Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine: Modulation by dietary folate

American Journal of Pathology

Volumn 149, Issue 4, 1996, Pages 1129-1137

  Kim, Young In ^a,b,d   Pogribny, Igor P ^c   Salomon, Robert N ^a,b   Choi, Sang Woon ^a   Smith, Donald E ^a   James, S Jill ^b   Mason, Joel B ^a,b  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; DIMETHYLHYDRAZINE; FOLIC ACID;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DNA METHYLATION; FOLATE METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR SUPPRESSOR GENE; VITAMIN INTAKE;

ANIMALS; COLON; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; DNA METHYLATION; EXONS; FOLIC ACID; GENES, P53; MALE; MONOMETHYLHYDRAZINE; PRECANCEROUS CONDITIONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0029815819     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Lashner BA, Heidenreich PA, Su GL, Kane SV, Hanauer SB: Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. Gastroenterology 1989, 97:255-259
2. Lashner BA: Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis. J Cancer Res Clin Oncol 1993, 119:549-554
3. Benito E, Stiggelbout A, Bosch FX, Obrador A, Kaldor J, Mulet M, Munoz N: Nutritional factors in colorectal cancer risk: a case-control study in Majorca. Int J Cancer 1991, 49:161-167
4. Benito E, Cabeza E, Moreno V, Obrador A, Bosch FX: Diet and colorectal adenomas: a case-control study in Majorca. Int J Cancer 1993, 55:213-219
5. Freudenheim JL, Graham S, Marshall JR, Haughey BP, Cholewinski S, Wilkinson G: Folate intake and carcinogenesis of the colon and rectum. Int J Epidemiol 1991, 20:368-374
6. Meyer F, White E: Alcohol and nutrients in relation to colon cancer in middle-aged adults. Am J Epidemiol 1993, 138:225-236
7. Giovannucci E, Stampfer MJ, Colditz GA, Rimm EB, Trichopoulos D, Rosner BA, Speizer FE, Willett WC: Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 1993, 85:875-883
8. Ferraroni M, La Vecchia C, D'Avanzo B, Negri E, Franceschi S, Decarli A: Selected micronutrient intake and the risk of colorectal cancer. Br J Cancer 1994, 70:1150-1155
9. Bird CL, Swendseid ME, White JS, Shikany JM, Hunt IF, Frankl HD, Lee ER, Longnecker MP, Haile RW: Red cell and plasma folate, folate consumption, and the risk of colorectal adenomatous polyps. Cancer Epidemiol Biomarkers Prev 1995, 4:709-714
10. Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Willet WC: Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst 1995, 87:265-273
11. Paspatis GA, Kalafatis E, Oros L, Xourgias V, Koutsioumpa P, Karamanolis DG: Folate status and adenomatous polyps: a colonoscopically controlled study. Dis Colon Rectum 1995, 38:64-68
12. Cravo ML, Mason JB, Dayal Y, Hutchinson M, Smith D, Selhub J, Rosenberg IH: Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats. Cancer Res 1992, 52:5002-5006
13. Kim YI, Salomon RN, Graeme-Cook F, Choi SW, Smith DE, Dallai GE, Mason JB: Dietary folate protects against the development of macroscopic colonic neoplasmia in a dose-responsive manner in rats. Gut 1996 (in press)
14. Kim YI, Mason JB: Folate, epithelial dysplasia and colon cancer. Proc Assoc Am Phys 1995, 107:218-227
15. Selhub J, Miller JW: The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 1992, 55:131-138
16. Razin A, Szyf M: DNA methylation patterns: formation and function. Biochim Biophys Acta 1984, 782:331-342
17. Laird PW, Jaenisch R: DNA methylation and cancer. Hum Mol Genet 1994, 3:1487-1495
18. Fearon ER, Jones PA: Progressing toward a molecular description of colorectal cancer development. FASEB J 1992, 6:2783-2390
19. Feinberg AP, Gehrke CW, Kuo KC, Ehrlich M: Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res 1988, 48:1159-1161
20. Goelz SE, Vogelstein B: Hypomethylation of DNA from benign and malignant human colonic neoplasm. Science 1985, 228:187-190
21. Feinberg AP, Vogelstein B: Hypomethylation distinguishes gene of some human cancers from their normal counterparts. Nature 1983, 301:89-91
22. Feinberg AP, Vogelstein B: Hypomethylation of ras oncogenes in primary human cancers. Biochem Biophys Res Commun 1983, 111:47-54
23. Cheah MSC, Wallace CD, Hoffman RM: Hypomethylation of DNA in human cancer cells: a site-specific change in the c-myc oncogene. J Natl Cancer Inst 1984, 73:1057-1061
24. Sharrard RM, Royds JA, Rogers S, Shorthouse AJ: Patterns of methylation of the c-myc gene in human colorectal cancer progression. Br J Cancer 1992, 65:667-672
25. Adany R, Iozzo RV: Hypomethylation of the decorin proteoglycan gene in human colon cancer. Biochem J 1991, 276:301-306
26. Adany R, Heimer R, Caterson B, Sorrell JM, Iozzo RV: Altered expression of chondroitin sulfate proteoglycan in the stroma of human colon carcinoma. J Biol Chem 1990, 265:11389-11396
27. Balaghi M, Wagner C: DNA methylation in folate deficiency: use of CpG methylase. Biochem Biophys Res Commun 1993, 193:1184-1190
28. Kim YI, Christman JK, Fleet JC, Cravo ML, Salomon RN, Smith D, Ordovas J, Selhub J, Mason JB: Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc specific hypomethylation of colonic DNA in rats. Am J Clin Nutr 1995, 61:1083-1090
29. Cravo M, Fidalgo P, Pereira AD, Gouveia-Oliveira A, Chaves P, Selhub J, Mason JB, Mira FC, Leitao CN: DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation. Eur J Cancer Prev 1994, 3:473-479
30. 6-methylguanine by alkylation of rat liver, colon, and kidney DNA following administration of 1,2-dimethylhydrazine. Cancer Res 1977, 37:4082-4087
31. Rogers AE, Nauss KM: Rodent models for carcinoma of the colon. Dig Dis Sci 1985, 30:87S-102S
32. Boehm TLJ, Drahovsky D: Hypomethylation of DNA in Raji cells after treatment with N-methyl-N-nitrosourea. Carcinogenesis 1981, 2:39-42
33. Wilson VL, Jones PA: Chemical carcinogen-mediated decreases in DNA 5-methylcytosine content of BALB/ 3T3 cells. Carcinogenesis 1984, 5:1027-1031
34. Cox R: DNA methylase inhibition in vitro by N-methyl-N'-nitro-N-nitrosoguanidine. Cancer Res 1980, 40: 61-63
35. 6-methylguanine residues. J Biol Chem 1991, 266:7985-7987
36. Weitzman SA, Turk PW, Milkowski DH, Kozlowski K: Free radical adducts induce alterations in DNA cytosine methylation. Proc Natl Acad Sci USA 1994, 91: 1261-1264
37. Bolden A, Ward C, Siedlecki JA, Weissbach A: DNA methylation: inhibition of de novo and maintenance methylation in vitro by RNA and synthetic polynucleotides. J Biol Chem 1984, 259:12437-12443
38. Hollsteir M, Sidransky D, Vogelstein B, Harris CC: p53 mutations in human cancers. Science 1991, 253:49-53
39. Walzem RL, Clifford AJ: Folate deficiency in rats fed diets containing free amino acids or intact proteins. J Nutr 1988, 118:1089-1096
40. American Institute of Nutrition: Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J Nutr 1977, 107:1340-1348
41. Reeves PG, Nielsen FH, Fahey GC Jr: AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993, 123:1939-1951
42. Martin MS, Martin F, Michiels R, Bastien H, Justrabo E, Borders M, Viry B: An experimental model for cancer of the colon and rectum. Digestion 1973, 8:22-34
43. Filipe MI: Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine: a morphological and histochemical study. Br J Cancer 1975, 32:60-77
44. Riddell RH, Goldman H, Ransohoff DF, Appelman HD, Fenoglio CM, Haggitt RC, Ahren C, Correa P, Hamilton SR, Morson BC, Sommers SC, Yardley JH: Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol 1983, 14:931-968
45. Tamura T: Microbiological assay of folate. Folic Acid Metabolism in Health and Disease. Edited by MF Picciano, ELR Stokstad, JF Gregory, New York, Wiley-Liss, 1990, pp 121-137
46. Wilson SD, Home DW: Use of glycerol-protected Lactobacillus casei for microbiological assay of folic acid. Clin Chem 1982, 28:1198-1200
47. Kim YI, Giuliano A, Hatch KD, Schneider A, Nour MA, Dallal GE, Selhub J, Mason JB: Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma. Cancer 1994, 74:893-899
48. Singer-Sam J, LeBon JM, Tanguay RL, Riggs AD: A quantitative Hpall-PCR assay to measure methylation of DNA from a small number of cells. Nucleic Acids Res 1990, 18:687
49. Singer-Sam J, Grant M, LeBon JM, Okuyama K, Chapman V, Monk M, Riggs AD: Use of a Hpall-polymerase chain reaction assay to study DNA methylation in the Pgk-1 CpG island of mouse embryos at the time of X-chromosome inactivation. Mol Cell Biol 1990, 10: 4987-4989
50. Magewu AN, Jones PA: Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer. Mol Cell Biol 1994, 14:4225-4232
51. Pogribny IP, Basnakian AG, Miller BJ, Lopatina NG, Poirier LA, James SJ: Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl deficient rats. Cancer Res 1995, 55:1894-1901
52. Nelson M, McClelland M: Site-specific methylation: effect on DNA modification methyltransferases and restriction endonucleases. Nucleic Acids Res 1991, 19: 2045-2071
53. Hulla JE, Schneider RP: Structure of the rat p53 tumor suppressor gene. Nucleic Acids Res 1993, 2:713-717
54. Kim YI, Pogribny IP, Basnakian AG, Miller JW, Selhub J, James SJ, Mason JB: Folate deficiency in rat induces DNA strand breaks and hypomethylation with the p53 tumor suppression gene. Am J Clin Nutr 1996 (in press)
55. Razin A, Cedar H: DNA methylation and gene expression. Microbiol Rev 1991, 55:451-458
56. Weissbach A, Ward C, Bolden A: Eukaryotic DNA methylation and gene expression. Curr Top Cell Regul 30:1-21
57. Keshet I, Leiman-Hurwitz J, Cedar H: DNA methylation affects the formation of active chromatin. Cell 1986, 44:535-543
58. Antequera F, Boyes J, Bird A: High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell 1990, 62:503-514
59. Antequera F, Macleod D, Bird AP: Specific protection of methylated CpGs in mammalian nuclei. Cell 1989, 58:509-517
60. Rideout WM III, Coetzee GA, Olumi AF, Jones PA: 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 gene. Science 1990, 249:1288-1290
61. Jones PA, Rideout WM III, Shen J-C, Spruck CH, Tsai YC: Methylation, mutation and cancer. Bioessays 1992, 14:33-36