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Volumn 46, Issue 4, 1999, Pages 559-567

Prevention of autoimmune attack by targeting specific T-cell receptors in a severe combined immunodeficiency mouse model of myasthenia gravis

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR; GAMMA INTERFERON; HLA DR3 ANTIGEN; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR;

EID: 0032834013     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(199910)46:4<559::AID-ANA3>3.0.CO;2-S     Document Type: Article
Times cited : (33)

References (45)
  • 2
    • 0018117040 scopus 로고
    • Thymic hyperplasia and neoplasia: A review of current concepts
    • Levine GD, Rosai J. Thymic hyperplasia and neoplasia: a review of current concepts. Hum Pathol 1978;9:495-515
    • (1978) Hum Pathol , vol.9 , pp. 495-515
    • Levine, G.D.1    Rosai, J.2
  • 3
    • 0025140118 scopus 로고
    • Myasthenia gravis: Effect of thymectomy in 425 patients: A 15-year experience
    • Molnar J, Szobor A. Myasthenia gravis: effect of thymectomy in 425 patients: a 15-year experience. Eur J Cardiothorac Surg 1990;4:8-14
    • (1990) Eur J Cardiothorac Surg , vol.4 , pp. 8-14
    • Molnar, J.1    Szobor, A.2
  • 4
    • 0023189057 scopus 로고
    • Acetylcholine receptors in human thymic myoid cells in situ: An immunohistological study
    • Schluep M, Willcox N, Vincent A, et al. Acetylcholine receptors in human thymic myoid cells in situ: an immunohistological study. Ann Neurol 1987;22:212-222
    • (1987) Ann Neurol , vol.22 , pp. 212-222
    • Schluep, M.1    Willcox, N.2    Vincent, A.3
  • 5
    • 0030587964 scopus 로고    scopus 로고
    • Expression of acetylcholine receptor genes in human thymic epithelial cells: Implications for myasthenia gravis
    • Wakkach A, Guyon T, Bruand C, et al. Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis. J Immunol 1996;157:3752-3760
    • (1996) J Immunol , vol.157 , pp. 3752-3760
    • Wakkach, A.1    Guyon, T.2    Bruand, C.3
  • 6
    • 0017889981 scopus 로고
    • In vitro synthesis of anti-acetylcholine-receptor antibody by thymic lymphocytes in myasthenia gravis
    • Vincent A, Scadding GK, Thomas HC, Newsom-Davis J. In vitro synthesis of anti-acetylcholine-receptor antibody by thymic lymphocytes in myasthenia gravis. Lancet 1978;1:305-307
    • (1978) Lancet , vol.1 , pp. 305-307
    • Vincent, A.1    Scadding, G.K.2    Thomas, H.C.3    Newsom-Davis, J.4
  • 7
    • 0025029359 scopus 로고
    • Thymic B cells from myasthenia gravis patients are activated B cells: Phenotypic and functional analysis
    • Leprince C, Cohen-Kaminsky S, Berrih-Aknin S, et al. Thymic B cells from myasthenia gravis patients are activated B cells: phenotypic and functional analysis. J Immunol 1990;145: 2115-2122
    • (1990) J Immunol , vol.145 , pp. 2115-2122
    • Leprince, C.1    Cohen-Kaminsky, S.2    Berrih-Aknin, S.3
  • 8
    • 0021243562 scopus 로고
    • Autoimmune human T lymphocytes specific for acetylcholine receptor
    • Hohlfeld R, Toyka KV, Heininger K, et al. Autoimmune human T lymphocytes specific for acetylcholine receptor. Nature 1984;310:244-246
    • (1984) Nature , vol.310 , pp. 244-246
    • Hohlfeld, R.1    Toyka, K.V.2    Heininger, K.3
  • 9
    • 0024600918 scopus 로고
    • Autoimmune T lymphocytes in myasthenia gravis: Determination of target epitopes using T lines and recombinant products of the mouse nicotinic acetylcholine receptor gene
    • Melms A, Chrestel S, Schalke BC, et al. Autoimmune T lymphocytes in myasthenia gravis: determination of target epitopes using T lines and recombinant products of the mouse nicotinic acetylcholine receptor gene. J Clin Invest 1989;83:785-790
    • (1989) J Clin Invest , vol.83 , pp. 785-790
    • Melms, A.1    Chrestel, S.2    Schalke, B.C.3
  • 10
    • 0030914912 scopus 로고    scopus 로고
    • Altered intrathymic T-cell repertoire in human myasthenia gravis
    • Truffault F, Cohen-Kaminsky S, Khalil I, et al. Altered intrathymic T-cell repertoire in human myasthenia gravis. Ann Neurol 1997;41:731-741
    • (1997) Ann Neurol , vol.41 , pp. 731-741
    • Truffault, F.1    Cohen-Kaminsky, S.2    Khalil, I.3
  • 11
    • 0030911161 scopus 로고    scopus 로고
    • Thymocyte Fas expression is dysregulated in myasthenia gravis patients with anti-acetylcholine receptor antibody
    • Moulian N, Bidault J, Truffault F, et al. Thymocyte Fas expression is dysregulated in myasthenia gravis patients with anti-acetylcholine receptor antibody. Blood 1997;89:3287-3295
    • (1997) Blood , vol.89 , pp. 3287-3295
    • Moulian, N.1    Bidault, J.2    Truffault, F.3
  • 12
    • 0027433123 scopus 로고
    • T cells within germinal centers are specific for the immunizing antigen
    • Fuller KA, Kanagawa O, Nahm MH. T cells within germinal centers are specific for the immunizing antigen. J Immunol 1993;151:4505-4512
    • (1993) J Immunol , vol.151 , pp. 4505-4512
    • Fuller, K.A.1    Kanagawa, O.2    Nahm, M.H.3
  • 14
    • 0026648331 scopus 로고
    • Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice: A new model of myasthenia gravis
    • Schonbeck S, Padberg F, Hohlfeld R, Wekerle H. Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice: a new model of myasthenia gravis. J Clin Invest 1992;90:245-250
    • (1992) J Clin Invest , vol.90 , pp. 245-250
    • Schonbeck, S.1    Padberg, F.2    Hohlfeld, R.3    Wekerle, H.4
  • 15
    • 0027310428 scopus 로고
    • The human-severe combined immunodeficiency myasthenic mouse model: A new approach for the study of myasthenia gravis
    • Martino G, DuPont BL, Wollmann RL, et al. The human-severe combined immunodeficiency myasthenic mouse model: a new approach for the study of myasthenia gravis. Ann Neurol 1993;34:48-56
    • (1993) Ann Neurol , vol.34 , pp. 48-56
    • Martino, G.1    DuPont, B.L.2    Wollmann, R.L.3
  • 16
    • 0027496488 scopus 로고
    • Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis
    • Vieira ML, Caillat-Zucman S, Gajdos P, et al. Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis. J Neuroimmunol 1993;47:115-222
    • (1993) J Neuroimmunol , vol.47 , pp. 115-222
    • Vieira, M.L.1    Caillat-Zucman, S.2    Gajdos, P.3
  • 17
    • 0015152367 scopus 로고
    • Studies in myasthenia gravis: Review of a twenty-year experience in over 1200 patients
    • Osserman KE, Genkins G. Studies in myasthenia gravis: review of a twenty-year experience in over 1200 patients. Mt Sinai J Med 1971;38:497-537
    • (1971) Mt Sinai J Med , vol.38 , pp. 497-537
    • Osserman, K.E.1    Genkins, G.2
  • 18
    • 0028962115 scopus 로고
    • Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus
    • Llorente L, Zou W, Levy Y, et al. Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J Exp Med 1995;181: 839-844
    • (1995) J Exp Med , vol.181 , pp. 839-844
    • Llorente, L.1    Zou, W.2    Levy, Y.3
  • 19
    • 0344639337 scopus 로고
    • 125I-labeled alpha-bungarotoxin binding at mouse motor endplates
    • 125I-labeled alpha-bungarotoxin binding at mouse motor endplates. Proc Natl Acad Sci USA 1974;71:1376-1378
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 1376-1378
    • Fertuck, H.C.1    Salpeter, M.M.2
  • 20
    • 0032128319 scopus 로고    scopus 로고
    • Regulation of acetylcholine receptor gene expression in human myasthenia gravis muscles: Evidence for a compensatory mechanism triggered by receptor loss
    • Guyon T, Wakkach A, Poea S, et al. Regulation of acetylcholine receptor gene expression in human myasthenia gravis muscles: evidence for a compensatory mechanism triggered by receptor loss. J Clin Invest 1998;102:249-263
    • (1998) J Clin Invest , vol.102 , pp. 249-263
    • Guyon, T.1    Wakkach, A.2    Poea, S.3
  • 21
    • 0029590111 scopus 로고
    • Quantification of cytokine gene expression by competitive PCR using a colorimetric assay
    • Zou W, Durand-Gasselin I, Dulioust A, et al. Quantification of cytokine gene expression by competitive PCR using a colorimetric assay. Eur Cytokine Netw 1995;6:257-264
    • (1995) Eur Cytokine Netw , vol.6 , pp. 257-264
    • Zou, W.1    Durand-Gasselin, I.2    Dulioust, A.3
  • 22
    • 0028839280 scopus 로고
    • T helper type 1/T helper type 2 cytokines and T cell death: Preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons
    • Estaquier J, Idziorek T, Zou W, et al. T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons. J Exp Med 1995;182:1759-1767
    • (1995) J Exp Med , vol.182 , pp. 1759-1767
    • Estaquier, J.1    Idziorek, T.2    Zou, W.3
  • 23
    • 0017755136 scopus 로고
    • Immune complexes (IgG and C3) at the motor end-plate in myasthenia gravis: Ultrastructural and light microscopic localization and electrophysiologic correlations
    • Engel AG, Lambert EH, Howard FM. Immune complexes (IgG and C3) at the motor end-plate in myasthenia gravis: ultrastructural and light microscopic localization and electrophysiologic correlations. Mayo Clin Proc 1977;52:267-280
    • (1977) Mayo Clin Proc , vol.52 , pp. 267-280
    • Engel, A.G.1    Lambert, E.H.2    Howard, F.M.3
  • 24
    • 0027263471 scopus 로고
    • Myasthenia gravis: Recognition of a human autoantigen at the molecular level
    • Protti MP, Manfredi AA, Horton RM, et al. Myasthenia gravis: recognition of a human autoantigen at the molecular level. Immunol Today 1993;14:363-368
    • (1993) Immunol Today , vol.14 , pp. 363-368
    • Protti, M.P.1    Manfredi, A.A.2    Horton, R.M.3
  • 25
    • 0031879167 scopus 로고    scopus 로고
    • T cell recognition of the acetylcholine receptor in myasthenia gravis
    • Conti-Fine BM, Navaneetham D, Karachunski PI, et al. T cell recognition of the acetylcholine receptor in myasthenia gravis. Ann NY Acad Sci 1998;841:283-308
    • (1998) Ann NY Acad Sci , vol.841 , pp. 283-308
    • Conti-Fine, B.M.1    Navaneetham, D.2    Karachunski, P.I.3
  • 26
    • 0026027752 scopus 로고
    • T-cell antigenic sites involved in myasthenia gravis: Correlations with antibody titre and disease severity
    • Berrih-Aknin S, Cohen-Kaminsky S, Lepage V, et al. T-cell antigenic sites involved in myasthenia gravis: correlations with antibody titre and disease severity. J Autoimmun 1991;4:137-153
    • (1991) J Autoimmun , vol.4 , pp. 137-153
    • Berrih-Aknin, S.1    Cohen-Kaminsky, S.2    Lepage, V.3
  • 27
    • 0031879061 scopus 로고    scopus 로고
    • Acetylcholine receptor-specific CD4+ T cells in myasthenia gravis patients have individual, but restricted TCR V beta usage
    • Raju R, Navaneetham D, Protti MP, et al. Acetylcholine receptor-specific CD4+ T cells in myasthenia gravis patients have individual, but restricted TCR V beta usage. Ann NY Acad Sci 1998;841:324-328
    • (1998) Ann NY Acad Sci , vol.841 , pp. 324-328
    • Raju, R.1    Navaneetham, D.2    Protti, M.P.3
  • 28
    • 0027293045 scopus 로고
    • T-cell receptor gene usage of acetylcholine receptor-specific T-helper cells
    • Melms A, Oksenberg JR, Malcherek G, et al. T-cell receptor gene usage of acetylcholine receptor-specific T-helper cells. Ann NY Acad Sci 1993;681:313-314
    • (1993) Ann NY Acad Sci , vol.681 , pp. 313-314
    • Melms, A.1    Oksenberg, J.R.2    Malcherek, G.3
  • 29
    • 0018943586 scopus 로고
    • Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis
    • Compston DA, Vincent A, Newsom-Davis J, Batchelor JR. Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain 1980;103:579-601
    • (1980) Brain , vol.103 , pp. 579-601
    • Compston, D.A.1    Vincent, A.2    Newsom-Davis, J.3    Batchelor, J.R.4
  • 30
    • 0029845450 scopus 로고    scopus 로고
    • Direct visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection
    • Wack A, Ladyman HM, Williams O, et al. Direct visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection. Int Immunol 1996;8:1537-1548
    • (1996) Int Immunol , vol.8 , pp. 1537-1548
    • Wack, A.1    Ladyman, H.M.2    Williams, O.3
  • 31
    • 0030748972 scopus 로고    scopus 로고
    • Physiologic human T-cell responses to OKT3 in the human peripheral blood lymphocyte-severe combined immunodeficiency mouse model
    • Dessureault S, Shpitz B, Alloo J, et al. Physiologic human T-cell responses to OKT3 in the human peripheral blood lymphocyte-severe combined immunodeficiency mouse model. Transplantation 1997;64:811-816
    • (1997) Transplantation , vol.64 , pp. 811-816
    • Dessureault, S.1    Shpitz, B.2    Alloo, J.3
  • 32
    • 0028233797 scopus 로고
    • CD4 engagement induces Fas antigen-dependent apoptosis of T cells in vivo
    • Wang ZQ, Dudhane A, Orlikowsky T, et al. CD4 engagement induces Fas antigen-dependent apoptosis of T cells in vivo. Eur J Immunol 1994;24:1549-1552
    • (1994) Eur J Immunol , vol.24 , pp. 1549-1552
    • Wang, Z.Q.1    Dudhane, A.2    Orlikowsky, T.3
  • 33
    • 0032030584 scopus 로고    scopus 로고
    • Lymphoproliferative disease in human peripheral blood mononuclear cell-injected SCID mice. IV. Differential activation of human Th1 and Th2 lymphocytes and influence of the atopic status on lymphoma development
    • Coppola V, Veronesi A, Indraccolo S, et al. Lymphoproliferative disease in human peripheral blood mononuclear cell-injected SCID mice. IV. Differential activation of human Th1 and Th2 lymphocytes and influence of the atopic status on lymphoma development. J Immunol 1998;160:2514-2522
    • (1998) J Immunol , vol.160 , pp. 2514-2522
    • Coppola, V.1    Veronesi, A.2    Indraccolo, S.3
  • 34
    • 0001123104 scopus 로고    scopus 로고
    • IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to leishmania major in BALB/c mice
    • Launois P, Maillard I, Pingel S, et al. IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity 1997;6:541-549
    • (1997) Immunity , vol.6 , pp. 541-549
    • Launois, P.1    Maillard, I.2    Pingel, S.3
  • 35
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux H, O'Garra A, Bigler M, Rouleau M, et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997;389:737-742
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3    Rouleau, M.4
  • 36
    • 9244225599 scopus 로고    scopus 로고
    • Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice
    • Mieza MA, Itoh T, Cui JQ, et al. Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice. J Immunol 1996;156:4035-4040
    • (1996) J Immunol , vol.156 , pp. 4035-4040
    • Mieza, M.A.1    Itoh, T.2    Cui, J.Q.3
  • 37
    • 0029121325 scopus 로고
    • Selective reduction of T cells bearing invariant V alpha 24 J alpha Q antigen receptor in patients with systemic sclerosis
    • Sumida T, Sakamoto A, Murata H, et al. Selective reduction of T cells bearing invariant V alpha 24 J alpha Q antigen receptor in patients with systemic sclerosis. J Exp Med 1995;182:1163-1168
    • (1995) J Exp Med , vol.182 , pp. 1163-1168
    • Sumida, T.1    Sakamoto, A.2    Murata, H.3
  • 38
    • 0031902708 scopus 로고    scopus 로고
    • IL-12 is involved in the induction of experimental autoimmune myasthenia gravis, an antibody-mediated disease
    • Moiola L, Galbiati F, Martino G, et al. IL-12 is involved in the induction of experimental autoimmune myasthenia gravis, an antibody-mediated disease. Eur J Immunol 1998;28:2487-2497
    • (1998) Eur J Immunol , vol.28 , pp. 2487-2497
    • Moiola, L.1    Galbiati, F.2    Martino, G.3
  • 39
    • 0032530374 scopus 로고    scopus 로고
    • The Th2 cytokine IL-4 is not required for the progression of antibody-dependent autoimmune myasthenia gravis
    • Balasa B, Deng C, Lee J, et al. The Th2 cytokine IL-4 is not required for the progression of antibody-dependent autoimmune myasthenia gravis. J Immunol 1998;161:2856-2862
    • (1998) J Immunol , vol.161 , pp. 2856-2862
    • Balasa, B.1    Deng, C.2    Lee, J.3
  • 40
    • 0019519330 scopus 로고
    • No direct correlation between serum anti-acetylcholine receptor antibody levels and clinical state of individual patients with myasthenia gravis
    • Roses AD, Olanow CW, McAdams MW, Lane RJ. No direct correlation between serum anti-acetylcholine receptor antibody levels and clinical state of individual patients with myasthenia gravis. Neurology 1981;31:220-224
    • (1981) Neurology , vol.31 , pp. 220-224
    • Roses, A.D.1    Olanow, C.W.2    McAdams, M.W.3    Lane, R.J.4
  • 41
    • 0022313034 scopus 로고
    • Measurement of junctional acetylcholine receptors in myasthenia gravis: Clinical correlates
    • Pestronk A, Drachman DB, Self SG. Measurement of junctional acetylcholine receptors in myasthenia gravis: clinical correlates. Muscle Nerve 1985;8:245-251
    • (1985) Muscle Nerve , vol.8 , pp. 245-251
    • Pestronk, A.1    Drachman, D.B.2    Self, S.G.3
  • 42
    • 16044361810 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with T-cell receptor peptides: Results of a double-blind pilot trial
    • Vandenbark AA, Chou YK, Whitham R, et al. Treatment of multiple sclerosis with T-cell receptor peptides: results of a double-blind pilot trial. Nat Med 1996;2:1109-1115
    • (1996) Nat Med , vol.2 , pp. 1109-1115
    • Vandenbark, A.A.1    Chou, Y.K.2    Whitham, R.3
  • 43
    • 0024425273 scopus 로고
    • Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis
    • Vandenbark AA, Hashim G, Offner H. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 1989;341: 541-544
    • (1989) Nature , vol.341 , pp. 541-544
    • Vandenbark, A.A.1    Hashim, G.2    Offner, H.3
  • 44
    • 0029886958 scopus 로고    scopus 로고
    • Immunization with T cell receptor V beta chain peptides deletes pathogenic T cells and prevents the induction of collagen-induced arthritis in mice
    • Haqqi TM, Qu XM, Anthony D, et al. Immunization with T cell receptor V beta chain peptides deletes pathogenic T cells and prevents the induction of collagen-induced arthritis in mice. J Clin Invest 1996;97:2849-2858
    • (1996) J Clin Invest , vol.97 , pp. 2849-2858
    • Haqqi, T.M.1    Qu, X.M.2    Anthony, D.3
  • 45
    • 9344245755 scopus 로고    scopus 로고
    • V beta 17 T cell receptor peptide vaccination in rheumatoid arthritis: Results of phase I dose escalation study
    • Moreland LW, Heck LW Jr, Koopman WJ, et al. V beta 17 T cell receptor peptide vaccination in rheumatoid arthritis: results of phase I dose escalation study. J Rheumatol 1996;23:1353-1362
    • (1996) J Rheumatol , vol.23 , pp. 1353-1362
    • Moreland, L.W.1    Heck L.W., Jr.2    Koopman, W.J.3


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