Role of JAK/STAT pathway in IL-6-induced activation of vascular smooth muscle cells

American Journal of Nephrology

Volumn 24, Issue 4, 2004, Pages 387-392

  Watanabe, Susumu ^a,d   Mu, Wei ^a,b   Kahn, Andrew ^c   Jing, Naijie ^a   Li, Jin H ^a   Lan, Hui Y ^a   Nakagawa, Takahiko ^a   Ohashi, Ryuji ^a   Johnson, Richard J ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

Author keywords

Atherosclerosis; Cell proliferation; Interleukin 6; Janus activated kinase; Monocyte chemoattractant protein 1; Signal and transducers and activators of transcription 3; Vascular smooth muscle cell

Indexed keywords

INTERLEUKIN 6; JANUS KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN TYROSINE KINASE INHIBITOR; STAT3 PROTEIN;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANIMALS; AORTA; ARTERIOSCLEROSIS; CELLS, CULTURED; CHEMOKINE CCL2; DNA; DNA-BINDING PROTEINS; ENZYME INHIBITORS; INTERLEUKIN-6; JANUS KINASE 2; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RATS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TYRPHOSTINS;

EID: 4644314473     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000079706     Document Type: Article

References (25)

1. Brasier AR, Recinos A 3rd, Eledrisi MS: Vascular in. ammation and the renin-angiotensin system. Arterioscler Thromb Vasc Biol 2002;22: 1257-1266.
2. Biasucci LM, Vitelli A, Liuzzo G, Altamura S, Caligiuri G, Monaco C, Rebuzzi AG, Ciliberto G, Maseri A: Elevated levels of interleukin-6 in unstable angina. Circulation 1996;94:874-877.
3. Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger WH Jr. Heimovitz H, Cohen HJ, Wallace R: Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med 1999;106:506-512.
4. Ikeda U, Ikeda M, Oohara T, Oguchi A, Kamitani T, Tsuruya Y, Kano S: Interleukin 6 stimulates growth of vascular smooth muscle cells in a PDGF-dependent manner. Am J Physiol 1991;260:H1713-H1717.
5. Onozaki K, Akiyama Y, Okano A, Hirano T, Kishimoto T, Hashimoto T, Yoshizawa K, Taniyama T: Synergistic regulatory effects of interleukin 6 and interleukin 1 on the growth and differentiation of human and mouse myeloid leukemic cell lines. Cancer Res 1989;49:3602-3607.
6. Loppnow H, Libby P: Adult human vascular endothelial cells express the IL6 gene differentially in response to LPS or IL1. Cell Immunol 1989;122:493-503.
7. Loppnow H, Libby P: Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6. J Clin Invest 1990;85:731-738.
8. Moriyama T, Fujibayashi M, Fujiwara Y, Kaneko T, Xia C, Imai E, Kamada T, Ando A, Ueda N: Angiotensin II stimulates interleukin-6 release from cultured mouse mesangial cells. J Am Soc Nephrol 1995;6:95-101.
9. Le JM, Vilcek J: Interleukin 6: A multifunctional cytokine regulating immune reactions and the acute phase protein response. Lab Invest 1989;61:588-602.
10. Williams N, Bertoncello I, Jackson H, Arnold J, Kavnoudias H: The role of interleukin 6 in megakaryocyte formation, megakaryocyte development and platelet production. Ciba Found Symp 1992;167:160-170.
11. Loppnow H, Libby P: Functional significance of human vascular smooth muscle cell-derived interleukin 1 in paracrine and autocrine regulation pathways. Exp Cell Res 1992;198:283-290.
12. Roth M, Nauck M, Tamm M, Perruchoud AP, Ziesche R, Block LH: Intracellular interleukin 6 mediates platelet-derived growth factor-induced proliferation of nontransformed cells. Proc Natl Acad Sci USA 1995;92:1312-1316.
13. Viedt C, Vogel J, Athanasiou T, Shen W, Orth SR, Kubler W, Kreuzer J: Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-kappaB and activator protein-1. Arterioscler Thromb Vasc Biol 2002;22:914-920.
14. Akira S, Nishio Y, Tanaka T, Inoue M, Matsusaka T, Wang XJ, Wei S, Yoshida N, Kishimoto T: Transcription factors NF-IL6 and APRF involved in gp130-mediated signaling pathway. Ann NY Acad Sci 1995;762:15-27; discussion 27-18.
15. Alonzi T, Maritano D, Gorgoni B, Rizzuto G, Libert C, Poli V: Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation (correction of activation) in the liver. Mol Cell Biol 2001;21:1621-1632.
16. Sherman CT, Brasier AR: Role of signal transducers and activators of transcription 1 and 3 in inducible regulation of the human angiotensinogen gene by interleukin-6. Mol Endocrinol 2001;15:441-457.
17. Burysek L, Syrovets T, Simmet T: The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and janus kinase (JAK)/STAT signaling pathways. J Biol Chem 2002;277:33509-33517.
18. Bowman T, Garcia R, Turkson J, Jove R: STATs in oncogenesis. Oncogene 2000;19:2474-2488.
19. Klouche M, Bhakdi S, Hemmes M, Rose-John S: Novel path to activation of vascular smooth muscle cells: Up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J Immunol 1999;163:4583-4589.
20. Liu H-W, Iwai M, Takeda-Matsubara Y, Wu L, Li J-M, Okumura M, Cui T-X, Horiuchi M: Effect of estrogen and AT1 receptor blocker on neointima formation. Hypertension 2002;40:451-457.
21. Negoro S, Kunisada K, Tone E, Funamoto M, Oh H, Kishimoto T, Yamauchi-Takihara K: Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction. Cardiovasc Res 2000;47:797-805.
22. Xuan YT, Guo Y, Han H, Zhu Y, Bolli R: An essential role of the Jak-STAT pathway in ischemic preconditioning. Proc Natl Acad Sci USA 2001;98:9050-9055.
23. Horiguchi A, Oya M, Marumo K, Murai M: STAT 3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P. Kidney Int 2002;61:926-938.
24. Viedt C, Vogel J, Athanasiou T, Shen W, Oth SR, Kubler W, Kreuzer J: Arterioscler Thromb Vasc Biol 2002;22:914-920.
25. Marrero MB, Schieffer B, Li B, Sun J, Harp JB, Ling BN: Role of Janus kinase/signal transducer and activator of transcription and mitogenactivated protein kinase cascades in angiotensin II- and platelet-derived growth factorinduced vascular smooth muscle cell proliferation. J Biol Chem 1997;272:24684-24690.