Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 25, Issue 2, 2010, Pages 204-215

  Desplat, Vanessa ^a   Moreau, Stephane ^b   Gay, Aurore ^a,b   Fabre, Solene Belisle ^b   Thiolat, Denis ^a   Massip, Stephane ^b   MacKy, Gregory ^a,b   Godde, Frederic ^a   Mossalayi, Djavad ^a   Jarry, Christian ^b   Guillon, Jean ^b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b Laboratoire de Pharmacochimie   (France)

Author keywords

Akt kinase; Antiproliferative agents; Inhibitor; Pyrrolo 1,2 a quinoxaline

Indexed keywords

1 (2 NITROPHENYL) 3 PHENYLPYRROLE 2 CARBOXYLIC ACID METHYL ESTER; 1 (2 NITROPHENYL) 4 METHYL 3 PHENYLPYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 1,3 DIHYDRO 1 [1 [4 (2 METHYL 3 PHENYLPYRROLO[1,2 A]QUINOXALIN 4 YL)BENZYL]PIPERIDIN 4 YL]2H BENZIMIDAZOL 2 ONE; 1,3 DIHYDRO 1 [1 [4 (2 PHENYLPYRROLO[1,2 A]QUINOXALIN 4 YL)BENZYL]PIPERIDIN 4 YL]2H BENZIMIDAZOL 2 ONE; 1,3 DIHYDRO 1 [1 [4 (3 PHENYLPYRROLO[1,2 A]QUINOXALIN 4 YL)BENZYL]PIPERIDIN 4 YL] 2H BENZIMIDAZOL 2 ONE; 2 METHYL 3 PHENYL 5H PYRROLO[1,2 A]QUINOXALIN 4 ONE; 2 PHENYL 5H PYRROLO[1,2 A]QUINOXALIN 4 ONE; 3 PHENYL 5H PYRROLO[1,2 A]QUINOXALIN 4 ONE; 4 (2 METHYL 3 PHENYLPYRROLO[1,2 A]QUINOXALIN 4 YL)BENZALDEHYDE; 4 (2 PHENYLPYRROLO[1,2 A]QUINOXALIN 4 YL)BENZALDEHYDE; 4 (3 PHENYLPYRROLO[1,2 A]QUINOXALIN 4 YL)BENZALDEHYDE; 4 (PYRROLO[1,2 A]QUINOXALIN 4 YL)BENZALDEHYDE; 4 CHLORO 2 METHYL 3 PHENYLPYRROLO[1,2 A]QUINOXALINE; 4 CHLORO 2 METHYL 3 PHENYLPYRROLO[1,2-A]QUINOXALINE; 4 CHLORO 2 PHENYLPYRROLO[1,2 A]QUINOXALINE; 4 CHLORO 2 PHENYLPYRROLO[1,2A]QUINOXALINE; 4 CHLORO 3 PHENYLPYRROLO[1,2 A]QUINOXALINE; 4 PHENYLPYRROLE 2 CARBOXYLIC ACID METHYL ESTER; 5 FLUORO 2 [1 [4 (2 PHENYLPYRROLO[1,2 A]QUINOXALIN 1 YL)BENZYL]PIPERIDIN 4 YL]1H BENZIMIDAZOLE; 5 FLUORO 2 [1 [4 (PYRROLO[1,2 A]QUINOXALIN 1 YL)BENZYL] PIPERIDIN 4 YL)1H BENZIMIDAZOLE; 5 FLUORO 2[1 [4 (2 METHYL 3 PHENYLPYRROLO[1,2 A]QUINOXALIN 1 YL)BENZYL]PIPERIDIN 4 YL] 1H BENZIMIDAZOLE; ANTINEOPLASTIC AGENT; ETHYL 4 (4 FORMYLPHENYL)PYRROLO[1,2 A]QUINOXALINE 2 CARBOXYLATE; ETHYL 4 [4 [(4 (2 OXO 2,3 DIHYDRO 1H BENZIMIDAZOL 1 YL)PIPERIDIN 1 YL)BENZYL]]PYRROLO[1,2 A]QUINOXALINE 2 CARBOXYLATE; ETHYL 4 [4 [(4 (5 FLUORO 1 BENZIMIDAZOL 2 YL)PIPERIDIN 1 YL)BENZYL]]PYRROLO[1,2 A]QUINOXALINE 2 CARBOXYLATE; PROTEIN KINASE B; PYRROLO[1,2 A]QUINOXALINE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN HL 60; CELL STRAIN K 562; CELL STRAIN U937; CONFERENCE PAPER; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL;

EID: 77949451313     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756360903169881     Document Type: Conference Paper

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