Induction of Autophagy by a Novel Small Molecule Improves Aβ Pathology and Ameliorates Cognitive Deficits

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Chu, Cheng ^a,b   Zhang, Xinjiang ^a   Ma, Wei ^c   Li, Li ^b   Wang, Wei ^a   Shang, Lu ^d   Fu, Peng ^e  

^a Medical College of Southeast University   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c Mu Dan Jiang Medical College   (China)

^d The Eighth Detachment Health Team of CAPF   (China)

^e SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ASPARAGINE; GTM 1; MAMMALIAN TARGET OF RAPAMYCIN; NEUROPROTECTIVE AGENT; PROTEIN KINASE B; RAPAMYCIN; THAPSIGARGIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; COGNITIVE DEFECT; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LEARNING; MEMORY; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN AGGREGATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; AUTOPHAGY; CELL LINE, TUMOR; COGNITION; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INTRACELLULAR SPACE; MEMORY; MICE; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; QUINAZOLINES; SMALL MOLECULE LIBRARIES;

MUS;

EID: 84878631905     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065367     Document Type: Article

References (45)

1. Mattson MP, (1997) Cellular actions of beta-amyloid precursor protein and its solubleand fibrillogenic derivatives. Physiological reviews 77: 1081-1132.
2. Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, et al. (2007) Reducing endogenrous Tau Ameliorates amyloid-β induced deficits in an Alzheimer's Disease mouse model. Scence 316, 750-754.
3. Wang E, Cuervo AM, (2010) Autophagy gone awry in neurodegenerative diseases. Nature Neuroscience 12 7: 805-810.
4. Anekonda TS, Wadsworth TL, Sabin R, Frahler K, Harris C, et al. (2011) Phytic acid as a potential treatment for Alzheimer's pathology: evidence from animal and in vitro models. Journal Alzheimer's Diseases 23 (1): 21-25.
5. Smita M, Arlan R, Randy S, Salvatore O, (2011) Inducing Autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. Pols One 6 (9): e25416.
6. Caccamo A, Majumder S, Richardson A, Strong R, Oddo S, (2010) Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-β and Tau. Biology Chemistry 23 285(17): 13107-13120.
7. Selkoe DJ, (2002) Alzheimer's disease is a synaptic failure. Science 298: 789-791.
8. Harper JD, Lansbury PT Jr, (1997) Models of amyloid seeding in Alzheimer's diseaseand scrapie: mechanistic truths and physiological consequences of thetime-dependent solubility of amyloid proteins. Annu Rev Biochem 66: 385-407.
9. Lee SJ, Liyanage U, Bickel PE, Xia W, Lansbury PT Jr, et al. (1998) A detergent-insoluble membrane compartment contains A beta in vivo. Nat Med 4: 730-734.
10. Bonda DJ, Lee HP, Lee HG, Friedlich AL, Perry G, et al. (2010) Novel therapeutics for Alzheimer's disease: an update. Curr Opin Drug Discov Devel 13: 235-246.
11. Ling D, Salvaterra PM, (2009) A central role for autophagy in Alzheimer-type neurodegeneration. Autophagy 5: 738-740.
12. Ling D, Salvaterra PM, (2011) Brain aging and Abeta neurotoxicity converge via deterioration in autophagy-lysosomal system: a conditional Drosophila model linking Alzheimer's neurodegeneration with aging. Acta Neuropathol 121: 183-191.
13. Madeo F, Eisenberg T, Kroemer G, (2009) Autophagy for the avoidance of neurodegeneration. Genes Dev 23: 2253-2259.
14. Wong E, Cuervo AM, (2010) Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 13: 805-811.
15. Martinez-Vicente M, Cuervo AM, (2007) Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol 6: 352-361.
16. Son SM, Song H, Byun J, Park KS, Jang HC, et al. (2012) Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions. Autophagy 8 (12): 1-3.
17. Chen Y, Klionsky DJ, (2011) The regulation of autophagy - unanswered questions. J Cell Sci. 15 124(2): 161-170.
18. Behrends C, Sowa ME, Gygi SP, Harper JW (2010) Network organization of the human autophagy system. Nature 466, 68-76.
19. Jeong JK, Moon MH, Lee YJ, Seol JW, Park SY (2012) Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity. Neurobiology of Aging 34 (2013) 146-156.
20. Bove J, Martinez-Vicente M, Vila M, (2011) Fighting neurodegeneration with rapamycin: mechanistic insights. Nat. Rev (12): 437-452.
21. Jimenez-Sanchez M, Thompson F, Zavodsky E, Rubinsztein DC, (2011) Autophagy and polyglutamine diseases. Prog. Neurobiol. Prog Neurobiol. 2012 May 97(2): 67-82.
22. Tian Y, Bustos V, Flajolet M, Greengard P (2011) A smallmoleculeenhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 25 1934-1942.
23. Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, et al. (2007) Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol 3: 331-338.
24. Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC, (2009) Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ 16: 46-56.
25. Liu J, Xia H, Kim M, Xu L, Li Y, et al. (2011) Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147: 223-234.
26. Tung YT, Wang BJ, Hu MK, Hsu WM, Lee H, et al. (2012) Autophagy: A double-edged sword in Alzheimer's disease. J Biosci. 37(1): 157-165.
27. Agholme L, Lindström T, Kågedal K, Marcusson J, Hallbeck M, (2010) Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons. Journal of Alzheimer's Disease, (20) 4: 1069-1082.
28. Yorimitsu T, Klionsky DJ, (2005) Autophagy: molecular machinery for self-eating. Cell Death Differ 12: 1542-1552.
29. Hung SY, Huang WP, Liou HC, Fu WM, (2009) Autophagy protects neuron from Abeta-induced cytotoxicity. Autophagy 5: 502-510.
30. Wadswortha TL, Bishopa JA, Pappub AS, Woltjerc RL, Quinna JF, (2008) Evaluation of Coenzyme Q as an Antioxidant Strategy for Alzheimer's Disease. J Alzheimers Dis. 14(2): 225-234.
31. Maezawa I, Hong HS, Wu HC, Battina SK, Rana S, et al. (2006) A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-b oligomeric complexes. Journal of Neurochemistry 98: 57-67.
32. Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, et al. (2007) Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol. 72(1): 29-39.
33. Desplat V, Moreau S, Gay A, Fabre SB, Thiolat D, et al. (2010) Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II. J Enzyme Inhib Med Chem. 25(2): 204-15.
34. Zhang L, Yu J, Pan H, Hu P, Hao Y, et al. (2007) Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A 104: 19023-19028.
35. Ganley JG, Wong PM, Gammoh N, Jiang X (2011) DistinctAutophagosomal-LysosomalFusionMechanism Revealed by Thapsigargin-Induced Autophagy Arrest. Molecular Cell 42, 731-743.
36. Hoyvik H, Gordon PB, Berg TO, Strømhaug PE, Seglen PO, (1991) Inhibition of Autophagic-Lysosomal Delivery and Autophagic Lactolysis by Asparagine. The Journal of Cell Biology, 113 (6): 1305-1312.
37. Florez-McClure ML, Hohsfield LA, Fonte G, Bealor MT, Link CD, (2007) Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. Elegans. Autophagy 3: 569-580.
38. Ling D, Song HJ, Garza D, Neufeld TP, Salvaterra PM (2009) Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila. PLoS One 4 e4201.
39. Zheng L, Roberg K, Jerhammar F, Marcusson J, Terman A, (2006) Autophagy of amyloid beta-protein in differentiated neuroblastoma cells exposed to oxidative stress. Neurosci. Lett. 394: 184-189.
40. Zheng L, Roberg K, Jerhammar F, Marcusson J, Terman A, (2006) Aβ Oxidative stress induces intralysosomal accumulation of Alzheimer amyloid beta-protein in cultured neuroblastoma cells. Ann. NY Acad. Sci. 1067: 248-251.
41. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, et al. (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 460, 392-395.
42. Sopher BL, Fukuchi K, Smith AC, Leppig KA, Furlong CE, et al. (1994) Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein. Brain Res Mol Brain Res 26: 207-217.
43. Jekabsone A, Mander PK, Tickler A, Sharpe M, Brown GC, (2006) Fibrillar beta-amyloid peptide Aβ1-40 activates microglial proliferation via stimulating TNF-α release and H2O2 derived from NADPH oxidase: a cell culture study. J Neuro- inflammation. 3 (24): 1-13.
44. Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, et al. (2003) Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss. PNAS, 100 (18): 10417-10422.
45. Boland B, Kumar A, Lee S, Platt FM, Wegiel J, et al. (2008) Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J. Neurosci. 28: 6926-6937.