Comparative analysis of homology models of the Ah receptor ligand binding domain: Verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor

Biochemistry

Volumn 52, Issue 4, 2013, Pages 714-725

  Fraccalvieri, Domenico ^a   Soshilov, Anatoly A ^b   Karchner, Sibel I ^c   Franks, Diana G ^c   Pandini, Alessandro ^d   Bonati, Laura ^a   Hahn, Mark E ^c   Denison, Michael S ^b  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WOODS HOLE OCEANOGRAPHIC INSTITUTION   (United States)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 ,3 ,7 ,8 TETRACHLORODIBENZO P DIOXINS; ARYL HYDROCARBON RECEPTOR; BINDING CAVITY; BINDING MODES; COMPARATIVE ANALYSIS; COMPARATIVE STUDIES; DIVERSE SPECIES; ENVIRONMENTAL CONTAMINANT; HIGH AFFINITY; HOMOLOGY MODELS; INTERNAL CAVITIES; LIGAND BINDING; LIGAND BINDING DOMAIN; RECEPTOR-LIGAND BINDING; SIDE-CHAINS; SITE DIRECTED MUTAGENESIS; STRUCTURAL DETERMINANTS; TOXIC EFFECT; ZEBRAFISH;

AMINO ACIDS; BINDING ENERGY; MAMMALS; TRANSCRIPTION FACTORS;

LIGANDS;

AMINO ACID; AROMATIC HYDROCARBON RECEPTOR; HISTIDINE; THREONINE; TYROSINE;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BIRD; CONTROLLED STUDY; DNA BINDING; FISH; LIGAND BINDING; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; AVIAN PROTEINS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; ENVIRONMENTAL POLLUTANTS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ARYL HYDROCARBON; STRUCTURAL HOMOLOGY, PROTEIN; TETRACHLORODIBENZODIOXIN; TRANSCRIPTIONAL ACTIVATION; ZEBRAFISH PROTEINS;

EID: 84873877186     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301457f     Document Type: Article

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