Detection of the TCDD binding-fingerprint within the Ah receptor ligand binding domain by structurally driven mutagenesis and functional analysis

Biochemistry

Volumn 48, Issue 25, 2009, Pages 5972-5983

  Pandini, Alessandro ^a   Soshilov, Anatoly A ^b   Song, Yujuan ^b   Zhao, Jing ^b   Bonati, Laura ^c   Denison, Michael S ^b  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARYL HYDROCARBON RECEPTOR; BASIC HELIX LOOP HELIXES; CONSERVED RESIDUES; DNA BINDING; ENVIRONMENTAL CONTAMINANT; EXPERIMENTAL VALIDATIONS; LIGAND BINDING; LIGAND BINDING DOMAIN; LIGAND STRUCTURE; MOLECULAR DETERMINANTS; MOLECULAR DOCKING SIMULATIONS; RECEPTOR-LIGAND BINDING; SITE DIRECTED MUTAGENESIS; STRUCTURAL MODELING; TETRACHLORODIBENZO P DIOXINS; THREE-DIMENSIONAL HOMOLOGY MODEL; WILD TYPES;

BINDING ENERGY; BIOCHEMISTRY; ENZYME ACTIVITY; FUNCTIONAL ANALYSIS; HYDROCARBONS; LIGANDS; MAMMALS; MUTAGENESIS; NUCLEIC ACIDS; PHOTOACOUSTIC SPECTROSCOPY; TRANSCRIPTION FACTORS;

BINDING SITES;

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; DNA;

ARTICLE; DNA BINDING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRICETINAE; DNA-BINDING PROTEINS; GUINEA PIGS; LIGANDS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE MAPPING; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RABBITS; RATS; RECEPTORS, ARYL HYDROCARBON; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TETRACHLORODIBENZODIOXIN;

MAMMALIA;

EID: 67649612842     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900259z     Document Type: Article

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