Central sympatholytics prolong survival in experimental sepsis

Critical Care

Volumn 13, Issue 1, 2009, Pages

  Hofer, Stefan ^a   Steppan, Jochen ^a   Wagner, Tanja ^a   Funke, Benjamin ^a   Lichtenstern, Christoph ^b   Martin, Eike ^a   Graf, Bernhard M ^c   Bierhaus, Angelika ^a   Weigand, Markus A ^b  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; CYTOKINE; DEXMEDETOMIDINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; SODIUM CHLORIDE; SOLVENT; CHOLINERGIC RECEPTOR; MUSCARINIC RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; CECUM; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DOWN REGULATION; DRUG PROTEIN BINDING; EXPERIMENTAL MODEL; FEMALE; LIGATION; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; PUNCTURE; RANDOMIZATION; SEPSIS; SURVIVAL TIME; TREATMENT FAILURE; ANIMAL; BLOOD; C57BL MOUSE; COMPARATIVE STUDY; DISEASE MODEL; HUMAN; METABOLISM; SURVIVAL RATE;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MICE; MICE, INBRED C57BL; RECEPTORS, CHOLINERGIC; RECEPTORS, MUSCARINIC; SEPSIS; SURVIVAL RATE; SYMPATHOLYTICS;

EID: 61649119660     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc7709     Document Type: Article

References (29)

1. Mann SJ Severe paroxysmal hypertension (pseudopheochromocytoma) Curr Hypertens Rep 2008, 10:12-18. 10.1007/s11906-008-0005-2 18367021
2. Elia N Culebras X Mazza C Schiffer E Tramer MR Clonidine as an adjuvant to intrathecal local anesthetics for surgery: Systematic review of randomized trials Reg Anesth Pain Med 2008, 33:159-167. 18299097
3. Alcohol withdrawal syndrome: How to predict, prevent, diagnose and treat it Prescrire Int 2007, 16:24-31. 17323538
4. Rapoport AM Bigal ME Preventive migraine therapy: What is new Neurol Sci 2004, 25(Suppl 3):S177-185. 10.1007/s10072-004-0281-9 15549532
5. Aantaa R Jalonen J Perioperative use of alpha2-adrenoceptor agonists and the cardiac patient Eur J Anaesthesiol 2006, 23:361-372. 10.1017/ S0265021506000378 16507202
6. Knaus AE Muthig V Schickinger S Moura E Beetz N Gilsbach R Hein L Alpha2-adrenoceptor subtypes - unexpected functions for receptors and ligands derived from gene-targeted mouse models Neurochem Int 2007, 51:277-281. 10.1016/j.neuint.2007.06.036 17664025
7. Pandharipande PP Pun BT Herr DL Maze M Girard TD Miller RR Shintani AK Thompson JL Jackson JC Deppen SA Stiles RA Dittus RS Bernard GR Ely EW Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: The MENDS randomized controlled trial JAMA 2007, 298:2644-2653. 10.1001/jama.298.22.2644 18073360
8. Martin J Parsch A Franck M Wernecke KD Fischer M Spies C Practice of sedation and analgesia in German intensive care units: Results of a national survey Crit Care 2005, 9:R117-123. 1175921 15774043 10.1186/ cc3035
9. Sica DA Centrally acting antihypertensive agents: An update J Clin Hypertens (Greenwich) 2007, 9:399-405. 10.1111/j.1524-6175.2007.07161.x 17485976
10. Rittirsch D Flierl MA Ward PA Harmful molecular mechanisms in sepsis Nat Rev Immunol 2008, 8:776-787. 10.1038/nri2402 18802444
11. Gertler R Brown HC Mitchell DH Silvius EN Dexmedetomidine: A novel sedative-analgesic agent Proc (Bayl Univ Med Cent) 2001, 14:13-21. 1291306 16369581
12. Baeuerle PA Pro-inflammatory signaling: Last pieces in the NF-kappaB puzzle? Curr Biol 1998, 8:R19-22. 10.1016/S0960-9822(98)70010-7 9427616
13. Wang H Bloom O Zhang M Vishnubhakat JM Ombrellino M Che J Frazier A Yang H Ivanova S Borovikova L Manogue KR Faist E Abraham E Andersson J Andersson U Molina PE Abumrad NN Sama A Tracey KJ HMG-1 as a late mediator of endotoxin lethality in mice Science 1999, 285:248-251. 10.1126/science.285.5425.248 10398600
14. Nathan C Points of control in inflammation Nature 2002, 420:846-852. 10.1038/nature01320 12490957
15. Kim MH Hahn TH The effect of clonidine pretreatment on the perioperative proinflammatory cytokines, cortisol, and ACTH responses in patients undergoing total abdominal hysterectomy Anesth Analg 2000, 90:1441-1444. 10.1097/00000539-200006000-00035 10825337
16. Spies CD Dubisz N Neumann T Blum S Muller C Rommelspacher H Brummer G Specht M Sanft C Hannemann L Striebel HW Schaffartzik W Therapy of alcohol withdrawal syndrome in intensive care unit patients following trauma: Results of a prospective, randomized trial Crit Care Med 1996, 24:414-422. 10.1097/00003246-199603000-00009 8625628
17. Bouchon A Facchetti F Weigand MA Colonna M TREM-1 amplifies inflammation and is a crucial mediator of septic shock Nature 2001, 410:1103-1107. 10.1038/35074114 11323674
18. Calandra T Echtenacher B Roy DL Pugin J Metz CN Hultner L Heumann D Mannel D Bucala R Glauser MP Protection from septic shock by neutralization of macrophage migration inhibitory factor Nat Med 2000, 6:164-170. 10.1038/72262 10655104
19. Echtenacher B Falk W Mannel DN Krammer PH Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis J Immunol 1990, 145:3762-3766. 2246512
20. Liliensiek B Weigand MA Bierhaus A Nicklas W Kasper M Hofer S Plachky J Grone HJ Kurschus FC Schmidt AM Yan SD Martin E Schleicher E Stern DM Hammerling GG Nawroth PP Arnold B Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response J Clin Invest 2004, 113:1641-1650. 419481 15173891
21. Hofmann MA Schiekofer S Isermann B Kanitz M Henkels M Joswig M Treusch A Morcos M Weiss T Borcea V Abdel Khalek AK Amiral J Tritschler H Ritz E Wahl P Ziegler R Bierhaus A Nawroth PP Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB Diabetologia 1999, 42:222-232. 10.1007/s001250051142 10064103
22. Wang H Liao H Ochani M Justiniani M Lin X Yang L Al-Abed Y Metz C Miller EJ Tracey KJ Ulloa L Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis Nat Med 2004, 10:1216-1221. 10.1038/nm1124 15502843
23. Hofer S Eisenbach C Lukic IK Schneider L Bode K Brueckmann M Mautner S Wente MN Encke J Werner J Dalpke AH Stremmel W Nawroth PP Martin E Krammer PH Bierhaus A Weigand MA Pharmacologic cholinesterase inhibition improves survival in experimental sepsis Crit Care Med 2008, 36:404-408. 18091537
24. Bohrer H Qiu F Zimmermann T Zhang Y Jllmer T Mannel D Bottiger BW Stern DM Waldherr R Saeger HD Ziegler R Bierhaus A Martin E Nawroth PP Role of NFkappaB in the mortality of sepsis J Clin Invest 1997, 100:972-985. 508272 9276714 10.1172/JCI119648
25. Woiciechowsky C Schoning B Cobanov J Lanksch WR Volk HD Docke WD Early IL-6 plasma concentrations correlate with severity of brain injury and pneumonia in brain-injured patients J Trauma 2002, 52:339-345. 10.1097/ 00005373-200202000-00021 11834998
26. Tracey KJ Physiology and immunology of the cholinergic antiinflammatory pathway J Clin Invest 2007, 117:289-296. 1783813 17273548 10.1172/ JCI30555
27. Borovikova LV Ivanova S Zhang M Yang H Botchkina GI Watkins LR Wang H Abumrad N Eaton JW Tracey KJ Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin Nature 2000, 405:458-462. 10.1038/35013070 10839541
28. van Westerloo DJ Giebelen IA Florquin S Daalhuisen J Bruno MJ de Vos AF Tracey KJ Poll van der T The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis J Infect Dis 2005, 191:2138-2148. 10.1086/430323 15898001
29. Coates KM Flood P Ketamine and its preservative, benzethonium chloride, both inhibit human recombinant alpha7 and alpha4beta2 neuronal nicotinic acetylcholine receptors in Xenopus oocytes Br J Pharmacol 2001, 134:871-879. 1573008 11606328 10.1038/sj.bjp.0704315