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Volumn 19, Issue 18, 2013, Pages 3210-3214

Cdc20: A potential novel therapeutic target for cancer treatment

Author keywords

Cancer; Cdc20; Cell growth; Oncogene; Therapy; Ubiquitination

Indexed keywords

ANTINEOPLASTIC AGENT; CELL CYCLE PROTEIN 20; CELL CYCLE PROTEIN 20 INHIBITOR; UNCLASSIFIED DRUG;

EID: 84878833718     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612811319180005     Document Type: Review
Times cited : (102)

References (54)
  • 1
    • 33748991453 scopus 로고    scopus 로고
    • Ubiquitin and ubiquitin-likeproteins in cancer pathogenesis
    • Hoeller D, Hecker CM, Dikic I. Ubiquitin and ubiquitin-likeproteins in cancer pathogenesis. Nat Rev Cancer 2006; 6: 776-88.
    • (2006) Nat Rev Cancer , vol.6 , pp. 776-788
    • Hoeller, D.1    Hecker, C.M.2    Dikic, I.3
  • 2
    • 44349122993 scopus 로고    scopus 로고
    • Deregulated proteolysis by the F-boxproteins SKP2 and beta-TrCP: Tipping the scales of cancer
    • Frescas D, Pagano M. Deregulated proteolysis by the F-boxproteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer 2008; 8: 438-49.
    • (2008) Nat Rev Cancer , vol.8 , pp. 438-449
    • Frescas, D.1    Pagano, M.2
  • 3
    • 33646345376 scopus 로고    scopus 로고
    • Ubiquitin ligases: Cell-cycle controland cancer
    • Nakayama K I, Nakayama K. Ubiquitin ligases: cell-cycle controland cancer. Nat Rev Cancer 2006; 6: 369-81.
    • (2006) Nat Rev Cancer , vol.6 , pp. 369-381
    • Nakayama, K.I.1    Nakayama, K.2
  • 5
    • 77958465476 scopus 로고    scopus 로고
    • APC/C-Cdh1:From cell cycle to cellular differentiation and genomic integrity
    • Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y. APC/C-Cdh1:from cell cycle to cellular differentiation and genomic integrity. Cell Cycle 2010; 9: 3904-12.
    • (2010) Cell Cycle , vol.9 , pp. 3904-3912
    • Qiao, X.1    Zhang, L.2    Gamper, A.M.3    Fujita, T.4    Wan, Y.5
  • 6
    • 80054757923 scopus 로고    scopus 로고
    • Non-mitotic functions ofthe Anaphase-Promoting Complex
    • Eguren M, Manchado E, Malumbres M. Non-mitotic functions ofthe Anaphase-Promoting Complex. Semin Cell Dev Biol 2011; 22: 572-8.
    • (2011) Semin Cell Dev Biol , vol.22 , pp. 572-578
    • Eguren, M.1    Manchado, E.2    Malumbres, M.3
  • 7
    • 79955863105 scopus 로고    scopus 로고
    • Targeting the anaphase promotingcomplex: Common pathways for viral infection and cancer therapy
    • Smolders L, Teodoro JG. Targeting the anaphase promotingcomplex: common pathways for viral infection and cancer therapy. Expert Opin Ther Targets 2011; 15: 767-80.
    • (2011) Expert Opin Ther Targets , vol.15 , pp. 767-780
    • Smolders, L.1    Teodoro, J.G.2
  • 8
    • 0014804012 scopus 로고
    • Genetic control of the cell-divisioncycle in yeast. I. Detection of mutants
    • Hartwell LH, Culotti J, Reid B. Genetic control of the cell-divisioncycle in yeast. I. Detection of mutants. Proc Natl Acad Sci USA 1970; 66: 352-9.
    • (1970) Proc Natl Acad Sci USA , vol.66 , pp. 352-359
    • Hartwell, L.H.1    Culotti, J.2    Reid, B.3
  • 9
    • 0015847513 scopus 로고
    • Genetic Controlof the Cell Division Cycle in Yeast V. Genetic Analysis of Cdc Mutants
    • Hartwell LH, Mortimer RK, Culotti J, Culotti M. Genetic Controlof the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants. Genetics 1973; 74: 267-86.
    • (1973) Genetics , vol.74 , pp. 267-286
    • Hartwell, L.H.1    Mortimer, R.K.2    Culotti, J.3    Culotti, M.4
  • 10
    • 0035865138 scopus 로고    scopus 로고
    • Securin degradation is mediated by fzy and fzr,and is required for complete chromatid separation but not for cytokinesis
    • Zur A, Brandeis M. Securin degradation is mediated by fzy and fzr,and is required for complete chromatid separation but not for cytokinesis. EMBO J 2001; 20: 792-801.
    • (2001) EMBO J , vol.20 , pp. 792-801
    • Zur, A.1    Brandeis, M.2
  • 11
    • 0001598759 scopus 로고    scopus 로고
    • Cdc20 is essential for thecyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast
    • Lim H H, Goh P Y, Surana U. Cdc20 is essential for thecyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast. Curr Biol 1998; 8: 231-4.
    • (1998) Curr Biol , vol.8 , pp. 231-234
    • Lim, H.H.1    Goh, P.Y.2    Surana, U.3
  • 12
    • 0344578064 scopus 로고    scopus 로고
    • APC(Cdc20)promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5
    • Shirayama M, Toth A, Galova M, Nasmyth K. APC(Cdc20)promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5. Nature 1999; 402: 203-7.
    • (1999) Nature , vol.402 , pp. 203-207
    • Shirayama, M.1    Toth, A.2    Galova, M.3    Nasmyth, K.4
  • 13
    • 0035795408 scopus 로고    scopus 로고
    • Anaphase-promotingcomplex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
    • Geley S, Kramer E, Gieffers C, et al. Anaphase-promotingcomplex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. J Cell Biol 2001; 153: 137-48.
    • (2001) J Cell Biol , vol.153 , pp. 137-148
    • Geley, S.1    Kramer, E.2    Gieffers, C.3
  • 14
    • 0034673282 scopus 로고    scopus 로고
    • Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex
    • Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Hatakeyama M. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex. Biochem Biophys Res Commun 2000; 268: 530-4.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 530-534
    • Ohtoshi, A.1    Maeda, T.2    Higashi, H.3    Ashizawa, S.4    Hatakeyama, M.5
  • 15
    • 0037126610 scopus 로고    scopus 로고
    • APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box
    • Hames RS, Wattam SL, Yamano H, Bacchieri R, Fry AM. APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box. EMBO J 2001; 20: 7117-27.
    • (2001) EMBO J , vol.20 , pp. 7117-7127
    • Hames, R.S.1    Wattam, S.L.2    Yamano, H.3    Bacchieri, R.4    Fry, A.M.5
  • 16
    • 34547174700 scopus 로고    scopus 로고
    • APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase
    • Amador V, Ge S, Santamaria PG, Guardavaccaro D, Pagano M.APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell 2007; 27: 462-73.
    • (2007) Mol Cell , vol.27 , pp. 462-473
    • Amador, V.1    Ge, S.2    Santamaria, P.G.3    Guardavaccaro, D.4    Pagano, M.5
  • 17
    • 77954884045 scopus 로고    scopus 로고
    • Phosphorylationof Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest
    • Harley ME, Allan LA, Sanderson HS, Clarke PR. Phosphorylationof Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. EMBO J 2010; 29: 2407-20.
    • (2010) EMBO J , vol.29 , pp. 2407-2420
    • Harley, M.E.1    Allan, L.A.2    Sanderson, H.S.3    Clarke, P.R.4
  • 18
    • 67649424560 scopus 로고    scopus 로고
    • p21 in cancer: Intricate networks and multipleactivities
    • Abbas T, Dutta A. p21 in cancer: intricate networks and multipleactivities. Nat Rev Cancer 2009; 9: 400-14.
    • (2009) Nat Rev Cancer , vol.9 , pp. 400-414
    • Abbas, T.1    Dutta, A.2
  • 19
    • 0141505118 scopus 로고    scopus 로고
    • S-phase checkpointcontrols mitosis via an APC-independent Cdc20p function
    • Clarke DJ, Segal M, Andrews CA, et al. S-phase checkpointcontrols mitosis via an APC-independent Cdc20p function. Nat Cell Biol 2003; 5: 928-35.
    • (2003) Nat Cell Biol , vol.5 , pp. 928-935
    • Clarke, D.J.1    Segal, M.2    Andrews, C.A.3
  • 20
    • 40449137094 scopus 로고    scopus 로고
    • CDC20, a potentialcancer therapeutic target, is negatively regulated by p53
    • Kidokoro T, Tanikawa C, Furukawa Y, et al. CDC20, a potentialcancer therapeutic target, is negatively regulated by p53. Oncogene 2008; 27: 1562-71.
    • (2008) Oncogene , vol.27 , pp. 1562-1571
    • Kidokoro, T.1    Tanikawa, C.2    Furukawa, Y.3
  • 21
    • 0032525783 scopus 로고    scopus 로고
    • The checkpoint protein MAD2 andthe mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
    • Fang G, Yu H, Kirschner M W. The checkpoint protein MAD2 andthe mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev 1998; 12: 1871-83.
    • (1998) Genes Dev , vol.12 , pp. 1871-1883
    • Fang, G.1    Yu, H.2    Kirschner, M.W.3
  • 22
    • 0343986407 scopus 로고    scopus 로고
    • Structure of the Mad2 spindleassembly checkpoint protein and its interaction with Cdc20
    • Luo X, Fang G, Coldiron M, et al. Structure of the Mad2 spindleassembly checkpoint protein and its interaction with Cdc20. Nat Struct Biol 2000; 7: 224-9.
    • (2000) Nat Struct Biol , vol.7 , pp. 224-229
    • Luo, X.1    Fang, G.2    Coldiron, M.3
  • 23
    • 0035370009 scopus 로고    scopus 로고
    • Emi1 is a mitotic regulatorthat interacts with Cdc20 and inhibits the anaphase promoting complex
    • Reimann JD, Freed E, Hsu JY, et al. Emi1 is a mitotic regulatorthat interacts with Cdc20 and inhibits the anaphase promoting complex. Cell 2001; 105: 645-55.
    • (2001) Cell , vol.105 , pp. 645-655
    • Reimann, J.D.1    Freed, E.2    Hsu, J.Y.3
  • 24
    • 0035893917 scopus 로고    scopus 로고
    • Emi1regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins
    • Reimann JD, Gardner BE, Margottin-Goguet F, Jackson PK. Emi1regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins. Genes Dev 2001; 15: 3278-85.
    • (2001) Genes Dev , vol.15 , pp. 3278-3285
    • Reimann, J.D.1    Gardner, B.E.2    Margottin-Goguet, F.3    Jackson, P.K.4
  • 25
    • 0033620688 scopus 로고    scopus 로고
    • Budding yeast Bub2is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2
    • Fraschini R, Formenti E, Lucchini G, Piatti S. Budding yeast Bub2is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2. J Cell Biol 1999; 145: 979-91.
    • (1999) J Cell Biol , vol.145 , pp. 979-991
    • Fraschini, R.1    Formenti, E.2    Lucchini, G.3    Piatti, S.4
  • 26
    • 34247376926 scopus 로고    scopus 로고
    • Anaphase initiation isregulated by antagonistic ubiquitination and deubiquitination activities
    • Stegmeier F, Rape M, Draviam VM, et al. Anaphase initiation isregulated by antagonistic ubiquitination and deubiquitination activities. Nature 2007; 446: 876-81.
    • (2007) Nature , vol.446 , pp. 876-881
    • Stegmeier, F.1    Rape, M.2    Draviam, V.M.3
  • 27
    • 1642602695 scopus 로고    scopus 로고
    • The tumour suppressorRASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex
    • Song MS, Song SJ, Ayad NG, et al. The tumour suppressorRASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol 2004; 6: 129-37.
    • (2004) Nat Cell Biol , vol.6 , pp. 129-137
    • Song, M.S.1    Song, S.J.2    Ayad, N.G.3
  • 28
    • 84865618134 scopus 로고    scopus 로고
    • The cellular functions of RASSF1A and itsinactivation in prostate cancer
    • Amin KS, Banerjee PP. The cellular functions of RASSF1A and itsinactivation in prostate cancer. J Carcinog 2012; 11: 3.
    • (2012) J Carcinog , vol.11 , pp. 3
    • Amin, K.S.1    Banerjee, P.P.2
  • 29
    • 79952306961 scopus 로고    scopus 로고
    • The prognostic value of RASSF1Apromoter hypermethylation in non-small cell lung carcinoma: A systematic review and meta-analysis
    • Wang J, Wang B, Chen X, Bi J. The prognostic value of RASSF1Apromoter hypermethylation in non-small cell lung carcinoma: a systematic review and meta-analysis. Carcinogenesis 2011; 32: 411-6.
    • (2011) Carcinogenesis , vol.32 , pp. 411-416
    • Wang, J.1    Wang, B.2    Chen, X.3    Bi, J.4
  • 30
    • 33744505111 scopus 로고    scopus 로고
    • Nore1 andRASSF1 regulation of cell proliferation and of the MST1/2 kinases
    • Avruch J, Praskova M, Ortiz-Vega S, Liu M, Zhang XF. Nore1 andRASSF1 regulation of cell proliferation and of the MST1/2 kinases. Methods Enzymol 2006; 407: 290-310.
    • (2006) Methods Enzymol , vol.407 , pp. 290-310
    • Avruch, J.1    Praskova, M.2    Ortiz-Vega, S.3    Liu, M.4    Zhang, X.F.5
  • 31
    • 65549154498 scopus 로고    scopus 로고
    • Aurora A regulatesprometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity
    • Song SJ, Song MS, Kim SJ, et al. Aurora A regulatesprometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity. Cancer Res 2009; 69: 2314-23.
    • (2009) Cancer Res , vol.69 , pp. 2314-2323
    • Song, S.J.1    Song, M.S.2    Kim, S.J.3
  • 32
    • 84866850568 scopus 로고    scopus 로고
    • The APC/C Subunit Mnd2/Apc15Promotes Cdc20 Autoubiquitination and Spindle Assembly Checkpoint Inactivation
    • Foster SA, Morgan DO. The APC/C Subunit Mnd2/Apc15Promotes Cdc20 Autoubiquitination and Spindle Assembly Checkpoint Inactivation. Mol Cell 2012.
    • (2012) Mol Cell
    • Foster, S.A.1    Morgan, D.O.2
  • 33
    • 80053561641 scopus 로고    scopus 로고
    • APC15drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment
    • Mansfeld J, Collin P, Collins MO, Choudhary JS, Pines J. APC15drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Nat Cell Biol 2011; 13: 1234-43.
    • (2011) Nat Cell Biol , vol.13 , pp. 1234-1243
    • Mansfeld, J.1    Collin, P.2    Collins, M.O.3    Choudhary, J.S.4    Pines, J.5
  • 34
    • 80054769188 scopus 로고    scopus 로고
    • SIRT2 maintainsgenome integrity and suppresses tumorigenesis through regulating APC/C activity
    • Kim HS, Vassilopoulos A, Wang RH, et al. SIRT2 maintainsgenome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell 2011; 20: 487-99.
    • (2011) Cancer Cell , vol.20 , pp. 487-499
    • Kim, H.S.1    Vassilopoulos, A.2    Wang, R.H.3
  • 35
    • 84864881214 scopus 로고    scopus 로고
    • Dephosphorylation of Cdc20is required for its C-box-dependent activation of the APC/C
    • Labit H, Fujimitsu K, Bayin NS, et al. Dephosphorylation of Cdc20is required for its C-box-dependent activation of the APC/C. EMBO J 2012; 31: 3351-62.
    • (2012) EMBO J , vol.31 , pp. 3351-3362
    • Labit, H.1    Fujimitsu, K.2    Bayin, N.S.3
  • 36
    • 78649846540 scopus 로고    scopus 로고
    • MicroRNA-449a levels increase by several orders of magnitude duringmucociliary differentiation of airway epithelia
    • Lize M, Herr C, Klimke A, Bals R, Dobbelstein M. MicroRNA-449a levels increase by several orders of magnitude duringmucociliary differentiation of airway epithelia. Cell Cycle 2010; 9: 4579-83.
    • (2010) Cell Cycle , vol.9 , pp. 4579-4583
    • Lize, M.1    Herr, C.2    Klimke, A.3    Bals, R.4    Dobbelstein, M.5
  • 37
    • 84864391525 scopus 로고    scopus 로고
    • Coordinated effects ofmicroRNA-494 induce G 2/M arrest in human cholangiocarcinoma
    • Yamanaka S, Campbell NR, An F, et al. Coordinated effects ofmicroRNA-494 induce G 2/M arrest in human cholangiocarcinoma. Cell Cycle 2012; 11.
    • (2012) Cell Cycle , pp. 11
    • Yamanaka, S.1    Campbell, N.R.2    An, F.3
  • 38
    • 80052041185 scopus 로고    scopus 로고
    • MicroRNA regulation byRNA-binding proteins and its implications for cancer
    • van Kouwenhove M, Kedde M, Agami R. MicroRNA regulation byRNA-binding proteins and its implications for cancer. Nat Rev Cancer 2011; 11: 644-56.
    • (2011) Nat Rev Cancer , vol.11 , pp. 644-656
    • van Kouwenhove, M.1    Kedde, M.2    Agami, R.3
  • 39
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs microRNAs with a rolein cancer
    • Esquela-Kerscher A, Slack F J. Oncomirs microRNAs with a rolein cancer. Nat Rev Cancer 2006; 6: 259-69.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 40
    • 61449172876 scopus 로고    scopus 로고
    • Strong inducible knockdownof APC/CCdc20 does not cause mitotic arrest in human somatic cells
    • Baumgarten AJ, Felthaus J, Wasch R. Strong inducible knockdownof APC/CCdc20 does not cause mitotic arrest in human somatic cells. Cell Cycle 2009; 8: 643-6.
    • (2009) Cell Cycle , vol.8 , pp. 643-646
    • Baumgarten, A.J.1    Felthaus, J.2    Wasch, R.3
  • 41
    • 34247635494 scopus 로고    scopus 로고
    • Loss of Cdc20 causes a securin-dependentmetaphase arrest in two-cell mouse embryos
    • Li M, York JP, Zhang P. Loss of Cdc20 causes a securin-dependentmetaphase arrest in two-cell mouse embryos. Mol Cell Biol 2007; 27: 3481-8.
    • (2007) Mol Cell Biol , vol.27 , pp. 3481-3488
    • Li, M.1    York, J.P.2    Zhang, P.3
  • 42
    • 78650004841 scopus 로고    scopus 로고
    • Targeting mitoticexit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55alpha,delta phosphatase
    • Manchado E, Guillamot M, de Carcer G, et al. Targeting mitoticexit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55alpha,delta phosphatase. Cancer Cell 2010; 18: 641-54.
    • (2010) Cancer Cell , vol.18 , pp. 641-654
    • Manchado, E.1    Guillamot, M.2    de Carcer, G.3
  • 43
    • 84855871486 scopus 로고    scopus 로고
    • Ganodermanontriol (GDNT) exerts itseffect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA
    • Jiang J, Jedinak A, Sliva D. Ganodermanontriol (GDNT) exerts itseffect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA. Biochem Biophys Res Commun 2011; 415: 325-9.
    • (2011) Biochem Biophys Res Commun , vol.415 , pp. 325-329
    • Jiang, J.1    Jedinak, A.2    Sliva, D.3
  • 44
    • 79951786395 scopus 로고    scopus 로고
    • Identification andvalidation of genes involved in cervical tumourigenesis
    • Rajkumar T, Sabitha K, Vijayalakshmi N, et al. Identification andvalidation of genes involved in cervical tumourigenesis. BMC Cancer 2011; 11: 80.
    • (2011) BMC Cancer , vol.11 , pp. 80
    • Rajkumar, T.1    Sabitha, K.2    Vijayalakshmi, N.3
  • 45
    • 55849100002 scopus 로고    scopus 로고
    • Gene expression profilingin glioblastoma and immunohistochemical evaluation of IGFBP-2 and CDC20
    • Marucci G, Morandi L, Magrini E, et al. Gene expression profilingin glioblastoma and immunohistochemical evaluation of IGFBP-2 and CDC20. Virchows Arch 2008; 453: 599-609.
    • (2008) Virchows Arch , vol.453 , pp. 599-609
    • Marucci, G.1    Morandi, L.2    Magrini, E.3
  • 46
    • 33745451273 scopus 로고    scopus 로고
    • Tissue array analysis ofexpression microarray candidates identifies markers associated with tumor grade and outcome in serous epithelial ovarian cancer
    • Ouellet V, Guyot MC, Le Page C, et al. Tissue array analysis ofexpression microarray candidates identifies markers associated with tumor grade and outcome in serous epithelial ovarian cancer. Int J Cancer 2006; 119: 599-607.
    • (2006) Int J Cancer , vol.119 , pp. 599-607
    • Ouellet, V.1    Guyot, M.C.2    Le Page, C.3
  • 48
    • 19944425959 scopus 로고    scopus 로고
    • Identification of gastric cancer-related genes using a cDNA microarray containing novel expressed sequence tags expressed in gastric cancer cells
    • Kim JM, Sohn HY, Yoon SY, et al. Identification of gastric cancer-related genes using a cDNA microarray containing novel expressed sequence tags expressed in gastric cancer cells. Clin Cancer Res 2005; 11: 473-82.
    • (2005) Clin Cancer Res , vol.11 , pp. 473-482
    • Kim, J.M.1    Sohn, H.Y.2    Yoon, S.Y.3
  • 49
    • 84865135210 scopus 로고    scopus 로고
    • Overexpression of CDC20predicts poor prognosis in primary non-small cell lung cancer patients
    • Kato T, Daigo Y, Aragaki M, et al. Overexpression of CDC20predicts poor prognosis in primary non-small cell lung cancer patients. J Surg Oncol 2012.
    • (2012) J Surg Oncol
    • Kato, T.1    Daigo, Y.2    Aragaki, M.3
  • 50
    • 84859193216 scopus 로고    scopus 로고
    • Increased CDC20 expression isassociated with pancreatic ductal adenocarcinoma differentiation and progression
    • Chang DZ, Ma Y, Ji B, et al. Increased CDC20 expression isassociated with pancreatic ductal adenocarcinoma differentiation and progression. J Hematol Oncol 2012; 5: 15.
    • (2012) J Hematol Oncol , vol.5 , pp. 15
    • Chang, D.Z.1    Ma, Y.2    Ji, B.3
  • 51
    • 77957947338 scopus 로고    scopus 로고
    • Pharmacologic inhibition of theanaphase-promoting complex induces a spindle checkpointdependent mitotic arrest in the absence of spindle damage
    • Zeng X, Sigoillot F, Gaur S, et al. Pharmacologic inhibition of theanaphase-promoting complex induces a spindle checkpointdependent mitotic arrest in the absence of spindle damage. Cancer Cell 2010; 18: 382-95.
    • (2010) Cancer Cell , vol.18 , pp. 382-395
    • Zeng, X.1    Sigoillot, F.2    Gaur, S.3
  • 52
    • 84859021896 scopus 로고    scopus 로고
    • NAHA, a novelhydroxamic acid-derivative, inhibits growth and angiogenesis of breast cancer in vitro and in vivo
    • Jiang J, Thyagarajan-Sahu A, Krchnak V, et al. NAHA, a novelhydroxamic acid-derivative, inhibits growth and angiogenesis of breast cancer in vitro and in vivo. PLoS One 2012; 7: e34283.
    • (2012) PLoS One , vol.7
    • Jiang, J.1    Thyagarajan-Sahu, A.2    Krchnak, V.3
  • 53
    • 78649918823 scopus 로고    scopus 로고
    • Novel medicinal mushroom blend suppressesgrowth and invasiveness of human breast cancer cells
    • Jiang J, Sliva D. Novel medicinal mushroom blend suppressesgrowth and invasiveness of human breast cancer cells. Int J Oncol 2010; 37: 1529-36.
    • (2010) Int J Oncol , vol.37 , pp. 1529-1536
    • Jiang, J.1    Sliva, D.2
  • 54
    • 70349452101 scopus 로고    scopus 로고
    • Evidence that mitoticexit is a better cancer therapeutic target than spindle assembly
    • Huang H C, Shi J, Orth JD, Mitchison TJ. Evidence that mitoticexit is a better cancer therapeutic target than spindle assembly. Cancer Cell 2009; 16: 347-58.
    • (2009) Cancer Cell , vol.16 , pp. 347-358
    • Huang, H.C.1    Shi, J.2    Orth, J.D.3    Mitchison, T.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.