Prostaglandin DP receptors positively coupled to adenylyl cyclase in embryonic bovine tracheal (EBTr) cells: Pharmacological characterization using agonists and antagonists

British Journal of Pharmacology

Volumn 127, Issue 1, 1999, Pages 204-210

  Crider, J Y ^a   Griffin, B W ^a   Sharif, N A ^a  

^a ALCON RESEARCH LTD   (United States)

Author keywords

Adenylyl cyclase; AH6809; BW245C; BWA868C; Cyclic AMP; DP receptor; EBTr cells; Prostaglandin; RS93520; ZK118182

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 3 BENZYL 5 (6 CARBOXYHEXYL) 1 (2 CYCLOHEXYL 2 HYDROXYETHYLAMINO)HYDANTOIN; 5 (6 CARBOXYHEXYL) 1 (3 CYCLOHEXYL 3 HYDROXYPROPYL)HYDANTOIN; 6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; 9BETA CHLORO 15 CYCLOHEXYL 9 DEOXY 16,17,18,19,20 PENTANOR 3 OXAPROSTAGLANDIN F2 ALPHA; 9BETA CHLORO 15 CYCLOHEXYL 9 DEOXY 16,17,18,19,20 PENTANORPROSTAGLANDIN F2 ALPHA; ADENYLATE CYCLASE; BUTAPROST; CLOPROSTENOL; CYCLIC AMP; ENPROSTIL; FLUPROSTENOL; ILOPROST; MISOPROSTOL; PHXA 85; PROSTACYCLIN; PROSTAGLANDIN D2; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; RECEPTOR SUBTYPE; RS 93520; SQ 27986; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATTLE; CONTROLLED STUDY; EMBRYO; NONHUMAN; PRIORITY JOURNAL; TRACHEA;

EID: 0032903864     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702490     Document Type: Article

References (45)

1. Alexander, S.P.H. & Peters, J.A. (1998). 1998 receptor and ion channel nomenclature supplement. Trends Pharmacol. Sci., (Suppl)., Ninth edition. pp 64-66; Elsevier Salna Ltd.
2. 2 receptors on human platelets by analogs of prostacyclin. Prostaglandins, 42, 105-119.
3. Andersen, N.H. & Ramwell, P.W. (1974). Biological aspects of prostaglandins. Arch. Intern. Med., 133, 30-50.
4. Arunlakshana, O. & Schild, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother., 14, 48-58.
5. Boie, Y., Sawyer, N., Slipetz, D.M., Metters, K.M. & Abramovitz, M. (1995). Molecular cloning and characterization of the human prostanoid DP receptor. J. Biol. Chem., 270, 18910-18916.
6. Camras, C.B. & Alm, A. (1997). Initial clinical studies with prostaglandins and their analogues. Survey Ophthal., 41 (Suppl. 2), S61-S68.
7. 50) of an enzymatic reaction. Biochem. Pharmacol., 22, 3099-3108.
8. Coleman, R.A., Humphrey, P.P.A., Kennedy, I. & Lumley, P. (1984). Prostanoid receptors: The development of a working classification. Trends Pharmacol. Sci., 5, 303-306.
9. Coleman, R.A., Smith, W.L. & Narumiya, S. (1994). VIII. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev., 46, 205-229.
10. 2 receptor in human nonpigmented ciliary epithelial cells. J. Ocular Pharmacol. Ther., 14, 293-304.
11. 2 analog ZK118182. Eur. J. Pharmacol., 258, 207-213.
12. Fernandes, B. & Crankshaw, D. (1995). Functional characterization of the prostanoid DP receptor in human myometrium. Eur. J. Pharmacol., 283, 73-81.
13. 2. Br. J. Pharmacol., 104, 541-554.
14. Giles, H., Leff, P., Bolofo, M.L., Kelly, M.G. & Robertson, A.D. (1989). The classification of prostaglandin DP-receptors in platelets and vasculature using BWA868C, a novel, selective and potent competitive antagonist. Br. J. Pharmacol., 96, 291-300.
15. Griffin, B.W., Magnino, P.E., Pang, I.-H. & Sharif, N.A. (1998). Pharmacological characterization of an FP prostaglandin receptor on rat vascular smooth muscle cells (A7r5) coupled to phosphoinositide turnover and intracellular calcium mobilization. J. Pharmacol. Expt. Ther., 286, 411-418.
16. Griffin, B.W., Williams, G.W., Crider, J.Y. & Sharif, N.A. (1997). FP prostaglandin receptors mediating inositol phosphate generation and calcium mobilization in Swiss 3T3 cells: A pharmacological study. J. Pharmacol. Expt. Ther., 281, 845-854.
17. Hirata, M., KakizuKa, A., Aizawa, M., Ushikubi, F. & Narumiya, S. (1994). Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. Proc. Natl. Acad. Sci. U.S.A., 91, 11192-11196.
18. 2, a biochemical perspective. Pros. Leuko. Essent. Fatty Acids, 37, 219-234.
19. 2-responsive cell line from bovine embryonic trachea. Br. J. Pharmacol., 99, 13-14.
20. 2-induced bronchoconstriction is mediated only in part by the thromboxane prostanoid receptor. Eur. Respir. J., 8, 411-415.
21. Keery, R.J. & Lumley, P. (1988). AH6809, a prostaglandin DP-receptor blocking drug on human platelets. Br. J. Pharmacol., 94, 745-754.
22. Kennedy, I., Coleman, R.A., Humphrey, P.P.A., Levy, G.P. & Lumley, P. (1982). Studies on the characterization of prostanoid receptors: a proposed classification. Prostaglandins, 24, 667-689.
23. Kiriyama, M., Ushikubi, F., Kobayashi, T., Hirata, M., Sugimoto, Y. & Narumiya, S. (1997). Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol., 122, 217-224.
24. 2 (DP) receptors: estimation of affinities and relative efficacies for a series of novel bicyclic ligands (With an appendix on goodness-of-fit analyses). Br. J. Pharmacol., 106, 996-1003.
25. - secretion in dog tracheal epithelium. Eur. J. Pharmacol., 304, 117-122.
26. Liu, Y.J., Jackson, D.M. & Blackham, A. (1996b). Effects of BW A868C, a selective prostaglandin DP receptor antagonist, in dog isolated vascular preparations. Eur. J. Pharmacol., 303, 187-192.
27. Lydford, S.J., Mckechnie, K.C.W. & Dougall, I.G. (1996). Pharmacological studies on prostanoid receptors in the rabbit isolated saphenous vein: a comparison with the rabbit isolated ear artery. Br. J. Pharmacol., 117, 13-20.
28. 2 receptor stimulation elicits ocular hypotensive effects in rabbits and cats. Eur. J. Pharmacol., 275, 245-250.
29. Michel, A.D. & Whiting, R.L. (1984). Analysis of ligand binding data using a microcomputer. Br. J. Pharmacol., 83, 460P.
30. Namba, T., Oida, H., Sugimoto, Y., Kakizuka, A., Negishi, M., Ichikawa, A. & Narumiya, S. (1994). cDNA cloning of the mouse prostacyclin receptor. J. Biol. Chem., 269, 9986-9992.
31. Negishi, M., Sugimoto, Y. & Ichikawa, A. (1993). Prostanoid receptors and their biological actions. Prog. Lipid Res., 32, 417-434.
32. Narumiya, S. (1994). Prostanoid receptors: Structure, function, and distribution. In: Cellular generation, transport, and effects of eicosanoids: biological roles and pharmacological intervention, ed. Goetzl, E.J., Lewis, R.A. and Rola-Pleszczynski, M. pp. 126-138, New York: The New York Academy of Sciences.
33. 2 in a fibroblastic cell line (EBTr). Eicosanoids, 3, 213-218.
34. Rangachari, P.K., Betti, P.-A., Prior, E.T. & Roberts II, L.J. (1995). Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium; an argument for a different DP receptor? J. Pharmacol. Exp. Ther., 275, 611-617.
35. Senior, J., Marshall, K., Sangha, R. & Clayton, J.K. (1993). In vitro characterization of prostanoid receptors on human myometrium at term pregnancy. Br. J. Pharmacol., 108, 501-506.
36. Sharif, N.A., Crider, J.Y., Griffin, B.W., Davis, T.L. & Howe, W.E. (1997). Pharmacological analysis of mast cell mediator and neurotransmitter receptors coupled to adenylate cyclase and phospholipase C on immunocytochemically-defined human conjunctival epithelial cells. J. Ocular Pharmacol. Ther., 13, 321-336.
37. 3H]GR65630 binding. Br. J. Pharmacol., 102, 919-925.
38. Sharif, N.A. & Xu, S.X. (1996). Pharmacological characterization of bradykinin receptors coupled to phosphoinositide turnover in SV40-immortalized human trabecular meshwork cells. Exp. Eye Res., 63, 631-637.
39. 3 and FP receptor binding sites in bovine corpus luteum: characterization and correlation with functional data. J. Pharmacol. Expt. Ther., 286, 1094-1102.
40. 2 in primary cultures of bovine adrenal medullary cells: identification of the responsive population as fibroblasts. Biochim. Biophys. Acta., 1011, 75-80.
41. 2 and BW245C activation of human platelet adenylate cyclase. Br. J. Pharmacol., 96, 301-306.
42. Wheeldon, A. & Verday, C.J. (1993). Characterization of the inhibitory prostanoid receptors on human neutrophils. Br. J. Pharmacol., 108, 1051-1054.
43. 2-bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists. Br. J. Pharmacol., 121, 649-656.
44. 2 receptor antagonist. Biochem. Pharmacol., 50, 1731-1733.
45. Wright, D.H., Metters, K.M., Abramovitz, M. & Fordhutchinson, A.W. (1998). Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br. J. Pharmacol., 123, 1317-1324.