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Volumn 8, Issue 6, 2013, Pages

Inverse Agonist and Pharmacochaperone Properties of MK-0524 on the Prostanoid DP1 Receptor

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BREFELDIN A; CALNEXIN; CHAPERONE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; INVERSE STIMULATING AGENT; LAROPIPRANT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PERTUSSIS TOXIN; PHARMACOCHAPERONE; PROSTAGLANDIN D2; PROSTANOID DP RECEPTOR 1; PROTEIN; PROTEIN ANKRD13C; UNCLASSIFIED DRUG;

EID: 84878821413     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065767     Document Type: Article
Times cited : (21)

References (97)
  • 2
    • 0035862329 scopus 로고    scopus 로고
    • Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
    • Hirai H, Tanaka K, Yoshie O, Ogawa K, Kenmotsu K, et al. (2001) Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. The Journal of Experimental Medicine 193: 255-261.
    • (2001) The Journal of Experimental Medicine , vol.193 , pp. 255-261
    • Hirai, H.1    Tanaka, K.2    Yoshie, O.3    Ogawa, K.4    Kenmotsu, K.5
  • 3
    • 0025909039 scopus 로고
    • The possible role of prostaglandin D2 in the long-lasting airways vasodilatation induced by allergen in the sensitized pig
    • Alving K, Matran R, Lundberg JM, (1991) The possible role of prostaglandin D2 in the long-lasting airways vasodilatation induced by allergen in the sensitized pig. Acta Physiologica Scandinavica 143: 93-103.
    • (1991) Acta Physiologica Scandinavica , vol.143 , pp. 93-103
    • Alving, K.1    Matran, R.2    Lundberg, J.M.3
  • 6
    • 0028245181 scopus 로고
    • Inhibition of human platelets and polymorphonuclear neutrophils by the potent and metabolically stable prostaglandin D2 analog ZK 118.182
    • Darius H, Michael-Hepp J, Thierauch KH, Fisch A, (1994) Inhibition of human platelets and polymorphonuclear neutrophils by the potent and metabolically stable prostaglandin D2 analog ZK 118.182. European Journal of Pharmacology 258: 207-213.
    • (1994) European Journal of Pharmacology , vol.258 , pp. 207-213
    • Darius, H.1    Michael-Hepp, J.2    Thierauch, K.H.3    Fisch, A.4
  • 7
    • 0022377745 scopus 로고
    • Different responsiveness of prostaglandin D2-sensitive systems to prostaglandin D2 and its analogues
    • Narumiya S, Toda N, (1985) Different responsiveness of prostaglandin D2-sensitive systems to prostaglandin D2 and its analogues. British Journal of Pharmacology 85: 367-375.
    • (1985) British Journal of Pharmacology , vol.85 , pp. 367-375
    • Narumiya, S.1    Toda, N.2
  • 8
    • 3042705826 scopus 로고    scopus 로고
    • Ramatroban (BAY u 3405): A novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor
    • Ishizuka T, Matsui T, Okamoto Y, Ohta A, Shichijo M, (2004) Ramatroban (BAY u 3405): A novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor. Cardiovascular Drug Reviews 22: 71-90.
    • (2004) Cardiovascular Drug Reviews , vol.22 , pp. 71-90
    • Ishizuka, T.1    Matsui, T.2    Okamoto, Y.3    Ohta, A.4    Shichijo, M.5
  • 12
    • 0038138607 scopus 로고    scopus 로고
    • The second PGD(2) receptor CRTH2: Structure, properties, and functions in leukocytes
    • Nagata K, Hirai H, (2003) The second PGD(2) receptor CRTH2: Structure, properties, and functions in leukocytes. Prostaglandins, Leukotrienes, and Essential Fatty Acids 69: 169-177.
    • (2003) Prostaglandins, Leukotrienes, and Essential Fatty Acids , vol.69 , pp. 169-177
    • Nagata, K.1    Hirai, H.2
  • 13
    • 0028985630 scopus 로고
    • Selective prostaglandin D2 receptor stimulation elicits ocular hypotensive effects in rabbits and cats
    • Matsugi T, Kageyama M, Nishimura K, Giles H, Shirasawa E, (1995) Selective prostaglandin D2 receptor stimulation elicits ocular hypotensive effects in rabbits and cats. European Journal of Pharmacology 275: 245-250.
    • (1995) European Journal of Pharmacology , vol.275 , pp. 245-250
    • Matsugi, T.1    Kageyama, M.2    Nishimura, K.3    Giles, H.4    Shirasawa, E.5
  • 15
    • 0021823255 scopus 로고
    • Studies on the mechanism of central cardiovascular and temperature responses to prostaglandin D2
    • Forstermann U, Heldt R, Hertting G, (1985) Studies on the mechanism of central cardiovascular and temperature responses to prostaglandin D2. Prostaglandins, Leukotrienes, and Medicine 18: 301-308.
    • (1985) Prostaglandins, Leukotrienes, and Medicine , vol.18 , pp. 301-308
    • Forstermann, U.1    Heldt, R.2    Hertting, G.3
  • 20
    • 84862701957 scopus 로고    scopus 로고
    • Prostaglandin D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway
    • Yue L, Durand M, Lebeau Jacob MC, Hogan P, McManus S, et al. (2012) Prostaglandin D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway. Bone 51: 338-346.
    • (2012) Bone , vol.51 , pp. 338-346
    • Yue, L.1    Durand, M.2    Lebeau Jacob, M.C.3    Hogan, P.4    McManus, S.5
  • 21
    • 33750178069 scopus 로고    scopus 로고
    • Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway
    • Chiba T, Kanda A, Ueki S, Ito W, Kamada Y, et al. (2006) Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway. International Archives of Allergy and Immunology 141: 300-307.
    • (2006) International Archives of Allergy and Immunology , vol.141 , pp. 300-307
    • Chiba, T.1    Kanda, A.2    Ueki, S.3    Ito, W.4    Kamada, Y.5
  • 23
    • 69249211014 scopus 로고    scopus 로고
    • Prostanoid receptor antagonists: Development strategies and therapeutic applications
    • Jones RL, Giembycz MA, Woodward DF, (2009) Prostanoid receptor antagonists: Development strategies and therapeutic applications. British Journal of Pharmacology 158: 104-145.
    • (2009) British Journal of Pharmacology , vol.158 , pp. 104-145
    • Jones, R.L.1    Giembycz, M.A.2    Woodward, D.F.3
  • 24
    • 0034012172 scopus 로고    scopus 로고
    • Affinities, selectivities, potencies, and intrinsic activities of natural and synthetic prostanoids using endogenous receptors: Focus on DP class prostanoids
    • Sharif NA, Crider JY, Xu SX, Williams GW, (2000) Affinities, selectivities, potencies, and intrinsic activities of natural and synthetic prostanoids using endogenous receptors: Focus on DP class prostanoids. The Journal of Pharmacology and Experimental Therapeutics 293: 321-328.
    • (2000) The Journal of Pharmacology and Experimental Therapeutics , vol.293 , pp. 321-328
    • Sharif, N.A.1    Crider, J.Y.2    Xu, S.X.3    Williams, G.W.4
  • 25
    • 0032903864 scopus 로고    scopus 로고
    • Prostaglandin DP receptors positively coupled to adenylyl cyclase in embryonic bovine tracheal (EBTr) cells: Pharmacological characterization using agonists and antagonists
    • Crider JY, Griffin BW, Sharif NA, (1999) Prostaglandin DP receptors positively coupled to adenylyl cyclase in embryonic bovine tracheal (EBTr) cells: Pharmacological characterization using agonists and antagonists. British Journal of Pharmacology 127: 204-210.
    • (1999) British Journal of Pharmacology , vol.127 , pp. 204-210
    • Crider, J.Y.1    Griffin, B.W.2    Sharif, N.A.3
  • 26
    • 0024477713 scopus 로고
    • Antagonism of PGD2 vasodepressor responses in the rat in vivo by the novel, selective antagonist, BW A868C
    • Hamid-Bloomfield S, Whittle BJ, (1989) Antagonism of PGD2 vasodepressor responses in the rat in vivo by the novel, selective antagonist, BW A868C. British Journal of Pharmacology 96: 307-312.
    • (1989) British Journal of Pharmacology , vol.96 , pp. 307-312
    • Hamid-Bloomfield, S.1    Whittle, B.J.2
  • 27
    • 33847345910 scopus 로고    scopus 로고
    • Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopent a[b]indol-3-yl]-acetic acid (MK-0524)
    • Sturino CF, O'Neill G, Lachance N, Boyd M, Berthelette C, et al. (2007) Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopent a[b]indol-3-yl]-acetic acid (MK-0524). Journal of Medicinal Chemistry 50: 794-806.
    • (2007) Journal of Medicinal Chemistry , vol.50 , pp. 794-806
    • Sturino, C.F.1    O'Neill, G.2    Lachance, N.3    Boyd, M.4    Berthelette, C.5
  • 30
    • 0345735773 scopus 로고    scopus 로고
    • Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling
    • Baker JG, Hall IP, Hill SJ, (2003) Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling. Molecular Pharmacology 64: 1357-1369.
    • (2003) Molecular Pharmacology , vol.64 , pp. 1357-1369
    • Baker, J.G.1    Hall, I.P.2    Hill, S.J.3
  • 33
    • 20744434986 scopus 로고    scopus 로고
    • Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2
    • Werry TD, Gregory KJ, Sexton PM, Christopoulos A, (2005) Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2. Journal of Neurochemistry 93: 1603-1615.
    • (2005) Journal of Neurochemistry , vol.93 , pp. 1603-1615
    • Werry, T.D.1    Gregory, K.J.2    Sexton, P.M.3    Christopoulos, A.4
  • 35
    • 31844446495 scopus 로고    scopus 로고
    • Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery
    • Bond RA, Ijzerman AP, (2006) Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery. Trends in Pharmacological Sciences 27: 92-96.
    • (2006) Trends in Pharmacological Sciences , vol.27 , pp. 92-96
    • Bond, R.A.1    Ijzerman, A.P.2
  • 37
    • 22944487986 scopus 로고    scopus 로고
    • Multiple signaling states of G-protein-coupled receptors
    • Perez DM, Karnik SS, (2005) Multiple signaling states of G-protein-coupled receptors. Pharmacological Reviews 57: 147-161.
    • (2005) Pharmacological Reviews , vol.57 , pp. 147-161
    • Perez, D.M.1    Karnik, S.S.2
  • 38
    • 33846020543 scopus 로고    scopus 로고
    • Small molecule pharmacological chaperones: From thermodynamic stabilization to pharmaceutical drugs
    • Arakawa T, Ejima D, Kita Y, Tsumoto K, (2006) Small molecule pharmacological chaperones: From thermodynamic stabilization to pharmaceutical drugs. Biochimica Et Biophysica Acta 1764: 1677-1687.
    • (2006) Biochimica Et Biophysica Acta , vol.1764 , pp. 1677-1687
    • Arakawa, T.1    Ejima, D.2    Kita, Y.3    Tsumoto, K.4
  • 39
    • 7244253015 scopus 로고    scopus 로고
    • Pharmacologic rescue of conformationally-defective proteins: Implications for the treatment of human disease
    • Ulloa-Aguirre A, Janovick JA, Brothers SP, Conn PM, (2004) Pharmacologic rescue of conformationally-defective proteins: Implications for the treatment of human disease. Traffic (Copenhagen, Denmark) 5: 821-837.
    • (2004) Traffic (Copenhagen, Denmark) , vol.5 , pp. 821-837
    • Ulloa-Aguirre, A.1    Janovick, J.A.2    Brothers, S.P.3    Conn, P.M.4
  • 40
    • 3442880434 scopus 로고    scopus 로고
    • Functional rescue of the constitutively internalized V2 vasopressin receptor mutant R137H by the pharmacological chaperone action of SR49059
    • Bernier V, Lagace M, Lonergan M, Arthus MF, Bichet DG, et al. (2004) Functional rescue of the constitutively internalized V2 vasopressin receptor mutant R137H by the pharmacological chaperone action of SR49059. Molecular Endocrinology (Baltimore, Md.) 18: 2074-2084.
    • (2004) Molecular Endocrinology (Baltimore, Md.) , vol.18 , pp. 2074-2084
    • Bernier, V.1    Lagace, M.2    Lonergan, M.3    Arthus, M.F.4    Bichet, D.G.5
  • 41
    • 0036322898 scopus 로고    scopus 로고
    • Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: Misrouted proteins as a novel disease etiology and therapeutic target
    • Janovick JA, Maya-Nunez G, Conn PM, (2002) Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: Misrouted proteins as a novel disease etiology and therapeutic target. The Journal of Clinical Endocrinology and Metabolism 87: 3255-3262.
    • (2002) The Journal of Clinical Endocrinology and Metabolism , vol.87 , pp. 3255-3262
    • Janovick, J.A.1    Maya-Nunez, G.2    Conn, P.M.3
  • 43
    • 33846849199 scopus 로고    scopus 로고
    • Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2
    • Gallant MA, Slipetz D, Hamelin E, Rochdi MD, Talbot S, et al. (2007) Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2. European Journal of Pharmacology 557: 115-123.
    • (2007) European Journal of Pharmacology , vol.557 , pp. 115-123
    • Gallant, M.A.1    Slipetz, D.2    Hamelin, E.3    Rochdi, M.D.4    Talbot, S.5
  • 44
    • 0030006864 scopus 로고    scopus 로고
    • Identification of prostanoid receptors in rabbit non-pigmented ciliary epithelial cells
    • Bhattacherjee P, Jacobs N, Coca-Prados M, Paterson C, (1996) Identification of prostanoid receptors in rabbit non-pigmented ciliary epithelial cells. Experimental Eye Research 62: 491-498.
    • (1996) Experimental Eye Research , vol.62 , pp. 491-498
    • Bhattacherjee, P.1    Jacobs, N.2    Coca-Prados, M.3    Paterson, C.4
  • 45
    • 0024547972 scopus 로고
    • The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist
    • Giles H, Leff P, Bolofo ML, Kelly MG, Robertson AD, (1989) The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. British Journal of Pharmacology 96: 291-300.
    • (1989) British Journal of Pharmacology , vol.96 , pp. 291-300
    • Giles, H.1    Leff, P.2    Bolofo, M.L.3    Kelly, M.G.4    Robertson, A.D.5
  • 47
    • 0031913845 scopus 로고    scopus 로고
    • Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist
    • Wright DH, Metters KM, Abramovitz M, Ford-Hutchinson AW, (1998) Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. British Journal of Pharmacology 123: 1317-1324.
    • (1998) British Journal of Pharmacology , vol.123 , pp. 1317-1324
    • Wright, D.H.1    Metters, K.M.2    Abramovitz, M.3    Ford-Hutchinson, A.W.4
  • 48
    • 0030598636 scopus 로고    scopus 로고
    • Partial agonist effects of BW A868C, a selective DP receptor antagonist, on cl- secretion in dog tracheal epithelium
    • Liu YJ, Jackson DM, Blackham A, Leff P, (1996) Partial agonist effects of BW A868C, a selective DP receptor antagonist, on cl- secretion in dog tracheal epithelium. European Journal of Pharmacology 304: 117-122.
    • (1996) European Journal of Pharmacology , vol.304 , pp. 117-122
    • Liu, Y.J.1    Jackson, D.M.2    Blackham, A.3    Leff, P.4
  • 49
    • 0033605423 scopus 로고    scopus 로고
    • Internalization of the TXA2 receptor alpha and beta isoforms. role of the differentially spliced cooh terminus in agonist-promoted receptor internalization
    • Parent JL, Labrecque P, Orsini MJ, Benovic JL, (1999) Internalization of the TXA2 receptor alpha and beta isoforms. role of the differentially spliced cooh terminus in agonist-promoted receptor internalization. The Journal of Biological Chemistry 274: 8941-8948.
    • (1999) The Journal of Biological Chemistry , vol.274 , pp. 8941-8948
    • Parent, J.L.1    Labrecque, P.2    Orsini, M.J.3    Benovic, J.L.4
  • 50
    • 77649190267 scopus 로고    scopus 로고
    • Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: Identification of a recycling motif
    • Roy SJ, Parent A, Gallant MA, de Brum-Fernandes AJ, Stankova J, et al. (2010) Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: Identification of a recycling motif. European Journal of Pharmacology 630: 10-18.
    • (2010) European Journal of Pharmacology , vol.630 , pp. 10-18
    • Roy, S.J.1    Parent, A.2    Gallant, M.A.3    de Brum-Fernandes, A.J.4    Stankova, J.5
  • 51
    • 27744469168 scopus 로고    scopus 로고
    • The intracellular trafficking of the G protein-coupled receptor TPbeta depends on a direct interaction with Rab11
    • Hamelin E, Theriault C, Laroche G, Parent JL, (2005) The intracellular trafficking of the G protein-coupled receptor TPbeta depends on a direct interaction with Rab11. The Journal of Biological Chemistry 280: 36195-36205.
    • (2005) The Journal of Biological Chemistry , vol.280 , pp. 36195-36205
    • Hamelin, E.1    Theriault, C.2    Laroche, G.3    Parent, J.L.4
  • 52
    • 0035831509 scopus 로고    scopus 로고
    • Role of the differentially spliced carboxyl terminus in thromboxane A2 receptor trafficking: Identification of a distinct motif for tonic internalization
    • Parent JL, Labrecque P, Driss Rochdi M, Benovic JL, (2001) Role of the differentially spliced carboxyl terminus in thromboxane A2 receptor trafficking: Identification of a distinct motif for tonic internalization. The Journal of Biological Chemistry 276: 7079-7085.
    • (2001) The Journal of Biological Chemistry , vol.276 , pp. 7079-7085
    • Parent, J.L.1    Labrecque, P.2    Driss Rochdi, M.3    Benovic, J.L.4
  • 53
    • 0347627709 scopus 로고    scopus 로고
    • Constitutive activity and inverse agonists of G protein-coupled receptors: A current perspective
    • Milligan G, (2003) Constitutive activity and inverse agonists of G protein-coupled receptors: A current perspective. Molecular Pharmacology 64: 1271-1276.
    • (2003) Molecular Pharmacology , vol.64 , pp. 1271-1276
    • Milligan, G.1
  • 54
  • 57
    • 33751162165 scopus 로고    scopus 로고
    • Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy
    • Galandrin S, Bouvier M, (2006) Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Molecular Pharmacology 70: 1575-1584.
    • (2006) Molecular Pharmacology , vol.70 , pp. 1575-1584
    • Galandrin, S.1    Bouvier, M.2
  • 58
    • 33845316454 scopus 로고    scopus 로고
    • The V2 vasopressin receptor stimulates ERK1/2 activity independently of heterotrimeric G protein signalling
    • Charest PG, Oligny-Longpre G, Bonin H, Azzi M, Bouvier M, (2007) The V2 vasopressin receptor stimulates ERK1/2 activity independently of heterotrimeric G protein signalling. Cellular Signalling 19: 32-41.
    • (2007) Cellular Signalling , vol.19 , pp. 32-41
    • Charest, P.G.1    Oligny-Longpre, G.2    Bonin, H.3    Azzi, M.4    Bouvier, M.5
  • 59
    • 0035816704 scopus 로고    scopus 로고
    • Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor
    • Ghanouni P, Gryczynski Z, Steenhuis JJ, Lee TW, Farrens DL, et al. (2001) Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor. The Journal of Biological Chemistry 276: 24433-24436.
    • (2001) The Journal of Biological Chemistry , vol.276 , pp. 24433-24436
    • Ghanouni, P.1    Gryczynski, Z.2    Steenhuis, J.J.3    Lee, T.W.4    Farrens, D.L.5
  • 60
    • 34447650979 scopus 로고    scopus 로고
    • Versatility of GPCR recognition by drugs: From biological implications to therapeutic relevance
    • Bosier B, Hermans E, (2007) Versatility of GPCR recognition by drugs: From biological implications to therapeutic relevance. Trends in Pharmacological Sciences 28: 438-446.
    • (2007) Trends in Pharmacological Sciences , vol.28 , pp. 438-446
    • Bosier, B.1    Hermans, E.2
  • 61
    • 77952354490 scopus 로고    scopus 로고
    • Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on new drug discovery
    • Kenakin T, Miller LJ, (2010) Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacological Reviews 62: 265-304.
    • (2010) Pharmacological Reviews , vol.62 , pp. 265-304
    • Kenakin, T.1    Miller, L.J.2
  • 63
    • 33846909764 scopus 로고    scopus 로고
    • "Phenotypic" pharmacology: The influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology
    • Nelson CP, Challiss RA, (2007) "Phenotypic" pharmacology: The influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology. Biochemical Pharmacology 73: 737-751.
    • (2007) Biochemical Pharmacology , vol.73 , pp. 737-751
    • Nelson, C.P.1    Challiss, R.A.2
  • 64
    • 33947259630 scopus 로고    scopus 로고
    • Inverse agonism: From curiosity to accepted dogma, but is it clinically relevant?
    • Parra S, Bond RA, (2007) Inverse agonism: From curiosity to accepted dogma, but is it clinically relevant? Current Opinion in Pharmacology 7: 146-150.
    • (2007) Current Opinion in Pharmacology , vol.7 , pp. 146-150
    • Parra, S.1    Bond, R.A.2
  • 65
    • 33751284236 scopus 로고    scopus 로고
    • Inverse agonism or neutral antagonism at G-protein coupled receptors: A medicinal chemistry challenge worth pursuing?
    • Greasley PJ, Clapham JC, (2006) Inverse agonism or neutral antagonism at G-protein coupled receptors: A medicinal chemistry challenge worth pursuing? European Journal of Pharmacology 553: 1-9.
    • (2006) European Journal of Pharmacology , vol.553 , pp. 1-9
    • Greasley, P.J.1    Clapham, J.C.2
  • 66
    • 1642495639 scopus 로고    scopus 로고
    • Efficacy as a vector: The relative prevalence and paucity of inverse agonism
    • Kenakin T, (2004) Efficacy as a vector: The relative prevalence and paucity of inverse agonism. Molecular Pharmacology 65: 2-11.
    • (2004) Molecular Pharmacology , vol.65 , pp. 2-11
    • Kenakin, T.1
  • 70
    • 0029816971 scopus 로고    scopus 로고
    • Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors
    • Gardella TJ, Luck MD, Jensen GS, Schipani E, Potts JT, Jr, et al, (1996) Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors. Endocrinology 137: 3936-3941.
    • (1996) Endocrinology , vol.137 , pp. 3936-3941
    • Gardella, T.J.1    Luck, M.D.2    Jensen, G.S.3    Schipani, E.4    Potts Jr., J.T.5
  • 71
    • 77952415656 scopus 로고    scopus 로고
    • Beyond desensitization: Physiological relevance of arrestin-dependent signaling
    • Luttrell LM, Gesty-Palmer D, (2010) Beyond desensitization: Physiological relevance of arrestin-dependent signaling. Pharmacological Reviews 62: 305-330.
    • (2010) Pharmacological Reviews , vol.62 , pp. 305-330
    • Luttrell, L.M.1    Gesty-Palmer, D.2
  • 72
    • 2542484525 scopus 로고    scopus 로고
    • Ligand-selective dissociation of activation and internalization of the parathyroid hormone (PTH) receptor: Conditional efficacy of PTH peptide fragments
    • Sneddon WB, Magyar CE, Willick GE, Syme CA, Galbiati F, et al. (2004) Ligand-selective dissociation of activation and internalization of the parathyroid hormone (PTH) receptor: Conditional efficacy of PTH peptide fragments. Endocrinology 145: 2815-2823.
    • (2004) Endocrinology , vol.145 , pp. 2815-2823
    • Sneddon, W.B.1    Magyar, C.E.2    Willick, G.E.3    Syme, C.A.4    Galbiati, F.5
  • 74
    • 0033621812 scopus 로고    scopus 로고
    • Interaction with gbetagamma is required for membrane targeting and palmitoylation of galpha(s) and galpha(q)
    • Evanko DS, Thiyagarajan MM, Wedegaertner PB, (2000) Interaction with gbetagamma is required for membrane targeting and palmitoylation of galpha(s) and galpha(q). The Journal of Biological Chemistry 275: 1327-1336.
    • (2000) The Journal of Biological Chemistry , vol.275 , pp. 1327-1336
    • Evanko, D.S.1    Thiyagarajan, M.M.2    Wedegaertner, P.B.3
  • 75
    • 0035830863 scopus 로고    scopus 로고
    • Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome
    • Petaja-Repo UE, Hogue M, Laperriere A, Bhalla S, Walker P, et al. (2001) Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome. The Journal of Biological Chemistry 276: 4416-4423.
    • (2001) The Journal of Biological Chemistry , vol.276 , pp. 4416-4423
    • Petaja-Repo, U.E.1    Hogue, M.2    Laperriere, A.3    Bhalla, S.4    Walker, P.5
  • 76
    • 0037007201 scopus 로고    scopus 로고
    • Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation
    • Petaja-Repo UE, Hogue M, Bhalla S, Laperriere A, Morello JP, et al. (2002) Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation. The EMBO Journal 21: 1628-1637.
    • (2002) The EMBO Journal , vol.21 , pp. 1628-1637
    • Petaja-Repo, U.E.1    Hogue, M.2    Bhalla, S.3    Laperriere, A.4    Morello, J.P.5
  • 78
    • 8744236215 scopus 로고    scopus 로고
    • Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors
    • Wuller S, Wiesner B, Loffler A, Furkert J, Krause G, et al. (2004) Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors. The Journal of Biological Chemistry 279: 47254-47263.
    • (2004) The Journal of Biological Chemistry , vol.279 , pp. 47254-47263
    • Wuller, S.1    Wiesner, B.2    Loffler, A.3    Furkert, J.4    Krause, G.5
  • 79
    • 0038147442 scopus 로고    scopus 로고
    • Endoplasmic reticulum retention, degradation, and aggregation of olfactory G-protein coupled receptors
    • Lu M, Echeverri F, Moyer BD, (2003) Endoplasmic reticulum retention, degradation, and aggregation of olfactory G-protein coupled receptors. Traffic (Copenhagen, Denmark) 4: 416-433.
    • (2003) Traffic (Copenhagen, Denmark) , vol.4 , pp. 416-433
    • Lu, M.1    Echeverri, F.2    Moyer, B.D.3
  • 80
    • 10144252497 scopus 로고    scopus 로고
    • Endoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expression
    • Lu M, Staszewski L, Echeverri F, Xu H, Moyer BD, (2004) Endoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expression. BMC Cell Biology 5: 34.
    • (2004) BMC Cell Biology , vol.5 , pp. 34
    • Lu, M.1    Staszewski, L.2    Echeverri, F.3    Xu, H.4    Moyer, B.D.5
  • 81
    • 33746730393 scopus 로고    scopus 로고
    • Effective inefficiency': Cellular control of protein trafficking as a mechanism of post-translational regulation
    • Conn PM, Janovick JA, Brothers SP, Knollman PE, (2006) 'Effective inefficiency': Cellular control of protein trafficking as a mechanism of post-translational regulation. The Journal of Endocrinology 190: 13-16.
    • (2006) The Journal of Endocrinology , vol.190 , pp. 13-16
    • Conn, P.M.1    Janovick, J.A.2    Brothers, S.P.3    Knollman, P.E.4
  • 82
    • 33750915929 scopus 로고    scopus 로고
    • Protein folding as posttranslational regulation: Evolution of a mechanism for controlled plasma membrane expression of a G protein-coupled receptor
    • Conn PM, Knollman PE, Brothers SP, Janovick JA, (2006) Protein folding as posttranslational regulation: Evolution of a mechanism for controlled plasma membrane expression of a G protein-coupled receptor. Molecular Endocrinology (Baltimore, Md.) 20: 3035-3041.
    • (2006) Molecular Endocrinology (Baltimore, Md.) , vol.20 , pp. 3035-3041
    • Conn, P.M.1    Knollman, P.E.2    Brothers, S.P.3    Janovick, J.A.4
  • 83
    • 0029588528 scopus 로고
    • Differential glycosylation and intracellular trafficking for the long and short isoforms of the D2 dopamine receptor
    • Fishburn CS, Elazar Z, Fuchs S, (1995) Differential glycosylation and intracellular trafficking for the long and short isoforms of the D2 dopamine receptor. The Journal of Biological Chemistry 270: 29819-29824.
    • (1995) The Journal of Biological Chemistry , vol.270 , pp. 29819-29824
    • Fishburn, C.S.1    Elazar, Z.2    Fuchs, S.3
  • 85
    • 58249090329 scopus 로고    scopus 로고
    • Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective alpha(1b)-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers
    • Canals M, Lopez-Gimenez JF, Milligan G, (2009) Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective alpha(1b)-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers. The Biochemical Journal 417: 161-172.
    • (2009) The Biochemical Journal , vol.417 , pp. 161-172
    • Canals, M.1    Lopez-Gimenez, J.F.2    Milligan, G.3
  • 86
    • 84855295987 scopus 로고    scopus 로고
    • Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis
    • Maicas N, Ibanez L, Alcaraz MJ, Ubeda A, Ferrandiz ML, (2012) Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis. Arthritis and Rheumatism 64: 130-140.
    • (2012) Arthritis and Rheumatism , vol.64 , pp. 130-140
    • Maicas, N.1    Ibanez, L.2    Alcaraz, M.J.3    Ubeda, A.4    Ferrandiz, M.L.5
  • 87
    • 18844451476 scopus 로고    scopus 로고
    • In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadism in humans expressing compound heterozygous alleles
    • Leanos-Miranda A, Ulloa-Aguirre A, Janovick JA, Conn PM, (2005) In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadism in humans expressing compound heterozygous alleles. The Journal of Clinical Endocrinology and Metabolism 90: 3001-3008.
    • (2005) The Journal of Clinical Endocrinology and Metabolism , vol.90 , pp. 3001-3008
    • Leanos-Miranda, A.1    Ulloa-Aguirre, A.2    Janovick, J.A.3    Conn, P.M.4
  • 88
    • 77952333017 scopus 로고    scopus 로고
    • Pharmacochaperoning of the A1 adenosine receptor is contingent on the endoplasmic reticulum
    • Malaga-Dieguez L, Yang Q, Bauer J, Pankevych H, Freissmuth M, et al. (2010) Pharmacochaperoning of the A1 adenosine receptor is contingent on the endoplasmic reticulum. Molecular Pharmacology 77: 940-952.
    • (2010) Molecular Pharmacology , vol.77 , pp. 940-952
    • Malaga-Dieguez, L.1    Yang, Q.2    Bauer, J.3    Pankevych, H.4    Freissmuth, M.5
  • 90
    • 79955575162 scopus 로고    scopus 로고
    • International union of basic and clinical pharmacology. LXXXIII: Classification of prostanoid receptors, updating 15 years of progress
    • Woodward DF, Jones RL, Narumiya S, (2011) International union of basic and clinical pharmacology. LXXXIII: Classification of prostanoid receptors, updating 15 years of progress. Pharmacological Reviews 63: 471-538.
    • (2011) Pharmacological Reviews , vol.63 , pp. 471-538
    • Woodward, D.F.1    Jones, R.L.2    Narumiya, S.3
  • 91
    • 8844254704 scopus 로고    scopus 로고
    • Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis
    • Arai I, Takano N, Hashimoto Y, Futaki N, Sugimoto M, et al. (2004) Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis. European Journal of Pharmacology 505: 229-235.
    • (2004) European Journal of Pharmacology , vol.505 , pp. 229-235
    • Arai, I.1    Takano, N.2    Hashimoto, Y.3    Futaki, N.4    Sugimoto, M.5
  • 92
    • 33846089351 scopus 로고    scopus 로고
    • Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice
    • Arai I, Takaoka A, Hashimoto Y, Honma Y, Koizumi C, et al. (2007) Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. European Journal of Pharmacology 556: 207-214.
    • (2007) European Journal of Pharmacology , vol.556 , pp. 207-214
    • Arai, I.1    Takaoka, A.2    Hashimoto, Y.3    Honma, Y.4    Koizumi, C.5
  • 93
    • 34250677710 scopus 로고    scopus 로고
    • The anti-pruritic efficacy of TS-022, a prostanoid DP1 receptor agonist, is dependent on the endogenous prostaglandin D2 level in the skin of NC/Nga mice
    • Sugimoto M, Arai I, Futaki N, Hashimoto Y, Sakurai T, et al. (2007) The anti-pruritic efficacy of TS-022, a prostanoid DP1 receptor agonist, is dependent on the endogenous prostaglandin D2 level in the skin of NC/Nga mice. European Journal of Pharmacology 564: 196-203.
    • (2007) European Journal of Pharmacology , vol.564 , pp. 196-203
    • Sugimoto, M.1    Arai, I.2    Futaki, N.3    Hashimoto, Y.4    Sakurai, T.5
  • 94
    • 33847143728 scopus 로고    scopus 로고
    • Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells
    • Hammad H, Kool M, Soullie T, Narumiya S, Trottein F, et al. (2007) Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. The Journal of Experimental Medicine 204: 357-367.
    • (2007) The Journal of Experimental Medicine , vol.204 , pp. 357-367
    • Hammad, H.1    Kool, M.2    Soullie, T.3    Narumiya, S.4    Trottein, F.5


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