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Volumn 8, Issue 6, 2013, Pages

Ginsenosides Are Novel Naturally-Occurring Aryl Hydrocarbon Receptor Ligands

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; GINSENOSIDE; GINSENOSIDE F 11; GINSENOSIDE PPD; GINSENOSIDE PPT; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RB 3; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GINSENOSIDE RH 1; GINSENOSIDE RH 2; UNCLASSIFIED DRUG;

EID: 84878829776     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066258     Document Type: Article
Times cited : (16)

References (53)
  • 2
    • 0024997614 scopus 로고
    • Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs)
    • Safe S, (1990) Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit Rev Toxicol 21: 51-88.
    • (1990) Crit Rev Toxicol , vol.21 , pp. 51-88
    • Safe, S.1
  • 3
    • 84155196846 scopus 로고    scopus 로고
    • Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor
    • Denison MS, Soshilov AA, He G, DeGroot DE, Zhao B, (2011) Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol Sci 124: 1-22.
    • (2011) Toxicol Sci , vol.124 , pp. 1-22
    • Denison, M.S.1    Soshilov, A.A.2    He, G.3    DeGroot, D.E.4    Zhao, B.5
  • 4
    • 0033531928 scopus 로고    scopus 로고
    • Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptor
    • Kazlauskas A, Poellinger L, Pongratz I, (1999) Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptor. J Biol Chem 274: 13519-13524.
    • (1999) J Biol Chem , vol.274 , pp. 13519-13524
    • Kazlauskas, A.1    Poellinger, L.2    Pongratz, I.3
  • 5
    • 0031882767 scopus 로고    scopus 로고
    • Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity
    • Meyer BK, Pray-Grant MG, Vanden Heuvel JP, Perdew GH, (1998) Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. Mol Cell Biol 18: 978-988.
    • (1998) Mol Cell Biol , vol.18 , pp. 978-988
    • Meyer, B.K.1    Pray-Grant, M.G.2    Vanden Heuvel, J.P.3    Perdew, G.H.4
  • 6
    • 0028987872 scopus 로고
    • The aryl hydrocarbon receptor complex
    • Hankinson O, (1995) The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol 35: 307-340.
    • (1995) Annu Rev Pharmacol Toxicol , vol.35 , pp. 307-340
    • Hankinson, O.1
  • 7
    • 80053389918 scopus 로고    scopus 로고
    • Ligand displaces heat shock protein 90 from overlapping binding sites within the aryl hydrocarbon receptor ligand-binding domain
    • Soshilov A, Denison MS, (2011) Ligand displaces heat shock protein 90 from overlapping binding sites within the aryl hydrocarbon receptor ligand-binding domain. J of Biol Chem 286: 35275-35282.
    • (2011) J of Biol Chem , vol.286 , pp. 35275-35282
    • Soshilov, A.1    Denison, M.S.2
  • 9
    • 0034617461 scopus 로고    scopus 로고
    • Flavones and flavonols at dietary levels inhibit a transformation of aryl hydrocarbon receptor induced by dioxin
    • Ashida H, Fukuda I, Yamashita T, Kanazawa K, (2000) Flavones and flavonols at dietary levels inhibit a transformation of aryl hydrocarbon receptor induced by dioxin. FEBS Lett 476: 213-217.
    • (2000) FEBS Lett , vol.476 , pp. 213-217
    • Ashida, H.1    Fukuda, I.2    Yamashita, T.3    Kanazawa, K.4
  • 10
    • 84873838885 scopus 로고    scopus 로고
    • AHR ligands: promiscuity in binding and diversity in response
    • edited by Pohjanvirta R, John Wiley & Sons, Inc. Hoboken, NJ
    • DeGroot D, He G, Fraccalvieri D, Bonati L, Pandini A, et al. (2011) AHR ligands: promiscuity in binding and diversity in response. In: The Ah receptor in biology and toxicology, edited by Pohjanvirta R. 63-79, John Wiley & Sons, Inc. Hoboken, NJ.
    • (2011) The Ah receptor in biology and toxicology , pp. 63-79
    • DeGroot, D.1    He, G.2    Fraccalvieri, D.3    Bonati, L.4    Pandini, A.5
  • 11
    • 0038768712 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals
    • Denison MS, Nagy SR, (2003) Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 43: 309-334.
    • (2003) Annu Rev Pharmacol Toxicol , vol.43 , pp. 309-334
    • Denison, M.S.1    Nagy, S.R.2
  • 12
    • 0034667405 scopus 로고    scopus 로고
    • Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency
    • Hestermann EV, Stegeman JJ, Hahn ME, (2000) Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency. Toxicol Appl Pharmacol 168: 160-172.
    • (2000) Toxicol Appl Pharmacol , vol.168 , pp. 160-172
    • Hestermann, E.V.1    Stegeman, J.J.2    Hahn, M.E.3
  • 14
    • 0027436253 scopus 로고
    • Inhibitory effects by oral administration of ginsenoside Rh2 on the growth of human ovarian cancer cells in nude mice
    • Tode T, Kikuchi Y, Kita T, Hirata J, Imaizumi E, et al. (1993) Inhibitory effects by oral administration of ginsenoside Rh2 on the growth of human ovarian cancer cells in nude mice. Oncol. J Cancer Res Clin 120: 24-36.
    • (1993) Oncol. J Cancer Res Clin , vol.120 , pp. 24-36
    • Tode, T.1    Kikuchi, Y.2    Kita, T.3    Hirata, J.4    Imaizumi, E.5
  • 15
    • 56949098411 scopus 로고    scopus 로고
    • Induction of cytochrome P4501A1 expression by ginsenoside Rg1 and Rb1 in HepG2 cells
    • Wang Y, Ye X, Ma Z, Liang Q, Lu B, et al. (2008) Induction of cytochrome P4501A1 expression by ginsenoside Rg1 and Rb1 in HepG2 cells. European journal of pharmacology 601: 73-78.
    • (2008) European Journal of Pharmacology , vol.601 , pp. 73-78
    • Wang, Y.1    Ye, X.2    Ma, Z.3    Liang, Q.4    Lu, B.5
  • 16
    • 0034676509 scopus 로고    scopus 로고
    • Is CYP1A1 induction always related to AHR signaling pathway?
    • Delescluse C, Lemaire G, Sousa G, Rahmani R, (2000) Is CYP1A1 induction always related to AHR signaling pathway? Toxicology 153: 73-82.
    • (2000) Toxicology , vol.153 , pp. 73-82
    • Delescluse, C.1    Lemaire, G.2    Sousa, G.3    Rahmani, R.4
  • 17
    • 34347327220 scopus 로고    scopus 로고
    • Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro
    • Hu W, Sorrentino C, Denison MS, Kolaja K, Fielden MR, (2007) Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro. Mol Pharmacol 71: 1475-1486.
    • (2007) Mol Pharmacol , vol.71 , pp. 1475-1486
    • Hu, W.1    Sorrentino, C.2    Denison, M.S.3    Kolaja, K.4    Fielden, M.R.5
  • 19
    • 26844566935 scopus 로고    scopus 로고
    • Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals
    • Garrison PM, Tullis K, Aarts JM, Brouwer A, Giesy JP, et al. (1996) Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam Appl Toxicol 30: 194-203.
    • (1996) Fundam Appl Toxicol , vol.30 , pp. 194-203
    • Garrison, P.M.1    Tullis, K.2    Aarts, J.M.3    Brouwer, A.4    Giesy, J.P.5
  • 20
    • 2342489432 scopus 로고    scopus 로고
    • Comparison of recombinant cell bioassays for the detection of Ah receptor agonists
    • Han D, Nagy SR, Denison MS, (2004) Comparison of recombinant cell bioassays for the detection of Ah receptor agonists. Biofactors 20(1): 11-22.
    • (2004) Biofactors , vol.20 , Issue.1 , pp. 11-22
    • Han, D.1    Nagy, S.R.2    Denison, M.S.3
  • 21
    • 0010636992 scopus 로고    scopus 로고
    • Analysis of the Ah receptor signal transduction pathway
    • (Maines M, Costa LG, Reed DJ, Sassa S and Sipes IG, eds.), John Wiley and Sons, NY
    • Denison MS, Rogers JM, Rushing SR, Jones CL, Tetangco SC, et al. (2002) Analysis of the Ah receptor signal transduction pathway, in: Current Protocols in Toxicology (Maines M, Costa LG, Reed DJ, Sassa S and Sipes IG, eds.). pp 4.8.1-4.8.45, John Wiley and Sons, NY.
    • (2002) Current Protocols in Toxicology , pp. 1-45
    • Denison, M.S.1    Rogers, J.M.2    Rushing, S.R.3    Jones, C.L.4    Tetangco, S.C.5
  • 22
    • 82355168493 scopus 로고    scopus 로고
    • New Aryl Hydrocarbon Receptor Homology Model Targeted to Improve Docking Reliability
    • Motto I, Bordogna A, Soshilov AA, Denison MS, Bonati L, (2011) New Aryl Hydrocarbon Receptor Homology Model Targeted to Improve Docking Reliability. J Chem Inf Model 51: 2868-2881.
    • (2011) J Chem Inf Model , vol.51 , pp. 2868-2881
    • Motto, I.1    Bordogna, A.2    Soshilov, A.A.3    Denison, M.S.4    Bonati, L.5
  • 23
    • 0027136282 scopus 로고
    • Comparative protein modeling by satisfaction of spatial restraints
    • Sali A, Blundell TL, (1993) Comparative protein modeling by satisfaction of spatial restraints. J Mol Biol 234: 779-815.
    • (1993) J Mol Biol , vol.234 , pp. 779-815
    • Sali, A.1    Blundell, T.L.2
  • 25
    • 0033810049 scopus 로고    scopus 로고
    • Modeling of loops in protein structures
    • Fiser A, Do RK, Sali A, (2000) Modeling of loops in protein structures. Protein Sci 9: 1753-1773.
    • (2000) Protein Sci , vol.9 , pp. 1753-1773
    • Fiser, A.1    Do, R.K.2    Sali, A.3
  • 26
    • 33749578940 scopus 로고    scopus 로고
    • Statistical potential for assessment and prediction of protein structures
    • Shen M, Sali A, (2006) Statistical potential for assessment and prediction of protein structures. Protein Sci 15: 2507-2524.
    • (2006) Protein Sci , vol.15 , pp. 2507-2524
    • Shen, M.1    Sali, A.2
  • 27
    • 84878840144 scopus 로고    scopus 로고
    • MacroModel, version 9.9, Schrödinger, LLC: New York, NY, 2012
    • MacroModel, version 9.9, Schrödinger, LLC: New York, NY, 2012.
  • 28
    • 84878849515 scopus 로고    scopus 로고
    • Maestro, version 9.3, Schrödinger, LLC: New York, NY, 2012
    • Maestro, version 9.3, Schrödinger, LLC: New York, NY, 2012.
  • 29
    • 0035913529 scopus 로고    scopus 로고
    • Evaluation and Reparametrization of the OPLS-AA Force Field for Proteins via Comparison with Accurate Quantum Chemical Calculations on Peptides
    • Kaminski GA, Friesner RA, Tirado-Rives J, Jorgensen WL, (2001) Evaluation and Reparametrization of the OPLS-AA Force Field for Proteins via Comparison with Accurate Quantum Chemical Calculations on Peptides. J Phys Chem B 105: 6474-6487.
    • (2001) J Phys Chem B , vol.105 , pp. 6474-6487
    • Kaminski, G.A.1    Friesner, R.A.2    Tirado-Rives, J.3    Jorgensen, W.L.4
  • 31
    • 84878857859 scopus 로고    scopus 로고
    • Glide, version 5.8, Schrödinger, LLC: New York, NY, 2012
    • Glide, version 5.8, Schrödinger, LLC: New York, NY, 2012.
  • 32
    • 33750124980 scopus 로고    scopus 로고
    • Extra precision Glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes
    • Friesner RA, Murphy RB, Repasky MP, Frye LL, Greenwood JR, et al. (2006) Extra precision Glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes. J Med Chem 49: 6177-6196.
    • (2006) J Med Chem , vol.49 , pp. 6177-6196
    • Friesner, R.A.1    Murphy, R.B.2    Repasky, M.P.3    Frye, L.L.4    Greenwood, J.R.5
  • 33
    • 67349231225 scopus 로고    scopus 로고
    • CYP1A1 and CYP1A2 expression: Comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines
    • Shigeyuki Uno, Kaori Endo, Yuji Ishida, Chise Tateno, Makoto Makishima, et al. (2009) CYP1A1 and CYP1A2 expression: Comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines. Toxicology and Applied Pharmacology 237: 119-126.
    • (2009) Toxicology and Applied Pharmacology , vol.237 , pp. 119-126
    • Shigeyuki, U.1    Kaori, E.2    Yuji, I.3    Chise, T.4    Makoto, M.5
  • 34
    • 78649537557 scopus 로고    scopus 로고
    • Predicting the accuracy of protein-ligand docking on homology models
    • Bordogna A, Pandini A, Bonati L, (2011) Predicting the accuracy of protein-ligand docking on homology models. J Comput Chem 32: 81-98.
    • (2011) J Comput Chem , vol.32 , pp. 81-98
    • Bordogna, A.1    Pandini, A.2    Bonati, L.3
  • 35
    • 84873877186 scopus 로고    scopus 로고
    • Comparative analysis of homology models of the Ah receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor
    • Fraccalvieri D, Soshilov AA, Karchner SI, Franks DG, Pandini A, et al. (2013) Comparative analysis of homology models of the Ah receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry 52: 714-725.
    • (2013) Biochemistry , vol.52 , pp. 714-725
    • Fraccalvieri, D.1    Soshilov, A.A.2    Karchner, S.I.3    Franks, D.G.4    Pandini, A.5
  • 36
    • 33846337559 scopus 로고    scopus 로고
    • Structural and functional characterization of the Aryl hydrocarbon receptor ligand binding domain by homology modeling and mutational analysis
    • Pandini A, Denison MS, Song Y, Soshilov AA, Bonati L, (2007) Structural and functional characterization of the Aryl hydrocarbon receptor ligand binding domain by homology modeling and mutational analysis. Biochemistry 46: 696-708.
    • (2007) Biochemistry , vol.46 , pp. 696-708
    • Pandini, A.1    Denison, M.S.2    Song, Y.3    Soshilov, A.A.4    Bonati, L.5
  • 37
    • 67649612842 scopus 로고    scopus 로고
    • Detection of the TCDD binding fingerprint within the Ah receptor ligand binding domain by structurally driven mutagenesis and functional analysis, Biochemistry
    • Pandini A, Soshilov AA, Song Y, Zhao J, Bonati L, et al. (2009) Detection of the TCDD binding fingerprint within the Ah receptor ligand binding domain by structurally driven mutagenesis and functional analysis, Biochemistry. 48: 5972-5983.
    • (2009) , vol.48 , pp. 5972-5983
    • Pandini, A.1    Soshilov, A.A.2    Song, Y.3    Zhao, J.4    Bonati, L.5
  • 38
    • 0023033162 scopus 로고
    • Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols
    • Denison MS, Vella LM, Okey AB, (1986) Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols. J Biol Chem 261: 3987-3995.
    • (1986) J Biol Chem , vol.261 , pp. 3987-3995
    • Denison, M.S.1    Vella, L.M.2    Okey, A.B.3
  • 39
    • 0026046412 scopus 로고
    • Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Bjeldanes LF, Kim JY, Grose KR, Bartholomew JC, Bradfield CA, (1991) Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Proc Natl Acad Sci U S A 88: 9543-9547.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 9543-9547
    • Bjeldanes, L.F.1    Kim, J.Y.2    Grose, K.R.3    Bartholomew, J.C.4    Bradfield, C.A.5
  • 40
    • 0032535055 scopus 로고    scopus 로고
    • Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor
    • Ciolino HP, Daschner PJ, Yeh GC, (1998) Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor. Cancer Res 58: 5707-5012.
    • (1998) Cancer Res , vol.58 , pp. 5012-5707
    • Ciolino, H.P.1    Daschner, P.J.2    Yeh, G.C.3
  • 41
    • 0037308773 scopus 로고    scopus 로고
    • Agonist but not antagonist ligands induce conformational change in the mouse aryl hydrocarbon receptor as detected by partial proteolysis
    • Henry EC, Gasiewicz TA, (2003) Agonist but not antagonist ligands induce conformational change in the mouse aryl hydrocarbon receptor as detected by partial proteolysis. Mol Pharmacol 63: 392-400.
    • (2003) Mol Pharmacol , vol.63 , pp. 392-400
    • Henry, E.C.1    Gasiewicz, T.A.2
  • 42
    • 77956173985 scopus 로고    scopus 로고
    • Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction
    • Mukai R, Shirai Y, Saito N, Fukuda I, Nishiumi S, et al. (2010) Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction. Arch Biochem Biophys 501: 134-141.
    • (2010) Arch Biochem Biophys , vol.501 , pp. 134-141
    • Mukai, R.1    Shirai, Y.2    Saito, N.3    Fukuda, I.4    Nishiumi, S.5
  • 43
    • 80155148225 scopus 로고    scopus 로고
    • You AHR what you eat: linking diet and immunity
    • Hooper LV, (2011) You AHR what you eat: linking diet and immunity. Cell 147: 489-491.
    • (2011) Cell , vol.147 , pp. 489-491
    • Hooper, L.V.1
  • 44
    • 80155164160 scopus 로고    scopus 로고
    • Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation
    • Li Y, Innocentin S, Withers DR, Roberts NA, Gallagher AR, et al. (2011) Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 147: 620-629.
    • (2011) Cell , vol.147 , pp. 620-629
    • Li, Y.1    Innocentin, S.2    Withers, D.R.3    Roberts, N.A.4    Gallagher, A.R.5
  • 45
    • 59149097969 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways
    • Puga A, Ma C, Marlowe JL, (2009) The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. Biochem Pharmacol 77: 713-722.
    • (2009) Biochem Pharmacol , vol.77 , pp. 713-722
    • Puga, A.1    Ma, C.2    Marlowe, J.L.3
  • 46
    • 0036158617 scopus 로고    scopus 로고
    • Development of a green fluorescent protein-based cell bioassay for the rapid and inexpensive detection and characterization of ah receptor agonists
    • Nagy SR, Sanborn JR, Hammock BD, Denison MS, (2002) Development of a green fluorescent protein-based cell bioassay for the rapid and inexpensive detection and characterization of ah receptor agonists. Toxicol Sci 65: 200-210.
    • (2002) Toxicol Sci , vol.65 , pp. 200-210
    • Nagy, S.R.1    Sanborn, J.R.2    Hammock, B.D.3    Denison, M.S.4
  • 47
    • 0034021184 scopus 로고    scopus 로고
    • Ah receptor-based chemical screening bioassays: application and limitations for the detection of Ah receptor agonists
    • Seidel SD, Li V, Winter GM, Rogers WJ, Martinez EI, et al. (2000) Ah receptor-based chemical screening bioassays: application and limitations for the detection of Ah receptor agonists. Toxicol Sci 55: 107-115.
    • (2000) Toxicol Sci , vol.55 , pp. 107-115
    • Seidel, S.D.1    Li, V.2    Winter, G.M.3    Rogers, W.J.4    Martinez, E.I.5
  • 48
    • 0016806097 scopus 로고
    • Effect of ginseng saponins on cholesterol metabolism. I. The level and the synthesis of serum and liver cholesterol in rats treated with ginsenosides
    • Sakakibara K, Shibata Y, Higashi T, Sanada S, Shoji J, (1975) Effect of ginseng saponins on cholesterol metabolism. I. The level and the synthesis of serum and liver cholesterol in rats treated with ginsenosides. Chem Pharm Bull (Tokyo) 23: 1009-1016.
    • (1975) Chem Pharm Bull (Tokyo) , vol.23 , pp. 1009-1016
    • Sakakibara, K.1    Shibata, Y.2    Higashi, T.3    Sanada, S.4    Shoji, J.5
  • 49
    • 79959563146 scopus 로고    scopus 로고
    • Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation-the key step of inflammation
    • Joh EH, Lee IA, Jung IH, Kim DH, (2011) Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation-the key step of inflammation. Biochemical pharmacology 82: 278-286.
    • (2011) Biochemical Pharmacology , vol.82 , pp. 278-286
    • Joh, E.H.1    Lee, I.A.2    Jung, I.H.3    Kim, D.H.4
  • 50
    • 0036266324 scopus 로고    scopus 로고
    • Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component
    • Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, et al. (2002) Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 51: 1851-1858.
    • (2002) Diabetes , vol.51 , pp. 1851-1858
    • Attele, A.S.1    Zhou, Y.P.2    Xie, J.T.3    Wu, J.A.4    Zhang, L.5
  • 52
    • 0029853361 scopus 로고    scopus 로고
    • Cardiovascular protection by ginsenosides and their nitric oxide releasing action
    • Chen X, (1996) Cardiovascular protection by ginsenosides and their nitric oxide releasing action. Clinical and experimental pharmacology and physiology 23: 728-732.
    • (1996) Clinical and Experimental Pharmacology and Physiology , vol.23 , pp. 728-732
    • Chen, X.1
  • 53
    • 0028340930 scopus 로고
    • Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2
    • Sato K, Mochizuki M, Saiki I, Yoo YC, Samukawa K, et al. (1994) Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2. Biological & pharmaceutical bulletin 17: 635-639.
    • (1994) Biological & Pharmaceutical Bulletin , vol.17 , pp. 635-639
    • Sato, K.1    Mochizuki, M.2    Saiki, I.3    Yoo, Y.C.4    Samukawa, K.5


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