Affinities, selectivities, potencies, and intrinsic activities of natural and synthetic prostanoids using endogenous receptors: Focus on DP class prostanoids

Journal of Pharmacology and Experimental Therapeutics

Volumn 293, Issue 2, 2000, Pages 321-328

  Sharif, Najam A ^a   Crider, Julie Y ^a   Xu, Shouxi X ^a   Williams, Gary W ^a  

^a ALCON RESEARCH LTD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYCLOHEXYL 3' HYDROXYPROP 1 YNYL 3 HYDROXYBICYCLO[4.2.0]OCT 7 YLIDENE; 5 (6 CARBOXYHEXYL) 1 (3 CYCLOHEXYL 3 HYDROXYPROPYL)HYDANTOIN; 7 [3 (3 CYCLOHEXYL 3 HYDROXY 1 PROPENYL) 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; 9BETA CHLORO 15 CYCLOHEXYL 9 DEOXY 16,17,18,19,20 PENTANOR 3 OXAPROSTAGLANDIN F2 ALPHA; 9BETA CHLORO 15 CYCLOHEXYL 9 DEOXY 16,17,18,19,20 PENTANORPROSTAGLANDIN F2 ALPHA; CYCLIC AMP; PROSTACYCLIN; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTANOID; PROSTANOID RECEPTOR; RS 93520; SQ 27986; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATTLE; CONCENTRATION RESPONSE; DISSOCIATION CONSTANT; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR SENSITIVITY;

3T3 CELLS; ADENYLATE CYCLASE; ALPROSTADIL; ANIMALS; BLOOD PLATELETS; CELL LINE; CHO CELLS; CRICETINAE; EPOPROSTENOL; HUMANS; MICE; PHOSPHATIDYLINOSITOLS; PROSTAGLANDIN D2; PROSTAGLANDINS; PROSTAGLANDINS D; PROSTAGLANDINS F; PROSTAGLANDINS, SYNTHETIC; RECEPTORS, PROSTAGLANDIN;

EID: 0034012172     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Armstrong RA, Lawrence RA, Jones RL, Wilson NH and Collier A (1989) Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors. Br J Pharmacol 97:657-668.
2. Arunlakshana O and Schild HO (1959) Some quantitative uses of drug antagonists. Br J Pharmacol Chemother 14:48-58.
3. Blair IA, Hensby CN and McDermot J (1980) Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic hybrid: Prostanoid structure-activity relationships. Br J Pharmacol 69:519-525.
4. 1A receptors: Variations in intrinsic activity studied in transfected HeLa cells. Naunyn-Schmiedeberg's Arch Pharmacol 345:257-263.
5. Bowen WP and Jerman J (1995) Nonlinear regression using spreadsheets. Trends Pharmacol Sci 16:413-417.
6. 50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
7. 4 antagonist, AH22921, in Advances in Prostaglandin, Thromboxane and Leukotriene Research (Samuelson B, Paoletti R and Ramwell P eds) pp 241-246, Raven Press, New York.
8. Coleman RA, Smith WL and Narumiya S (1994) VIII International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46:205-229.
9. 2 receptor. J Clin Invest 64:586-590.
10. Crider JY, Griffin BW and Sharif NA (1999) Prostaglandin DP receptors positively coupled to adenylyl cyclase in embryonic bovine tracheal (EBTr) cells: Pharmacological characterization using agonists and antagonists. Br J Pharmacol 127:204-210.
11. 4 prostaglandin receptors coupled positively to adenylyl cyclase in Chinese hamster ovary cells: Pharmacological characterization. Prostagland Leukot Essent Fatty Acids 62:21-26.
12. Fernandas B and Crankshaw D (1995) Functional characterization of the prostanoid DP receptor in human myometrium. Eur J Pharmacol 283:73-81.
13. Furchgott RF (1972) The classification of adrenoreceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory, in Handbook of Experimental Pharmacology, Catecholamines (Blaschko H and Muscholl E eds) pp 283-335, Springer-Verlag, Berlin.
14. Giles H, Leff P, Bolofo ML, Kelly MG and Robertson AD (1989) The classification of prostaglandin DP-receptors in platelets and vasculature using BWA868C, a novel, selective and potent competitive antagonist. Br J Pharmacol 96:291-300.
15. 2α (FP) receptor. J Pharmacol Exp Ther 290:1278-1284.
16. 2 in anesthetized guinea-pigs: Effect of DP-antagonist BWA868C. Br J Pharmacol 100:761-767.
17. 2-receptor stimulated cyclic AMP synthesis in cultured human non-pigmented ciliary epithelium. Exp Eye Res 58:563-566.
18. Kenakin T (1996) The classification of seven transmembrane receptors in recombinant expression systems. Pharmacol Rev 48:413-463.
19. Kenakin T (1997) Differences between natural and recombinant G protein-coupled receptor systems with varying receptor-G protein stoichiometry. Trends Pharmacol Sci 18:456-464.
20. Kiriyania M, Ushikubi F, Kobayashi T, Hirata M, Sugimoto Y and Narumiya S (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol 122:217-224.
21. 2 (DP) receptors: Estimation of affinities and relative efficacies for a series of novel bicyclic ligands with an appendix on goodness-of-fit analyses. Br J Pharmacol 106:996-1003.
22. Liu YJ, Jackson DM and Blackham A (1996a) Effects of BWA868C, a selective prostaglandin DP receptor antagonist, in dog isolated vascular preparations. Eur J Pharmacol 303:187-192.
23. - secretion in dog tracheal epithelium. Eur J Pharmacol 304:117-122.
24. Lydford SJ, McKechnie KCW and Dougall IG (1996) Pharmacological studies on prostanoid receptors in the rabbit isolated saphenous vein: A comparison with the rabbit isolated ear artery. Br J Pharmacol 117:13-20.
25. 2 receptor stimulation elicits ocular hypotensive effects in rabbits and cats. Eur J Pharmacol 275:245-250.
26. McDermot J, Barnes PJ, Waddell KA, Dollery CT and Blair IA (1981) Prostacyclin binding to guinea pig pulmonary receptors. Eur J Pharmacol 75:127-130.
27. McPherson GA (1983) A practical computer based approach to the analysis of radioligand binding experiments. Comput Prog Biomed 17:107-114.
28. Ogletree ML and Allen GT (1992) Interspecies differences in thromboxane receptors: Studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J Pharmacol Exp Ther 260:789-794.
29. Ohia SE and Jumblatt JE (1990) Prejunctional inhibitory effects of prostanoids on sympathetic neurotransmission in the rabbit iris-ciliary body. J Pharmacol Exp Ther 255:11-16.
30. Rangachari PK, Betti P-A, Prior ET and Roberts IILJ (1995) Effects of a selective DP receptor agonist (BW245C) and antagonist (BWA868C) on the canine colonie epithelium: An argument for a different DP receptor? J Pharmacol Exp Ther 275:611-617.
31. 2-analogues. Adv Prostagland Thromboxane Leukot Res 21:591-594.
32. Sharif NA, Crider JY, Griffin BW, Davis TL and Howe WE (1997) Pharmacological analysis of mast cell mediator and neurotransmitter receptors coupled to adenylate cyclase and phospholipase C in immunocytochemically-defined human conjunctival epithelial cells. J Ocular Pharmacol Ther 13:321-336.
33. 3H]9-β-[+]fluprostenol): Carboxylic acid of travoprost (AL-6221), a novel FP prostaglandin to study the pharmacology and autoradiographic localization of the FP receptor. J Pharm Pharmacol 51:685-694.
34. 3 and FP prostaglandin receptor binding sites in bovine corpus luteum: Characterization and correlation with functional data. J Pharmacol Exp Ther 286:1094-1102.
35. 2 to rat brain synaptic membrane: Occurrence, properties and distribution. J Biol Chem 257:13570-13575.
36. 2-receptor. Prostaglandins 35:855-868.
37. 2 receptors. Prostaglandins 25:13-28.
38. 2 and BW245C activation of human platelet adenylate cyclase. Br J Pharmacol 96:301-306.
39. Wiernas TK, Griffin BW and Sharif NA (1997) The expression of functionally-coupled bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists. Br J Pharmacol 121: 649-656.
40. Wright DH, Metters KM, Abramovitz M and Ford-Hutchinson AW (1998) Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol 123:1317-1324.