Hypertension: Physiology and pathophysiology

Comprehensive Physiology

Volumn 2, Issue 4, 2012, Pages 2393-2442

  Hall, John E ^a   Granger, Joey P ^a   do Carmo, Jussara M ^a   da Silva, Alexandre A ^a   Dubinion, John ^a   George, Eric ^a   Hamza, Shereen ^a   Speed, Joshua ^a   Hall, Michael E ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BLOOD PRESSURE; EXTRACELLULAR FLUID; FEEDBACK SYSTEM; FEMALE; GENETIC PREDISPOSITION; GENOTYPE ENVIRONMENT INTERACTION; GLOMERULUS FILTRATION RATE; HUMAN; HYPERTENSION; KIDNEY; MALE; METABOLISM; NATRIURESIS; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SEXUAL DEVELOPMENT; WEIGHT GAIN;

BLOOD PRESSURE; EXTRACELLULAR FLUID; FEEDBACK, PHYSIOLOGICAL; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GLOMERULAR FILTRATION RATE; HUMANS; HYPERTENSION; KIDNEY; MALE; NATRIURESIS; OBESITY; RENIN-ANGIOTENSIN SYSTEM; SEX CHARACTERISTICS; WEIGHT GAIN;

EID: 84878964648     PISSN: None     EISSN: 20404603     Source Type: Journal    
DOI: 10.1002/cphy.c110058     Document Type: Article

References (283)

1. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285: 2486-2497, 2001.
2. Abate NI,Mansour YH, Tuncel M, Arbique D, Chavoshan B, Kizilbash A, Howell-Stampley T, Vongpatanasin W, Victor RG. Overweight and sympathetic overactivity in black Americans. Hypertension 38: 379-383, 2001.
3. Adler GK, Williams GH. Aldosterone: Villain or protector? Hypertension 50: 31-32, 2007.
4. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr. Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and InternationalAssociation for the Study of Obesity. Circulation 120: 1640-1645, 2009.
5. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome-a new worldwide definition.AConsensus Statement from the InternationalDiabetes Federation. Diabet Med 23: 469-480, 2006.
6. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15: 539-553, 1998.
7. Alexander BT, Cockrell KL, Massey MB, Bennett WA, Granger JP. Tumor necrosis factor-alpha-induced hypertension in pregnant rats results in decreased renal neuronal nitric oxide synthase expression. Am J Hypertens 15: 170-175, 2002.
8. Alexander BT, Rinewalt AN, Cockrell KL, Massey MB, Bennett WA, Granger JP. Endothelin type a receptor blockade attenuates the hypertension in response to chronic reductions in uterine perfusion pressure. Hypertension 37: 485-489, 2001.
9. Alexander J, Dustan HP, Sims EAH, Tarazi R. Report of the Hypertension Task Force. 70-1631, 61-77. 1979. Washington, DC, U.S. Government Printing Office, U.S. Department of Health, Education, and Welfare Publication (NIH).
10. Alonso-Galicia M, Brands MW, Zappe DH, Hall JE. Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activity. Hypertension 28: 1047-1054, 1996.
11. AssmannG, Schulte H. The Prospective Cardiovascular Munster (PROCAM) study: Prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease. Am Heart J 116: 1713-1724, 1988.
12. Bagnall AJ, Kelland NF, Gulliver-Sloan F, Davenport AP, Gray GA, Yanagisawa M,Webb DJ, Kotelevtsev YV. Deletion of endothelial cell endothelin B receptors does not affect blood pressure or sensitivity to salt. Hypertension 48: 286-293, 2006.
13. Bakris GL, Lindholm LH, Black HR, Krum H, Linas S, Linseman JV, Arterburn S, Sager P, Weber M. Divergent results using clinic and ambulatory blood pressures: Report of a darusentan-resistant hypertension trial. Hypertension 56: 824-830, 2010.
14. Baylis C. Nitric oxide deficiency in chronic kidney disease. Am J Physiol Renal Physiol 294: F1-F9, 2008.
15. Bengis RG, Coleman TG. Antihypertensive effect of prolonged blockade of angiotensin formation in benign and malignant, one-and two-kidney Goldblatt hypertensive rats. Clin Sci (Lond) 57: 53-62, 1979.
16. BianchiG, Tenconi LT, Lucca R. Effect in the conscious dog of constriction of the renal artery to a sole remaining kidney on haemodynamics, sodium balance, body fluid volumes, plasma renin concentration and pressor responsiveness to angiotensin. Clin Sci 38: 741-766, 1970.
17. Bickel CA, Verbalis JG, Knepper MA, Ecelbarger CA. Increased renal Na-K-ATPase, NCC, and beta-ENaC abundance in obese Zucker rats. Am J Physiol Renal Physiol 281: F639-F648, 2001.
18. Biglieri EG, Kater CE.Mineralocorticoids in congenital adrenal hyperplasia. J Steroid Biochem Mol Biol 40: 493-499, 1991.
19. Boger RH. Asymmetric dimethylarginine (ADMA) and cardiovascular disease: Insights from prospective clinical trials. Vasc Med 10(Suppl 1): S19-S25, 2005.
20. Bonnet F, Deprele C, Sassolas A, Moulin P, Alamartine E, Berthezene F, Berthoux F. Excessive body weight as a new independent risk factor for clinical and pathological progression in primary IgA nephritis. Am J Kidney Dis 37: 720-727, 2001.
21. Boustany CM, Brown DR, Randall DC, Cassis LA. AT1-receptor antagonism reverses the blood pressure elevation associated with dietinduced obesity. Am J Physiol Regul Integr Comp Physiol 289: R181-R186, 2005.
22. Brands MW, Lee DL. Psychosocial stress and hypertension. In: Lip GHY, Hall JE, editors. Comprehensive Hypertension. Philadelphia: Mosby-Elsevier, 2007, pp. 501-511.
23. Brenner BM, Cooper ME, de ZD, Keane WF, Mitch WE, Parving HH, Remuzzi G, Snapinn SM, Zhang Z, Shahinfar S. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 345: 861-869, 2001.
24. Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, Horan MJ, Labarthe D. Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension 25: 305-313, 1995.
25. Calhoun DA. Is there an unrecognized epidemic of primary aldosteronism? Pro. Hypertension 50: 447-453, 2007.
26. Calhoun DA, Nishizaka MK, Zaman MA, Thakkar RB, Weissmann P. Hyperaldosteronism among black and white subjects with resistant hypertension. Hypertension 40: 892-896, 2002.
27. Campese VM. Salt sensitivity in hypertension. Renal and cardiovascular implications. Hypertension 23: 531-550, 1994.
28. Carlstrom M, Brown RD, Edlund J, Sallstrom J, Larsson E, Teerlink T, Palm F, Wahlin N, Persson AE. Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals. Am J Physiol Renal Physiol 294: F362-F370, 2008.
29. Carlyle M, Jones OB, Kuo JJ, Hall JE. Chronic cardiovascular and renal actions of leptin: Role of adrenergic activity. Hypertension 39: 496-501, 2002.
30. Carretero OA, Oparil S. Essential hypertension. Part I: Definition and etiology. Circulation 101: 329-335, 2000.
31. Chae CU, Lee RT, Rifai N, Ridker PM. Blood pressure and inflammation in apparently healthy men. Hypertension 38: 399-403, 2001.
32. Chen PY, Sanders PW. L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats. J Clin Invest 88: 1559-1567, 1991.
33. Cheng HF, Harris RC. Cyclooxygenases, the kidney, and hypertension. Hypertension 43: 525-530, 2004.
34. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jr., Jones DW, Materson BJ, Oparil S, Wright JT, Jr., Roccella EJ. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42: 1206-1252, 2003.
35. Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115: 940-950, 2005.
36. Chughtai HL, Morgan TM, Rocco M, Stacey B, Brinkley TE, Ding J, Nicklas B, Hamilton C, Hundley WG. Renal sinus fat and poor blood pressure control in middle-aged and elderly individuals at risk for cardiovascular events. Hypertension 56: 901-906, 2010.
37. Conrad KP, Benyo DF. Placental cytokines and the pathogenesis of preeclampsia. Am J Reprod Immunol 37: 240-249, 1997.
38. Cowley AW Jr. Long-term control of arterial blood pressure. Physiol Rev 72: 231-300, 1992.
39. Cowley AW, Jr., Lohmeier TE. Changes in renal vascular sensitivity and arterial pressure associated with sodium intake during long-term intrarenal norepinephrine infusion in dogs. Hypertension 1: 549-558, 1979.
40. Cowley AW, Jr., Mori T, Mattson D, Zou AP. Role of renal NO production in the regulation of medullary blood flow. Am J Physiol Regul Integr Comp Physiol 284: R1355-R1369, 2003.
41. Crowley SD, Gurley SB, Herrera MJ, Ruiz P, Griffiths R, Kumar AP, Kim HS, Smithies O, Le TH, Coffman TM. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A 103: 17985-17990, 2006.
42. Crowley SD, Song YS, Lin EE, Griffiths R, Kim HS, Ruiz P. Lymphocyte responses exacerbate angiotensin II-dependent hypertension. Am J Physiol Regul Integr Comp Physiol 298: R1089-R1097, 2010.
43. Cui J, Hopper JL, Harrap SB. Genes and family environment explain correlations between blood pressure and body mass index. Hypertension 40: 7-12, 2002.
44. da Silva AA, do CJ, Dubinion J, Hall JE. The role of the sympathetic nervous system in obesity-related hypertension. Curr Hypertens Rep 11: 206-211, 2009.
45. da Silva AA, Kuo JJ, Hall JE. Role of hypothalamic melanocortin 3/4-receptors in mediating chronic cardiovascular, renal, and metabolic actions of leptin. Hypertension 43: 1312-1317, 2004.
46. Dampney RA, Horiuchi J, Killinger S, Sheriff MJ, Tan PS, McDowall LM. Long-term regulation of arterial blood pressure by hypothalamic nuclei: Some critical questions. Clin Exp Pharmacol Physiol 32: 419-425, 2005.
47. Davy KP, Hall JE. Obesity and hypertension: Two epidemics or one? Am J Physiol Regul Integr Comp Physiol 286: R803-R813, 2004.
48. de Paula RB, da Silva AA, Hall JE. Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration. Hypertension 43: 41-47, 2004.
49. DiBona GF. Neural control of the kidney: Past, present, and future. Hypertension 41: 621-624, 2003.
50. DiBona GF, Esler M. Translational medicine: The antihypertensive effect of renal denervation. Am J Physiol Regul Integr Comp Physiol 298: R245-R253, 2010.
51. Dikalov S, Griendling KK, Harrison DG. Measurement of reactive oxygen species in cardiovascular studies. Hypertension 49: 717-727, 2007.
52. Dluhy RG, Lifton RP. Glucocorticoid-remediable aldosteronism (GRA): Diagnosis, variability of phenotype and regulation of potassium homeostasis. Steroids 60: 48-51, 1995.
53. do Carmo JM, da Silva AA, Cai Z, Lin S, Dubinion JH, Hall JE. Control of blood pressure, appetite, and glucose by leptin in mice lacking leptin receptors in proopiomelanocortin neurons. Hypertension 57: 918-926, 2011.
54. Donners MM, Daemen MJ, Cleutjens KB, Heeneman S. Inflammation and restenosis: Implications for therapy. Ann Med 35: 523-531, 2003.
55. Dubey RK, Oparil S, Imthurn B, Jackson EK. Sex hormones and hypertension. Cardiovasc Res 53: 688-708, 2002.
56. Dubey RK, Zhang HY, Reddy SR, BoegeholdMA,Kotchen TA. Pioglitazone attenuates hypertension and inhibits growth of renal arteriolar smooth muscle in rats. Am J Physiol 265: R726-R732, 1993.
57. Dunnill MS, Halley W. Some observations on the quantitative anatomy of the kidney. J Pathol 110: 113-121, 1973.
58. Dzielak DJ. Immune mechanisms in experimental and essential hypertension. Am J Physiol 260: R459-R467, 1991.
59. Eng E, Veniant M, Floege J, Fingerle J, Alpers CE, Menard J, Clozel JP, Johnson RJ. Renal proliferative and phenotypic changes in rats with two-kidney, one-clip Goldblatt hypertension. Am J Hypertens 7: 177-185, 1994.
60. Engeli S, Sharma AM. The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension. J Mol Med 79: 21-29, 2001.
61. Esler M. The sympathetic system and hypertension. Am J Hypertens 13: 99S-105S, 2000.
62. Esler M, Straznicky N, Eikelis N, Masuo K, Lambert G, Lambert E. Mechanisms of sympathetic activation in obesity-related hypertension. Hypertension 48: 787-796, 2006.
63. Facemire CS, Nixon AB, Griffiths R, Hurwitz H, Coffman TM. Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression. Hypertension 54: 652-658, 2009.
64. Fallo F, Paoletta A, Tona F, Boscaro M, Sonino N. Response of hypertension to conventional antihypertensive treatment and/or steroidogenesis inhibitors in Cushing's syndrome. J Intern Med 234: 595-598, 1993.
65. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1: 27-31, 1995.
66. Ford ES. Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S. Diabetes Care 28: 2745-2749, 2005.
67. Fortuno A, Bidegain J, Robador PA, Hermida J, Lopez-Sagaseta J, Beloqui O, Diez J, Zalba G. Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: Potential clinical implications in hypertension. Hypertension 54: 744-750, 2009.
68. Fujita T. Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome. Hypertension 55: 813-818, 2010.
69. Fuller PJ, Young MJ. Mechanisms of mineralocorticoid action. Hypertension 46: 1227-1235, 2005.
70. Funder JW. Reconsidering the roles of the mineralocorticoid receptor. Hypertension 53: 286-290, 2009.
71. Gao Q,WolfgangMJ, Neschen S,Morino K, Horvath TL, Shulman GI, Fu XY. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A 101: 4661-4666, 2004.
72. Gariepy CE, Cass DT, Yanagisawa M. Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color. Proc Natl Acad Sci U S A 93: 867-872, 1996.
73. Gariepy CE, Ohuchi T, Williams SC, Richardson JA, Yanagisawa M. Salt-sensitive hypertension in endothelin-B receptor-deficient rats. J Clin Invest 105: 925-933, 2000.
74. Garovic VD, Hilliard AA, Turner ST. Monogenic forms of low-renin hypertension. Nat Clin Pract Nephrol 2: 624-630, 2006.
75. Garovic VD, Textor SC. Renovascular hypertension and ischemic nephropathy. Circulation 112: 1362-1374, 2005.
76. Garrison RJ, Kannel WB, Stokes J, III, Castelli WP. Incidence and precursors of hypertension in young adults: The Framingham Offspring Study. Prev Med 16: 235-251, 1987.
77. Garvin JL, Ortiz PA. The role of reactive oxygen species in the regulation of tubular function. Acta Physiol Scand 179: 225-232, 2003.
78. Gavras H, Brunner HB, Vaughan ED, Laragh JH. Angiotensin-sodium interaction in blood pressure maintenance of renal hypertensive and normotensive rats. Science 180: 1369-1371, 1973.
79. Ge Y, Bagnall A, Stricklett PK, Strait K,Webb DJ, Kotelevtsev Y, Kohan DE. Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention. Am J Physiol Renal Physiol 291: F1274-F1280, 2006.
80. Ge Y, Bagnall A, Stricklett PK, Webb D, Kotelevtsev Y, Kohan DE. Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention. Am J Physiol Renal Physiol 295: F1635-F1640, 2008.
81. Geller DS, Farhi A, Pinkerton N, Fradley M, Moritz M, Spitzer A, Meinke G, Tsai FT, Sigler PB, Lifton RP. Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science 289: 119-123, 2000.
82. Gilbert JS, Ryan MJ, LaMarca BB, Sedeek M, Murphy SR, Granger JP. Pathophysiology of hypertension during preeclampsia: Linking placental ischemia with endothelial dysfunction. Am J Physiol Heart Circ Physiol 294: H541-H550, 2008.
83. Goldblatt H, Lynch J, Hanzal RF, Summerville WW. Studies on experimental hypertension: I. The production of persistent elevation of systolic blood pressure by means of renal ischemia. J Exp Med 59: 347-379, 1934.
84. Goldstein DS, Eisenhofer G, Flynn JA,WandG, Pacak K. Diagnosis and localization of pheochromocytoma. Hypertension 43: 907-910, 2004.
85. Goodfriend TL, Calhoun DA. Resistant hypertension, obesity, sleep apnea, and aldosterone: Theory and therapy. Hypertension 43: 518-524, 2004.
86. Granger J, Novak J, Schnackenberg C, Williams S, Reinhart GA. Role of renal nerves in mediating the hypertensive effects of nitric oxide synthesis inhibition. Hypertension 27: 613-618, 1996.
87. Granger JP. Endothelin. Am J Physiol Regul Integr Comp Physiol 285: R298-R301, 2003.
88. Granger JP. Vascular endothelial growth factor inhibitors and hypertension: Acentral role for the kidney and endothelial factors? Hypertension 54: 465-467, 2009.
89. Granger JP, Abram S, Stec D, Chandler D, LaMarca B. Endothelin, the kidney, and hypertension. Curr Hypertens Rep 8: 298-303, 2006.
90. Granger JP, Alexander BT. Abnormal pressure-natriuresis in hypertension: Role of nitric oxide. Acta Physiol Scand 168: 161-168, 2000.
91. Granger JP, Opgenorth TJ, Salazar J, Romero JC, Burnett JC Jr. Longterm hypotensive and renal effects of atrial natriuretic peptide. Hypertension 8: II112-II116, 1986.
92. Grassi G, Seravalle G, Cattaneo BM, Bolla GB, Lanfranchi A, Colombo M, Giannattasio C, Brunani A, Cavagnini F, Mancia G. Sympathetic activation in obese normotensive subjects. Hypertension 25: 560-563, 1995.
93. Grassi G, Seravalle G, Dell'Oro R, Trevano FQ, Bombelli M, Scopelliti F, Facchini A, Mancia G. Comparative effects of candesartan and hydrochlorothiazide on blood pressure, insulin sensitivity, and sympathetic drive in obese hypertensive individuals: Results of the CROSS study. J Hypertens 21: 1761-1769, 2003.
94. Greenfield JR, Miller JW, Keogh JM, Henning E, Satterwhite JH, Cameron GS, Astruc B, Mayer JP, Brage S, See TC, Lomas DJ, O'Rahilly S, Farooqi IS. Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med 360: 44-52, 2009.
95. Griffin KA, Abu-Amarah I, Picken M, Bidani AK. Renoprotection by ACE inhibition or aldosterone blockade is blood pressure-dependent. Hypertension 41: 201-206, 2003.
96. Grosser T, Fries S, FitzGerald GA. Biological basis for the cardiovascular consequences of COX-2 inhibition: Therapeutic challenges and opportunities. J Clin Invest 116: 4-15, 2006.
97. Guyenet PG. The sympathetic control of blood pressure. Nat Rev Neurosci 7: 335-346, 2006.
98. Guyton AC. Arterial pressure and hypertension. In: Circulatory Physiology II. Philadelphia: WB Saunders, 1980, pp. 1-564.
99. Guyton AC. The surprising kidney-fluid mechanism for pressure control-its infinite gain! Hypertension 16: 725-730, 1990.
100. Guyton AC, Coleman TG, Granger HJ. Circulation: Overall regulation. Annu Rev Physiol 34: 13-46, 1972.
101. Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov S, Goronzy J, Weyand C, Harrison DG. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med 204: 2449-2460, 2007.
102. Haarbo J, Marslew U, Gotfredsen A, Christiansen C. Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause. Metabolism 40: 1323-1326, 1991.
103. Hall JE. Guyton and Hall Textbook of MedicalPhysiology. Philadelphia: Elsevier, 2011.
104. Hall JE, Coleman TG. Systemic hemodynamics and regional blood flow. In: Izzo JL, Jr.,Black HC, editors. Hypertension Primer.American Heart Association, 2008, pp. 132-135.
105. Hall JE, Granger JP. Regulation of fluid and electrolyte balance in hypertension: Role of hormones and peptides. In: Battegay EJ, Lip GHY, Bakris GL, editors. Hypertension: Principles and Practice. Boca Raton: Taylor & Francis, 2005, pp. 121-142.
106. Hall JE, Granger JP, Jones DW, Hall ME. Pathophysiology of hypertension. In: Fuster V, Walsh RA, Harrington RA, editors. Hurst's The Heart. McGraw-Hill, Inc., 2011, pp. 1549-1584.
107. Hall JE, Jones DW, Henegar J, Dwyer TW, Kuo J. Obesity hypertension, and renal disease. In: by Eckel RH, editor. Obesity: Mechanisms and Clinical Management. Philadelphia: Lippincott, Williams & Wilkins, 2003, pp. 273-300.
108. Hall JE. Control of sodium excretion by angiotensin II: Intrarenal mechanisms and blood pressure regulation. Am J Physiol 250: R960-R972, 1986.
109. Hall JE. Renal function in one-kidney, one-clip hypertension and low renin essential hypertension. Am J Hypertens 4: 523S-533S, 1991.
110. Hall JE. The kidney, hypertension, and obesity. Hypertension 41: 625-633, 2003.
111. Hall JE, Brands MW, Dixon WN, Smith MJ Jr. Obesity-induced hypertension. Renal function and systemic hemodynamics. Hypertension 22: 292-299, 1993.
112. Hall JE, Brands MW,Henegar JR. Angiotensin II and long-term arterial pressure regulation: The overriding dominance of the kidney. J Am Soc Nephrol 10(Suppl 12): S258-S265, 1999a.
113. Hall JE, Brands MW, Henegar JR. Mechanisms of hypertension and kidney disease in obesity. Ann N Y Acad Sci 892: 91-107, 1999b.
114. Hall JE, Brands MW, Mizelle HL, Gaillard CA, Hildebrandt DA. Chronic intrarenal hyperinsulinemia does not cause hypertension. Am J Physiol 260: F663-F669, 1991.
115. Hall JE, Brands MW, Zappe DH, Alonso GM. Insulin resistance, hyperinsulinemia, and hypertension: Causes, consequences, or merely correlations? Proc Soc Exp Biol Med 208: 317-329, 1995.
116. Hall JE, Brands MW, Zappe DH, Alonso-Galicia M. Cardiovascular actions of insulin: Are they important in long-term blood pressure regulation? Clin Exp Pharmacol Physiol 22: 689-700, 1995.
117. Hall JE, Brands MW, Zappe DH, Dixon WN, Mizelle HL, Reinhart GA, Hildebrandt DA. Hemodynamic and renal responses to chronic hyperinsulinemia in obese, insulin-resistant dogs. Hypertension 25: 994-1002, 1995.
118. Hall JE, Crook ED, JonesDW,WoffordMR, Dubbert PM.Mechanisms of obesity-associated cardiovascular and renal disease. Am J Med Sci 324: 127-137, 2002.
119. Hall JE, da Silva AA, do Carmo JM, Dubinion J, Hamza S, Munusamy S, Smith G, Stec DE. Obesity-induced hypertension: Role of sympathetic nervous system, leptin, and melanocortins. J Biol Chem 285: 17271-17276, 2010.
120. Hall JE, Granger JP, Smith MJ, Jr., Premen AJ. Role of renal hemodynamics and arterial pressure in aldosterone "escape". Hypertension 6: I183-I192, 1984.
121. Hall JE, Guyton AC, Brands MW. Pressure-volume regulation in hypertension. Kidney Int Suppl 55: S35-S41, 1996.
122. Hall JE, Guyton AC, Smith MJ, Jr., Coleman TG. Blood pressure and renal function during chronic changes in sodium intake: Role of angiotensin. Am J Physiol 239: F271-F280, 1980.
123. Hall JE, Henegar JR, Dwyer TM, Liu J, da Silva AA, Kuo JJ, Tallam L. Is obesity a major cause of chronic kidney disease? Adv Ren Replace Ther 11: 41-54, 2004.
124. Hall JE, Hildebrandt DA, Kuo J. Obesity hypertension: Role of leptin and sympathetic nervous system. Am JHypertens 14: 103S-115S, 2001.
125. Hall JE, Mizelle HL, Woods LL, Montani JP. Pressure natriuresis and control of arterial pressure during chronic norepinephrine infusion. J Hypertens 6: 723-731, 1988.
126. Hall JE, Summers RL, Brands MW, Keen H, Alonso-Galicia M. Resistance to metabolic actions of insulin and its role in hypertension. Am J Hypertens 7: 772-788, 1994.
127. Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets R, Lu Y, Canessa C, Iwasaki T, Rossier B, Lifton RP. Hypertension caused by a truncated epithelial sodium channel gamma subunit: Genetic heterogeneity of Liddle syndrome. Nat Genet 11: 76-82, 1995.
128. Harrison DG, Guzik TJ, Goronzy J, Weyand C. Is hypertension an immunologic disease? Curr Cardiol Rep 10: 464-469, 2008.
129. Harrison DG, Guzik TJ, Lob HE, Madhur MS, Marvar PJ, Thabet SR, Vinh A, Weyand CM. Inflammation, immunity, and hypertension. Hypertension 57: 132-140, 2011.
130. Hayakawa H, Hirata Y, Suzuki E, Kimura K, Kikuchi K, Nagano T, Hirobe M, Omata M. Long-term administration of L-arginine improves nitric oxide release from kidney in deoxycorticosterone acetate-salt hypertensive rats. Hypertension 23: 752-756, 1994.
131. He J, Klag MJ, Whelton PK, Chen JY, Mo JP, Qian MC, Mo PS, He GQ. Migration, blood pressure pattern, and hypertension: The Yi Migrant Study. Am J Epidemiol 134: 1085-1101, 1991.
132. Hsu CY, McCulloch CE, Iribarren C, Darbinian J, Go AS. Body mass index and risk for end-stage renal disease. Ann Intern Med 144: 21-28, 2006.
133. Jiroutek MR, Chen MH, Johnston CC, Longcope C. Changes in reproductive hormones and sex hormone-binding globulin in a group of postmenopausal women measured over 10 years. Menopause 5: 90-94, 1998.
134. Johnson RJ, Rodriguez-Iturbe B, Nakagawa T, Kang DH, Feig DI, Herrera-Acosta J. Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertension. Hypertension 45: 326-330, 2005.
135. Jones DW, Kim JS, Andrew ME, Kim SJ, Hong YP. Body mass index and blood pressure in Korean men and women: The Korean National Blood Pressure Survey. J Hypertens 12: 1433-1437, 1994.
136. Jones DW, Miller ME, Wofford MR, Anderson DC, Jr., Cameron ME, Willoughby DL, Adair CT, King NS. The effect of weight loss intervention on antihypertensive medication requirements in the hypertension Optimal Treatment (HOT) study. Am J Hypertens 12: 1175-1180, 1999.
137. Julius S, Gudbrandsson T, Jamerson K, Tariq SS, Andersson O. The hemodynamic link between insulin resistance and hypertension. J Hypertens 9: 983-986, 1991.
138. Kahn R, Buse J, Ferrannini E, SternM. The metabolic syndrome: Time for a critical appraisal: Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 28: 2289-2304, 2005.
139. Kambham N, Markowitz GS, Valeri AM, Lin J, D'Agati VD. Obesityrelated glomerulopathy: An emerging epidemic. Kidney Int 59: 1498-1509, 2001.
140. Kaplan NM. Clinical Hypertension. Philadelphia: Lippincott, William & Wilkins, 2002.
141. Kassab S, Kato T,Wilkins FC, Chen R, Hall JE, Granger JP. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension 25: 893-897, 1995.
142. Kassab S, Miller MT, Novak J, Reckelhoff J, Clower B, Granger JP. Endothelin-A receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats. Hypertension 31: 397-402, 1998.
143. Kassab S, Novak J, Miller T, Kirchner K, Granger J. Role of endothelin in mediating the attenuated renal hemodynamics in Dahl salt-sensitive hypertension. Hypertension 30: 682-686, 1997.
144. Kimura G, Brenner BM. The renal basis for salt sensitivity in hypertension. In: Laragh JH, Brenner BM, editors. Hypertension: Pathophysiology, Diagnosis, and Management. New York: Raven Press, 2011, pp. 1569-1588.
145. Kirchner KA, Scanlon PH, Jr., Dzielak DJ, Hester RL. Endotheliumderived relaxing factor responses in Doca-salt hypertensive rats. Am J Physiol 265: R568-R572, 1993.
146. Knox FG, Granger JP. Control of sodium excretion: An integrative approach. In: Windhager E, editor. Handbook of Renal Physiology. New York: Oxford Press, 1992, pp. 927-967.
147. Kohan DE. The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure. Curr Opin Nephrol Hypertens 15: 34-40, 2006.
148. Krum H, Sobotka P, Mahfoud F, Bohm M, Esler M, Schlaich M. Device-based antihypertensive therapy: Therapeutic modulation of the autonomic nervous system. Circulation 123: 209-215, 2011.
149. Krum H, Viskoper RJ, Lacourciere Y, Budde M, Charlon V. The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators. N Engl J Med 338: 784-790, 1998.
150. Kuo JJ, Jones OB, Hall JE. Inhibition of NO synthesis enhances chronic cardiovascular and renal actions of leptin. Hypertension 37: 670-676, 2001.
151. Kurtz TW. Genome-wide association studies will unlock the genetic basis of hypertension: Con side of the argument. Hypertension 56: 1021-1025, 2010.
152. Kurtz TW, Gardner DG. Transcription-modulating drugs: A new frontier in the treatment of essential hypertension. Hypertension 32: 380-386, 1998.
153. Laffer CL, Laniado-Schwartzman M,Wang MH, Nasjletti A, Elijovich F. 20-HETE and furosemide-induced natriuresis in salt-sensitive essential hypertension. Hypertension 41: 703-708, 2003.
154. Laffer CL, Laniado-Schwartzman M,Wang MH, Nasjletti A, Elijovich F. Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic acid in human salt-sensitive versus salt-resistant hypertension. Circulation 107: 574-578, 2003.
155. LaMarca B, Speed J, Fournier L, Babcock SA, Berry H, Cockrell K, Granger JP. Hypertension in response to chronic reductions in uterine perfusion in pregnant rats: Effect of tumor necrosis factor-alpha blockade. Hypertension 52: 1161-1167, 2008.
156. LaMarca BB, BennettWA, Alexander BT, Cockrell K, Granger JP. Hypertension produced by reductions in uterine perfusion in the pregnant rat: Role of tumor necrosis factor-alpha. Hypertension 46: 1022-1025, 2005.
157. LaMarca BB, Cockrell K, Sullivan E, Bennett W, Granger JP. Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats. Hypertension 46: 82-86, 2005.
158. LaMarca BD, Alexander BT, Gilbert JS, Ryan MJ, Sedeek M, Murphy SR, Granger JP. Pathophysiology of hypertension in response to placental ischemia during pregnancy: A central role for endothelin? Gend Med 5(Suppl A): S133-S138, 2008.
159. Landsberg L. Feast or famine: The sympathetic nervous system response to nutrient intake. Cell Mol Neurobiol 26: 497-508, 2006.
160. Langston JB, Guyton AC, Douglas BH, Dorsett PE. Effect of changes in salt intake on arterial pressure and renal function in partially nephrectomized dogs. Circ Res 12: 508-512, 1963.
161. Laragh JH. Nephron heterogeneity: Clue to the pathogenesis of essential hypertension and effectiveness of angiotensin-converting enzyme inhibitor treatment. Am J Med 87: 2S-14S, 1989.
162. Lassegue B, Griendling KK. NADPH oxidases: Functions and pathologies in the vasculature. Arterioscler Thromb Vasc Biol 30: 653-661, 2010.
163. Laughlin GA, Barrett-Connor E, Kritz-Silverstein D, von MD. Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: The Rancho Bernardo Study. J Clin Endocrinol Metab 85: 645-651, 2000.
164. Lawes CM, Vander HS, Rodgers A. Global burden of blood-pressurerelated disease, 2001. Lancet 371: 1513-1518, 2008.
165. Lee DL, Sturgis LC, Labazi H, Osborne JB, Jr., Fleming C, Pollock JS, Manhiani M, Imig JD, Brands MW. Angiotensin II hypertension is attenuated in interleukin-6 knockout mice. Am J Physiol Heart Circ Physiol 290: H935-H940, 2006.
166. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 355: 992-1005, 2006.
167. Levy D, EhretGB, Rice K,Verwoert GC, Launer LJ, DehghanA,Glazer NL, Morrison AC, Johnson AD, Aspelund T, Aulchenko Y, Lumley T, Kottgen A, Vasan RS, Rivadeneira F, Eiriksdottir G, Guo X, Arking DE, Mitchell GF, Mattace-Raso FU, Smith AV, Taylor K, Scharpf RB, Hwang SJ, Sijbrands EJ, Bis J, Harris TB, Ganesh SK, O'Donnell CJ, Hofman A, Rotter JI, Coresh J, Benjamin EJ, Uitterlinden AG, Heiss G, Fox CS,Witteman JC, Boerwinkle E,Wang TJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, van Duijn CM. Genome-wide association study of blood pressure and hypertension. Nat Genet 41: 677-687, 2009.
168. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality:Ameta-analysis of individual data for one million adults in 61 prospective studies. Lancet 360: 1903-1913, 2002.
169. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med 329: 1456-1462, 1993.
170. Lewis EJ, Hunsicker LG, Clarke WR, Berl T, Pohl MA, Lewis JB, Ritz E, Atkins RC, Rohde R, Raz I. Renoprotective effect of the angiotensinreceptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 345: 851-860, 2001.
171. Lifton RP. Molecular genetics of human blood pressure variation. Science 272: 676-680, 1996.
172. Lifton RP, Dluhy RG, Powers M, Rich GM, Gutkin M, Fallo F, Gill JR, Jr., Feld L, Ganguly A, Laidlaw JC. Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase. Nat Genet 2: 66-74, 1992.
173. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 104: 545-556, 2001.
174. Lindheimer MD, Kanter D. Interpreting abnormal proteinuria in pregnancy: The need for a more pathophysiological approach. Obstet Gynecol 115: 365-375, 2010.
175. Lloyd-Jones D, Adams R, Carnethon M, De SG, Ferguson TB, Flegal K, Ford E, Furie K, Go A, Greenlund K, Haase N, Hailpern S, Ho M, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermottM,Meigs J,Mozaffarian D, Nichol G, O'Donnell C, Roger V, Rosamond W, Sacco R, Sorlie P, Stafford R, Steinberger J, Thom T, Wasserthiel-Smoller S,Wong N,Wylie-Rosett J, Hong Y. Heart disease and stroke statistics-2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119: e21-e181, 2009.
176. Lockette W, Otsuka Y, CarreteroO. The loss of endothelium-dependent vascular relaxation in hypertension. Hypertension 8: II61-II66, 1986.
177. Lohmeier TE, Dwyer TM, Irwin ED, Rossing MA, Kieval RS. Prolonged activation of the baroreflex abolishes obesity-induced hypertension. Hypertension 49: 1307-1314, 2007.
178. Lohmeier TE, Hildebrandt DA, Warren S, May PJ, Cunningham JT. Recent insights into the interactions between the baroreflex and the kidneys in hypertension. Am J Physiol Regul Integr Comp Physiol 288: R828-R836, 2005.
179. Lohmeier TE, Iliescu R. Chronic lowering of blood pressure by carotid baroreflex activation: Mechanisms and potential for hypertension therapy. Hypertension 57: 880-886, 2011.
180. Longini IM, Jr., Higgins MW, Hinton PC, Moll PP, Keller JB. Environmental and genetic sources of familial aggregation of blood pressure in Tecumseh, Michigan. Am J Epidemiol 120: 131-144, 1984.
181. Luft FC. Molecular genetics of human hypertension. J Hypertens 16: 1871-1878, 1998.
182. Luft FC. Mendelian forms of human hypertension and mechanisms of disease. Clin Med Res 1: 291-300, 2003.
183. Luft FC. Geneticism of essential hypertension. Hypertension 43: 1155-1159, 2004.
184. Luscher TF, Raij L, Vanhoutte PM. Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats. Hypertension 9: 157-163, 1987.
185. Luscher TF, Vanhoutte PM. Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension 8: 344-348, 1986.
186. LynchAI, Claas SA, Arnett DK. Areviewof the role of atrial natriuretic peptide gene polymorphisms in hypertension and its sequelae. Curr Hypertens Rep 11: 35-42, 2009.
187. Machnik A.,Neuhofer W, Jantsch J,Dahlmann A, Tammela T, Machura K, Park JK, Beck FX, Muller DN, DererW, Goss J, Ziomber A, Dietsch P, Wagner H, van RN, Kurtz A, Hilgers KF, Alitalo K, Eckardt KU, Luft FC, Kerjaschki D, Titze J. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-Cdependent buffering mechanism. Nat Med 15: 545-552, 2009.
188. Maharaj AS, D'Amore PA. Roles for VEGF in the adult. Microvasc Res 74: 100-113, 2007.
189. Manger WM. An overview of pheochromocytoma: History, current concepts, vagaries, and diagnostic challenges. Ann N Y Acad Sci 1073: 1-20, 2006.
190. Manning RD, Jr., Hu L. Nitric oxide regulates renal hemodynamics and urinary sodium excretion in dogs. Hypertension 23: 619-625, 1994.
191. Manning RD, Jr., Meng S, Tian N. Renal and vascular oxidative stress and salt-sensitivity of arterial pressure. Acta Physiol Scand 179: 243-250, 2003.
192. Mark AL, Shaffer RA, Correia ML,Morgan DA, Sigmund CD, Haynes WG. Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. J Hypertens 17: 1949-1953, 1999.
193. Matsuoka H, Itoh S, Kimoto M, Kohno K, Tamai O,Wada Y, Yasukawa H, Iwami G, Okuda S, Imaizumi T. Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension. Hypertension 29: 242-247, 1997.
194. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111: 649-658, 2003.
195. McCormick JA, Ellison DH. TheWNKs: Atypical protein kinases with pleiotropic actions. Physiol Rev 91: 177-219, 2011.
196. Melo LG, Steinhelper ME, Pang SC, Tse Y, Ackermann U. ANP in regulation of arterial pressure and fluid-electrolyte balance: Lessons from genetic mouse models. Physiol Genomics 3: 45-58, 2000.
197. Melo LG, Veress AT, Chong CK, Pang SC, Flynn TG, Sonnenberg H. Salt-sensitive hypertension in ANP knockout mice: Potential role of abnormal plasma renin activity. Am J Physiol 274: R255-R261, 1998.
198. Messerli FH, Christie B, DeCarvalho JG, Aristimuno GG, Suarez DH, DreslinskiGR, Frohlich ED.Obesity and essential hypertension. Hemodynamics, intravascular volume, sodium excretion, and plasma renin activity. Arch Intern Med 141: 81-85, 1981.
199. Morgan DA, Thedens DR, Weiss R, Rahmouni K. Mechanisms mediating renal sympathetic activation to leptin in obesity. Am J Physiol Regul Integr Comp Physiol 295: R1730-R1736, 2008.
200. Morris DL, Rui L. Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab 297: E1247-E1259, 2009.
201. Mune T, Rogerson FM, Nikkila H, Agarwal AK, White PC. Human hypertension caused by mutations in the kidney isozyme of 11 betahydroxysteroid dehydrogenase. Nat Genet 10: 394-399, 1995.
202. Munzberg H, MyersMG Jr. Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 8: 566-570, 2005.
203. Murphy SR, LaMarca BB, Cockrell K, Granger JP. Role of endothelin in mediating soluble fms-like tyrosine kinase 1-induced hypertension in pregnant rats. Hypertension 55: 394-398, 2010.
204. Nakamura T, Alberola AM, Granger JP. Role of renal interstitial pressure as a mediator of sodium retention during systemic blockade of nitric oxide. Hypertension 21: 956-960, 1993.
205. Nakov R, Pfarr E, Eberle S. Darusentan: An effective endothelinA receptor antagonist for treatment of hypertension. Am J Hypertens 15: 583-589, 2002.
206. Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL, Brown M, Dominiczak A, Newhouse SJ, Samani NJ, Webster J, Zeggini E, Beckmann JS, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G,WaterworthDM,Yuan X, Groop L, Orho-MelanderM,Allione A, Di GA, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C,Vineis P, Barroso I, Sandhu MS, Luben RN, Crawford GJ, Jousilahti P, Perola M, Boehnke M, Bonnycastle LL, Collins FS, Jackson AU, Mohlke KL, Stringham HM, Valle TT, Willer CJ, Bergman RN, Morken MA, Doring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A,Wichmann HE, Kathiresan S, Marrugat J, O'Donnell CJ, Schwartz SM, Siscovick DS, Subirana I, Freimer NB, Hartikainen AL, McCarthy MI, O'Reilly PF, Peltonen L, Pouta A, de Jong PE, Snieder H, van Gilst W.H., Clarke R, Goel A, Hamsten A, Peden JF, Seedorf U, Syvanen AC, Tognoni G, Lakatta EG, Sanna S, Scheet P, Schlessinger D, Scuteri A, Dorr M, Ernst F, Felix SB, Homuth G, Lorbeer R, Reffelmann T, Rettig R, Volker U, Galan P, Gut IG, Hercberg S, Lathrop GM, Zelenika D, Deloukas P, Soranzo N, Williams FM, Zhai G, Salomaa V, Laakso M, Elosua R, Forouhi NG, Volzke H, Uiterwaal CS, van der Schouw YT, Numans ME, Matullo G, Navis G, Berglund G, Bingham SA, Kooner JS, Connell JM, Bandinelli S, Ferrucci L, Watkins H, Spector TD, Tuomilehto J, Altshuler D, Strachan DP, Laan M, Meneton P, Wareham NJ, Uda M, Jarvelin MR, Mooser V, Melander O, Loos RJ, Elliott P, Abecasis GR, Caulfield M, Munroe PB. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 41: 666-676, 2009.
207. Norman RA, Jr., Dzielak DJ. Role of renal nerves in onset and maintenance of spontaneous hypertension. Am J Physiol 243: H284-H288, 1982.
208. Norman RA, Jr., Galloway PG, Dzielak DJ, Huang M. Mechanisms of partial renal infarct hypertension. J Hypertens 6: 397-403, 1988.
209. O'Shaughnessy KM, Karet FE. Salt handling and hypertension. J Clin Invest 113: 1075-1081, 2004.
210. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 295: 1549-1555, 2006.
211. Okuda T, Grollman A. Passive transfer of autoimmune induced hypertension in the rat by lymph node cells. Tex Rep Biol Med 25: 257-264, 1967.
212. Ong KL, Cheung BM, Man YB, Lau CP, Lam KS. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension 49: 69-75, 2007.
213. Orfila C, Damase-Michel C, Lepert JC, Montastruc JL, Suc JM, Montastruc P, Girolami JP. Renal morphological changes after sinoaortic denervation in dogs. Hypertension 21: 758-766, 1993.
214. Orshal JM, Khalil RA. Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant rats. Hypertension 43: 434-444, 2004.
215. Ortiz PA, Garvin JL. Role of nitric oxide in the regulation of nephron transport. Am J Physiol Renal Physiol 282: F777-F784, 2002.
216. Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 84: 3686-3695, 1999.
217. Ozbey N, Sencer E, Molvalilar S, Orhan Y. Body fat distribution and cardiovascular disease risk factors in pre-and postmenopausal obese women with similar BMI. Endocr J 49: 503-509, 2002.
218. Parving HH, Hommel E, Smidt UM. Protection of kidney function and decrease in albuminuria by captopril in insulin dependent diabetics with nephropathy. BMJ 297: 1086-1091, 1988.
219. Patel A, Layne S, Watts D, Kirchner KA. L-arginine administration normalizes pressure natriuresis in hypertensive Dahl rats. Hypertension 22: 863-869, 1993.
220. Pechanova O, Simko F. Chronic antioxidant therapy fails to ameliorate hypertension: Potential mechanisms behind. J Hypertens Suppl 27: S32-S36, 2009.
221. Perkovic V, Huxley R,Wu Y, PrabhakaranD,MacMahon S. The burden of blood pressure-related disease:Aneglected priority for global health. Hypertension 50: 991-997, 2007.
222. Peterson JR, Burmeister MA, Tian X, Zhou Y, Guruju MR, Stupinski JA, Sharma RV, Davisson RL. Genetic silencing of Nox2 and Nox4 reveals differential roles of these NADPH oxidase homologues in the vasopressor and dipsogenic effects of brain angiotensin II. Hypertension 54: 1106-1114, 2009.
223. Pollock DM, Pollock JS. Evidence for endothelin involvement in the response to high salt. Am J Physiol Renal Physiol 281: F144-F150, 2001.
224. Pontiroli AE, Alberetto M, Pozza G. Patients with insulinoma show insulin resistance in the absence of arterial hypertension. Diabetologia 35: 294-295, 1992.
225. Praga M, Hernandez E, Herrero JC, Morales E, Revilla Y, Diaz-Gonzalez R, Rodicio JL. Influence of obesity on the appearance of proteinuria and renal insufficiency after unilateral nephrectomy. Kidney Int 58: 2111-2118, 2000.
226. Prasad VS, Palaniswamy C, Frishman WH. Endothelin as a clinical target in the treatment of systemic hypertension. Cardiol Rev 17: 181-191, 2009.
227. Rahmouni K, Correia ML, Haynes WG, Mark AL. Obesity-associated hypertension: New insights into mechanisms. Hypertension 45: 9-14, 2005.
228. Reaven GM. The metabolic syndrome: Is this diagnosis necessary? Am J Clin Nutr 83: 1237-1247, 2006.
229. Reckelhoff JF, Fortepiani LA. Novel mechanisms responsible for postmenopausal hypertension. Hypertension 43: 918-923, 2004.
230. Reckelhoff JF, Romero JC. Role of oxidative stress in angiotensininduced hypertension. Am J Physiol Regul Integr Comp Physiol 284: R893-R912, 2003.
231. Reisin E, Weir MR, Falkner B, Hutchinson HG, Anzalone DA, Tuck ML. Lisinopril versus hydrochlorothiazide in obese hypertensive patients: A multicenter placebo-controlled trial. Treatment in Obese Patients With Hypertension (TROPHY) Study Group. Hypertension 30: 140-145, 1997.
232. Roberts JM, Pearson GD, Cutler JA, Lindheimer MD. Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy. Hypertens Pregnancy 22: 109-127, 2003.
233. Robles RG, Villa E, Santirso R, Martinez J, Ruilope LM, Cuesta C, Sancho JM. Effects of captopril on sympathetic activity, lipid and carbohydrate metabolism in a model of obesity-induced hypertension in dogs. Am J Hypertens 6: 1009-1015, 1993.
234. Rocchini AP. The influence of obesity in hypertension. News Physiol Sci 5: 245-249, 1990.
235. Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 82: 131-185, 2002.
236. Romero JC,Reckelhoff JF. State-of-the-Art lecture.Role of angiotensin and oxidative stress in essential hypertension. Hypertension 34: 943-949, 1999.
237. Romero-Corral A, Caples SM, Lopez-Jimenez F, Somers VK. Interactions between obesity and obstructive sleep apnea: Implications for treatment. Chest 137: 711-719, 2010.
238. Rumantir MS, Vaz M, Jennings GL, Collier G, Kaye DM, Seals DR, Wiesner GH, Brunner-La Rocca HP, Esler MD. Neural mechanisms in human obesity-related hypertension. J Hypertens 17: 1125-1133, 1999.
239. Salom MG, Lahera V, Miranda-Guardiola F, Romero JC. Blockade of pressure natriuresis induced by inhibition of renal synthesis of nitric oxide in dogs. Am J Physiol 262: F718-F722, 1992.
240. Sanders PW. Salt intake, endothelial cell signaling, and progression of kidney disease. Hypertension 43: 142-146, 2004.
241. Sattar N, McCarey DW, Capell H, McInnes IB. Explaining how "highgrade" systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation 108: 2957-2963, 2003.
242. Sawicki PT, Baba T, Berger M, Starke A. Normal blood pressure in patients with insulinoma despite hyperinsulinemia and insulin resistance. J Am Soc Nephrol 3: S64-S68, 1992.
243. Schiffrin EL. Vascular endothelin in hypertension. Vascul Pharmacol 43: 19-29, 2005.
244. Schlaich MP, Sobotka PA, Krum H, Whitbourn R, Walton A, Esler MD. Renal denervation as a therapeutic approach for hypertension: Novel implications for an old concept. Hypertension 54: 1195-1201, 2009.
245. Schnackenberg C, Patel AR, Kirchner KA, Granger JP. Nitric oxide, the kidney and hypertension. Clin Exp Pharmacol Physiol 24: 600-606, 1997.
246. Schnackenberg CG, Tabor BL, Strong MH, Granger JP. Inhibition of intrarenal NO stimulates renin secretion through a macula densamediated mechanism. Am J Physiol 272: R879-R886, 1997.
247. Sedeek MH, Llinas MT, Drummond H, Fortepiani L, Abram SR, Alexander BT, Reckelhoff JF, Granger JP. Role of reactive oxygen species in endothelin-induced hypertension. Hypertension 42: 806-810, 2003.
248. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 31: 409-414, 1998.
249. Shi H, Seeley RJ, Clegg DJ. Sexual differences in the control of energy homeostasis. Front Neuroendocrinol 30: 396-404, 2009.
250. Shultz PJ, Tolins JP. Adaptation to increased dietary salt intake in the rat. Role of endogenous nitric oxide. J Clin Invest 91: 642-650, 1993.
251. Sigmon DH, Beierwaltes WH. Nitric oxide influences blood flow distribution in renovascular hypertension. Hypertension 23: I34-I39, 1994.
252. Staff AC, Ranheim T, Khoury J, Henriksen T. Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia. Am J Obstet Gynecol 180: 587-592, 1999.
253. Stevens VJ, Obarzanek E, Cook NR, Lee IM, Appel LJ, Smith WD,Milas NC,Mattfeldt-BemanM, Belden L, Bragg C,Millstone M, Raczynski J, Brewer A, Singh B, Cohen J. Long-term weight loss and changes in blood pressure: Results of the Trials of Hypertension Prevention, phase II. Ann Intern Med 134: 1-11, 2001.
254. Stowasser M, Gordon RD, Tunny TJ, Klemm SA, Finn WL, Krek AL. Familial hyperaldosteronism type II: Five families with a new variety of primary aldosteronism. Clin Exp Pharmacol Physiol 19: 319-322, 1992.
255. Sugarman HJ, Windsor ACJ, Bessos MK, Wolfe L. Intra-abdominal pressure, sagittal abdominal diameter and obesity co-morbidity. J Intern Med 241: 71-79, 1997.
256. Svendsen UG. Evidence for an initial, thymus independent and a chronic, thymus dependent phase of DOCA and salt hypertension in mice. Acta Pathol Microbiol Scand A 84: 523-528, 1976.
257. Tallam LS, da Silva AA, Hall JE. Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin. Hypertension 48: 58-64, 2006.
258. Taniyama Y, Griendling KK. Reactive oxygen species in the vasculature: Molecular and cellular mechanisms. Hypertension 42: 1075-1081, 2003.
259. Thurston H, Bing RF, Marks ES, Swales JD. Response of chronic renovascular hypertension to surgical correction or prolonged blockade of the renin-angiotensin system by two inhibitors in the rat. Clin Sci (Lond) 58: 15-20, 1980.
260. Vesely DL. Atrial natriuretic peptides in pathophysiological diseases. Cardiovasc Res 51: 647-658, 2001.
261. Vongpatanasin W. Autonomic regulation of blood pressure in menopause. Semin Reprod Med 27: 338-345, 2009.
262. Weber MA, Black H, Bakris G, Krum H, Linas S, Weiss R, Linseman JV, Wiens BL, Warren MS, Lindholm LH. A selective endothelinreceptor antagonist to reduce blood pressure in patients with treatmentresistant hypertension:Arandomised, double-blind, placebo-controlled trial. Lancet 374: 1423-1431, 2009.
263. Weinberger MH. Salt sensitivity of blood pressure in humans. Hypertension 27: 481-490, 1996.
264. Weinberger MH, Fineberg NS, Fineberg SE, Weinberger M. Salt sensitivity, pulse pressure, and death in normal and hypertensive humans. Hypertension 37: 429-432, 2001.
265. Weyer C, Pratley RE, Snitker S, Spraul M, Ravussin E, Tataranni PA. Ethnic differences in insulinemia and sympathetic tone as links between obesity and blood pressure. Hypertension 36: 531-537, 2000.
266. Whelton PK. Epidemiology of hypertension. Lancet 344: 101-106, 1994.
267. White FN, Grollman A. Autoimmune factors associated with infarction of the kidney. Nephron 1: 93-102, 1964.
268. Whitworth JA, Mangos GJ, Kelly JJ. Cushing, cortisol, and cardiovascular disease. Hypertension 36: 912-916, 2000.
269. Wilcox CS. Reactive oxygen species: Roles in blood pressure and kidney function. Curr Hypertens Rep 4: 160-166, 2002.
270. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP. Human hypertension caused by mutations in WNK kinases. Science 293: 1107-1112, 2001.
271. WoffordMR, Anderson DC, Jr., Brown CA, JonesDW, Miller ME,Hall JE. Antihypertensive effect of alpha-and beta-adrenergic blockade in obese and lean hypertensive subjects. Am J Hypertens 14: 694-698, 2001.
272. Wolk R, Shamsuzzaman AS, Somers VK. Obesity, sleep apnea, and hypertension. Hypertension 42: 1067-1074, 2003.
273. Wustmann K, Kucera JP, Scheffers I, Mohaupt M, Kroon AA, de Leeuw PW, Schmidli J, Allemann Y, Delacretaz E. Effects of chronic baroreceptor stimulation on the autonomic cardiovascular regulation in patients with drug-resistant arterial hypertension. Hypertension 54: 530-536, 2009.
274. Yach D, Stuckler D, Brownell KD. Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. NatMed 12: 62-66, 2006.
275. Yanagisawa M,Kurihara H, Kimura S, Tomobe Y,KobayashiM,Mitsui Y, Yazaki Y, Goto K,Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411-415, 1988.
276. Yanes LL, Reckelhoff JF. Postmenopausal hypertension. Am J Hypertens 24: 740-749, 2011.
277. Yang R, Barouch LA. Leptin signaling and obesity: Cardiovascular consequences. Circ Res 101: 545-559, 2007.
278. Young WF Jr. Minireview: Primary aldosteronism-changing concepts in diagnosis and treatment. Endocrinology 144: 2208-2213, 2003.
279. Zandi-Nejad K, Luyckx VA, Brenner BM. Adult hypertension and kidney disease: The role of fetal programming. Hypertension 47: 502-508, 2006.
280. Zhang EE, Chapeau E, Hagihara K, Feng GS. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci U S A 101: 16064-16069, 2004.
281. Zhang F, Sowers JR, Ram JL, Standley PR, Peuler JD. Effects of pioglitazone on calcium channels in vascular smooth muscle. Hypertension 24: 170-175, 1994.
282. Zhou CC, Zhang Y, Irani RA, Zhang H, Mi T, Popek EJ, Hicks MJ, Ramin SM, Kellems RE, Xia Y. Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice. Nat Med 14: 855-862, 2008.
283. Zhu X, Wu S, Dahut WL, Parikh CR. Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: Systematic review and meta-analysis. Am J Kidney Dis 49: 186-193, 2007.