TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1823, Issue 10, 2012, Pages 1914-1924

  Barrera, Lawrence N ^a,b   Cassidy, Aedin ^a   Wang, Wei ^a   Wei, Taotao ^c   Belshaw, Nigel J ^b   Johnson, Ian T ^b   Brigelius Flohé, Regina ^d   Bao, Yongping ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^c INSTITUTE OF BIOPHYSICS   (China)

^d GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

Author keywords

Colon cancer; Gastrointestinal glutathione peroxidase; Isothiocyanate; Nrf2; Selenium; Thioredoxin reductase

Indexed keywords

FREE RADICAL; GLUTATHIONE PEROXIDASE 2; HYDROGEN PEROXIDE; IBERIN; ISOTHIOCYANIC ACID DERIVATIVE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SE METHYLSELENOCYSTEINE; SELENIUM; SELENOPROTEIN; SODIUM SELENITE; SULFORAPHANE; THIOREDOXIN REDUCTASE 1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CELL PROTECTION; CELL STRAIN CACO 2; CELL SURVIVAL; CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

CACO-2 CELLS; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CYTOPROTECTION; DIETARY SUPPLEMENTS; ENZYME INDUCTION; FREE RADICALS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GLUTATHIONE PEROXIDASE; HUMANS; HYDROGEN PEROXIDE; IMMUNOBLOTTING; ISOTHIOCYANATES; NF-E2-RELATED FACTOR 2; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; RNA, SMALL INTERFERING; SELENIUM; SUBCELLULAR FRACTIONS; THIOREDOXIN REDUCTASE 1; TIME FACTORS; UP-REGULATION;

EID: 84864803153     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2012.07.007     Document Type: Article

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