Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs

Shock

Volumn 38, Issue 1, 2012, Pages 92-97

  Yoshitomi, Osamu ^a   Cho, Sungsam ^a   Hara, Tetsuya ^a   Shibata, Itsuko ^a   Maekawa, Takuji ^a   Ureshino, Hiroyuki ^a   Sumikawa, Koji ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

!2 adrenergic agonist; Dexmedetomidine; myocardial ischemia; myocardial stunning; norepinephrine

Indexed keywords

DEXMEDETOMIDINE;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; FEMALE; HEART ARRHYTHMIA; HEART FIBRILLATION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE TACHYCARDIA; HEMODYNAMICS; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; REPERFUSION INJURY; SWINE;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ANIMALS; ARRHYTHMIAS, CARDIAC; CARDIOTONIC AGENTS; CORONARY CIRCULATION; DEXMEDETOMIDINE; DRUG EVALUATION, PRECLINICAL; FEMALE; HEMODYNAMICS; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIAL STUNNING; NOREPINEPHRINE; SUS SCROFA;

EID: 84862771601     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e318254d3fb     Document Type: Article

References (32)

1. Kloner RA: Does reperfusion injury exist in humans? J Am Coll Cardiol 21:537-545, 1993. (Pubitemid 23047942)
2. Kloner RA, Bolli R, Marban E, Reinlib L, Braunwald E: Medical and cellular implications of stunning, hibernation, and preconditioning; an NHLBI workshop. Circulation 97:1848-1867, 1998. (Pubitemid 28213629)
3. Hagar JM, Hale SL, Kloner RA: Effect of preconditioning ischemia on reperfusion arrhythmias after coronary artery occlusion and reperfusion in the rat. Circ Res 68:61-68, 1991.
4. Schömig A, Richardt G: The role of catecholamines in ischemia. J Cardiovasc Pharmacol 16:S105-S112, 1990.
5. Lameris TW, de Zeeuw S, Alberts G, Boomsma F, Duncker DJ, Verdouw PD, Veld AJ, van Den Meiracker AH: Time course and mechanism of myocardial catecholamine release during transient ischemia in vivo. Circulation 101: 2645-2650, 2000. (Pubitemid 30350645)
6. Miura T, Kawamura S, Tatsuno H, Ikeda Y, Mikami S, Iwamoto H, Okamura T, Iwatate M, Kimura M, Dairaku Y, et al.: Ischemic preconditioning attenuates cardiac sympathetic nerve injury via ATP-sensitive potassium channels during myocardial ischemia. Circulation 104:1053-1058, 2001. (Pubitemid 32803884)
7. Roekaerts PM, Prinzen FW, Lange SD: Beneficial effects of dexmedetomidine on ischaemic myocardium of anaesthetized dogs. Br J Anaesth 77:427-429, 1996. (Pubitemid 26300878)
8. Roekaerts PM, Prinzen FW, Willigers HM, Lange SD: The effects of !2-adrenergic stimulation with mivazerol on myocardial blood flow and function during coronary artery stenosis in anesthetized dogs. Anesth Analg 82:702-711, 1996. (Pubitemid 26112823)
9. Meissner A, Weber TP, Van Aken H, Zbieranek K, Rolf N: Clonidine improve recovery from myocardial stunning in conscious chronically instrumented dogs. Anesth Analg 87:1009-1014, 1998. (Pubitemid 28501149)
10. Matkó I, Fehér E, Vizi ES: Receptor mediated presynaptic modulation of the release of noradrenaline in human papillary muscle. Cardiovasc Res 28: 700-704, 1994.
11. Maze M, Tranquilli W: alpha-2 Adrenoceptor agonists: defining the role in clinical anesthesia. Anesthesiology 74:581-605, 1991.
12. Biccard BM, Goga S, de Beurs J: Dexmedetomidine and cardiac protection for non-cardiac surgery: a meta-analysis of randomised controlled trials. Anaesthesia 63:4-14, 2008. (Pubitemid 350233216)
13. Venn RM, Karol MD, Grounds RM: Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive care. Br J Anaesth 88:669-675, 2002. (Pubitemid 34498595)
14. Bolli R: Mechanism of myocardial Bstunning[. Circulation 82:723-738, 1990.
15. Lombardi F, Verrier RL, Lown B: Relationship between sympathetic neural activity, coronary dynamics, and vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion. Am Heart J 105:958-965, 1983. (Pubitemid 13101304)
16. Shindo T, Akiyama T, Yamazaki T, Ninomiya I: Increase in myocardial interstitial norepinephrine during a short period of coronary occlusion. J Auton Nerv Syst 48:91-96, 1994. (Pubitemid 24120676)
17. Shindo T, Akiyama T, Yamazaki T, Ninomiya I: Regional myocardial interstitial norepinephrine kinetics during coronary occlusion and reperfusion. Am J Physiol 270:H245-H251, 1996.
18. Chen H, Higashino H, Maeda K, Zhang Z, Ohta Y, Wang Z, Su DF, Yuan WJ: Reduction of cardiac norepinephrine improves postischemic heart function in stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol 38: 821-832, 2001. (Pubitemid 33104692)
19. Kono M, Morita S, Hayashi T, Saitoh M, Fuke N, Rubsamen R: The effects of intravenous clonidine on regional myocardial function in a canine model of regional myocardial ischemia. Anesth Analg 78:1047-1052, 1994. (Pubitemid 24164347)
20. Willigers HM, Prinzen FW, Roekaerts PM, de Lange S, Durieux ME: Dexmedetomidine decreases perioperative myocardial lactate release in dogs. Anesth Analg 96:657-664, 2003. (Pubitemid 36245547)
21. Cai JJ, Morgan DA, Haynes WG, Martins JB, Lee HC: !2-Adrenergic stimulation is protective against ischemia-reperfusion-induced ventricular arrhythmias in vivo. Am J Physiol 283:H2606-H2611, 2002. (Pubitemid 35345969)
22. Heusch G, Schipke J, Thamer V: Clonidine prevents the sympathetic initiation and aggravation of poststenotic myocardial ischemia. J Cardiovasc Pharmacol 7:1176-1182, 1985. (Pubitemid 16180100)
23. Chilian WM, Ackell PH: Transmural differences in sympathetic coronary constriction during exercise in the presence of coronary stenosis. Circ Res 62:216-225, 1988. (Pubitemid 18041944)
24. Miyamoto MI, Rockman HA, Guth BD, Heusch G, Ross J Jr: Effect of alphaadrenergic stimulation on regional contractile function and myocardial blood flow with and without ischemia. Circulation 84:1715-1724, 1991.
25. Kitakaze M, Hori M, Gotoh K, Sato H, Iwakura K, Kitabatake A, Inoue M, Kamada T: Beneficial effects of !2-adrenoceptor activity on ischemic myocardium during coronary hypoperfusion in dogs. Cir Res 65:1632-1645, 1989.
26. Flacke WE, Flacke JW, Bloor BC, McIntee DF, Sagan M: Effects of dexmedetomidine on systemic and coronary hemodynamics in the anesthetized dog. J Cardiothorac Vasc Anesth 17:41-49, 1993. (Pubitemid 23065635)
27. Lawrence CJ, Prinzen FW, de Lange S: The effect of dexmedetomidine on the balance of myocardial energy requirement and oxygen supply and demand. Anesth Analg 82:544-550, 1996. (Pubitemid 26072959)
28. Okada H, Kurita T, Mochizuki T, Morita K, Sato S. The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts. Resuscitation 74:538-545, 2007. (Pubitemid 47176759)
29. Guo H, Takahashi S, Cho S, Hara T, Tomiyasu S, Sumikawa K: The effects of dexmedetomidine on left ventricular function during hypoxia and reoxygenation in isolated rat hearts. Anesth Analg 100:629-635, 2005. (Pubitemid 40300050)
30. Mimuro S, Katoh T, Suzuki A, Yu S, Adachi YU, Uraoka M, Sano H, Sato S: Deterioration of myocardial injury due to dexmedetomidine administration after myocardial ischaemia. Resuscitation 81:1714-1717, 2010.
31. Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD: The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 93:382-394, 2000. (Pubitemid 30620311)
32. Götberg M, van der Pals J, Götberg M, Olivecrona GK, Kanski M, Koul S, Otto A, Engblom H, Ugander M, Arheden H, et al.: Optimal timing of hypothermia in relation to myocardial reperfusion. Basic Res Cardiol 106:697-708, 2011.