A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension

Journal of Biological Chemistry

Volumn 288, Issue 23, 2013, Pages 16557-16566

  Schwappacher, Raphaela ^a   Kilic, Ana ^b   Kojonazarov, Baktybek ^c   Lang, Michaela ^c   Diep, Thuan ^a   Zhuang, Shunhui ^a   Gawlowski, Thomas ^a   Schermuly, Ralph T ^c   Pfeifer, Alexander ^b   Boss, Gerry R ^a   Pilz, Renate B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BONN   (Germany)

^c JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABNORMAL VASCULAR REMODELING; BONE MORPHOGENETIC PROTEINS; MOLECULAR MECHANISM; PULMONARY ARTERIAL HYPERTENSION; PULMONARY ARTERIAL HYPERTENSION (PAH); PULMONARY ARTERY SMOOTH MUSCLE CELLS; THERAPEUTIC EFFECTS; VASCULAR REMODELING;

CELL DEATH; DISEASE CONTROL; GENES; MAMMALS; SIGNALING; TRANSCRIPTION;

SIGNAL TRANSDUCTION;

BONE MORPHOGENETIC PROTEIN; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE 1; RIOCIGUAT; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PULMONARY HYPERTENSION; RAT; SIGNAL TRANSDUCTION;

BONE MORPHOGENETIC PROTEIN (BMP); CYCLIC GMP (CGMP); PROTEIN KINASE G (PKG); PULMONARY HYPERTENSION; SMAD TRANSCRIPTION FACTOR;

ANIMALS; CELL LINE, TRANSFORMED; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASE TYPE I; HUMANS; HYPERTENSION, PULMONARY; MATRIX METALLOPROTEINASES, SECRETED; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RATS; SIGNAL TRANSDUCTION; SMAD PROTEINS;

MUS; RATTUS;

EID: 84878761110     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.458729     Document Type: Article

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