Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activation

Journal of Translational Medicine

Volumn 11, Issue 1, 2013, Pages

  Si, Yanna ^a   Bao, Hongguang ^a   Han, Liu ^a   Shi, Hongwei ^a   Zhang, Yuan ^a   Xu, Li ^a   Liu, Chenhui ^a   Wang, Jinsong ^a   Yang, Xiaobing ^a   Vohra, Akbar ^b   Ma, Daqing ^c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

AG490; Dexmedetomidine; Ischemia and Reperfusion Injury; JAK STAT; Renoprotection

Indexed keywords

ATIPAMEZOLE; CASPASE 3; DEXMEDETOMIDINE; DIMETHYL SULFOXIDE; INTERCELLULAR ADHESION MOLECULE 1; JANUS KINASE; JANUS KINASE 2; MONOCYTE CHEMOTACTIC PROTEIN 1; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; CCL2 PROTEIN, RAT; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; EPITHELIUM CELL; HISTOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY TUBULE EPITHELIUM; LAPAROTOMY; MALE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BLOOD; DRUG EFFECTS; KIDNEY; KIDNEY FUNCTION TEST; KIDNEY TUBULE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; WISTAR RAT;

ANIMALS; APOPTOSIS; CASPASE 3; CHEMOKINE CCL2; DEXMEDETOMIDINE; EPITHELIAL CELLS; INTERCELLULAR ADHESION MOLECULE-1; JANUS KINASES; KIDNEY; KIDNEY FUNCTION TESTS; KIDNEY TUBULES; MALE; PHOSPHORYLATION; PROTECTIVE AGENTS; RATS, WISTAR; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS;

EID: 84878653278     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-11-141     Document Type: Article

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