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Volumn 52, Issue 4, 2013, Pages 1327-1341

Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro

Author keywords

Colorectal cancer; Epigenetics; Isothiocyanates; Selenium

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA METHYLTRANSFERASE; ESTROGEN RECEPTOR ALPHA; IBERIN; ISOTHIOCYANIC ACID DERIVATIVE; MESSENGER RNA; SE METHYLSELENOCYSTEINE; SELENIUM DERIVATIVE; SODIUM SELENITE; SULFORAPHANE; UNCLASSIFIED DRUG;

EID: 84878615059     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-012-0442-1     Document Type: Article
Times cited : (25)

References (66)
  • 1
    • 84878621737 scopus 로고    scopus 로고
    • Regulation of signaling pathways by selenium in cancer
    • Y-J Surh (eds) 25 CRC Press Boca Raton
    • Lu J, Hu H, Jiang C (2009) Regulation of signaling pathways by selenium in cancer. In: Surh Y-J (ed) Dietary modulation of cell signaling pathways, vol 25. CRC Press, Boca Raton, pp 273-313
    • (2009) Dietary Modulation of Cell Signaling Pathways , pp. 273-313
    • Lu, J.1    Hu, H.2    Jiang, C.3
  • 2
    • 79961102553 scopus 로고    scopus 로고
    • Dietary selenomethionine increases exon-specific DNA methylation of the p53 gene in rat liver and colon mucosa
    • 10.3945/jn.111.140715 10.3945/jn.111.140715 1:CAS:528: DC%2BC3MXpslGltLo%3D
    • Zeng H, Yan L, Cheng WH, Uthus EO (2011) Dietary selenomethionine increases exon-specific DNA methylation of the p53 gene in rat liver and colon mucosa. J Nutr 141(8):1464-1468. doi: 10.3945/jn.111.140715
    • (2011) J Nutr , vol.141 , Issue.8 , pp. 1464-1468
    • Zeng, H.1    Yan, L.2    Cheng, W.H.3    Uthus, E.O.4
  • 3
    • 0034533186 scopus 로고    scopus 로고
    • Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 cells and in vivo in rat liver and colon
    • 1:CAS:528:DC%2BD3cXptVKmtLg%3D
    • Davis CD, Uthus EO, Finley JW (2000) Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 cells and in vivo in rat liver and colon. J Nutr 130(12):2903-2909
    • (2000) J Nutr , vol.130 , Issue.12 , pp. 2903-2909
    • Davis, C.D.1    Uthus, E.O.2    Finley, J.W.3
  • 4
    • 0036170179 scopus 로고    scopus 로고
    • Dietary selenite and azadeoxycytidine treatments affect dimethylhydrazine-induced aberrant crypt formation in rat colon and DNA methylation in HT-29 cells
    • 1:CAS:528:DC%2BD38XhtFGnsrY%3D
    • Davis CD, Uthus EO (2002) Dietary selenite and azadeoxycytidine treatments affect dimethylhydrazine-induced aberrant crypt formation in rat colon and DNA methylation in HT-29 cells. J Nutr 132(2):292-297
    • (2002) J Nutr , vol.132 , Issue.2 , pp. 292-297
    • Davis, C.D.1    Uthus, E.O.2
  • 5
    • 0032848137 scopus 로고    scopus 로고
    • Selenium metabolism, selenoproteins and mechanisms of cancer prevention: Complexities with thioredoxin reductase
    • 10.1093/carcin/20.9.1657 10.1093/carcin/20.9.1657 1:CAS:528: DyaK1MXlvFWqsL8%3D
    • Ganther HE (1999) Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis 20(9):1657-1666. doi: 10.1093/carcin/20.9.1657
    • (1999) Carcinogenesis , vol.20 , Issue.9 , pp. 1657-1666
    • Ganther, H.E.1
  • 6
    • 0026083843 scopus 로고
    • Chemical form of selenium, critical metabolites, and cancer prevention
    • 1:CAS:528:DyaK3MXhtlGltL0%3D
    • Ip C, Hayes C, Budnick RM, Ganther HE (1991) Chemical form of selenium, critical metabolites, and cancer prevention. Cancer Res 51(2):595-600
    • (1991) Cancer Res , vol.51 , Issue.2 , pp. 595-600
    • Ip, C.1    Hayes, C.2    Budnick, R.M.3    Ganther, H.E.4
  • 8
    • 65349138314 scopus 로고    scopus 로고
    • Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways
    • 10.1186/1756-8722-1-6 10.1186/1756-8722-1-6
    • Lu Q, Lin X, Feng J, Zhao X, Gallagher R, Lee MY, Chiao JW, Liu D (2008) Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways. J Hematol Oncol 1:6. doi: 10.1186/1756-8722-1-6
    • (2008) J Hematol Oncol , vol.1 , pp. 6
    • Lu, Q.1    Lin, X.2    Feng, J.3    Zhao, X.4    Gallagher, R.5    Lee, M.Y.6    Chiao, J.W.7    Liu, D.8
  • 9
    • 33846217828 scopus 로고    scopus 로고
    • Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer
    • 10.1002/mc.20258 1:CAS:528:DC%2BD2sXmsFeisw%3D%3D
    • Wang LG, Beklemisheva A, Liu XM, Ferrari AC, Feng J, Chiao JW (2007) Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer. Mol Carcinog 46(1):24-31
    • (2007) Mol Carcinog , vol.46 , Issue.1 , pp. 24-31
    • Wang, L.G.1    Beklemisheva, A.2    Liu, X.M.3    Ferrari, A.C.4    Feng, J.5    Chiao, J.W.6
  • 10
    • 72249122960 scopus 로고    scopus 로고
    • Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention
    • 10.3945/jn.109.113332 10.3945/jn.109.113332 1:CAS:528: DC%2BC3cXhsFeisLk%3D
    • Ho E, Clarke JD, Dashwood RH (2009) Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. J Nutr 139(12):2393-2396. doi: 10.3945/jn.109.113332
    • (2009) J Nutr , vol.139 , Issue.12 , pp. 2393-2396
    • Ho, E.1    Clarke, J.D.2    Dashwood, R.H.3
  • 11
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • 10.1016/0092-8674(90)90186-I 1:CAS:528:DyaK3cXktlyhtrg%3D
    • Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61(5):759-767
    • (1990) Cell , vol.61 , Issue.5 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 12
    • 0034100967 scopus 로고    scopus 로고
    • Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics
    • 10.1046/j.1365-2184.2000.00159.x 1:STN:280:DC%2BD3c3gtlKrtg%3D%3D
    • Roncucci L, Pedroni M, Vaccina F, Benatti P, Marzona L, De Pol A (2000) Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics. Cell Prolif 33(1):1-18
    • (2000) Cell Prolif , vol.33 , Issue.1 , pp. 1-18
    • Roncucci, L.1    Pedroni, M.2    Vaccina, F.3    Benatti, P.4    Marzona, L.5    De Pol, A.6
  • 13
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • 10.1126/science.959840 1:STN:280:DyaE283ntFWmsw%3D%3D
    • Nowell PC (1976) The clonal evolution of tumor cell populations. Science 194(4260):23-28
    • (1976) Science , vol.194 , Issue.4260 , pp. 23-28
    • Nowell, P.C.1
  • 14
    • 27544492603 scopus 로고    scopus 로고
    • Origins of the mutational origin of cancer
    • 10.1093/ije/dyi134 10.1093/ije/dyi134
    • Edler L, Kopp-Schneider A (2005) Origins of the mutational origin of cancer. Int J Epidemiol 34(5):1168-1170. doi: 10.1093/ije/dyi134
    • (2005) Int J Epidemiol , vol.34 , Issue.5 , pp. 1168-1170
    • Edler, L.1    Kopp-Schneider, A.2
  • 15
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • 10.1016/j.cell.2007.01.029 10.1016/j.cell.2007.01.029 1:CAS:528:DC%2BD2sXis12ju7k%3D
    • Jones PA, Baylin SB (2007) The epigenomics of cancer. Cell 128(4):683-692. doi: 10.1016/j.cell.2007.01.029
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 16
    • 61549121083 scopus 로고    scopus 로고
    • DNA methylation and cancer pathways in gastrointestinal tumors
    • 10.2217/14622416.9.12.1917 10.2217/14622416.9.12.1917 1:CAS:528:DC%2BD1cXhsFWjtbrN
    • Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M (2008) DNA methylation and cancer pathways in gastrointestinal tumors. Pharmacogenomics 9(12):1917-1928. doi: 10.2217/14622416.9.12.1917
    • (2008) Pharmacogenomics , vol.9 , Issue.12 , pp. 1917-1928
    • Suzuki, H.1    Tokino, T.2    Shinomura, Y.3    Imai, K.4    Toyota, M.5
  • 17
    • 0035870248 scopus 로고    scopus 로고
    • A gene hypermethylation profile of human cancer
    • 1:CAS:528:DC%2BD3MXjtFSjt7g%3D
    • Esteller M, Corn PG, Baylin SB, Herman JG (2001) A gene hypermethylation profile of human cancer. Cancer Res 61(8):3225-3229
    • (2001) Cancer Res , vol.61 , Issue.8 , pp. 3225-3229
    • Esteller, M.1    Corn, P.G.2    Baylin, S.B.3    Herman, J.G.4
  • 18
    • 23844549937 scopus 로고    scopus 로고
    • Methylation of the ESR1 CpG island in the colorectal mucosa is an 'all or nothing' process in healthy human colon, and is accelerated by dietary folate supplementation in the mouse
    • 10.1042/bst0330709 1:CAS:528:DC%2BD2MXmvFSmsr8%3D
    • Belshaw NJ, Elliott GO, Williams EA, Mathers JC, Buckley L, Bahari B, Johnson IT (2005) Methylation of the ESR1 CpG island in the colorectal mucosa is an 'all or nothing' process in healthy human colon, and is accelerated by dietary folate supplementation in the mouse. Biochem Soc Trans 33(Pt 4):709-711. doi: 10.1042/bst0330709
    • (2005) Biochem Soc Trans , vol.33 , Issue.PART 4 , pp. 709-711
    • Belshaw, N.J.1    Elliott, G.O.2    Williams, E.A.3    Mathers, J.C.4    Buckley, L.5    Bahari, B.6    Johnson, I.T.7
  • 19
    • 0028001087 scopus 로고
    • Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
    • 10.1038/ng0894-536 1:CAS:528:DyaK2cXlsFSntb0%3D
    • Issa J-PJ, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB (1994) Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 7(4):536-540
    • (1994) Nat Genet , vol.7 , Issue.4 , pp. 536-540
    • Issa, J.-P.1    Ottaviano, Y.L.2    Celano, P.3    Hamilton, S.R.4    Davidson, N.E.5    Baylin, S.B.6
  • 20
    • 0020318869 scopus 로고
    • Variability of DNA methylation patterns during serial passage of human diploid fibroblasts
    • 10.1073/pnas.79.13.3949 1:STN:280:DyaL383nsFSnsA%3D%3D
    • Shmookler Reis RJ, Goldstein S (1982) Variability of DNA methylation patterns during serial passage of human diploid fibroblasts. Proc Natl Acad Sci USA 79(13):3949-3953
    • (1982) Proc Natl Acad Sci USA , vol.79 , Issue.13 , pp. 3949-3953
    • Shmookler Reis, R.J.1    Goldstein, S.2
  • 21
    • 0025006860 scopus 로고
    • High levels of de Novo methylation and altered chromatin structure at CpG islands in cell lines
    • 10.1016/0092-8674(90)90015-7 1:CAS:528:DyaK3cXlt1Omt78%3D
    • Antequera F, Boyes J, Bird A (1990) High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines. Cell 62(3):503-514
    • (1990) Cell , vol.62 , Issue.3 , pp. 503-514
    • Antequera, F.1    Boyes, J.2    Bird, A.3
  • 22
    • 0025945632 scopus 로고
    • DNA methylation and gene expression
    • 1:CAS:528:DyaK3MXmsV2js7g%3D
    • Razin A, Cedar H (1991) DNA methylation and gene expression. Microbiol Mol Biol Rev 55(3):451-458
    • (1991) Microbiol Mol Biol Rev , vol.55 , Issue.3 , pp. 451-458
    • Razin, A.1    Cedar, H.2
  • 23
    • 46349091799 scopus 로고    scopus 로고
    • Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa
    • 10.1038/sj.bjc.6604432 10.1038/sj.bjc.6604432 1:CAS:528: DC%2BD1cXnvFerurc%3D
    • Belshaw NJ, Elliott GO, Foxall RJ, Dainty JR, Pal N, Coupe A, Garg D, Bradburn DM, Mathers JC, Johnson IT (2008) Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa. Br J Cancer 99(1):136-142. doi: 10.1038/sj.bjc.6604432
    • (2008) Br J Cancer , vol.99 , Issue.1 , pp. 136-142
    • Belshaw, N.J.1    Elliott, G.O.2    Foxall, R.J.3    Dainty, J.R.4    Pal, N.5    Coupe, A.6    Garg, D.7    Bradburn, D.M.8    Mathers, J.C.9    Johnson, I.T.10
  • 24
    • 34547812688 scopus 로고    scopus 로고
    • Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa
    • 10.1111/j.1349-7006.2007.00548.x 10.1111/j.1349-7006.2007.00548.x 1:CAS:528:DC%2BD2sXhtVaksrvL
    • Iacopetta B, Grieu F, Phillips M, Ruszkiewicz A, Moore J, Minamoto T, Kawakami K (2007) Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa. Cancer Sci 98(9):1454-1460. doi: 10.1111/j.1349-7006.2007.00548.x
    • (2007) Cancer Sci , vol.98 , Issue.9 , pp. 1454-1460
    • Iacopetta, B.1    Grieu, F.2    Phillips, M.3    Ruszkiewicz, A.4    Moore, J.5    Minamoto, T.6    Kawakami, K.7
  • 25
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • 10.1006/meth.2001.1262 1:CAS:528:DC%2BD38XhtFelt7s%3D
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25(4):402-408
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 26
    • 34547904256 scopus 로고    scopus 로고
    • Widely variable endogenous retroviral methylation levels in human placenta
    • 10.1093/nar/gkm455 10.1093/nar/gkm455 1:CAS:528:DC%2BD2sXpt1Cisbc%3D
    • Reiss D, Zhang Y, Mager DL (2007) Widely variable endogenous retroviral methylation levels in human placenta. Nucleic Acids Res 35(14):4743-4754. doi: 10.1093/nar/gkm455
    • (2007) Nucleic Acids Res , vol.35 , Issue.14 , pp. 4743-4754
    • Reiss, D.1    Zhang, Y.2    Mager, D.L.3
  • 27
    • 0031869119 scopus 로고    scopus 로고
    • Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation
    • 10.1093/carcin/19.4.597 10.1093/carcin/19.4.597 1:CAS:528: DyaK1cXjtVGgsbc%3D
    • Fiala ES, Staretz ME, Pandya GA, El-Bayoumy K, Hamilton SR (1998) Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation. Carcinogenesis 19(4):597-604. doi: 10.1093/carcin/19.4.597
    • (1998) Carcinogenesis , vol.19 , Issue.4 , pp. 597-604
    • Fiala, E.S.1    Staretz, M.E.2    Pandya, G.A.3    El-Bayoumy, K.4    Hamilton, S.R.5
  • 28
    • 0343953594 scopus 로고    scopus 로고
    • Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia
    • 1:CAS:528:DyaK1cXht1antL8%3D
    • Myohanen SK, Baylin SB, Herman JG (1998) Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia. Cancer Res 58(4):591-593
    • (1998) Cancer Res , vol.58 , Issue.4 , pp. 591-593
    • Myohanen, S.K.1    Baylin, S.B.2    Herman, J.G.3
  • 30
    • 0030825309 scopus 로고    scopus 로고
    • COBRA: A sensitive and quantitative DNA methylation assay
    • 10.1093/nar/25.12.2532 10.1093/nar/25.12.2532 1:CAS:528: DyaK2sXktlSrsbo%3D
    • Xiong Z, Laird PW (1997) COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res 25(12):2532-2534. doi: 10.1093/nar/25.12. 2532
    • (1997) Nucleic Acids Res , vol.25 , Issue.12 , pp. 2532-2534
    • Xiong, Z.1    Laird, P.W.2
  • 32
    • 39149091066 scopus 로고    scopus 로고
    • Environment, diet and CpG island methylation: Epigenetic signals in gastrointestinal neoplasia
    • 10.1016/j.fct.2007.09.101 1:CAS:528:DC%2BD1cXitlOitr0%3D
    • Johnson IT, Belshaw NJ (2008) Environment, diet and CpG island methylation: epigenetic signals in gastrointestinal neoplasia. Food Chem Toxicol 46(4):1346-1359
    • (2008) Food Chem Toxicol , vol.46 , Issue.4 , pp. 1346-1359
    • Johnson, I.T.1    Belshaw, N.J.2
  • 33
    • 79959742774 scopus 로고    scopus 로고
    • Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells
    • doi: 10.1002/mnfr.201000547
    • Clarke JD, Hsu A, Yu Z, Dashwood RH, Ho E (2011) Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res. doi: 10.1002/mnfr.201000547
    • (2011) Mol Nutr Food Res.
    • Clarke, J.D.1    Hsu, A.2    Yu, Z.3    Dashwood, R.H.4    Ho, E.5
  • 34
    • 4143130097 scopus 로고    scopus 로고
    • A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase
    • 10.1158/0008-5472.can-04-1326 10.1158/0008-5472.CAN-04-1326 1:CAS:528:DC%2BD2cXmslaksr0%3D
    • Myzak MC, Karplus PA, Chung F-L, Dashwood RH (2004) A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res 64(16):5767-5774. doi: 10.1158/0008-5472.can-04-1326
    • (2004) Cancer Res , vol.64 , Issue.16 , pp. 5767-5774
    • Myzak, M.C.1    Karplus, P.A.2    Chung, F.-L.3    Dashwood, R.H.4
  • 35
    • 78649351179 scopus 로고    scopus 로고
    • Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin
    • 10.1186/1756-8722-3-48 10.1186/1756-8722-3-48 1:CAS:528: DC%2BC3cXhsFagtrvJ
    • Jiang S, Ma X, Huang Y, Xu Y, Zheng R, Chiao JW (2010) Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin. J Hematol Oncol 3:48. doi: 10.1186/1756-8722-3-48
    • (2010) J Hematol Oncol , vol.3 , pp. 48
    • Jiang, S.1    Ma, X.2    Huang, Y.3    Xu, Y.4    Zheng, R.5    Chiao, J.W.6
  • 36
    • 56049083256 scopus 로고    scopus 로고
    • Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells
    • 10.1093/carcin/bgn179 10.1093/carcin/bgn179 1:CAS:528:DC%2BD1cXhtlalsLfN
    • Xiang N, Zhao R, Song G, Zhong W (2008) Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. Carcinogenesis 29(11):2175-2181. doi: 10.1093/carcin/bgn179
    • (2008) Carcinogenesis , vol.29 , Issue.11 , pp. 2175-2181
    • Xiang, N.1    Zhao, R.2    Song, G.3    Zhong, W.4
  • 38
    • 0033563083 scopus 로고    scopus 로고
    • CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression
    • 1:CAS:528:DyaK1MXjsVygt7k%3D
    • Eads CA, Danenberg KD, Kawakami K, Saltz LB, Danenberg PV, Laird PW (1999) CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res 59(10):2302-2306
    • (1999) Cancer Res , vol.59 , Issue.10 , pp. 2302-2306
    • Eads, C.A.1    Danenberg, K.D.2    Kawakami, K.3    Saltz, L.B.4    Danenberg, P.V.5    Laird, P.W.6
  • 39
    • 0035231405 scopus 로고    scopus 로고
    • Regulation of the DNA methylation machinery and its role in cellular transformation
    • 10.1016/S0079-6603(01)69044-5 1:CAS:528:DC%2BD3MXntFGltbc%3D
    • Szyf M, Detich N (2001) Regulation of the DNA methylation machinery and its role in cellular transformation. Prog Nucleic Acid Res Mol Biol 69:47-79
    • (2001) Prog Nucleic Acid Res Mol Biol , vol.69 , pp. 47-79
    • Szyf, M.1    Detich, N.2
  • 40
    • 0025880514 scopus 로고
    • Growth regulation of mouse DNA methyltransferase gene expression
    • 1:CAS:528:DyaK3MXksVaitLo%3D
    • Szyf M, Bozovic V, Tanigawa G (1991) Growth regulation of mouse DNA methyltransferase gene expression. J Biol Chem 266(16):10027-10030
    • (1991) J Biol Chem , vol.266 , Issue.16 , pp. 10027-10030
    • Szyf, M.1    Bozovic, V.2    Tanigawa, G.3
  • 41
    • 7944237475 scopus 로고    scopus 로고
    • Dietary isothiocyanates inhibit Caco-2 Cell proliferation and induce G2/M phase cell cycle arrest, DNA damage, and G2/M checkpoint activation
    • 1:CAS:528:DC%2BD2cXhtVSnsbbK
    • Visanji JM, Duthie SJ, Pirie L, Thompson DG, Padfield PJ (2004) Dietary isothiocyanates inhibit Caco-2 Cell proliferation and induce G2/M phase cell cycle arrest, DNA damage, and G2/M checkpoint activation. J Nutr 134(11):3121-3126
    • (2004) J Nutr , vol.134 , Issue.11 , pp. 3121-3126
    • Visanji, J.M.1    Duthie, S.J.2    Pirie, L.3    Thompson, D.G.4    Padfield, P.J.5
  • 42
    • 36749004377 scopus 로고    scopus 로고
    • Selenium as an anticancer nutrient: Roles in cell proliferation and tumor cell invasion
    • 10.1016/j.jnutbio.2007.02.005
    • Zeng H, Combs GF Jr (2008) Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion. J Nutr Biochem 19(1):1-7
    • (2008) J Nutr Biochem , vol.19 , Issue.1 , pp. 1-7
    • Zeng, H.1    Combs, Jr.G.F.2
  • 43
    • 34548388292 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase i protein and maintains DNA methylation
    • 10.1016/j.cellsig.2007.06.014 1:CAS:528:DC%2BD2sXhtVWmtb3F
    • Sun L, Zhao H, Xu Z, Liu Q, Liang Y, Wang L, Cai X, Zhang L, Hu L, Wang G, Zha X (2007) Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation. Cell Signal 19(11):2255-2263
    • (2007) Cell Signal , vol.19 , Issue.11 , pp. 2255-2263
    • Sun, L.1    Zhao, H.2    Xu, Z.3    Liu, Q.4    Liang, Y.5    Wang, L.6    Cai, X.7    Zhang, L.8    Hu, L.9    Wang, G.10    Zha, X.11
  • 44
    • 0034658196 scopus 로고    scopus 로고
    • Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells
    • 10.1093/nar/28.10.2108 10.1093/nar/28.10.2108 1:CAS:528: DC%2BD3cXktFSrurY%3D
    • Robertson KD, Keyomarsi K, Gonzales FA, Velicescu M, Jones PA (2000) Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells. Nucleic Acids Res 28(10):2108-2113. doi: 10.1093/nar/28.10.2108
    • (2000) Nucleic Acids Res , vol.28 , Issue.10 , pp. 2108-2113
    • Robertson, K.D.1    Keyomarsi, K.2    Gonzales, F.A.3    Velicescu, M.4    Jones, P.A.5
  • 45
    • 0035127794 scopus 로고    scopus 로고
    • Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis
    • doi: 10.1053/jhep.2001.22507
    • Saito Y, Kanai Y, Sakamoto M, Saito H, Ishii H, Hirohashi S (2001) Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology 33(3):561-568. doi: 10.1053/jhep.2001.22507
    • (2001) Hepatology , vol.33 , Issue.3 , pp. 561-568
    • Saito, Y.1    Kanai, Y.2    Sakamoto, M.3    Saito, H.4    Ishii, H.5    Hirohashi, S.6
  • 46
    • 0037598752 scopus 로고    scopus 로고
    • Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas
    • 10.1002/ijc.11127 10.1002/ijc.11127 1:CAS:528:DC%2BD3sXktlOqsb8%3D
    • Saito Y, Kanai Y, Nakagawa T, Sakamoto M, Saito H, Ishii H, Hirohashi S (2003) Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. Int J Cancer 105(4):527-532. doi: 10.1002/ijc.11127
    • (2003) Int J Cancer , vol.105 , Issue.4 , pp. 527-532
    • Saito, Y.1    Kanai, Y.2    Nakagawa, T.3    Sakamoto, M.4    Saito, H.5    Ishii, H.6    Hirohashi, S.7
  • 47
    • 79960036643 scopus 로고    scopus 로고
    • MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1
    • 10.1093/carcin/bgr081 10.1093/carcin/bgr081 1:CAS:528: DC%2BC3MXosVOlsbY%3D
    • Wang H, Wu J, Meng X, Ying X, Zuo Y, Liu R, Pan Z, Kang T, Huang W (2011) MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1. Carcinogenesis 32(7):1033-1042. doi: 10.1093/carcin/bgr081
    • (2011) Carcinogenesis , vol.32 , Issue.7 , pp. 1033-1042
    • Wang, H.1    Wu, J.2    Meng, X.3    Ying, X.4    Zuo, Y.5    Liu, R.6    Pan, Z.7    Kang, T.8    Huang, W.9
  • 49
    • 0021918938 scopus 로고
    • Selenite: A good inhibitor of rat-liver DNA methylase
    • 1:CAS:528:DyaL2MXptF2qtQ%3D%3D
    • Cox R (1985) Selenite: a good inhibitor of rat-liver DNA methylase. Biochem Int 10(1):63-69
    • (1985) Biochem Int , vol.10 , Issue.1 , pp. 63-69
    • Cox, R.1
  • 50
    • 0022962063 scopus 로고
    • A study of the mechanism of selenite-induced hypomethylated DNA and differentiation of friend erythroleukemic cells
    • 10.1093/carcin/7.12.2015 10.1093/carcin/7.12.2015 1:CAS:528: DyaL2sXkvFCgs7Y%3D
    • Cox R, Goorha S (1986) A study of the mechanism of selenite-induced hypomethylated DNA and differentiation of friend erythroleukemic cells. Carcinogenesis 7(12):2015-2018. doi: 10.1093/carcin/7.12.2015
    • (1986) Carcinogenesis , vol.7 , Issue.12 , pp. 2015-2018
    • Cox, R.1    Goorha, S.2
  • 51
    • 2642574054 scopus 로고    scopus 로고
    • CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1
    • 10.1038/ng1365 10.1038/ng1365 1:CAS:528:DC%2BD2cXksVajt7Y%3D
    • Ting AH, Jair KW, Suzuki H, Yen RW, Baylin SB, Schuebel KE (2004) CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1. Nat Genet 36(6):582-584. doi: 10.1038/ng1365
    • (2004) Nat Genet , vol.36 , Issue.6 , pp. 582-584
    • Ting, A.H.1    Jair, K.W.2    Suzuki, H.3    Yen, R.W.4    Baylin, S.B.5    Schuebel, K.E.6
  • 52
    • 70350046301 scopus 로고    scopus 로고
    • Rethinking how DNA methylation patterns are maintained
    • 10.1038/nrg2651 1:CAS:528:DC%2BD1MXht1KrtbrK
    • Jones PA, Liang G (2009) Rethinking how DNA methylation patterns are maintained. Nat Rev Genet 10(11):805-811
    • (2009) Nat Rev Genet , vol.10 , Issue.11 , pp. 805-811
    • Jones, P.A.1    Liang, G.2
  • 53
    • 33751101893 scopus 로고    scopus 로고
    • Global DNA and p53 region-specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation
    • 1:CAS:528:DC%2BD28XhtFGqtLbO
    • Wasson GR, McGlynn AP, McNulty H, O'Reilly SL, McKelvey-Martin VJ, McKerr G, Strain JJ, Scott J, Downes CS (2006) Global DNA and p53 region-specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation. J Nutr 136(11):2748-2753
    • (2006) J Nutr , vol.136 , Issue.11 , pp. 2748-2753
    • Wasson, G.R.1    McGlynn, A.P.2    McNulty, H.3    O'Reilly, S.L.4    McKelvey-Martin, V.J.5    McKerr, G.6    Strain, J.J.7    Scott, J.8    Downes, C.S.9
  • 54
    • 0033635671 scopus 로고    scopus 로고
    • Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells
    • 10.1207/S15327914NC372-18 1:CAS:528:DC%2BD3MXhtlOjtA%3D%3D
    • Duthie SJ, Narayanan S, Blum S, Pirie L, Brand GM (2000) Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutr Cancer 37(2):245-251
    • (2000) Nutr Cancer , vol.37 , Issue.2 , pp. 245-251
    • Duthie, S.J.1    Narayanan, S.2    Blum, S.3    Pirie, L.4    Brand, G.M.5
  • 56
    • 79957731140 scopus 로고    scopus 로고
    • The selenium content of cell culture serum influences redox-regulated gene expression
    • 10.2144/000113666 1:CAS:528:DC%2BC3MXntVGjsL8%3D
    • Karlenius TC, Shah F, Yu WC, Hawkes HJ, Tinggi U, Clarke FM, Tonissen KF (2011) The selenium content of cell culture serum influences redox-regulated gene expression. Biotechniques 50(5):295-301. doi: 10.2144/000113666
    • (2011) Biotechniques , vol.50 , Issue.5 , pp. 295-301
    • Karlenius, T.C.1    Shah, F.2    Yu, W.C.3    Hawkes, H.J.4    Tinggi, U.5    Clarke, F.M.6    Tonissen, K.F.7
  • 57
    • 78651289917 scopus 로고    scopus 로고
    • Global DNA methylation measurement by HPLC using low amounts of DNA
    • 10.1002/biot.201000267 10.1002/biot.201000267 1:CAS:528: DC%2BC3MXjsVOnsg%3D%3D
    • Armstrong KM, Bermingham EN, Bassett SA, Treloar BP, Roy NC, Barnett MP (2011) Global DNA methylation measurement by HPLC using low amounts of DNA. Biotechnol J 6(1):113-117. doi: 10.1002/biot.201000267
    • (2011) Biotechnol J , vol.6 , Issue.1 , pp. 113-117
    • Armstrong, K.M.1    Bermingham, E.N.2    Bassett, S.A.3    Treloar, B.P.4    Roy, N.C.5    Barnett, M.P.6
  • 58
    • 79959542741 scopus 로고    scopus 로고
    • The von Hippel-Lindau (VHL) tumor-suppressor gene is down-regulated by selenium deficiency in Caco-2 cells and rat colon mucosa
    • doi: 10.1007/s12011-010-8764-4
    • Uthus E, Begaye A, Ross S, Zeng H (2010) The von Hippel-Lindau (VHL) tumor-suppressor gene is down-regulated by selenium deficiency in Caco-2 cells and rat colon mucosa. Biol Trace Elem Res:1-9. doi: 10.1007/s12011-010-8764-4
    • (2010) Biol Trace Elem Res , pp. 1-9
    • Uthus, E.1    Begaye, A.2    Ross, S.3    Zeng, H.4
  • 59
    • 0029815819 scopus 로고    scopus 로고
    • Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate
    • 1:CAS:528:DyaK28XmsFOmtLc%3D
    • Kim YI, Pogribny IP, Salomon RN, Choi SW, Smith DE, James SJ, Mason JB (1996) Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate. Am J Pathol 149(4):1129-1137
    • (1996) Am J Pathol , vol.149 , Issue.4 , pp. 1129-1137
    • Kim, Y.I.1    Pogribny, I.P.2    Salomon, R.N.3    Choi, S.W.4    Smith, D.E.5    James, S.J.6    Mason, J.B.7
  • 60
    • 0031022797 scopus 로고    scopus 로고
    • Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene
    • 1:CAS:528:DyaK2sXjsFSjtg%3D%3D
    • Kim YI, Pogribny IP, Basnakian AG, Miller JW, Selhub J, James SJ, Mason JB (1997) Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am J Clin Nutr 65(1):46-52
    • (1997) Am J Clin Nutr , vol.65 , Issue.1 , pp. 46-52
    • Kim, Y.I.1    Pogribny, I.P.2    Basnakian, A.G.3    Miller, J.W.4    Selhub, J.5    James, S.J.6    Mason, J.B.7
  • 61
    • 77955352742 scopus 로고    scopus 로고
    • Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines
    • 10.1371/journal.pone.0011457 10.1371/journal.pone.0011457
    • Meeran SM, Patel SN, Tollefsbol TO (2010) Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS ONE 5(7):e11457. doi: 10.1371/journal.pone.0011457
    • (2010) PLoS ONE , vol.5 , Issue.7 , pp. 11457
    • Meeran, S.M.1    Patel, S.N.2    Tollefsbol, T.O.3
  • 62
    • 84862292886 scopus 로고    scopus 로고
    • The impact of nutrition on differential methylated regions of the genome
    • 10.3945/an.111.001008 10.3945/an.111.001008 1:CAS:528:DC%2BC3MXhs1CrtrbP
    • Parle-McDermott A, Ozaki M (2011) The impact of nutrition on differential methylated regions of the genome. Adv Nutr Int Rev J 2(6):463-471. doi: 10.3945/an.111.001008
    • (2011) Adv Nutr Int Rev J , vol.2 , Issue.6 , pp. 463-471
    • Parle-Mcdermott, A.1    Ozaki, M.2
  • 63
    • 30744479491 scopus 로고    scopus 로고
    • Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains
    • 10.1096/fj.05-4707com 10.1096/fj.05-4707com 1:CAS:528: DC%2BD28XislSntA%3D%3D
    • Niculescu MD, Craciunescu CN, Zeisel SH (2006) Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB J 20(1):43-49. doi: 10.1096/fj.05-4707com
    • (2006) FASEB J , vol.20 , Issue.1 , pp. 43-49
    • Niculescu, M.D.1    Craciunescu, C.N.2    Zeisel, S.H.3
  • 64
    • 0035057219 scopus 로고    scopus 로고
    • Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2′-deoxycytidine
    • 1:CAS:528:DC%2BD3MXisVSqsro%3D
    • Karpf AR, Moore BC, Ririe TO, Jones DA (2001) Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2′-deoxycytidine. Mol Pharmacol 59(4):751-757
    • (2001) Mol Pharmacol , vol.59 , Issue.4 , pp. 751-757
    • Karpf, A.R.1    Moore, B.C.2    Ririe, T.O.3    Jones, D.A.4
  • 65
    • 60249094793 scopus 로고    scopus 로고
    • Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines
    • 10.1182/blood-2008-02-140038 10.1182/blood-2008-02-140038 1:CAS:528:DC%2BD1MXht1Wnsb8%3D
    • Qin T, Jelinek J, Si J, Shu J, Issa JP (2009) Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines. Blood 113(3):659-667. doi: 10.1182/blood-2008-02-140038
    • (2009) Blood , vol.113 , Issue.3 , pp. 659-667
    • Qin, T.1    Jelinek, J.2    Si, J.3    Shu, J.4    Issa, J.P.5
  • 66
    • 27244461109 scopus 로고    scopus 로고
    • Array-based analysis of genomic DNA methylation patterns of the tumour suppressor gene p16INK4A promoter in colon carcinoma cell lines
    • 10.1093/nar/gni072 10.1093/nar/gni072
    • Mund C, Beier V, Bewerunge P, Dahms M, Lyko F, Hoheisel JD (2005) Array-based analysis of genomic DNA methylation patterns of the tumour suppressor gene p16INK4A promoter in colon carcinoma cell lines. Nucleic Acids Res 33(8):e73. doi: 10.1093/nar/gni072
    • (2005) Nucleic Acids Res , vol.33 , Issue.8 , pp. 73
    • Mund, C.1    Beier, V.2    Bewerunge, P.3    Dahms, M.4    Lyko, F.5    Hoheisel, J.D.6


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