Endoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expression

BMC Cell Biology

Volumn 5, Issue , 2004, Pages

  Lu, Min ^a   Staszewski, Lena ^a,b   Echeverri, Fernando ^a   Xu, Hong ^a   Moyer, Bryan D ^a  

^a Senomyx Inc   (United States)

^b Kalypsys Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CATION CHANNEL; CYCLIC NUCLEOTIDE; G PROTEIN COUPLED RECEPTOR; PROTEASOME; UBIQUITIN; EUGENOL; HYBRID PROTEIN; PROTEASOME INHIBITOR; RHODOPSIN;

ARTICLE; AUTOPHAGY; BIOSYNTHESIS; CALCIUM CELL LEVEL; CELL MEMBRANE; CELL TRANSPORT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; GOLGI COMPLEX; HUMAN; HUMAN CELL; OLFACTORY DISCRIMINATION; OLFACTORY NERVE; OLFACTORY RECEPTOR; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CHANNEL GATING; DRUG EFFECT; GENE EXPRESSION; METABOLISM; MOUSE; ODOR; PROTEIN TRANSPORT;

ANIMALS; AUTOPHAGY; CELL LINE; ENDOPLASMIC RETICULUM; EUGENOL; GENE EXPRESSION; GOLGI APPARATUS; HUMANS; ION CHANNEL GATING; MICE; ODORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PROTEIN TRANSPORT; RECEPTORS, ODORANT; RECOMBINANT FUSION PROTEINS; RHODOPSIN; UBIQUITIN;

EID: 10144252497     PISSN: 14712121     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2121-5-34     Document Type: Article

References (45)

1. Firestein S: How the olfactory system makes sense of scents. Nature 2001, 413:211-218.
2. Mombaerts P: How smell develops. Nat Neurosci 2001, 4 Suppl:1192-1198.
3. Buck L, Axel R: A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 1991, 65:175-187.
4. Mombaerts P: Genes and ligands for odorant, vomeronasal and taste receptors. Nat Rev Neurosci 2004, 5:263-278.
5. Gimelbrant AA, Stoss TD, Landers TM, McClintock TS: Truncation releases olfactory receptors from the endoplasmic reticulum of heterologous cells. J Neurochem 1999, 72:2301-2311.
6. McClintock TS, Sammeta N: Trafficking prerogatives of olfactory receptors. Neuroreport 2003, 14:1547-1552.
7. Lu M, Echeverri F, Moyer BD: Endoplasmic reticulum retention, degradation, and aggregation of olfactory g-protein coupled receptors. Traffic 2003, 4:416-433.
8. Kajiya K, Inaki K, Tanaka M, Haga T, Kataoka H, Touhara K: Molecular bases of odor discrimination: Reconstitution of olfactory receptors that recognize overlapping sets of odorants. J Neurosci 2001, 21:6018-6025.
9. Kaupp UB, Seifert R: Cyclic nucleotide-gated ion channels. Physiol Rev 2002, 82:769-824.
10. Reinscheid RK, Kim J, Zeng J, Civelli O: High-throughput realtime monitoring of G(s)-coupled receptor activation in intact cells using cyclic nucleotide-gated channels. Eur J Pharmacol 2003, 478:27-34.
11. Rich TC, Tse TE, Rohan JG, Schaack J, Karpen JW: In vivo assessment of local phosphodiesterase activity using tailored cyclic nucleotide-gated channels as cAMP sensors. J Gen Physiol 2001, 118:63-78.
12. Ronnett GV, Moon C: G proteins and olfactory signal transduction. Annu Rev Physiol 2002, 64:189-222.
13. Jones DT, Reed RR: Golf: an olfactory neuron specific-G protein involved in odorant signal transduction. Science 1989, 244:790-795.
14. Jones DT, Masters SB, Bourne HR, Reed RR: Biochemical characterization of three stimulatory GTP-binding proteins. The large and small forms of Gs and the olfactory-specific G-protein, Golf. J Biol Chem 1990, 265:2671-2676.
15. Xia Z, Choi EJ, Wang F, Storm DR: The type III calcium/calmodulin-sensitive adenylyl cyclase is not specific to olfactory sensory neurons. Neurosci Lett 1992, 144: 69-173.
16. Krautwurst D, Yau KW, Reed RR: Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell 1998, 95:917-926.
17. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ: T2Rs function as bitter taste receptors. Cell 2000, 100:703-711.
18. Katada S, Nakagawa T, Kataoka H, Touhara K: Odorant response assays for a heterologously expressed olfactory receptor. Biochem Biophys Res Commun 2003, 305:964-969.
19. Katada S, Tanaka M, Touhara K: Structural determinants for membrane trafficking and G protein selectivity of a mouse olfactory receptor. J Neurochem 2004, 90:1453-1463.
20. Zhao H, Ivic L, Otaki JM, Hashimoto M, Mikoshiba K, Firestein S: Functional expression of a mammalian odorant receptor. Science 1998, 279:237-242.
21. Seglen PO, Gordon PB: 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A 1982, 79:1889-1892.
22. Meng L, Mohan R, Kwok BH, Elofsson M, Sin N, Crews CM: Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci U S A 1999, 96: 0403-10408.
23. Kopito RR, Sitia R: Aggresomes and Russell bodies. Symptoms of cellular indigestion? EMBO Rep 2000, 1: 25-231.
24. Fortun J, Dunn W. A., Jr., Joy S, Li J, Notterpek L: Emerging role for autophagy in the removal of aggresomes in Schwann cells. J Neurosci 2003, 23:10672-10680.
25. Ravikumar B, Duden R, Rubinsztein DC: Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet 2002, 11:1107-1117.
26. Saito H, Matsunami M, Roberts R, Chi Q, Matsunami H: Molecules that regulate translocation and function of mammalian odorant receptors [abstract]. AChems 2004, 26:33 (abstract # 128).
27. Gobeil F., Jr., Vazquez-Tello A, Marrache AM, Bhattacharya M, Checchin D, Bkaily G, Lachapelle P, Ribeiro-Da-Silva A, Chemtob S: Nuclear prostaglandin signaling system: biogenesis and actions via heptahelical receptors. Can J Physiol Pharmacol 2003, 81: 96-204.
28. Boivin B, Chevalier D, Villeneuve LR, Rousseau E, Allen BG: Functional endothelin receptors are present on nuclei in cardiac ventricular myocytes. J Biol Chem 2003, 278:29153-29163.
29. O'Malley KL, Jong YJ, Gonchar Y, Burkhalter A, Romano C: Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons. J Biol Chem 2003, 278:28210-28219.
30. Klausner RD, Donaldson JG, Lippincott-Schwartz J: Brefeldin A: insights into the control of membrane traffic and organelle structure. J Cell Biol 1992, 116:1071-1080.
31. Jockers R, Angers S, Da Silva A, Benaroch P, Strosberg AD, Bouvier M, Marullo S: Beta(2)-adrenergic receptor down-regulation. Evidence for a pathway that does not require endocytosis. J Biol Chem 1999, 274:28900-28908.
32. Mollenhauer HH, Morre DJ, Rowe LD: Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochim Biophys Acta 1990, 1031: 25-246.
33. Kuismanen E, Saraste J: Low temperature-induced transport blocks as tools to manipulate membrane traffic. Methods Cell Biol 1989, 32:257-274.
34. Zhang K, Kaufman RJ: Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem 2004, 279:25935-25938.
35. Morello JP, Petaja-Repo UE, Bichet DG, Bouvier M: Pharmacological chaperones: a new twist on receptor folding. Trends Pharmacol Sci 2000, 21:466-469.
36. Petaja-Repo UE, Hogue M, Bhalla S, Laperriere A, Morello JP, Bouvier M: Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation. Embo J 2002, 21:1628-1637.
37. Li T, Sandberg MA, Pawlyk BS, Rosner B, Hayes KC, Dryja TP, Berson EL: Effect of vitamin A supplementation on rhodopsin mutants threonine-17 --> methionine and proline-347 --> serine in transgenic mice and in cell cultures. Proc Natl Acad Sci U S A 1998, 95: 1933-11938.
38. Novoradovskaya N, Lee J, Yu ZX, Ferrans VJ, Brantly M: Inhibition of intracellular degradation increases secretion of a mutant form of alpha1-antitrypsin associated with profound deficiency. J Clin Invest 1998, 101:2693-2701.
39. Lim M, McKenzie K, Floyd AD, Kwon E, Zeitlin PL: Modulation of deltaF508 cystic fibrosis transmembrane regulator trafficking and function with 4-phenylbutyrate and flavonoids. Am J Respir Cell Mol Biol 2004, 31:351-357.
40. deCarvalho AV, Ndi CP, Tsopmo A, Tane P, Ayafor J, Connolly JD, Teem JL: A novel natural product compound enhances cAMPregulated chloride conductance of cells expressing CFTR[delta]F508. Mol Med 2002, 8:75-87.
41. Loffing-Cueni D, Loffing J, Shaw C, Taplin AM, Govindan M, Stanton CR, Stanton BA: Trafficking of GFP-tagged DeltaF508-CFTR to the plasma membrane in a polarized epithelial cell line. Am J Physiol Cell Physiol 2001, 281:C1889-97.
42. Wojcikiewicz RJ: Regulated ubiquitination of proteins in GPCR-initiated signaling pathways. Trends Pharmacol Sci 2004, 25:35-41.
43. Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ: Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 2001, 294: 307-1313.
44. Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E: Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A 2002, 99:4692-4696.
45. Chyb S, Dahanukar A, Wickens A, Carlson JR: Drosophila Gr5a encodes a taste receptor tuned to trehalose. Proc Natl Acad Sci U S A 2003, 100 Suppl 2:14526-14530.