Structural and functional characterization of the aryl hydrocarbon receptor ligand binding domain by homology modeling and mutational analysis

Biochemistry

Volumn 46, Issue 3, 2007, Pages 696-708

  Pandini, Alessandro ^a   Denison, Michael S ^b   Song, Yujuan ^b   Soshilov, Anatoly A ^b   Bonati, Laura ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; DNA SEQUENCES; MOLECULAR DYNAMICS; MOLECULAR STRUCTURE; MUTAGENESIS; PROTEINS;

ANDROGEN RECEPTOR (AR); DNA BINDING; LIGAND BINDING; MUTATIONS;

HYDROCARBONS;

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1BETA; HYPOXIA INDUCIBLE FACTOR 2ALPHA;

ARTICLE; CONTROLLED STUDY; LIGAND BINDING; MOLECULAR MODEL; MUTAGENESIS; MUTATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR UPREGULATION; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BINDING SITES; HUMANS; LIGANDS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ARYL HYDROCARBON; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY, PROTEIN; TRANSCRIPTION FACTORS;

EID: 33846337559     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061460t     Document Type: Article

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