Role of hypothalamic melanocortin 3/4-receptors in mediating chronic cardiovascular, renal, and metabolic actions of leptin

Hypertension

Volumn 43, Issue 6, 2004, Pages 1312-1317

  Da Silva, Alexandre A ^a,b   Kuo, Jay J ^a   Hall, John E ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Blood pressure; Hypertension; Insulin; Obesity

Indexed keywords

INSULIN; LEPTIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE];

ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; FOOD INTAKE; HEART RATE; HYPOTHALAMUS; INSULIN BLOOD LEVEL; KIDNEY METABOLISM; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SATIETY; WEIGHT REDUCTION;

ANIMALS; BLOOD PRESSURE; DIURESIS; EATING; HEART RATE; HEMODYNAMIC PROCESSES; HYPOTHALAMUS; INFUSION PUMPS, IMPLANTABLE; INSULIN; KIDNEY; LEPTIN; MALE; MELANOCYTE-STIMULATING HORMONES; NATRIURESIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; RENIN; SATIETY RESPONSE; WEIGHT GAIN;

EID: 2542465882     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000128421.23499.b9     Document Type: Article

References (23)

1. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404:661-671.
2. Haynes WG, Sivitz WI, Morgan DA, Walsh SA, Mark AL. Sympathetic and cardiorenal actions of leptin. Hypertension. 1997;30:619-623.
3. Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest. 1997;100:270-278.
4. Dunbar JC, Hu Y, Lu H. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes. 1997;46:2040-2043.
5. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension. 1998;31:409-414.
6. Carlyle M, Jones OB, Kuo JJ, Hall JE. Chronic cardiovascular and renal actions of leptin: role of adrenergic activity. Hypertension. 2002;39:496-501.
7. Castro MG, Morrison E. Post-translational processing of proopiomelanocortin in the pituitary and in the brain. Crit Rev Neurobiol. 1997;11:35-57.
8. Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell. 2001;23:531-543.
9. Seeley RJ, Yagaloff KA, Fisher SL, Burn P, Thiele TE, van Dijk G, Baskin DG, Schwartz MW. Melanocortin receptors in leptin effects. Nature. 1997;390:349.
10. Satoh N, Ogawa Y, Katsuura G, Numata Y, Masuzaki H, Yoshimasa Y, Nakao K. Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system. Neurosci Lett. 1998;249:107-110.
11. Haynes WG, Morgon DA, Djalali A, Sivitz WI, Mark AL. Interaction between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension. 1999;33:542-547.
12. Rahmouni K, Haynes WG, Morgan DA, Mark AL. Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. J Neurosci. 2003;23(14):5998-6004.
13. Kuo JJ, Silva AA, Hall JE. Hypothalamic melanocortin receptors and chronic regulation of arterial pressure and renal function. Hypertension. 2003;41:768-774.
14. Hall JE, Hildebrandt DA, Kuo JJ. Obesity hypertension: role of leptin and sympathetic nervous system. Am J Hypertens. 2001;14:103S-115S.
15. Wofford WG, Anderson DC, Brown CA, Jones DW, Miller MM, Hall JE. Antihypertensive effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects. Am J Hypertens. 2001;14:694-698.
16. Muzumbar R, Ma X, Yang X, Atzmon G, Bernstein J, Karkanias G, Barzilai N. Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. FASEB J. 2003;17(9):1130-1132.
17. Obici S, Feng Z, Tan J, Liu L, Karkanias G, Rossetti L. Central melanocortin receptors regulate insulin action. J Clin Invest. 2001;108:1079-1085.
18. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 1997;88:131-141.
19. Hidaka S, Yoshimatsu H, Kondou S, Tsuruta Y, Oka K, Noguchi H, Okamoto K, Sakino H, Teshima Y, Okeda T, Sakata T. Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats. FASEB J. 2002;16(6):509-518.
20. Lin C, Higginbotham DA, Judd RL, White BD. Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats. Am J Physiol Endocrinol Metab. 2002;282:E1084-E1091.
21. Rahmouni K, Haynes WG, Morgan DA, Mark AL. Selective resistance to central neural administration of leptin in agouti obese mice. Hypertension. 2002;39:486-490.
22. Tsuruta Y, Yoshimatsu H, Hidaka S, Kondou S, Okamoto K, Sakata T. Hyperleptinemia in A(y)/a mice upregulates arcuate cocaine- and amphetamine-regulated transcript expression. Am J Physiol Endocrinol Metab. 2002;282:E967-E973.
23. Kim MS, Rossi M, Abbott CR, AlAhmed SH, Smith DM, Bloom SR. Sustained orexigenic effect of Agouti related protein may be not mediated by the melanocortin 4 receptor. Peptides. 2002;23:1069-1076.