    Kalies, I.2    Ernst, M.3    Ketelsen, U.P.4    Wekerle, H.5
  • 13
    • 0025277903 scopus 로고
    • Immune studies in human immunodeficiency virus infection with myasthenia gravis: a case report
    • Nath A., Kerman R.H., Novak I.S., Wolinsky J.S. Immune studies in human immunodeficiency virus infection with myasthenia gravis: a case report. Neurology 1990, 40:581-583.
    • (1990) Neurology , vol.40 , pp. 581-583
    • Nath, A.1    Kerman, R.H.2    Novak, I.S.3    Wolinsky, J.S.4
  • 14
    • 0033044909 scopus 로고    scopus 로고
    • Myasthenia in SCID mice grafted with myasthenic patient lymphocytes: role of CD4+ and CD8+ cells
    • Wang Z.Y., Karachunski P.I., Howard J.F., Conti-Fine B.M. Myasthenia in SCID mice grafted with myasthenic patient lymphocytes: role of CD4+ and CD8+ cells. Neurology 1999, 52:484-497.
    • (1999) Neurology , vol.52 , pp. 484-497
    • Wang, Z.Y.1    Karachunski, P.I.2    Howard, J.F.3    Conti-Fine, B.M.4
  • 15
    • 0028299965 scopus 로고
    • Major histocompatibility complex class II gene disruption prevents experimental autoimmune myasthenia gravis
    • Kaul R., Shenoy M., Goluszko E., Christadoss P. Major histocompatibility complex class II gene disruption prevents experimental autoimmune myasthenia gravis. J Immunol 1994, 152:3152-3157.
    • (1994) J Immunol , vol.152 , pp. 3152-3157
    • Kaul, R.1    Shenoy, M.2    Goluszko, E.3    Christadoss, P.4
  • 16
    • 84879188812 scopus 로고    scopus 로고
    • The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes
    • (this issue)
    • Marx A., Pfister F., Schalke B., Saruhan-Direskeneli G., Melms A., Ströbel P. The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes. Autoimmun Rev 2013, 12:875-884. (this issue).
    • (2013) Autoimmun Rev , vol.12 , pp. 875-884
    • Marx, A.1    Pfister, F.2    Schalke, B.3    Saruhan-Direskeneli, G.4    Melms, A.5    Ströbel, P.6
  • 17
    • 0021329452 scopus 로고
    • Anti-AChR antibodies, thymic histology, and T cell subsets in myasthenia gravis
    • Berrih S., Morel E., Gaud C., Raimond F., Le Brigand H., Bach J.F. Anti-AChR antibodies, thymic histology, and T cell subsets in myasthenia gravis. Neurology 1984, 34:66-71.
    • (1984) Neurology , vol.34 , pp. 66-71
    • Berrih, S.1    Morel, E.2    Gaud, C.3    Raimond, F.4    Le Brigand, H.5    Bach, J.F.6
  • 19
    • 0019815610 scopus 로고
    • Thymus cells in myasthenia gravis selectively enhance production of anti-acetylcholine-receptor antibody by autologous blood lymphocytes
    • Newsom-Davis J., Willcox N., Calder L. Thymus cells in myasthenia gravis selectively enhance production of anti-acetylcholine-receptor antibody by autologous blood lymphocytes. N Engl J Med 1981, 305:1313-1318.
    • (1981) N Engl J Med , vol.305 , pp. 1313-1318
    • Newsom-Davis, J.1    Willcox, N.2    Calder, L.3
  • 20
    • 0022474111 scopus 로고
    • Antibodies to acetylcholine receptor and tetanus toxoid: in vitro synthesis by thymic lymphocytes
    • Lisak R.P., Levinson A.I., Zweiman B., Kornstein M.J. Antibodies to acetylcholine receptor and tetanus toxoid: in vitro synthesis by thymic lymphocytes. J Immunol 1986, 137:1221-1225.
    • (1986) J Immunol , vol.137 , pp. 1221-1225
    • Lisak, R.P.1    Levinson, A.I.2    Zweiman, B.3    Kornstein, M.J.4
  • 21
    • 0023263064 scopus 로고
    • Invitro antiacetylcholine receptor antibody-synthesis by myasthenia-gravis patient lymphocytes-correlations with thymic histology and thymic epithelial-cell interactions
    • Safar D., Berrih-Aknin S., Morel E. Invitro antiacetylcholine receptor antibody-synthesis by myasthenia-gravis patient lymphocytes-correlations with thymic histology and thymic epithelial-cell interactions. J Clin Immunol 1987, 7:225-234.
    • (1987) J Clin Immunol , vol.7 , pp. 225-234
    • Safar, D.1    Berrih-Aknin, S.2    Morel, E.3
  • 22
    • 0022632729 scopus 로고
    • Specific activation of lymphocytes against acetylcholine receptor in the thymus in myasthenia gravis
    • Fujii Y., Hashimoto J., Monden Y., Ito T., Nakahara K., Kawashima Y. Specific activation of lymphocytes against acetylcholine receptor in the thymus in myasthenia gravis. J Immunol 1986, 136:887-891.
    • (1986) J Immunol , vol.136 , pp. 887-891
    • Fujii, Y.1    Hashimoto, J.2    Monden, Y.3    Ito, T.4    Nakahara, K.5    Kawashima, Y.6
  • 23
    • 0035197779 scopus 로고    scopus 로고
    • Analysis of immunoglobulin secretion by lymph organs with myasthenia gravis
    • Yoshikawa H., Satoh K., Yasukawa Y., Yamada M. Analysis of immunoglobulin secretion by lymph organs with myasthenia gravis. Acta Neurol Scand 2001, 103:53-58.
    • (2001) Acta Neurol Scand , vol.103 , pp. 53-58
    • Yoshikawa, H.1    Satoh, K.2    Yasukawa, Y.3    Yamada, M.4
  • 24
    • 0026648331 scopus 로고
    • Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice. A new model of myasthenia gravis
    • Schonbeck S., Padberg F., Hohlfeld R., Wekerle H. Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice. A new model of myasthenia gravis. J Clin Invest 1992, 90:245-250.
    • (1992) J Clin Invest , vol.90 , pp. 245-250
    • Schonbeck, S.1    Padberg, F.2    Hohlfeld, R.3    Wekerle, H.4
  • 25
    • 0032834013 scopus 로고    scopus 로고
    • Prevention of autoimmune attack by targeting specific T-cell receptors in a severe combined immunodeficiency mouse model of myasthenia gravis [see comments]
    • Aissaoui A., Klingel-Schmitt I., Couderc J., Chateau D., Romagne F., Jambou F., et al. Prevention of autoimmune attack by targeting specific T-cell receptors in a severe combined immunodeficiency mouse model of myasthenia gravis [see comments]. Ann Neurol 1999, 46:559-567.
    • (1999) Ann Neurol , vol.46 , pp. 559-567
    • Aissaoui, A.1    Klingel-Schmitt, I.2    Couderc, J.3    Chateau, D.4    Romagne, F.5    Jambou, F.6
  • 26
    • 0025819525 scopus 로고
    • Anti-acetylcholine receptor antibodies decrease after thymectomy in patients with myasthenia gravis. Clinical correlations
    • Kuks J.B., Oosterhuis H.J., Limburg P.C., The T.H. Anti-acetylcholine receptor antibodies decrease after thymectomy in patients with myasthenia gravis. Clinical correlations. J Autoimmun 1991, 4:197-211.
    • (1991) J Autoimmun , vol.4 , pp. 197-211
    • Kuks, J.B.1    Oosterhuis, H.J.2    Limburg, P.C.3    The, T.H.4
  • 28
    • 20044374002 scopus 로고    scopus 로고
    • Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG
    • Leite M.I., Strobel P., Jones M., Micklem K., Moritz R., Gold R., et al. Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG. Ann Neurol 2005, 57:444-448.
    • (2005) Ann Neurol , vol.57 , pp. 444-448
    • Leite, M.I.1    Strobel, P.2    Jones, M.3    Micklem, K.4    Moritz, R.5    Gold, R.6
  • 30
    • 84879158291 scopus 로고    scopus 로고
    • The thymus autoimmune Myasthenia Gravis - Paradigm for a tertiary lymphoid organ. Rev Neurol in press.
    • Weiss JM, Cufi P, Le Panse R, Berrih-Aknin S. The thymus in autoimmune Myasthenia Gravis - Paradigm for a tertiary lymphoid organ. Rev Neurol in press.
    • Weiss, J.M.1    Cufi, P.2    Le Panse, R.3    Berrih-Aknin, S.4
  • 32
    • 33751558801 scopus 로고    scopus 로고
    • Microarrays reveal distinct gene signatures in the thymus of seropositive and seronegative myasthenia gravis patients and the role of CC chemokine ligand 21 in thymic hyperplasia
    • Le Panse R., Cizeron-Clairac G., Bismuth J., Berrih-Aknin S. Microarrays reveal distinct gene signatures in the thymus of seropositive and seronegative myasthenia gravis patients and the role of CC chemokine ligand 21 in thymic hyperplasia. J Immunol 2006, 177:7868-7879.
    • (2006) J Immunol , vol.177 , pp. 7868-7879
    • Le Panse, R.1    Cizeron-Clairac, G.2    Bismuth, J.3    Berrih-Aknin, S.4
  • 33
    • 0032536373 scopus 로고    scopus 로고
    • B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
    • Legler D.F., Loetscher M., Roos R.S., Clark-Lewis I., Baggiolini M., Moser B. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 1998, 187:655-660.
    • (1998) J Exp Med , vol.187 , pp. 655-660
    • Legler, D.F.1    Loetscher, M.2    Roos, R.S.3    Clark-Lewis, I.4    Baggiolini, M.5    Moser, B.6
  • 35
    • 0033679060 scopus 로고    scopus 로고
    • BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis
    • Luther S.A., Lopez T., Bai W., Hanahan D., Cyster J.G. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity 2000, 12:471-481.
    • (2000) Immunity , vol.12 , pp. 471-481
    • Luther, S.A.1    Lopez, T.2    Bai, W.3    Hanahan, D.4    Cyster, J.G.5
  • 36
    • 0037881917 scopus 로고    scopus 로고
    • Ectopic LT alpha beta directs lymphoid organ neogenesis with concomitant expression of peripheral node addressin and a HEV-restricted sulfotransferase
    • Drayton D.L., Ying X., Lee J., Lesslauer W., Ruddle N.H. Ectopic LT alpha beta directs lymphoid organ neogenesis with concomitant expression of peripheral node addressin and a HEV-restricted sulfotransferase. J Exp Med 2003, 197:1153-1163.
    • (2003) J Exp Med , vol.197 , pp. 1153-1163
    • Drayton, D.L.1    Ying, X.2    Lee, J.3    Lesslauer, W.4    Ruddle, N.H.5
  • 37
    • 84873196393 scopus 로고    scopus 로고
    • SDF-1/CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients
    • Weiss J.M., Cufi P., Bismuth J., Eymard B., Fadel E., Berrih-Aknin S., et al. SDF-1/CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients. Immunobiology 2013, 218:373-381.
    • (2013) Immunobiology , vol.218 , pp. 373-381
    • Weiss, J.M.1    Cufi, P.2    Bismuth, J.3    Eymard, B.4    Fadel, E.5    Berrih-Aknin, S.6
  • 38
    • 36148945270 scopus 로고    scopus 로고
    • The paradox of CD5-expressing B cells in systemic lupus erythematosus
    • Youinou P., Renaudineau Y. The paradox of CD5-expressing B cells in systemic lupus erythematosus. Autoimmun Rev 2007, 7:149-154.
    • (2007) Autoimmun Rev , vol.7 , pp. 149-154
    • Youinou, P.1    Renaudineau, Y.2
  • 39
    • 0026651934 scopus 로고
    • Levels of CD5+ B lymphocytes do not differ between patients with myasthenia gravis and healthy individuals
    • Yi Q., Ahlberg R., Pirskanen R., Lefvert A. Levels of CD5+ B lymphocytes do not differ between patients with myasthenia gravis and healthy individuals. Neurology 1992, 42:1081-1084.
    • (1992) Neurology , vol.42 , pp. 1081-1084
    • Yi, Q.1    Ahlberg, R.2    Pirskanen, R.3    Lefvert, A.4
  • 40
    • 0026635736 scopus 로고
    • Effect of clinical status and treatment on the frequency of CD5+ B cells in patients with myasthenia gravis
    • Ragheb S., Lisak R.P. Effect of clinical status and treatment on the frequency of CD5+ B cells in patients with myasthenia gravis. Neurology 1992, 42:1076-1080.
    • (1992) Neurology , vol.42 , pp. 1076-1080
    • Ragheb, S.1    Lisak, R.P.2
  • 42
    • 0029655289 scopus 로고    scopus 로고
    • Synthesis of anti-acetylcholine receptor antibodies by CD5- B cells from peripheral blood of myasthenia gravis patients
    • Heidenreich F., Jovin T. Synthesis of anti-acetylcholine receptor antibodies by CD5- B cells from peripheral blood of myasthenia gravis patients. J Neurol 1996, 243:57-62.
    • (1996) J Neurol , vol.243 , pp. 57-62
    • Heidenreich, F.1    Jovin, T.2
  • 43
    • 0033278099 scopus 로고    scopus 로고
    • Cell-surface expression of lymphocyte activation markers in myasthenia gravis
    • Ragheb S., Bealmear B., Lisak R. Cell-surface expression of lymphocyte activation markers in myasthenia gravis. Autoimmunity 1999, 31:55-66.
    • (1999) Autoimmunity , vol.31 , pp. 55-66
    • Ragheb, S.1    Bealmear, B.2    Lisak, R.3
  • 44
    • 0030904235 scopus 로고    scopus 로고
    • Expression of CD23 in the germinal center of thymus from myasthenia gravis patients
    • Murai H., Hara H., Hatae T., Kobayashi T., Watanabe T. Expression of CD23 in the germinal center of thymus from myasthenia gravis patients. J Neuroimmunol 1997, 76:61-69.
    • (1997) J Neuroimmunol , vol.76 , pp. 61-69
    • Murai, H.1    Hara, H.2    Hatae, T.3    Kobayashi, T.4    Watanabe, T.5
  • 46
    • 78149311525 scopus 로고    scopus 로고
    • The life span of short-lived plasma cells is partly determined by a block on activation of apoptotic caspases acting in combination with endoplasmic reticulum stress
    • Auner H.W., Beham-Schmid C., Dillon N., Sabbattini P. The life span of short-lived plasma cells is partly determined by a block on activation of apoptotic caspases acting in combination with endoplasmic reticulum stress. Blood 2010, 116:3445-3455.
    • (2010) Blood , vol.116 , pp. 3445-3455
    • Auner, H.W.1    Beham-Schmid, C.2    Dillon, N.3    Sabbattini, P.4
  • 48
    • 0036046188 scopus 로고    scopus 로고
    • ACh receptor protein drives primary and memory autoantibody responses in chimeric human-SCID mice
    • Yoshikawa H., Lennon V. ACh receptor protein drives primary and memory autoantibody responses in chimeric human-SCID mice. Clin Immunol 2002, 104:128-137.
    • (2002) Clin Immunol , vol.104 , pp. 128-137
    • Yoshikawa, H.1    Lennon, V.2
  • 50
  • 51
    • 80052558224 scopus 로고    scopus 로고
    • Lack of evidence for Epstein-Barr virus infection in myasthenia gravis thymus
    • Meyer M., Hols A.K., Liersch B., Leistner R., Gellert K., Schalke B., et al. Lack of evidence for Epstein-Barr virus infection in myasthenia gravis thymus. Ann Neurol 2011, 70:515-518.
    • (2011) Ann Neurol , vol.70 , pp. 515-518
    • Meyer, M.1    Hols, A.K.2    Liersch, B.3    Leistner, R.4    Gellert, K.5    Schalke, B.6
  • 52
    • 84860916035 scopus 로고    scopus 로고
    • High anti-EBNA-1 IgG levels are associated with early-onset myasthenia gravis
    • Csuka D., Banati M., Rozsa C., Füst G., Illes Z. High anti-EBNA-1 IgG levels are associated with early-onset myasthenia gravis. Eur J Neurol 2012, 19:842-846.
    • (2012) Eur J Neurol , vol.19 , pp. 842-846
    • Csuka, D.1    Banati, M.2    Rozsa, C.3    Füst, G.4    Illes, Z.5
  • 57
    • 0036240295 scopus 로고    scopus 로고
    • Cytokine secretion by peripheral blood mononuclear cells in myasthenia gravis
    • Yoshikawa H., Satoh K., Yasukawa Y., Yamada M. Cytokine secretion by peripheral blood mononuclear cells in myasthenia gravis. J Clin Neurosci 2002, 9:133-136.
    • (2002) J Clin Neurosci , vol.9 , pp. 133-136
    • Yoshikawa, H.1    Satoh, K.2    Yasukawa, Y.3    Yamada, M.4
  • 58
    • 0034129733 scopus 로고    scopus 로고
    • Muscle autoantibodies in subgroups of myasthenia gravis patients
    • Romi F., Skeie G.O., Aarli J.A., Gilhus N.E. Muscle autoantibodies in subgroups of myasthenia gravis patients. J Neurol 2000, 247:369-375.
    • (2000) J Neurol , vol.247 , pp. 369-375
    • Romi, F.1    Skeie, G.O.2    Aarli, J.A.3    Gilhus, N.E.4
  • 59
    • 0010655052 scopus 로고
    • Immunological disturbances in myasthenia gravis with a report of Hashimoto's disease developing after thymectomy
    • Simpson J.A. Immunological disturbances in myasthenia gravis with a report of Hashimoto's disease developing after thymectomy. J Neurol Neurosurg Psychiatry 1964, 27:485-492.
    • (1964) J Neurol Neurosurg Psychiatry , vol.27 , pp. 485-492
    • Simpson, J.A.1
  • 60
    • 0024397883 scopus 로고
    • Associated disorders in myasthenia gravis: autoimmune diseases and their relation to thymectomy
    • Thorlacius S., Aarli J.A., Riise T., Matre R., Johnsen H.J. Associated disorders in myasthenia gravis: autoimmune diseases and their relation to thymectomy. Acta Neurol Scand 1989, 80:290-295.
    • (1989) Acta Neurol Scand , vol.80 , pp. 290-295
    • Thorlacius, S.1    Aarli, J.A.2    Riise, T.3    Matre, R.4    Johnsen, H.J.5
  • 61
    • 0026081375 scopus 로고
    • Individual germinal centres of myasthenia gravis human thymuses contain polyclonal activated B cells that express all the Vh and Vk families
    • Guigou V., Emilie D., Berrih-Aknin S., Fumoux F., Fougereau M., Schiff C. Individual germinal centres of myasthenia gravis human thymuses contain polyclonal activated B cells that express all the Vh and Vk families. Clin Exp Immunol 1991, 83:262-266.
    • (1991) Clin Exp Immunol , vol.83 , pp. 262-266
    • Guigou, V.1    Emilie, D.2    Berrih-Aknin, S.3    Fumoux, F.4    Fougereau, M.5    Schiff, C.6
  • 62
    • 0035881829 scopus 로고    scopus 로고
    • Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis
    • Sims G., Shiono H., Willcox N., Stott D. Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis. J Immunol 2001, 167:1935-1944.
    • (2001) J Immunol , vol.167 , pp. 1935-1944
    • Sims, G.1    Shiono, H.2    Willcox, N.3    Stott, D.4
  • 63
  • 64
    • 0027163842 scopus 로고
    • Interleukin-6 overproduction by cultured thymic epithelial cells from patients with myasthenia gravis is potentially involved in thymic hyperplasia
    • Cohen-Kaminsky S., Devergne O., Delattre R.M., Klingel-Schmitt I., Emilie D., Galanaud P., et al. Interleukin-6 overproduction by cultured thymic epithelial cells from patients with myasthenia gravis is potentially involved in thymic hyperplasia. Eur Cytokine Netw 1993, 4:121-132.
    • (1993) Eur Cytokine Netw , vol.4 , pp. 121-132
    • Cohen-Kaminsky, S.1    Devergne, O.2    Delattre, R.M.3    Klingel-Schmitt, I.4    Emilie, D.5    Galanaud, P.6
  • 65
    • 79951943070 scopus 로고    scopus 로고
    • Blocking of IL-6 suppresses experimental autoimmune myasthenia gravis
    • Aricha R., Mizrachi K., Fuchs S., Souroujon M.C. Blocking of IL-6 suppresses experimental autoimmune myasthenia gravis. J Autoimmun 2011, 36:135-141.
    • (2011) J Autoimmun , vol.36 , pp. 135-141
    • Aricha, R.1    Mizrachi, K.2    Fuchs, S.3    Souroujon, M.C.4
  • 66
    • 83655203256 scopus 로고    scopus 로고
    • Immunotherapeutic implication of IL-6 blockade
    • Tanaka T., Kishimoto T. Immunotherapeutic implication of IL-6 blockade. Immunotherapy 2012, 4:87-105.
    • (2012) Immunotherapy , vol.4 , pp. 87-105
    • Tanaka, T.1    Kishimoto, T.2
  • 67
    • 0034141735 scopus 로고    scopus 로고
    • Lymphocyte polyclonal activation: a pitfall for vaccine design against infectious agents
    • Reina-San-Martin B., Cosson A., Minoprio P. Lymphocyte polyclonal activation: a pitfall for vaccine design against infectious agents. Parasitol Today 2000, 16:62-67.
    • (2000) Parasitol Today , vol.16 , pp. 62-67
    • Reina-San-Martin, B.1    Cosson, A.2    Minoprio, P.3
  • 68
    • 36249027092 scopus 로고    scopus 로고
    • Polyclonal B cell activation in infections: infectious agents' devilry or defense mechanism of the host?
    • Montes C., Acosta-Rodríguez E., Merino M., Bermejo D., Gruppi A. Polyclonal B cell activation in infections: infectious agents' devilry or defense mechanism of the host?. J Leukoc Biol 2007, 82:1027-1032.
    • (2007) J Leukoc Biol , vol.82 , pp. 1027-1032
    • Montes, C.1    Acosta-Rodríguez, E.2    Merino, M.3    Bermejo, D.4    Gruppi, A.5
  • 71
    • 0033538468 scopus 로고    scopus 로고
    • BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    • Moore P.A., Belvedere O., Orr A., Pieri K., LaFleur D.W., Feng P., et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999, 285:260-263.
    • (1999) Science , vol.285 , pp. 260-263
    • Moore, P.A.1    Belvedere, O.2    Orr, A.3    Pieri, K.4    LaFleur, D.W.5    Feng, P.6
  • 72
    • 0033532634 scopus 로고    scopus 로고
    • BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    • Schneider P., MacKay F., Steiner V., Hofmann K., Bodmer J.L., Holler N., et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999, 189:1747-1756.
    • (1999) J Exp Med , vol.189 , pp. 1747-1756
    • Schneider, P.1    MacKay, F.2    Steiner, V.3    Hofmann, K.4    Bodmer, J.L.5    Holler, N.6
  • 73
    • 0036300545 scopus 로고    scopus 로고
    • Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes
    • Karpusas M., Cachero T.G., Qian F., Boriack-Sjodin A., Mullen C., Strauch K., et al. Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes. J Mol Biol 2002, 315:1145-1154.
    • (2002) J Mol Biol , vol.315 , pp. 1145-1154
    • Karpusas, M.1    Cachero, T.G.2    Qian, F.3    Boriack-Sjodin, A.4    Mullen, C.5    Strauch, K.6
  • 74
    • 0036183318 scopus 로고    scopus 로고
    • Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands
    • Liu Y., Xu L., Opalka N., Kappler J., Shu H.B., Zhang G. Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands. Cell 2002, 108:383-394.
    • (2002) Cell , vol.108 , pp. 383-394
    • Liu, Y.1    Xu, L.2    Opalka, N.3    Kappler, J.4    Shu, H.B.5    Zhang, G.6
  • 76
    • 16544385150 scopus 로고    scopus 로고
    • The biochemistry and biology of BAFF, APRIL and their receptors
    • Kalled S.L., Ambrose C., Hsu Y.M. The biochemistry and biology of BAFF, APRIL and their receptors. Curr Dir Autoimmun 2005, 8:206-242.
    • (2005) Curr Dir Autoimmun , vol.8 , pp. 206-242
    • Kalled, S.L.1    Ambrose, C.2    Hsu, Y.M.3
  • 77
    • 4043075603 scopus 로고    scopus 로고
    • TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology
    • Sasaki Y., Casola S., Kutok J.L., Rajewsky K., Schmidt-Supprian M. TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology. J Immunol 2004, 173:2245-2252.
    • (2004) J Immunol , vol.173 , pp. 2245-2252
    • Sasaki, Y.1    Casola, S.2    Kutok, J.L.3    Rajewsky, K.4    Schmidt-Supprian, M.5
  • 78
    • 4043146475 scopus 로고    scopus 로고
    • B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation
    • Shulga-Morskaya S., Dobles M., Walsh M.E., Ng L.G., MacKay F., Rao S.P., et al. B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation. J Immunol 2004, 173:2331-2341.
    • (2004) J Immunol , vol.173 , pp. 2331-2341
    • Shulga-Morskaya, S.1    Dobles, M.2    Walsh, M.E.3    Ng, L.G.4    MacKay, F.5    Rao, S.P.6
  • 79
    • 33747837100 scopus 로고    scopus 로고
    • BAFF, APRIL and their receptors: Structure, function and signaling
    • Bossen C., Schneider P. BAFF, APRIL and their receptors: Structure, function and signaling. Semin Immunol 2006, 18:263-275.
    • (2006) Semin Immunol , vol.18 , pp. 263-275
    • Bossen, C.1    Schneider, P.2
  • 80
    • 3142671331 scopus 로고    scopus 로고
    • B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells
    • Ng L.G., Sutherland A.P.R., Newton R., Qian F., Cachero T.G., Scott M.L., et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 2004, 173:807-817.
    • (2004) J Immunol , vol.173 , pp. 807-817
    • Ng, L.G.1    Sutherland, A.P.R.2    Newton, R.3    Qian, F.4    Cachero, T.G.5    Scott, M.L.6
  • 82
    • 0037332043 scopus 로고    scopus 로고
    • Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor
    • Seshasayee D., Valdez P., Yan M., Dixit V.M., Tumas D., Grewal I.S. Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity 2003, 18:279-288.
    • (2003) Immunity , vol.18 , pp. 279-288
    • Seshasayee, D.1    Valdez, P.2    Yan, M.3    Dixit, V.M.4    Tumas, D.5    Grewal, I.S.6
  • 84
  • 85
    • 0035860559 scopus 로고    scopus 로고
    • An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    • Schiemann B., Gommerman J.L., Vora K., Cachero T.G., Shulga-Morskaya S., Dobles M., et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 2001, 293:2111-2114.
    • (2001) Science , vol.293 , pp. 2111-2114
    • Schiemann, B.1    Gommerman, J.L.2    Vora, K.3    Cachero, T.G.4    Shulga-Morskaya, S.5    Dobles, M.6
  • 86
    • 0035007222 scopus 로고    scopus 로고
    • B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses
    • Xu S.L., Lam K.P. B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. Mol Cell Biol 2001, 21:4067-4074.
    • (2001) Mol Cell Biol , vol.21 , pp. 4067-4074
    • Xu, S.L.1    Lam, K.P.2
  • 87
    • 85047690330 scopus 로고    scopus 로고
    • BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
    • Avery D.T., Kalled S.L., Ellyard J.I., Ambrose C., Bixler S.A., Thien M., et al. BAFF selectively enhances the survival of plasmablasts generated from human memory B cells. J Clin Invest 2003, 112:286-297.
    • (2003) J Clin Invest , vol.112 , pp. 286-297
    • Avery, D.T.1    Kalled, S.L.2    Ellyard, J.I.3    Ambrose, C.4    Bixler, S.A.5    Thien, M.6
  • 88
    • 26444537116 scopus 로고    scopus 로고
    • BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors
    • Zhang X., Park C.S., Yoon S.O., Li L., Hsu Y.M., Ambrose C., et al. BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors. Int Immunol 2005, 17:779-788.
    • (2005) Int Immunol , vol.17 , pp. 779-788
    • Zhang, X.1    Park, C.S.2    Yoon, S.O.3    Li, L.4    Hsu, Y.M.5    Ambrose, C.6
  • 89
    • 38849104447 scopus 로고    scopus 로고
    • Regulated expression of BAFF-binding receptors during human B cell differentiation
    • Darce J.R., Arendt B.K., Wu X.S., Jelinek D.F. Regulated expression of BAFF-binding receptors during human B cell differentiation. J Immunol 2007, 179:7276-7286.
    • (2007) J Immunol , vol.179 , pp. 7276-7286
    • Darce, J.R.1    Arendt, B.K.2    Wu, X.S.3    Jelinek, D.F.4
  • 90
    • 0036753722 scopus 로고    scopus 로고
    • Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses
    • MacLennan I.C.M., Vinuesa C.G. Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses. Immunity 2002, 17:235-238.
    • (2002) Immunity , vol.17 , pp. 235-238
    • MacLennan, I.C.M.1    Vinuesa, C.G.2
  • 91
    • 0036312654 scopus 로고    scopus 로고
    • BAFF is a survival and maturation factor for mouse B cells
    • Rolink A.G., Tschopp J., Schneider P., Melchers F. BAFF is a survival and maturation factor for mouse B cells. Eur J Immunol 2002, 32:2004-2010.
    • (2002) Eur J Immunol , vol.32 , pp. 2004-2010
    • Rolink, A.G.1    Tschopp, J.2    Schneider, P.3    Melchers, F.4
  • 93
    • 0033428703 scopus 로고    scopus 로고
    • Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
    • Mackay F., Woodcock S.A., Lawton P., Ambrose C., Baetscher M., Schneider P., et al. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med 1999, 190:1697-1710.
    • (1999) J Exp Med , vol.190 , pp. 1697-1710
    • Mackay, F.1    Woodcock, S.A.2    Lawton, P.3    Ambrose, C.4    Baetscher, M.5    Schneider, P.6
  • 95
    • 26644472949 scopus 로고    scopus 로고
    • BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders
    • Rodig S.J., Shahsafaei A., Li B., Mackay C.R., Dorfman D.M. BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders. Hum Pathol 2005, 36:1113-1119.
    • (2005) Hum Pathol , vol.36 , pp. 1113-1119
    • Rodig, S.J.1    Shahsafaei, A.2    Li, B.3    Mackay, C.R.4    Dorfman, D.M.5
  • 96
    • 42949162823 scopus 로고    scopus 로고
    • A new class of reverse signaling costimulators belongs to the TNF family
    • Sun M., Fink P.J. A new class of reverse signaling costimulators belongs to the TNF family. J Immunol 2007, 179:4307-4312.
    • (2007) J Immunol , vol.179 , pp. 4307-4312
    • Sun, M.1    Fink, P.J.2
  • 97
    • 79951776113 scopus 로고    scopus 로고
    • Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses
    • Bossen C., Tardivel A., Willen L., Fletcher C.A., Perroud M., Beermann F., et al. Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses. Eur J Immunol 2011, 41:787-797.
    • (2011) Eur J Immunol , vol.41 , pp. 787-797
    • Bossen, C.1    Tardivel, A.2    Willen, L.3    Fletcher, C.A.4    Perroud, M.5    Beermann, F.6
  • 98
    • 1842633887 scopus 로고    scopus 로고
    • Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF
    • Lesley R., Xu Y., Kalled S.L., Hess D.M., Schwab S.R., Shu H.B., et al. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity 2004, 20:441-453.
    • (2004) Immunity , vol.20 , pp. 441-453
    • Lesley, R.1    Xu, Y.2    Kalled, S.L.3    Hess, D.M.4    Schwab, S.R.5    Shu, H.B.6
  • 99
    • 2942518502 scopus 로고    scopus 로고
    • Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches
    • Thien M., Phan T.G., Gardam S., Amesbury M., Basten A., Mackay F., et al. Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity 2004, 20:785-798.
    • (2004) Immunity , vol.20 , pp. 785-798
    • Thien, M.1    Phan, T.G.2    Gardam, S.3    Amesbury, M.4    Basten, A.5    Mackay, F.6
  • 100
    • 77958120721 scopus 로고    scopus 로고
    • Regulation of the B Cell Receptor Repertoire and Self-Reactivity by BAFF
    • Ota M., Duong B.H., Torkamani A., Doyle C.M., Gavin A.L., Ota T., et al. Regulation of the B Cell Receptor Repertoire and Self-Reactivity by BAFF. J Immunol 2010, 185:4128-4136.
    • (2010) J Immunol , vol.185 , pp. 4128-4136
    • Ota, M.1    Duong, B.H.2    Torkamani, A.3    Doyle, C.M.4    Gavin, A.L.5    Ota, T.6
  • 101
    • 33747838476 scopus 로고    scopus 로고
    • Regulation of B cell self-tolerance by BAFF
    • Brink R. Regulation of B cell self-tolerance by BAFF. Semin Immunol 2006, 18:276-283.
    • (2006) Semin Immunol , vol.18 , pp. 276-283
    • Brink, R.1
  • 102
    • 33748638386 scopus 로고    scopus 로고
    • Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production
    • Kalled S.L. Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production. Semin Immunol 2006, 18:290-296.
    • (2006) Semin Immunol , vol.18 , pp. 290-296
    • Kalled, S.L.1
  • 104
    • 0038142395 scopus 로고    scopus 로고
    • Macrophage- and dendritic cell-dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF
    • Craxton A., Magaletti D., Ryan E.J., Clark E.A. Macrophage- and dendritic cell-dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF. Blood 2003, 101:4464-4471.
    • (2003) Blood , vol.101 , pp. 4464-4471
    • Craxton, A.1    Magaletti, D.2    Ryan, E.J.3    Clark, E.A.4
  • 106
    • 44949253997 scopus 로고    scopus 로고
    • Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity
    • Krumbholz M., Faber H., Steinmeyer F., Hoffmann L.A., Kumpfel T., Pellkofer H., et al. Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity. Brain 2008, 131:1455-1463.
    • (2008) Brain , vol.131 , pp. 1455-1463
    • Krumbholz, M.1    Faber, H.2    Steinmeyer, F.3    Hoffmann, L.A.4    Kumpfel, T.5    Pellkofer, H.6
  • 107
    • 10744223505 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity
    • Hanada T., Yoshida H., Kato S., Tanaka K., Masutani K., Tsukada J., et al. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 2003, 19:437-450.
    • (2003) Immunity , vol.19 , pp. 437-450
    • Hanada, T.1    Yoshida, H.2    Kato, S.3    Tanaka, K.4    Masutani, K.5    Tsukada, J.6
  • 109
    • 54049132513 scopus 로고    scopus 로고
    • A potential role for B-cell activating factor in the pathogenesis of autoimmune myasthenia gravis
    • Ragheb S., Lisak R., Lewis R., Van Stavern G., Gonzales F., Simon K. A potential role for B-cell activating factor in the pathogenesis of autoimmune myasthenia gravis. Arch Neurol 2008, 65:1358-1362.
    • (2008) Arch Neurol , vol.65 , pp. 1358-1362
    • Ragheb, S.1    Lisak, R.2    Lewis, R.3    Van Stavern, G.4    Gonzales, F.5    Simon, K.6
  • 110
    • 83255187854 scopus 로고    scopus 로고
    • BAFF serum levels in myasthenia gravis: effects of therapy
    • Scuderi F., Alboini P.E., Bartoccioni E., Evoli A. BAFF serum levels in myasthenia gravis: effects of therapy. J Neurol 2011, 258:2284-2285.
    • (2011) J Neurol , vol.258 , pp. 2284-2285
    • Scuderi, F.1    Alboini, P.E.2    Bartoccioni, E.3    Evoli, A.4
  • 111
    • 0017171683 scopus 로고
    • Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value
    • Lindstrom J.M., Seybold M.E., Lennon V.A., Whittingham S., Duane D.D. Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value. Neurology 1976, 26:1054-1059.
    • (1976) Neurology , vol.26 , pp. 1054-1059
    • Lindstrom, J.M.1    Seybold, M.E.2    Lennon, V.A.3    Whittingham, S.4    Duane, D.D.5
  • 112
    • 0019519330 scopus 로고
    • No direct correlation between serum anti-acetylcholine receptor antibody-levels and clinical state of individual patients with myasthenia-gravis
    • Roses A.D., Olanow C.W., Mcadams M.W., Lane R.J.M. No direct correlation between serum anti-acetylcholine receptor antibody-levels and clinical state of individual patients with myasthenia-gravis. Neurology 1981, 31:220-224.
    • (1981) Neurology , vol.31 , pp. 220-224
    • Roses, A.D.1    Olanow, C.W.2    Mcadams, M.W.3    Lane, R.J.M.4
  • 113
    • 38049024061 scopus 로고    scopus 로고
    • Decrease of CD4(+)CD25(high)Foxp3(+) regulatory T cells and elevation of CD19(+)BAFF-R(+) B cells and soluble ICAM-1 in myasthenia gravis
    • Li X., Xiao B.G., Xi J.Y., Lu C.Z., Lu J.H. Decrease of CD4(+)CD25(high)Foxp3(+) regulatory T cells and elevation of CD19(+)BAFF-R(+) B cells and soluble ICAM-1 in myasthenia gravis. Clin Immunol 2008, 126:180-188.
    • (2008) Clin Immunol , vol.126 , pp. 180-188
    • Li, X.1    Xiao, B.G.2    Xi, J.Y.3    Lu, C.Z.4    Lu, J.H.5
  • 114
    • 34247373549 scopus 로고    scopus 로고
    • The expression of BAFF-binding receptors is not altered in multiple sclerosis or myasthenia gravis
    • Thangarajh M., Kisiswa L., Pirskanen R., Hillert J. The expression of BAFF-binding receptors is not altered in multiple sclerosis or myasthenia gravis. Scand J Immunol 2007, 65:461-466.
    • (2007) Scand J Immunol , vol.65 , pp. 461-466
    • Thangarajh, M.1    Kisiswa, L.2    Pirskanen, R.3    Hillert, J.4
  • 115
    • 0034995359 scopus 로고    scopus 로고
    • The thymus and myasthenia gravis
    • [x]
    • Ragheb S., Lisak R.P. The thymus and myasthenia gravis. Chest Surg Clin N Am 2001, 11:311-327. [x].
    • (2001) Chest Surg Clin N Am , vol.11 , pp. 311-327
    • Ragheb, S.1    Lisak, R.P.2
  • 116
    • 51649102734 scopus 로고    scopus 로고
    • Reflections on the "intrathymic pathogenesis" of myasthenia gravis
    • Hohlfeld R., Wekerle H. Reflections on the "intrathymic pathogenesis" of myasthenia gravis. J Neuroimmunol 2008, 201:21-27.
    • (2008) J Neuroimmunol , vol.201 , pp. 21-27
    • Hohlfeld, R.1    Wekerle, H.2
  • 118
    • 0030951608 scopus 로고    scopus 로고
    • Failure to down-regulate Bcl-2 protein in thymic germinal center B cells in myasthenia gravis
    • Shiono H., Fujii Y., Okumura M., Takeuchi Y., Inoue M., Matsuda H. Failure to down-regulate Bcl-2 protein in thymic germinal center B cells in myasthenia gravis. Eur J Immunol 1997, 27:805-809.
    • (1997) Eur J Immunol , vol.27 , pp. 805-809
    • Shiono, H.1    Fujii, Y.2    Okumura, M.3    Takeuchi, Y.4    Inoue, M.5    Matsuda, H.6
  • 119
    • 33748283337 scopus 로고    scopus 로고
    • The thymus is a source of B-cell-survival factors-APRIL and BAFF-in myasthenia gravis
    • Thangarajh M., Masterman T., Helgeland L., Rot U., Jonsson M., Eide G., et al. The thymus is a source of B-cell-survival factors-APRIL and BAFF-in myasthenia gravis. J Neuroimmunol 2006, 178:161-166.
    • (2006) J Neuroimmunol , vol.178 , pp. 161-166
    • Thangarajh, M.1    Masterman, T.2    Helgeland, L.3    Rot, U.4    Jonsson, M.5    Eide, G.6
  • 120
    • 33344475672 scopus 로고    scopus 로고
    • Lymphoid neogenesis in chronic inflammatory diseases
    • Aloisi F., Pujol-Borrell R. Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol 2006, 6:205-217.
    • (2006) Nat Rev Immunol , vol.6 , pp. 205-217
    • Aloisi, F.1    Pujol-Borrell, R.2
  • 121
    • 41949133387 scopus 로고    scopus 로고
    • BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells
    • Badr G., Borhis G., Lefevre E.A., Chaoul N., Deshayes F., Dessirier V., et al. BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells. Blood 2008, 111:2744-2754.
    • (2008) Blood , vol.111 , pp. 2744-2754
    • Badr, G.1    Borhis, G.2    Lefevre, E.A.3    Chaoul, N.4    Deshayes, F.5    Dessirier, V.6
  • 122
    • 77951228240 scopus 로고    scopus 로고
    • Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia
    • Shiao Y.M., Lee C.C., Hsu Y.H., Huang S.F., Lin C.Y., Li L.H., et al. Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia. J Neuroimmunol 2010, 221:101-106.
    • (2010) J Neuroimmunol , vol.221 , pp. 101-106
    • Shiao, Y.M.1    Lee, C.C.2    Hsu, Y.H.3    Huang, S.F.4    Lin, C.Y.5    Li, L.H.6
  • 123
  • 124
  • 125
    • 31144448140 scopus 로고    scopus 로고
    • Disruption of immunological tolerance: role of AIRE gene in autoimmunity
    • Rizzi M., Ferrera F., Filaci G., Indiveri F. Disruption of immunological tolerance: role of AIRE gene in autoimmunity. Autoimmun Rev 2006, 5:145-147.
    • (2006) Autoimmun Rev , vol.5 , pp. 145-147
    • Rizzi, M.1    Ferrera, F.2    Filaci, G.3    Indiveri, F.4
  • 126
    • 32944474710 scopus 로고    scopus 로고
    • Increased antigen presenting cell-mediated T cell activation in mice and patients without the autoimmune regulator
    • Ramsey C., Hassler S., Marits P., Kampe O., Surh C.A., Peltonen L., et al. Increased antigen presenting cell-mediated T cell activation in mice and patients without the autoimmune regulator. Eur J Immunol 2006, 36:305-317.
    • (2006) Eur J Immunol , vol.36 , pp. 305-317
    • Ramsey, C.1    Hassler, S.2    Marits, P.3    Kampe, O.4    Surh, C.A.5    Peltonen, L.6
  • 127
    • 33748714526 scopus 로고    scopus 로고
    • Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma
    • Hassler S., Ramse C., Karlsson M.C., Larsson D., Herrmann B., Rozell B., et al. Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma. Blood 2006, 108:1941-1948.
    • (2006) Blood , vol.108 , pp. 1941-1948
    • Hassler, S.1    Ramse, C.2    Karlsson, M.C.3    Larsson, D.4    Herrmann, B.5    Rozell, B.6
  • 129
    • 79151482847 scopus 로고    scopus 로고
    • The susceptibility of Aire(-/-) mice to experimental myasthenia gravis involves alterations in regulatory T cells
    • Aricha R., Feferman T., Scott H.S., Souroujon M.C., Berrih-Aknin S., Fuchs S. The susceptibility of Aire(-/-) mice to experimental myasthenia gravis involves alterations in regulatory T cells. J Autoimmun 2011, 36:16-24.
    • (2011) J Autoimmun , vol.36 , pp. 16-24
    • Aricha, R.1    Feferman, T.2    Scott, H.S.3    Souroujon, M.C.4    Berrih-Aknin, S.5    Fuchs, S.6
  • 130
    • 0004916827 scopus 로고
    • The immunopathogenesis of acquired (autoimmune) myasthenia gravis
    • Marcel Dekker, New York, R. Lisak (Ed.)
    • Ragheb S., Lisak R. The immunopathogenesis of acquired (autoimmune) myasthenia gravis. Handbook of myasthenia gravis and myasthenic syndromes 1994, 239-276. Marcel Dekker, New York. R. Lisak (Ed.).
    • (1994) Handbook of myasthenia gravis and myasthenic syndromes , pp. 239-276
    • Ragheb, S.1    Lisak, R.2
  • 131
    • 0031927167 scopus 로고    scopus 로고
    • Immune regulation and myasthenia gravis
    • Ragheb S., Lisak R.P. Immune regulation and myasthenia gravis. Ann N Y Acad Sci 1998, 841:210-224.
    • (1998) Ann N Y Acad Sci , vol.841 , pp. 210-224
    • Ragheb, S.1    Lisak, R.P.2
  • 132
    • 77950332103 scopus 로고    scopus 로고
    • Rituximab: mechanism of action
    • Weiner G.J. Rituximab: mechanism of action. Semin Hematol 2010, 47:115-123.
    • (2010) Semin Hematol , vol.47 , pp. 115-123
    • Weiner, G.J.1
  • 133
    • 84857502425 scopus 로고    scopus 로고
    • Efficacy of rituximab in 164 patients with biopsy-proven lupus nephritis: pooled data from European cohorts
    • Diaz-Lagares C., Croca S., Sangle S., Vital E.M., Catapano F., Martinez-Berriotxoa A., et al. Efficacy of rituximab in 164 patients with biopsy-proven lupus nephritis: pooled data from European cohorts. Autoimmun Rev 2012, 11:357-364.
    • (2012) Autoimmun Rev , vol.11 , pp. 357-364
    • Diaz-Lagares, C.1    Croca, S.2    Sangle, S.3    Vital, E.M.4    Catapano, F.5    Martinez-Berriotxoa, A.6
  • 135
    • 79959599976 scopus 로고    scopus 로고
    • Rituximab in the treatment of severe lupus myelopathy
    • Ye Y., Qian J., Gu Y., Chen X., Ye S. Rituximab in the treatment of severe lupus myelopathy. Clin Rheumatol 2011, 30:981-986.
    • (2011) Clin Rheumatol , vol.30 , pp. 981-986
    • Ye, Y.1    Qian, J.2    Gu, Y.3    Chen, X.4    Ye, S.5
  • 137
  • 138
    • 82755176118 scopus 로고    scopus 로고
    • Safety and effectiveness of rituximab in patients with rheumatoid arthritis following an inadequate response to 1 prior tumor necrosis factor inhibitor: the RESET Trial
    • Haraoui B., Bokarewa M., Kallmeyer I., Bykerk V.P. Safety and effectiveness of rituximab in patients with rheumatoid arthritis following an inadequate response to 1 prior tumor necrosis factor inhibitor: the RESET Trial. J Rheumatol 2011, 38:2548-2556.
    • (2011) J Rheumatol , vol.38 , pp. 2548-2556
    • Haraoui, B.1    Bokarewa, M.2    Kallmeyer, I.3    Bykerk, V.P.4
  • 139
    • 84857238940 scopus 로고    scopus 로고
    • Biological treatment of rheumatoid arthritis: towards a more cost-effective re-treatment regimen using rituximab?
    • Boumans M.J., Vos K., Gerlag D.M., Tak P.P. Biological treatment of rheumatoid arthritis: towards a more cost-effective re-treatment regimen using rituximab?. Ann Rheum Dis 2012, 71:472-473.
    • (2012) Ann Rheum Dis , vol.71 , pp. 472-473
    • Boumans, M.J.1    Vos, K.2    Gerlag, D.M.3    Tak, P.P.4
  • 140
    • 84860552196 scopus 로고    scopus 로고
    • Efficacy of rituximab in the treatment of rheumatoid arthritis. Influence of serologic status, coprescription of methotrexate and prior TNF-alpha inhibitors exposure
    • Solau-Gervais E., Prudhomme C., Philippe P., Duhamel A., Dupont-Creteur C., Legrand J.L., et al. Efficacy of rituximab in the treatment of rheumatoid arthritis. Influence of serologic status, coprescription of methotrexate and prior TNF-alpha inhibitors exposure. Joint Bone Spine 2012, 79:281-284.
    • (2012) Joint Bone Spine , vol.79 , pp. 281-284
    • Solau-Gervais, E.1    Prudhomme, C.2    Philippe, P.3    Duhamel, A.4    Dupont-Creteur, C.5    Legrand, J.L.6
  • 141
    • 79959962714 scopus 로고    scopus 로고
    • Rheumatoid arthritis: When should we use rituximab to treat RA?
    • Yazici Y. Rheumatoid arthritis: When should we use rituximab to treat RA?. Nat Rev Rheumatol 2011, 7:379-380.
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 379-380
    • Yazici, Y.1
  • 142
    • 77950538947 scopus 로고    scopus 로고
    • Effectiveness of rituximab treatment in primary Sjogren's syndrome: a randomized, double-blind, placebo-controlled trial
    • Meijer J.M., Meiners P.M., Vissink A., Spijkervet F.K., Abdulahad W., Kamminga N., et al. Effectiveness of rituximab treatment in primary Sjogren's syndrome: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2010, 62:960-968.
    • (2010) Arthritis Rheum , vol.62 , pp. 960-968
    • Meijer, J.M.1    Meiners, P.M.2    Vissink, A.3    Spijkervet, F.K.4    Abdulahad, W.5    Kamminga, N.6
  • 143
    • 82955239855 scopus 로고    scopus 로고
    • Efficacy of rituximab in primary Sjogren's syndrome with peripheral nervous system involvement: results from the AIR registry
    • Mekinian A., Ravaud P., Hatron P.Y., Larroche C., Leone J., Gombert B., et al. Efficacy of rituximab in primary Sjogren's syndrome with peripheral nervous system involvement: results from the AIR registry. Ann Rheum Dis 2012, 71:84-87.
    • (2012) Ann Rheum Dis , vol.71 , pp. 84-87
    • Mekinian, A.1    Ravaud, P.2    Hatron, P.Y.3    Larroche, C.4    Leone, J.5    Gombert, B.6
  • 144
    • 80052463563 scopus 로고    scopus 로고
    • Treatment of primary Sjogren's syndrome with anti-CD20 therapy (rituximab). A feasible approach or just a starting point?
    • Meiners P.M., Vissink A., Kallenberg C.G., Kroese F.G., Bootsma H. Treatment of primary Sjogren's syndrome with anti-CD20 therapy (rituximab). A feasible approach or just a starting point?. Expert Opin Biol Ther 2011, 11:1381-1394.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 1381-1394
    • Meiners, P.M.1    Vissink, A.2    Kallenberg, C.G.3    Kroese, F.G.4    Bootsma, H.5
  • 145
    • 82655171682 scopus 로고    scopus 로고
    • Translational Mini-Review Series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjogren's syndrome: clinical implications and effects of B cell-targeted therapies
    • Vossenkamper A., Lutalo P.M., Spencer J. Translational Mini-Review Series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjogren's syndrome: clinical implications and effects of B cell-targeted therapies. Clin Exp Immunol 2012, 167:7-14.
    • (2012) Clin Exp Immunol , vol.167 , pp. 7-14
    • Vossenkamper, A.1    Lutalo, P.M.2    Spencer, J.3
  • 147
    • 34547936733 scopus 로고    scopus 로고
    • Variable responses to rituximab treatment in neuromyelitis optica (Devic's disease)
    • Capobianco M., Malucchi S., di Sapio A., Gilli F., Sala A., Bottero R., et al. Variable responses to rituximab treatment in neuromyelitis optica (Devic's disease). Neurol Sci 2007, 28:209-211.
    • (2007) Neurol Sci , vol.28 , pp. 209-211
    • Capobianco, M.1    Malucchi, S.2    di Sapio, A.3    Gilli, F.4    Sala, A.5    Bottero, R.6
  • 148
    • 16844366404 scopus 로고    scopus 로고
    • An open label study of the effects of rituximab in neuromyelitis optica
    • Cree B.A., Lamb S., Morgan K., Chen A., Waubant E., Genain C. An open label study of the effects of rituximab in neuromyelitis optica. Neurology 2005, 64:1270-1272.
    • (2005) Neurology , vol.64 , pp. 1270-1272
    • Cree, B.A.1    Lamb, S.2    Morgan, K.3    Chen, A.4    Waubant, E.5    Genain, C.6
  • 149
    • 55949127730 scopus 로고    scopus 로고
    • Treatment of neuromyelitis optica with rituximab: retrospective analysis of 25 patients
    • Jacob A., Weinshenker B.G., Violich I., McLinskey N., Krupp L., Fox R.J., et al. Treatment of neuromyelitis optica with rituximab: retrospective analysis of 25 patients. Arch Neurol 2008, 65:1443-1448.
    • (2008) Arch Neurol , vol.65 , pp. 1443-1448
    • Jacob, A.1    Weinshenker, B.G.2    Violich, I.3    McLinskey, N.4    Krupp, L.5    Fox, R.J.6
  • 150
    • 4644352009 scopus 로고    scopus 로고
    • Response of myasthenia gravis to rituximab in a patient with non-Hodgkin lymphoma
    • Gajra A., Vajpayee N., Grethlein S.J. Response of myasthenia gravis to rituximab in a patient with non-Hodgkin lymphoma. Am J Hematol 2004, 77:196-197.
    • (2004) Am J Hematol , vol.77 , pp. 196-197
    • Gajra, A.1    Vajpayee, N.2    Grethlein, S.J.3
  • 151
    • 33645328823 scopus 로고    scopus 로고
    • Successful treatment of MuSK antibody-positive myasthenia gravis with rituximab
    • Hain B., Jordan K., Deschauer M., Zierz S. Successful treatment of MuSK antibody-positive myasthenia gravis with rituximab. Muscle Nerve 2006, 33:575-580.
    • (2006) Muscle Nerve , vol.33 , pp. 575-580
    • Hain, B.1    Jordan, K.2    Deschauer, M.3    Zierz, S.4
  • 152
    • 77956418989 scopus 로고    scopus 로고
    • Rituximab for severe myasthenia gravis-experience from five patients
    • Lindberg C., Bokarewa M. Rituximab for severe myasthenia gravis-experience from five patients. Acta Neurol Scand 2010, 122:225-228.
    • (2010) Acta Neurol Scand , vol.122 , pp. 225-228
    • Lindberg, C.1    Bokarewa, M.2
  • 154
    • 80053332007 scopus 로고    scopus 로고
    • Response of patients with refractory myasthenia gravis to rituximab: a retrospective study
    • Nowak R.J., Dicapua D.B., Zebardast N., Goldstein J.M. Response of patients with refractory myasthenia gravis to rituximab: a retrospective study. Ther Adv Neurol Disord 2011, 4:259-266.
    • (2011) Ther Adv Neurol Disord , vol.4 , pp. 259-266
    • Nowak, R.J.1    Dicapua, D.B.2    Zebardast, N.3    Goldstein, J.M.4
  • 155
    • 79952120618 scopus 로고    scopus 로고
    • Rituximab in the treatment of MuSK antibody-positive myasthenia gravis
    • Stein B., Bird S.J. Rituximab in the treatment of MuSK antibody-positive myasthenia gravis. J Clin Neuromuscul Dis 2011, 12:163-164.
    • (2011) J Clin Neuromuscul Dis , vol.12 , pp. 163-164
    • Stein, B.1    Bird, S.J.2
  • 156
    • 63349091321 scopus 로고    scopus 로고
    • Rituximab for myasthenia gravis: three case reports and review of the literature
    • Stieglbauer K., Topakian R., Schaffer V., Aichner F.T. Rituximab for myasthenia gravis: three case reports and review of the literature. J Neurol Sci 2009, 280:120-122.
    • (2009) J Neurol Sci , vol.280 , pp. 120-122
    • Stieglbauer, K.1    Topakian, R.2    Schaffer, V.3    Aichner, F.T.4
  • 157
    • 34250836228 scopus 로고    scopus 로고
    • Rituximab in refractory MuSK antibody myasthenia gravis
    • Thakre M., Inshasi J., Marashi M. Rituximab in refractory MuSK antibody myasthenia gravis. J Neurol 2007, 254:968-969.
    • (2007) J Neurol , vol.254 , pp. 968-969
    • Thakre, M.1    Inshasi, J.2    Marashi, M.3
  • 158
    • 0344874207 scopus 로고    scopus 로고
    • Successful treatment of refractory myasthenia gravis using rituximab: a pediatric case report
    • Wylam M.E., Anderson P.M., Kuntz N.L., Rodriguez V. Successful treatment of refractory myasthenia gravis using rituximab: a pediatric case report. J Pediatr 2003, 143:674-677.
    • (2003) J Pediatr , vol.143 , pp. 674-677
    • Wylam, M.E.1    Anderson, P.M.2    Kuntz, N.L.3    Rodriguez, V.4
  • 160
    • 84879161515 scopus 로고    scopus 로고
    • Diagnosis and therapy of myasthenia gravis with antibodies to muscle-specific kinase
    • (this issue)
    • Evoli A., Padua L. Diagnosis and therapy of myasthenia gravis with antibodies to muscle-specific kinase. Autoimmun Rev 2013, 12:931-935. (this issue).
    • (2013) Autoimmun Rev , vol.12 , pp. 931-935
    • Evoli, A.1    Padua, L.2
  • 161
    • 46849112624 scopus 로고    scopus 로고
    • IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis
    • Leite M.I., Jacob S., Viegas S., Cossins J., Clover L., Morgan B.P., et al. IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis. Brain 2008, 131:1940-1952.
    • (2008) Brain , vol.131 , pp. 1940-1952
    • Leite, M.I.1    Jacob, S.2    Viegas, S.3    Cossins, J.4    Clover, L.5    Morgan, B.P.6
  • 162
    • 34247613820 scopus 로고    scopus 로고
    • Increase of B cell-activating factor of the TNF family (BAFF) after rituximab treatment: insights into a new regulating system of BAFF production
    • Lavie F., Miceli-Richard C., Ittah M., Sellam J., Gottenberg J.E., Mariette X. Increase of B cell-activating factor of the TNF family (BAFF) after rituximab treatment: insights into a new regulating system of BAFF production. Ann Rheum Dis 2007, 66:700-703.
    • (2007) Ann Rheum Dis , vol.66 , pp. 700-703
    • Lavie, F.1    Miceli-Richard, C.2    Ittah, M.3    Sellam, J.4    Gottenberg, J.E.5    Mariette, X.6
  • 163
    • 34248597383 scopus 로고    scopus 로고
    • BAFF-modulated repopulation of B lymphocytes in the blood and salivary glands of rituximab-treated patients with Sjogren's syndrome
    • Pers J.O., Devauchelle V., Daridon C., Bendaoud B., Le Berre R., Bordron A., et al. BAFF-modulated repopulation of B lymphocytes in the blood and salivary glands of rituximab-treated patients with Sjogren's syndrome. Arthritis Rheum 2007, 56:1464-1477.
    • (2007) Arthritis Rheum , vol.56 , pp. 1464-1477
    • Pers, J.O.1    Devauchelle, V.2    Daridon, C.3    Bendaoud, B.4    Le Berre, R.5    Bordron, A.6
  • 164
    • 79251640439 scopus 로고    scopus 로고
    • Chemokine/cytokine profiling after rituximab: reciprocal expression of BCA-1/CXCL13 and BAFF in childhood OMS
    • Pranzatelli M.R., Tate E.D., Travelstead A.L., Verhulst S.J. Chemokine/cytokine profiling after rituximab: reciprocal expression of BCA-1/CXCL13 and BAFF in childhood OMS. Cytokine 2011, 53:384-389.
    • (2011) Cytokine , vol.53 , pp. 384-389
    • Pranzatelli, M.R.1    Tate, E.D.2    Travelstead, A.L.3    Verhulst, S.J.4
  • 165
    • 70350517490 scopus 로고    scopus 로고
    • Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis
    • Vallerskog T., Heimburger M., Gunnarsson I., Zhou W., Wahren-Herlenius M., Trollmo C., et al. Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis. Arthritis Res Ther 2006, 8:R167.
    • (2006) Arthritis Res Ther , vol.8
    • Vallerskog, T.1    Heimburger, M.2    Gunnarsson, I.3    Zhou, W.4    Wahren-Herlenius, M.5    Trollmo, C.6
  • 166
    • 77949499778 scopus 로고    scopus 로고
    • CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody
    • Awan F.T., Lapalombella R., Trotta R., Butchar J.P., Yu B., Benson D.M., et al. CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody. Blood 2010, 115:1204-1213.
    • (2010) Blood , vol.115 , pp. 1204-1213
    • Awan, F.T.1    Lapalombella, R.2    Trotta, R.3    Butchar, J.P.4    Yu, B.5    Benson, D.M.6
  • 167
    • 54249100952 scopus 로고    scopus 로고
    • Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemia
    • Horton H.M., Bernett M.J., Pong E., Peipp M., Karki S., Chu S.Y., et al. Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemia. Cancer Res 2008, 68:8049-8057.
    • (2008) Cancer Res , vol.68 , pp. 8049-8057
    • Horton, H.M.1    Bernett, M.J.2    Pong, E.3    Peipp, M.4    Karki, S.5    Chu, S.Y.6
  • 168
    • 84866559756 scopus 로고    scopus 로고
    • CD19 as an attractive target for antibody-based therapy
    • Hammer O. CD19 as an attractive target for antibody-based therapy. MAbs 2012, 4:571-577.
    • (2012) MAbs , vol.4 , pp. 571-577
    • Hammer, O.1
  • 169
    • 33646441357 scopus 로고    scopus 로고
    • Bortezomib: proteasome inhibition as an effective anticancer therapy
    • Richardson P.G., Mitsiades C. Bortezomib: proteasome inhibition as an effective anticancer therapy. Future Oncol 2005, 1:161-171.
    • (2005) Future Oncol , vol.1 , pp. 161-171
    • Richardson, P.G.1    Mitsiades, C.2
  • 170
    • 46749088320 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
    • Neubert K., Meister S., Moser K., Weisel F., Maseda D., Amann K., et al. The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med 2008, 14:748-755.
    • (2008) Nat Med , vol.14 , pp. 748-755
    • Neubert, K.1    Meister, S.2    Moser, K.3    Weisel, F.4    Maseda, D.5    Amann, K.6
  • 171
    • 79957653362 scopus 로고    scopus 로고
    • Successful use of bortezomib in a patient with systemic lupus erythematosus and multiple myeloma
    • Frohlich K., Holle J.U., Aries P.M., Gross W.L., Moosig F. Successful use of bortezomib in a patient with systemic lupus erythematosus and multiple myeloma. Ann Rheum Dis 2011, 70:1344-1345.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1344-1345
    • Frohlich, K.1    Holle, J.U.2    Aries, P.M.3    Gross, W.L.4    Moosig, F.5
  • 172
    • 79951838009 scopus 로고    scopus 로고
    • Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis
    • Gomez A.M., Vrolix K., Martinez-Martinez P., Molenaar P.C., Phernambucq M., van der Esch E., et al. Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis. J Immunol 2011, 186:2503-2513.
    • (2011) J Immunol , vol.186 , pp. 2503-2513
    • Gomez, A.M.1    Vrolix, K.2    Martinez-Martinez, P.3    Molenaar, P.C.4    Phernambucq, M.5    van der Esch, E.6
  • 173
    • 0242495115 scopus 로고    scopus 로고
    • Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator
    • Baker K.P., Edwards B.M., Main S.H., Choi G.H., Wager R.E., Halpern W.G., et al. Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator. Arthritis Rheum 2003, 48:3253-3265.
    • (2003) Arthritis Rheum , vol.48 , pp. 3253-3265
    • Baker, K.P.1    Edwards, B.M.2    Main, S.H.3    Choi, G.H.4    Wager, R.E.5    Halpern, W.G.6
  • 174
    • 79952070370 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
    • Navarra S.V., Guzman R.M., Gallacher A.E., Hall S., Levy R.A., Jimenez R.E., et al. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet 2011, 377:721-731.
    • (2011) Lancet , vol.377 , pp. 721-731
    • Navarra, S.V.1    Guzman, R.M.2    Gallacher, A.E.3    Hall, S.4    Levy, R.A.5    Jimenez, R.E.6
  • 175
    • 37049017404 scopus 로고    scopus 로고
    • Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade
    • Lin W.Y., Gong Q., Seshasayee D., Lin Z., Ou Q., Ye S., et al. Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade. Blood 2007, 110:3959-3967.
    • (2007) Blood , vol.110 , pp. 3959-3967
    • Lin, W.Y.1    Gong, Q.2    Seshasayee, D.3    Lin, Z.4    Ou, Q.5    Ye, S.6
  • 176
    • 49249090858 scopus 로고    scopus 로고
    • Nonclinical safety, pharmacokinetics, and pharmacodynamics of atacicept
    • Carbonatto M., Yu P., Bertolino M., Vigna E., Steidler S., Fava L., et al. Nonclinical safety, pharmacokinetics, and pharmacodynamics of atacicept. Toxicol Sci 2008, 105:200-210.
    • (2008) Toxicol Sci , vol.105 , pp. 200-210
    • Carbonatto, M.1    Yu, P.2    Bertolino, M.3    Vigna, E.4    Steidler, S.5    Fava, L.6
  • 177
    • 37149032474 scopus 로고    scopus 로고
    • Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial
    • Dall'Era M., Chakravarty E., Wallace D., Genovese M., Weisman M., Kavanaugh A., et al. Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial. Arthritis Rheum 2007, 56:4142-4150.
    • (2007) Arthritis Rheum , vol.56 , pp. 4142-4150
    • Dall'Era, M.1    Chakravarty, E.2    Wallace, D.3    Genovese, M.4    Weisman, M.5    Kavanaugh, A.6
  • 178
    • 38149114077 scopus 로고    scopus 로고
    • Atacicept in patients with rheumatoid arthritis: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study
    • Tak P.P., Thurlings R.M., Rossier C., Nestorov I., Dimic A., Mircetic V., et al. Atacicept in patients with rheumatoid arthritis: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study. Arthritis Rheum 2008, 58:61-72.
    • (2008) Arthritis Rheum , vol.58 , pp. 61-72
    • Tak, P.P.1    Thurlings, R.M.2    Rossier, C.3    Nestorov, I.4    Dimic, A.5    Mircetic, V.6
  • 179
    • 77954950402 scopus 로고    scopus 로고
    • Atacicept: targeting B cells in multiple sclerosis
    • Hartung H.-P., Kieseier B. Atacicept: targeting B cells in multiple sclerosis. Ther Adv Neurol Disord 2010, 3:205-216.
    • (2010) Ther Adv Neurol Disord , vol.3 , pp. 205-216
    • Hartung, H.-P.1    Kieseier, B.2
  • 180
    • 0035004320 scopus 로고    scopus 로고
    • Regulation of the T-independent humoral response by TACI
    • von Bulow G.U., van Deursen J.M., Bram R.J. Regulation of the T-independent humoral response by TACI. Immunity 2001, 14:573-582.
    • (2001) Immunity , vol.14 , pp. 573-582
    • von Bulow, G.U.1    van Deursen, J.M.2    Bram, R.J.3
  • 182
    • 0017361029 scopus 로고
    • Treatment of myasthenia gravis: long-term administration of corticosteroids with remarks on thymectomy
    • Johns T.R. Treatment of myasthenia gravis: long-term administration of corticosteroids with remarks on thymectomy. Adv Neurol 1977, 17:99-122.
    • (1977) Adv Neurol , vol.17 , pp. 99-122
    • Johns, T.R.1
  • 183
    • 0017072791 scopus 로고
    • Long-term administration of corticosteroids in myasthenia gravis
    • Mann J.D., Johns T.R., Campa J.F. Long-term administration of corticosteroids in myasthenia gravis. Neurology 1976, 26:729-740.
    • (1976) Neurology , vol.26 , pp. 729-740
    • Mann, J.D.1    Johns, T.R.2    Campa, J.F.3
  • 185
    • 34548171625 scopus 로고    scopus 로고
    • Myasthenic crisis: Guidelines for prevention and treatment
    • Jani-Acsadi A., Lisak R.P. Myasthenic crisis: Guidelines for prevention and treatment. J Neurol Sci 2007, 261:127-133.
    • (2007) J Neurol Sci , vol.261 , pp. 127-133
    • Jani-Acsadi, A.1    Lisak, R.P.2
  • 186
    • 79958765623 scopus 로고    scopus 로고
    • Comparison of IVIg and PLEX in patients with myasthenia gravis
    • Barth D., Nabavi Nouri M., Ng E., Nwe P., Bril V. Comparison of IVIg and PLEX in patients with myasthenia gravis. Neurology 2011, 76:2017-2023.
    • (2011) Neurology , vol.76 , pp. 2017-2023
    • Barth, D.1    Nabavi Nouri, M.2    Ng, E.3    Nwe, P.4    Bril, V.5
  • 187
    • 34047214672 scopus 로고    scopus 로고
    • IVIG in myasthenia gravis: getting enough "bang for the buck"
    • Meriggioli M.N. IVIG in myasthenia gravis: getting enough "bang for the buck". Neurology 2007, 68:803-804.
    • (2007) Neurology , vol.68 , pp. 803-804
    • Meriggioli, M.N.1
  • 188
    • 45249098275 scopus 로고    scopus 로고
    • IVIG treatment for myasthenia gravis: effectiveness, limitations, and novel therapeutic strategies
    • Zinman L., Bril V. IVIG treatment for myasthenia gravis: effectiveness, limitations, and novel therapeutic strategies. Ann N Y Acad Sci 2008, 1132:264-270.
    • (2008) Ann N Y Acad Sci , vol.1132 , pp. 264-270
    • Zinman, L.1    Bril, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.