MicroRNA-449a levels increase by several orders of magnitude during mucociliary differentiation of airway epithelia

Cell Cycle

Volumn 9, Issue 22, 2010, Pages 4579-4583

  Lizé, Muriel ^a   Herr, Christian ^b,c   Klimke, Alexander ^d   Bals, Robert ^b,c   Dobbelstein, Matthias ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Biomedizinisches Forschungszentrum   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

Airway epithelia; Apoptosis; MicroRNA; miR 34; miR 449; Tobacco smoke

Indexed keywords

CELL CYCLE PROTEIN 20; CELL CYCLE PROTEIN 20B; MICRORNA; MICRORNA 449A; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXJ1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CELL CYCLE PROGRESSION; EPITHELIUM CELL; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; MOUSE; MUCOCILIARY TRANSPORT; NONHUMAN; PROTEIN EXPRESSION; TESTIS; TISSUE DISTRIBUTION; TOBACCO; UPREGULATION;

MURINAE; NICOTIANA TABACUM;

EID: 78649846540     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.22.13870     Document Type: Article

References (26)

1. Metzger RJ, Klein OD, Martin GR, Krasnow MA. The branching programme of mouse lung development. Nature 2008; 453:745-50.
2. Maeda Y, Dave V, Whitsett JA. Transcriptional control of lung morphogenesis. Physiol Rev 2007; 87:219-44.
3. Bals R, Beisswenger C, Blouquit S, Chinet T. Isolation and air-liquid interface culture of human large airway and bronchiolar epithelial cells. J Cyst Fibros 2004; 3:49-51.
4. Ross AJ, Dailey LA, Brighton LE, Devlin RB. Transcriptional profiling of mucociliary differentiation in human airway epithelial cells. Am J Respir Cell Mol Biol 2007; 37:169-85.
5. Brody SL, Yan XH, Wuerffel MK, Song SK, Shapiro SD. Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice. Am J Respir Cell Mol Biol 2000; 23:45-51.
6. Chen J, Knowles HJ, Hebert JL, Hackett BP. Mutation of the mouse hepatocyte nuclear factor/forkhead homolog 4 gene results in an absence of cilia and random left-right asymmetry. J Clin Invest 1998; 102:1077-82.
7. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004; 5:522-31.
8. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 2007; 129:1401-14.
9. Harris KS, Zhang Z, McManus MT, Harfe BD, Sun X. Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci USA 2006; 103:2208-13.
10. Bhaskaran M, Wang Y, Zhang H, Weng T, Baviskar P, Guo Y, et al. MicroRNA-127 modulates fetal lung development. Physiol Genomics 2009; 37:268-78.
11. Wang Y, Weng T, Gou D, Chen Z, Chintagari NR, Liu L. Identification of rat lung-specific microRNAs by micoRNA microarray: valuable discoveries for the facilitation of lung research. BMC Genomics 2007; 8:29.
12. Williams AE, Moschos SA, Perry MM, Barnes PJ, Lindsay MA. Maternally imprinted microRNAs are differentially expressed during mouse and human lung development. Dev Dyn 2007; 236:572-80.
13. Zhang H, Mishra A, Chintagari NR, Gou D, Liu L. Micro-RNA-375 inhibits lung surfactant secretion by altering cytoskeleton reorganization. IUBMB Life 62:78-83.
14. Dong J, Jiang G, Asmann YW, Tomaszek S, Jen J, Kislinger T, et al. MicroRNA Networks in Mouse Lung Organogenesis. PLoS One 5:10854.
15. Lu Y, Okubo T, Rawlins E, Hogan BL. Epithelial progenitor cells of the embryonic lung and the role of microRNAs in their proliferation. Proc Am Thorac Soc 2008; 5:300-4.
16. Hermeking H. p53 enters the microRNA world. Cancer Cell 2007; 12:414-8.
17. Lize M, Pilarski S, Dobbelstein M. E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis. Cell Death Differ 17:452-8.
18. Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, et al. miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev 2009; 23:2388-93.
19. Beisswenger C, Platz J, Seifart C, Vogelmeier C, Bals R. Exposure of differentiated airway epithelial cells to volatile smoke in vitro. Respiration 2004; 71:402-9.
20. Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, et al. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci USA 2009; 106:2319-24.
21. Heguy A, Harvey BG, Leopold PL, Dolgalev I, Raman T, Crystal RG. Responses of the human airway epithelium transcriptome to in vivo injury. Physiol Genomics 2007; 29:139-48.
22. Wang Y, Brahmakshatriya V, Zhu H, Lupiani B, Reddy SM, Yoon BJ, et al. Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approach. BMC Genomics 2009; 10:512.
23. Williams AE, Larner-Svensson H, Perry MM, Campbell GA, Herrick SE, Adcock IM, et al. MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy. PLoS One 2009; 4:5889.
24. Pirngruber J, Shchebet A, Schreiber L, Shema E, Minsky N, Chapman RD, et al. CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3′-end processing. EMBO Rep 2009; 10:894-900.
25. Braun CJ, Zhang X, Savelyeva I, Wolff S, Moll UM, Schepeler T, et al. p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest. Cancer Res 2008; 68:10094-104.
26. Scheel AH, Beyer U, Agami R, Dobbelstein M. Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression. Cell Cycle 2009; 8:1426-32.