Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: Identification of a recycling motif

European Journal of Pharmacology

Volumn 630, Issue 1-3, 2010, Pages 10-18

  Roy, Sébastien J ^a   Parent, Audrey ^a   Gallant, Maxime A ^a   de Brum Fernandes, Artur J ^a,c   Stanková, Jana ^b,c   Parent, Jean Luc ^a,c  

^a Centre Hospitalier Universitaire de Sherbrooke   (Canada)

^b UNIVERSITY OF SHERBROOKE   (Canada)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Arrestin; CRTH2; G protein coupled receptor; GRKs; Internalization; PKC

Indexed keywords

ALANINE; AMINO ACID; ARRESTIN 3; ASPARTIC ACID; CHEMOATTRACTANT RECEPTOR HOMOLOGOUS MOLECULE EXPRESSED ON TH2 LYMPHOCYTES; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 5; GLUTAMIC ACID; LEUCINE; MEMBRANE PROTEIN; MONENSIN; PROSTAGLANDIN D2; SERINE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; INTERNALIZATION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN TRANSPORT; RECEPTOR UPREGULATION; SITE DIRECTED MUTAGENESIS; WILD TYPE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARRESTINS; CELL LINE; ENDOCYTOSIS; G-PROTEIN-COUPLED RECEPTOR KINASE 2; G-PROTEIN-COUPLED RECEPTOR KINASE 5; HUMANS; KIDNEY; MUTAGENESIS, SITE-DIRECTED; PROSTAGLANDIN D2; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; SEQUENCE DELETION; TRANSFECTION;

EID: 77649190267     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.12.022     Document Type: Article

References (34)

1. Cao T.T., Deacon H.W., Reczek D., Bretscher A., von Zastrow M. A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor. Nature 1999, 401:286-290.
2. Ferguson S.S. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol. Rev. 2001, 53:1-24.
3. Franco R., Casado V., Cortes A., Ferrada C., Mallol J., Woods A., Lluis C., Canela E.I., Ferre S. Basic concepts in G-protein-coupled receptor homo- and heterodimerization. Sci. World J. 2007, 7:48-57.
4. Fredericks Z.L., Pitcher J.A., Lefkowitz R.J. Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor. J. Biol. Chem. 1996, 271:13796-13803.
5. Gage R.M., Kim K.A., Cao T.T., von Zastrow M. A transplantable sorting signal that is sufficient to mediate rapid recycling of G protein-coupled receptors. J. Biol. Chem. 2001, 276:44712-44720.
6. Gage R.M., Matveeva E.A., Whiteheart S.W., von Zastrow M. Type I PDZ ligands are sufficient to promote rapid recycling of G Protein-coupled receptors independent of binding to N-ethylmaleimide-sensitive factor. J. Biol. Chem. 2005, 280:3305-3313.
7. Gallant M.A., Samadfam R., Hackett J.A., Antoniou J., Parent J.L., de Brum-Fernandes A.J. Production of prostaglandin D(2) by human osteoblasts and modulation of osteoprotegerin, RANKL, and cellular migration by DP and CRTH2 receptors. J. Bone Miner. Res. 2005, 20:672-681.
8. Gallant M.A., Slipetz D., Hamelin E., Rochdi M.D., Talbot S., de Brum-Fernandes A.J., Parent J.L. Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2. Eur. J. Pharmacol. 2007, 557:115-123.
9. Goodman O.B., Krupnick J.G., Santini F., Gurevich V.V., Penn R.B., Gagnon A.W., Keen J.H., Benovic J.L. Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature 1996, 383:447-450.
10. Hamelin E., Theriault C., Laroche G., Parent J.L. The intracellular trafficking of the G protein-coupled receptor TPbeta depends on a direct interaction with Rab11. J. Biol. Chem. 2005, 280:36195-36205.
11. Hanyaloglu A.C., von Zastrow M. Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu. Rev. Pharmacol. Toxicol. 2008, 48:537-568.
12. Hillier B.J., Christopherson K.S., Prehoda K.E., Bredt D.S., Lim W.A. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science 1999, 284:812-815.
13. Hirai H., Tanaka K., Yoshie O., Ogawa K., Kenmotsu K., Takamori Y., Ichimasa M., Sugamura K., Nakamura M., Takano S., Nagata K. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J. Exp. Med. 2001, 193:255-261.
14. Hirai H., Tanaka K., Takano S., Ichimasa M., Nakamura M., Nagata K. Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2. J. Immunol. 2002, 168:981-985.
15. Hu L.A., Tang Y., Miller W.E., Cong M., Lau A.G., Lefkowitz R.J., Hall R.A. beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-d-aspartate receptors. J. Biol. Chem. 2000, 275:38659-38666.
16. Krishnamurthy H., Kishi H., Shi M., Galet C., Bhaskaran R.S., Hirakawa T., Ascoli M. Postendocytotic trafficking of the follicle-stimulating hormone (FSH)-FSH receptor complex. Mol. Endocrinol. 2003, 17:2162-2176.
17. Laporte S.A., Oakley R.H., Holt J.A., Barak L.S., Caron M.G. The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits. J. Biol. Chem. 2000, 275:23120-23126.
18. Laroche G., Lepine M.C., Theriault C., Giguere P., Giguere V., Gallant M.A., de Brum-Fernandes A., Parent J.L. Oligomerization of the alpha and beta isoforms of the thromboxane A2 receptor: relevance to receptor signaling and endocytosis. Cell. Signal. 2005, 17:1373-1383.
19. Marchese A., Paing M.M., Temple B.R., Trejo J. G protein-coupled receptor sorting to endosomes and lysosomes. Annu. Rev. Pharmacol. Toxicol. 2008, 48:601-629.
20. Mayor F., Penela P., Ruiz-Gomez A. Role of G protein-coupled receptor kinase 2 and arrestins in beta-adrenergic receptor internalization. Trends Cardiovasc. Med. 1998, 8:234-240.
21. Monneret G., Gravel S., Diamond M., Rokach J., Powell W.S. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood 2001, 98:1942-1948.
22. Moore C.A., Milano S.K., Benovic J.L. Regulation of receptor trafficking by GRKs and arrestins. Annu. Rev. Physiol. 2007, 69:451-482.
23. Oakley R.H., Laporte S.A., Holt J.A., Caron M.G., Barak L.S. Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J. Biol. Chem. 2000, 275:17201-17210.
24. Oakley R.H., Laporte S.A., Holt J.A., Barak L.S., Caron M.G. Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis. J. Biol. Chem. 2001, 276:19452-19460.
25. Onorato J.J., Palczewski K., Regan J.W., Caron M.G., Lefkowitz R.J., Benovic J.L. Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. Biochemistry 1991, 30:5118-5125.
26. Paasche J.D., Attramadal T., Kristiansen K., Oksvold M.P., Johansen H.K., Huitfeldt H.S., Dahl S.G., Attramadal H. Subtype-specific sorting of the ETA endothelin receptor by a novel endocytic recycling signal for G protein-coupled receptors. Mol. Pharmacol. 2005, 67:1581-1590.
27. Palczewski K., Arendt A., McDowell J.H., Hargrave P.A. Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations. Biochemistry 1989, 28:8764-8770.
28. Parent J.L., Labrecque P., Orsini M.J., Benovic J.L. Internalization of the TXA2 receptor alpha and beta isoforms. Role of the differentially spliced cooh terminus in agonist-promoted receptor internalization. J. Biol. Chem. 1999, 274:8941-8948.
29. Parent J.L., Labrecque P., Driss Rochdi M., Benovic J.L. Role of the differentially spliced carboxyl terminus in thromboxane A2 receptor trafficking: identification of a distinct motif for tonic internalization. J. Biol. Chem. 2001, 276:7079-7085.
30. Premont R.T., Gainetdinov R.R. Physiological roles of G protein-coupled receptor kinases and arrestins. Annu. Rev. Physiol. 2007, 69:511-534.
31. Schroder R., Merten N., Mathiesen J.M., Martini L., Kruljac-Letunic A., Krop F., Blaukat A., Fang Y., Tran E., Ulven T., Drewke C., Whistler J., Pardo L., Gomeza J., Kostenis E. The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation. J. Biol. Chem. 2009, 284:1324-1336.
32. Theriault C., Rochdi M.D., Parent J.L. Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta). Biochemistry 2004, 43:5600-5607.
33. Trejo J. Internal PDZ ligands: novel endocytic recycling motifs for G protein-coupled receptors. Mol. Pharmacol. 2005, 67:1388-1390.
34. Xue L., Gyles S.L., Wettey F.R., Gazi L., Townsend E., Hunter M.G., Pettipher R. Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. J. Immunol. 2005, 175:6531-6536.