Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes

Journal of Molecular Biology

Volumn 315, Issue 5, 2002, Pages 1145-1154

  Karpusas, Michael ^a   Cachero, Teresa G ^a   Qian, Fang ^a   Boriack Sjodin, Ann ^a   Mullen, Colleen ^a   Strauch, Kathy ^a   Hsu, Yen Ming ^a   Kalled, Susan L ^a  

^a BIOGEN   (United States)

Author keywords

B lymphocyte; Blys; Cytokine; TNF ligand; Tumor necrosis factor

Indexed keywords

B CELL ACTIVATING FACTOR; B CELL ACTIVATING FACTOR RECEPTOR; B CELL MATURATION ANTIGEN; B LYMPHOCYTE RECEPTOR; MEMBRANE PROTEIN; TRAF INTERACTING RECEPTOR FOR TALL 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE ACTIVATION; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRICITY; EXTRACELLULAR SPACE; HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; RECEPTOR BINDING; SEQUENCE HOMOLOGY;

EID: 0036300545     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5296     Document Type: Article

References (48)

1. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens
2. BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator
3. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
4. BAFF mediates survival of peripheral immature B lymphocytes
5. BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population
6. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
7. The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily
8. TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation
9. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors
10. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF
11. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth
12. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization
13. Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS
14. Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI
15. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
16. Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice
17. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
18. Cutting edge: A role for B lymphocyte stimulator in systemic lupus erythematosus
19. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases
20. A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth
21. The TNF and TNF receptor superfamilies: Integrating mammalian biology
22. Structure of tumour necrosis factor
23. The structure of tumor necrosis factor-alpha at 2.6 Å resolution. Implications for receptor binding
24. The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9 Å resolution
25. 2 Å crystal structure of an extracellular fragment of human CD40 ligand
26. 2.8 Å resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity
27. A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL
28. Modularity in the TNF-receptor family
29. Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: Implications for TNF receptor activation
30. Triggering cell death: The crystal structure of Apo2L/TRAIL in a complex with death receptor 5
31. Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation
32. Crystal structure of TRAIL-DR5 complex identifies a critical role of the unique frame insertion in conferring recognition specificity
33. The role of polar interactions in the molecular recognition of CD40L with its receptor CD40
34. Assesment of comparative modeling in CASP2
35. Evaluation of comparative protein structure modeling by MODELLER-3
36. Processing of X-ray diffraction data collected in oscillation mode
37. Solvent content of protein crystals
38. AMoRe: An automated package for molecular replacement
39. The CCP4 suite: Programs for protein crystallography
40. Methodology employed for the structure determination of tumour necrosis factor, a case of high non-crystallographic symmetry
41. Automated MAD and MIR structure solution
42. Maximum likelihood density modification
43. Crystallography & NMR system: A new software for macromolecular structure determination
44. Procheck: A program toc check stereochemical quality of protein structures
45. Definition of general topological equivalence in protein structures. A procedure involving comparison of properties and relationships through simulated annealing and dynamic programming
46. RIBBONS
47. ALSCRIPT: A tool to format multiple sequence alignments